{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IZC4","secondaryAccessions":["Q3ZCR1","Q68DZ6","Q8N8K1","Q8TAV2"],"uniProtkbId":"RTKN2_HUMAN","entryAudit":{"firstPublicDate":"2007-11-13","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":182,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Rhotekin-2"}},"alternativeNames":[{"fullName":{"value":"Pleckstrin homology domain-containing family K member 1"},"shortNames":[{"value":"PH domain-containing family K member 1"}]}]},"genes":[{"geneName":{"value":"RTKN2"},"synonyms":[{"value":"PLEKHK1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15504364"}],"value":"May play an important role in lymphopoiesis"}],"commentType":"FUNCTION"},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8IZC4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8IZC4-2"],"sequenceIds":["VSP_029137","VSP_029138","VSP_029139"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8IZC4-3"],"sequenceIds":["VSP_029135","VSP_029136"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15504364"}],"value":"Expressed in lymphocytes, CD4 positive T-cells and bone marrow-derived cells. Also expressed in lung, colon, thymus and brain"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15120425"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15504364"}],"value":"Up-regulated in cells resistant to 25-hydroxy cholesterol (25-OHC). Down-regulated in lymphocytes activated by treatment with phytohemagglutinin (PHA)"}],"commentType":"INDUCTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC04837.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BC048002","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Rhotekin-2","featureId":"PRO_0000309326"},{"type":"Domain","location":{"start":{"value":5,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"REM-1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU01207"}]},{"type":"Domain","location":{"start":{"value":286,"modifier":"EXACT"},"end":{"value":393,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Region","location":{"start":{"value":495,"modifier":"EXACT"},"end":{"value":520,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":554,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":569,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_029135","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Alternative sequence","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_029136","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_029137","alternativeSequence":{"originalSequence":"K","alternativeSequences":["KSLVLFEDSLEGIQLAISQSFK"]}},{"type":"Alternative sequence","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":506,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_029138","alternativeSequence":{"originalSequence":"VLYPASEPLHDEKGKKRQAPL","alternativeSequences":["NNSNQLHNLQKLPATSKFLFT"]}},{"type":"Alternative sequence","location":{"start":{"value":507,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_029139","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in dbSNP:rs3765004","featureCrossReferences":[{"database":"dbSNP","id":"rs3765004"}],"featureId":"VAR_050516","alternativeSequence":{"originalSequence":"K","alternativeSequences":["T"]}},{"type":"Natural variant","location":{"start":{"value":462,"modifier":"EXACT"},"end":{"value":462,"modifier":"EXACT"}},"description":"in dbSNP:rs3125734","featureCrossReferences":[{"database":"dbSNP","id":"rs3125734"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_050517","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15504364","citationType":"journal article","authors":["Collier F.M.","Gregorio-King C.C.","Gough T.J.","Talbot C.D.","Walder K.","Kirkland M.A."],"citationCrossReferences":[{"database":"PubMed","id":"15504364"},{"database":"DOI","id":"10.1016/j.bbrc.2004.09.205"}],"title":"Identification and characterization of a lymphocytic Rho-GTPase effector: rhotekin-2.","publicationDate":"2004","journal":"Biochem. Biophys. Res. Commun.","firstPage":"1360","lastPage":"1369","volume":"324"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","TISSUE SPECIFICITY","FUNCTION","ALTERNATIVE SPLICING","INDUCTION BY PHA"]},{"referenceNumber":2,"citation":{"id":"15120425","citationType":"journal article","authors":["Gregorio-King C.C.","Gough T.","Van Der Meer G.J.","Hosking J.B.","Waugh C.M.","McLeod J.L.","Collier F.M.","Kirkland M.A."],"citationCrossReferences":[{"database":"PubMed","id":"15120425"},{"database":"DOI","id":"10.1016/j.jsbmb.2003.12.007"}],"title":"Mechanisms of resistance to the cytotoxic effects of oxysterols in human leukemic cells.","publicationDate":"2004","journal":"J. Steroid Biochem. Mol. Biol.","firstPage":"311","lastPage":"320","volume":"88"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","INDUCTION"]},{"referenceNumber":3,"citation":{"id":"15164054","citationType":"journal article","authors":["Deloukas P.","Earthrowl M.E.","Grafham D.V.","Rubenfield M.","French L.","Steward C.A.","Sims S.K.","Jones M.C.","Searle S.","Scott C.","Howe K.","Hunt S.E.","Andrews T.D.","Gilbert J.G.R.","Swarbreck D.","Ashurst J.L.","Taylor A.","Battles J.","Bird C.P.","Ainscough R.","Almeida J.P.","Ashwell R.I.S.","Ambrose K.D.