{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8K097","secondaryAccessions":["Q3TY22","Q8K1F6","Q9D6K4"],"uniProtkbId":"LFG2_MOUSE","entryAudit":{"firstPublicDate":"2003-11-21","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2002-10-01","entryVersion":158,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein lifeguard 2"}},"alternativeNames":[{"fullName":{"value":"Fas apoptotic inhibitory molecule 2"}},{"fullName":{"value":"Neural membrane protein 35"}}]},"genes":[{"geneName":{"value":"Faim2"},"synonyms":[{"value":"Kiaa0950"},{"value":"Lfg"},{"value":"Lfg2"},{"value":"Nmp35"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17635665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21209208"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21957071"}],"value":"Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Interacts with FAS/TNFRSF6 and BAX"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17635665"}],"value":"Membrane raft","id":"SL-0370"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Postsynaptic cell membrane","id":"SL-0219"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"Long"},{"value":"LFG-L"}],"isoformIds":["Q8K097-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"Short"},{"value":"LFG-S"}],"isoformIds":["Q8K097-2"],"sequenceIds":["VSP_008994"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17635665"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21957071"}],"value":"Brain. Highly expressed in cerebellum, also found in cortex, olfactory bulb, and hippocampus"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21957071"}],"value":"Mice show reduced cerebellar size and internal granular layer (IGL) thickness in early developmental stages, delayed Purkinje Cell (PC) development, with an abnormal morphology and reduced cellular density, increased caspase-8 and caspase-3 activity in PCs and higher sensitivity to Fas-mediated apoptosis"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the BI1 family. LFG subfamily"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC98056.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":317,"modifier":"EXACT"}},"description":"Protein lifeguard 2","featureId":"PRO_0000179088"},{"type":"Transmembrane","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":195,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":226,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":252,"modifier":"EXACT"},"end":{"value":272,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":291,"modifier":"EXACT"},"end":{"value":311,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":54,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Glycosylation","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Alternative sequence","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":84,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_008994","alternativeSequence":{"originalSequence":"SGSSGYEGGFPAG","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in Ref. 2; BAC98056","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":312,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"in Ref. 1; AAM46781","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0053","category":"Biological process","name":"Apoptosis"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0628","category":"Cellular component","name":"Postsynaptic cell membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-4U49BOKSR66BO","citationType":"submission","authors":["Sole C.","Segura M.F.","Bayascas J.R.","Comella J.X."],"title":"Cloning and characterization of the long form of mouse lifeguard (LFG-L), an anti Fas-apoptotic molecule.","publicationDate":"JAN-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"12693553","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Aizawa H.","Yuasa S.","Nakajima D.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"12693553"},{"database":"DOI","id":"10.1093/dnares/10.1.35"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"35","lastPage":"48","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Hippocampus","type":"TISSUE"},{"value":"Visual cortex","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Retina","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17635665","citationType":"journal article","authors":["Fernandez M.","Segura M.F.","Sole C.","Colino A.","Comella J.X.","Cena V."],"citationCrossReferences":[{"database":"PubMed","id":"17635665"},{"database":"DOI","id":"10.1111/j.1471-4159.2007.04767.x"}],"title":"Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment.","publicationDate":"2007","journal":"J. Neurochem.","firstPage":"190","lastPage":"203","volume":"103"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":6,"citation":{"id":"19784873","citationType":"journal article","authors":["Hu L.","Smith T.F.","Goldberger G."],"citationCrossReferences":[{"database":"PubMed","id":"19784873"},{"database":"DOI","id":"10.1007/s10495-009-0402-2"}],"title":"LFG: a candidate apoptosis regulatory gene family.","publicationDate":"2009","journal":"Apoptosis","firstPage":"1255","lastPage":"1265","volume":"14"},"referencePositions":["GENE FAMILY","NOMENCLATURE"]},{"referenceNumber":7,"citation":{"id":"21209208","citationType":"journal article","authors":["Reich A.","Spering C.","Gertz K.","Harms C.","Gerhardt E.","Kronenberg G.","Nave K.A.","Schwab M.","Tauber S.C.","Drinkut A.","Harms K.","Beier C.P.","Voigt A.","Goebbels S.","Endres M.","Schulz J.B."],"citationCrossReferences":[{"database":"PubMed","id":"21209208"},{"database":"DOI","id":"10.1523/jneurosci.2188-10.2011"}],"title":"Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia.","publicationDate":"2011","journal":"J. Neurosci.","firstPage":"225","lastPage":"233","volume":"31"},"referencePositions":["FUNCTION"]},{"referenceNumber":8,"citation":{"id":"21957071","citationType":"journal article","authors":["Hurtado de Mendoza T.","Perez-Garcia C.G.","Kroll T.T.","Hoong N.H.","O'Leary D.D.","Verma I.M."],"citationCrossReferences":[{"database":"PubMed","id":"21957071"},{"database":"DOI","id":"10.1073/pnas.1114226108"}],"title":"Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells.","publicationDate":"2011","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17189","lastPage":"17194","volume":"108"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF468028","properties":[{"key":"ProteinId","value":"AAM46781.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK013476","properties":[{"key":"ProteinId","value":"BAB28874.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK030513","properties":[{"key":"ProteinId","value":"BAC26999.