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Bates K.","Beasley H.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Cahill P.","Camire D.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.","Corby N.","Coulson A.","Dhami P.","Dutta I.","Dunn M.","Faulkner L.","Frankish A.","Frankland J.A.","Garner P.","Garnett J.","Gribble S.","Griffiths C.","Grocock R.","Gustafson E.","Hammond S.","Harley J.L.","Hart E.","Heath P.D.","Ho T.P.","Hopkins B.","Horne J.","Howden P.J.","Huckle E.","Hynds C.","Johnson C.","Johnson D.","Kana A.","Kay M.","Kimberley A.M.","Kershaw J.K.","Kokkinaki M.","Laird G.K.","Lawlor S.","Lee H.M.","Leongamornlert D.A.","Laird G.","Lloyd C.","Lloyd D.M.","Loveland J.","Lovell J.","McLaren S.","McLay K.E.","McMurray A.","Mashreghi-Mohammadi M.","Matthews L.","Milne S.","Nickerson T.","Nguyen M.","Overton-Larty E.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.","Rice C.M.","Rogosin A.","Ross M.T.","Sarafidou T.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Standring L.","Sycamore N.","Tester J.","Thorpe A.","Torcasso W.","Tracey A.","Tromans A.","Tsolas J.","Wall M.","Walsh J.","Wang H.","Weinstock K.","West A.P.","Willey D.L.","Whitehead S.L.","Wilming L.","Wray P.W.","Young L.","Chen Y.","Lovering R.C.","Moschonas N.K.","Siebert R.","Fechtel K.","Bentley D.","Durbin R.M.","Hubbard T.","Doucette-Stamm L.","Beck S.","Smith D.R.","Rogers J."],"citationCrossReferences":[{"database":"PubMed","id":"15164054"},{"database":"DOI","id":"10.1038/nature02462"}],"title":"The DNA sequence and comparative analysis of human chromosome 10.","publicationDate":"2004","journal":"Nature","firstPage":"375","lastPage":"381","volume":"429"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 341-609 (ISOFORM 1)","VARIANT ARG-462"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-609 (ISOFORM 2)","VARIANT ARG-462"]},{"referenceNumber":7,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 535-609 (ISOFORM 1)"],"referenceComments":[{"value":"Fetal kidney","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY150309","properties":[{"key":"ProteinId","value":"AAN71738.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC024597","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL607150","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471083","properties":[{"key":"ProteinId","value":"EAW54232.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC025765","properties":[{"key":"ProteinId","value":"AAH25765.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC048002","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC141821","properties":[{"key":"ProteinId","value":"AAI41822.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC142725","properties":[{"key":"ProteinId","value":"AAI42726.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK096671","properties":[{"key":"ProteinId","value":"BAC04837.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CR749217","properties":[{"key":"ProteinId","value":"CAH18074.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS7263.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IZC4-1"},{"database":"CCDS","id":"CCDS73140.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IZC4-3"},{"database":"RefSeq","id":"NP_001269870.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001282941.2"}],"isoformId":"Q8IZC4-3"},{"database":"RefSeq","id":"NP_660350.2","properties":[{"key":"NucleotideSequenceId","value":"NM_145307.4"}],"isoformId":"Q8IZC4-1"},{"database":"AlphaFoldDB","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"128576","properties":[{"key":"Interactions","value":"14"}]},{"database":"FunCoup","id":"Q8IZC4","properties":[{"key":"Number of interactors","value":"2582"}]},{"database":"IntAct","id":"Q8IZC4","properties":[{"key":"Interactions","value":"7"}]},{"database":"MINT","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"MUSIC2-C5210-RTKN2","properties":[{"key":"Evidences","value":"Osteosarcoma (U2OS) cell map - Anaphase-promoting and cell cycle kinase complexes (30 proteins)"}]},{"database":"STRING","id":"9606.ENSP00000362894","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8IZC4","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (3 sites)"}]},{"database":"iPTMnet","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"RTKN2","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74750788","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000362894","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71313","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IZC4-1"},{"database":"ProteomicsDB","id":"71314","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IZC4-2"},{"database":"ProteomicsDB","id":"71315","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IZC4-3"},{"database":"Pumba","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"28261","properties":[{"key":"antibodies","value":"138 antibodies from 24 providers"}]},{"database":"DNASU","id":"219790","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000373789.8","properties":[{"key":"ProteinId","value":"ENSP00000362894.3"},{"key":"GeneId","value":"ENSG00000182010.12"}],"isoformId":"Q8IZC4-1"},{"database":"Ensembl","id":"ENST00000395260.3","properties":[{"key":"ProteinId","value":"ENSP00000378678.3"},{"key":"GeneId","value":"ENSG00000182010.12"}],"isoformId":"Q8IZC4-3"},{"database":"GeneID","id":"219790","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:219790","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000373789.8","properties":[{"key":"ProteinId","value":"ENSP00000362894.3"},{"key":"RefSeqNucleotideId","value":"NM_145307.4"},{"key":"RefSeqProteinId","value":"NP_660350.2"}]},{"database":"UCSC","id":"uc001jlw.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8IZC4-1"},{"database":"AGR","id":"HGNC:19364","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162402276","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"219790","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"219790","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"RTKN2","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:19364","properties":[{"key":"GeneName","value":"RTKN2"}]},{"database":"HPA","id":"ENSG00000182010","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (lung)"}]},{"database":"MIM","id":"618450","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000182010","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000182010","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QRWR","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000157470","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_025066_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GNHKMVI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5817051at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IZC4","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000182010","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"219790","properties":[{"key":"hits","value":"32 hits in 1146 CRISPR screens"}]},{"database":"ChiTaRS","id":"RTKN2","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"219790","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IZC4","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8IZC4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"Q8IZC4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000182010","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lung and 114 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8IZC4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15504364"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15504364"}]},{"database":"GO","id":"GO:0002250","properties":[{"key":"GoTerm","value":"P:adaptive immune response"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26124677"}]},{"database":"GO","id":"GO:0030097","properties":[{"key":"GoTerm","value":"P:hemopoiesis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035556","properties":[{"key":"GoTerm","value":"P:intracellular signal transduction"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26124677"}]},{"database":"GO","id":"GO:0008284","properties":[{"key":"GoTerm","value":"P:positive regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd13249","properties":[{"key":"EntryName","value":"PH_rhotekin2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000274","properties":[{"key":"EntryName","value":"Rhotekin 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR012966","properties":[{"key":"EntryName","value":"AHD"}]},{"database":"InterPro","id":"IPR051364","properties":[{"key":"EntryName","value":"Cytokinesis/Rho-signaling"}]},{"database":"InterPro","id":"IPR011072","properties":[{"key":"EntryName","value":"HR1_rho-bd"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"PANTHER","id":"PTHR21538","properties":[{"key":"EntryName","value":"ANILLIN/RHOTEKIN RTKN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21538:SF21","properties":[{"key":"EntryName","value":"RHOTEKIN-2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08174","properties":[{"key":"EntryName","value":"Anillin"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00742","properties":[{"key":"EntryName","value":"Hr1"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51860","properties":[{"key":"EntryName","value":"REM_1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEGPSLRGPALRLAGLPTQQDCNIQEKIDLEIRMREGIWKLLSLSTQKDQVLHAVKNLMVCNARLMAYTSELQKLEEQIANQTGRCDVKFESKERTACKGKIAISDIRIPLMWKDSDHFSNKERSRRYAIFCLFKMGANVFDTDVVNVDKTITDICFENVTIFNEAGPDFQIKVEVYSCCTEESSITNTPKKLAKKLKTSISKATGKKISSVLQEEDDEMCLLLSSAVFGVKYNLLAHTTLTLESAEDSFKTHNLSINGNEESSFWLPLYGNMCCRLVAQPACMAEDAFAGFLNQQQMVEGLISWRRLYCVLRGGKLYCFYSPEEIEAKVEPALVVPINKETRIRAMDKDAKKRIHNFSVINPVPGQAITQIFAVDNREDLQKWMEAFWQHFFDLSQWKHCCEELMKIEIMSPRKPPLFLTKEATSVYHDMSIDSPMKLESLTDIIQKKIEETNGQFLIGQHEESLPPPWATLFDGNHQMVIQKKVLYPASEPLHDEKGKKRQAPLPPSDKLPFSLKSQSNTDQLVKDNWGKTSVSQTSSLDTKLSTLMHHLQKPMAAPRKLLPARRNRLSDGEHTDTKTNFEAKPVPAPRQKSIKDILDPRSWLQAQV","length":609,"molWeight":69304,"crc64":"928E5F197EBBDBE4","md5":"5CD4CB628DC9581CEBCC94FFB3CFE350"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"INDUCTION":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":2,"Region":2,"Coiled coil":1,"Compositional bias":1,"Alternative sequence":5,"Natural variant":2},"uniParcId":"UPI000007413A"}}