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK129246","properties":[{"key":"ProteinId","value":"BAC98056.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK158960","properties":[{"key":"ProteinId","value":"BAE34742.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC032278","properties":[{"key":"ProteinId","value":"AAH32278.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS37203.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8K097-1"},{"database":"CCDS","id":"CCDS88840.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8K097-2"},{"database":"RefSeq","id":"NP_001033747.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001038658.2"}],"isoformId":"Q8K097-2"},{"database":"RefSeq","id":"NP_082500.2","properties":[{"key":"NucleotideSequenceId","value":"NM_028224.4"}],"isoformId":"Q8K097-1"},{"database":"RefSeq","id":"XP_006521512.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006521449.5"}],"isoformId":"Q8K097-1"},{"database":"AlphaFoldDB","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"215353","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"Q8K097","properties":[{"key":"Number of interactors","value":"69"}]},{"database":"STRING","id":"10090.ENSMUSP00000023750","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q8K097","properties":[{"key":"glycosylation","value":"1 site, No reported glycans"}]},{"database":"GlyGen","id":"Q8K097","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000023750","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"291940","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8K097-1"},{"database":"ProteomicsDB","id":"291941","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8K097-2"},{"database":"Antibodypedia","id":"14095","properties":[{"key":"antibodies","value":"258 antibodies from 33 providers"}]},{"database":"DNASU","id":"72393","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000023750.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000023750.8"},{"key":"GeneId","value":"ENSMUSG00000023011.9"}],"isoformId":"Q8K097-1"},{"database":"Ensembl","id":"ENSMUST00000231171.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000155195.2"},{"key":"GeneId","value":"ENSMUSG00000023011.9"}],"isoformId":"Q8K097-2"},{"database":"GeneID","id":"72393","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:72393","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007xpp.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8K097-2"},{"database":"UCSC","id":"uc007xpq.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8K097-1"},{"database":"AGR","id":"MGI:1919643","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23017","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1919643","properties":[{"key":"GeneName","value":"Faim2"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000023011","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2322","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244890","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_058671_3_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FTGWYVY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"7933078at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"72393","properties":[{"key":"hits","value":"0 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8K097","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"Q8K097","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000023011","properties":[{"key":"ExpressionPatterns","value":"Expressed in superior frontal gyrus and 94 other cell types or tissues"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26582200"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26582200"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"26582200"}]},{"database":"GO","id":"GO:0045121","properties":[{"key":"GoTerm","value":"C:membrane raft"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"17635665"}]},{"database":"GO","id":"GO:0045211","properties":[{"key":"GoTerm","value":"C:postsynaptic membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005262","properties":[{"key":"GoTerm","value":"F:calcium channel activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0021681","properties":[{"key":"GoTerm","value":"P:cerebellar granular layer development"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21957071"}]},{"database":"GO","id":"GO:0021702","properties":[{"key":"GoTerm","value":"P:cerebellar Purkinje cell differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21957071"}]},{"database":"GO","id":"GO:0021680","properties":[{"key":"GoTerm","value":"P:cerebellar Purkinje cell layer development"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21957071"}]},{"database":"GO","id":"GO:0021549","properties":[{"key":"GoTerm","value":"P:cerebellum development"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21957071"}]},{"database":"GO","id":"GO:2001234","properties":[{"key":"GoTerm","value":"P:negative regulation of apoptotic signaling pathway"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21209208"}]},{"database":"GO","id":"GO:1902042","properties":[{"key":"GoTerm","value":"P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"26582200"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21209208"}]},{"database":"GO","id":"GO:0043523","properties":[{"key":"GoTerm","value":"P:regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17635665"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21957071"}]},{"database":"GO","id":"GO:0002931","properties":[{"key":"GoTerm","value":"P:response to ischemia"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"21209208"}]},{"database":"CDD","id":"cd10428","properties":[{"key":"EntryName","value":"LFG_like"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR006214","properties":[{"key":"EntryName","value":"Bax_inhibitor_1-related"}]},{"database":"PANTHER","id":"PTHR23291","properties":[{"key":"EntryName","value":"BAX INHIBITOR-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR23291:SF18","properties":[{"key":"EntryName","value":"PROTEIN LIFEGUARD 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01027","properties":[{"key":"EntryName","value":"Bax1-I"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTQGKLSVANKAPGTEGQQHQANGEKKDAPAVPSAPPSYEEATSGEGLKAGTFPQGPTAVPLHPSWAYVDPSGSSGYEGGFPAGHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFDFTSCQGVLFVLLMTLFFSGLLLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNRE","length":317,"molWeight":35258,"crc64":"A62D51BA49BCDB15","md5":"13BFF5B45368690A4D465DB98A9498C0"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Transmembrane":7,"Region":1,"Glycosylation":1,"Alternative sequence":1,"Sequence conflict":2},"uniParcId":"UPI00000E86BA"}}