{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IYR0","secondaryAccessions":["A8K969","E1P507","Q8N9U4"],"uniProtkbId":"CF206_HUMAN","entryAudit":{"firstPublicDate":"2003-08-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-08-29","entryVersion":153,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cilia- and flagella-associated protein 206"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:21405"}],"value":"CFAP206"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:21405"}],"value":"C6orf165"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PE87"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34255152"}],"value":"Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (By similarity). Required for the establishment of radial spokes in sperm flagella (PubMed:34255152)"}],"commentType":"FUNCTION"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q3KP44","geneName":"ANKRD55","intActId":"EBI-14493093"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q96GX9","geneName":"APIP","intActId":"EBI-359248"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N5M1","geneName":"ATPAF2","intActId":"EBI-1166928"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N9N5","geneName":"BANP","intActId":"EBI-744695"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N9N5-2","geneName":"BANP","intActId":"EBI-11524452"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9H2G9","geneName":"BLZF1","intActId":"EBI-2548012"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q6P1W5","geneName":"C1orf94","intActId":"EBI-946029"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q5TBE3-2","geneName":"C9orf153","intActId":"EBI-12159293"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q99626","geneName":"CDX2","intActId":"EBI-10899513"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8IYX8-2","geneName":"CEP57L1","intActId":"EBI-10181988"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"P27918","geneName":"CFP","intActId":"EBI-9038570"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N684-3","geneName":"CPSF7","intActId":"EBI-11523759"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"O43186","geneName":"CRX","intActId":"EBI-748171"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"A8MQ03","geneName":"CYSRT1","intActId":"EBI-3867333"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9NRI5-2","geneName":"DISC1","intActId":"EBI-11988027"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9NRA8","geneName":"EIF4ENIF1","intActId":"EBI-301024"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"P14136","geneName":"GFAP","intActId":"EBI-744302"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q49A26","geneName":"GLYR1","intActId":"EBI-2804292"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q96D09","geneName":"GPRASP2","intActId":"EBI-473189"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q14687","geneName":"GSE1","intActId":"EBI-372619"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8IYA8","geneName":"IHO1","intActId":"EBI-8638439"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9UKT9","geneName":"IKZF3","intActId":"EBI-747204"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q86T90","geneName":"KIAA1328","intActId":"EBI-3437878"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N4I8","geneName":"KLHL3","intActId":"EBI-10230467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q15323","geneName":"KRT31","intActId":"EBI-948001"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"O76011","geneName":"KRT34","intActId":"EBI-1047093"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q6A162","geneName":"KRT40","intActId":"EBI-10171697"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"O95678","geneName":"KRT75","intActId":"EBI-2949715"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q01546","geneName":"KRT76","intActId":"EBI-2952745"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q6PEX3","geneName":"KRTAP26-1","intActId":"EBI-3957672"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9BRK4","geneName":"LZTS2","intActId":"EBI-741037"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9Y5V3","geneName":"MAGED1","intActId":"EBI-716006"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q6FHY5","geneName":"MEOX2","intActId":"EBI-16439278"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"A9UHW6-2","geneName":"MIF4GD","intActId":"EBI-9118295"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"O00746","geneName":"NME4","intActId":"EBI-744871"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8WWB5","geneName":"PIH1D2","intActId":"EBI-10232538"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"P25786","geneName":"PSMA1","intActId":"EBI-359352"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"P62195","geneName":"PSMC5","intActId":"EBI-357745"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q04864-2","geneName":"REL","intActId":"EBI-10829018"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q13464","geneName":"ROCK1","intActId":"EBI-876651"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N6K7","geneName":"SAMD3","intActId":"EBI-748741"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8IYX7","geneName":"SAXO1","intActId":"EBI-3957636"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"O60504","geneName":"SORBS3","intActId":"EBI-741237"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"O94993","geneName":"SOX30","intActId":"EBI-742973"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q86TJ2-3","geneName":"TADA2B","intActId":"EBI-18173581"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q5VWN6","geneName":"TASOR2","intActId":"EBI-745958"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q99081","geneName":"TCF12","intActId":"EBI-722877"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q969V4","geneName":"TEKT1","intActId":"EBI-10180409"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9UBB9","geneName":"TFIP11","intActId":"EBI-1105213"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q08117","geneName":"TLE5","intActId":"EBI-717810"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"P14373","geneName":"TRIM27","intActId":"EBI-719493"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q9BYV2","geneName":"TRIM54","intActId":"EBI-2130429"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q5T124","geneName":"UBXN11","intActId":"EBI-746004"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q5T124-6","geneName":"UBXN11","intActId":"EBI-11524408"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N6Y0","geneName":"USHBP1","intActId":"EBI-739895"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8N1B4","geneName":"VPS52","intActId":"EBI-2799833"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IYR0","intActId":"EBI-749051"},"interactantTwo":{"uniProtKBAccession":"Q8NB15","geneName":"ZNF511","intActId":"EBI-10269136"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PE87"}],"value":"Cytoplasm, cytoskeleton, cilium axoneme","id":"SL-0304"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6PE87"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34255152"}],"value":"Highly expressed in testis"}],"commentType":"TISSUE SPECIFICITY"},{"commentType":"DISEASE","disease":{"diseaseId":"Spermatogenic failure 102","diseaseAccession":"DI-07092","acronym":"SPGF102","description":"An autosomal recessive, male infertility disorder characterized by reduced concentration of sperm, and immotile sperm due to multiple morphologic abnormalities of the flagella, including absent, short, coiled, and irregular-caliber flagella.","diseaseCrossReference":{"database":"MIM","id":"621387"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34255152"}]},"note":{"texts":[{"value":"The disease may be caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CFAP206 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAC04234.1","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Cilia- and flagella-associated protein 206","featureId":"PRO_0000089553"},{"type":"Region","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":592,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Natural variant","location":{"start":{"value":154,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"in dbSNP:rs13219364","featureCrossReferences":[{"database":"dbSNP","id":"rs13219364"}],"featureId":"VAR_033679","alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in dbSNP:rs16879281","featureCrossReferences":[{"database":"dbSNP","id":"rs16879281"}],"featureId":"VAR_033680","alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":489,"modifier":"EXACT"},"end":{"value":489,"modifier":"EXACT"}},"description":"in Ref. 1; BAF85273","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"},{"value":"Trachea","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"14574404","citationType":"journal article","authors":["Mungall A.J.","Palmer S.A.","Sims S.K.","Edwards C.A.","Ashurst J.L.","Wilming L.","Jones M.C.","Horton R.","Hunt S.E.","Scott C.E.","Gilbert J.G.R.","Clamp M.E.","Bethel G.","Milne S.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews T.D.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Banerjee R.","Barker D.J.","Barlow K.F.","Bates K.","Beare D.M.","Beasley H.","Beasley O.","Bird C.P.","Blakey S.E.","Bray-Allen S.","Brook J.","Brown A.J.","Brown J.Y.","Burford D.C.","Burrill W.","Burton J.","Carder C.","Carter N.P.","Chapman J.C.","Clark S.Y.","Clark G.","Clee C.M.","Clegg S.","Cobley V.","Collier R.E.","Collins J.E.","Colman L.K.","Corby N.R.","Coville G.J.","Culley K.M.","Dhami P.","Davies J.","Dunn M.","Earthrowl M.E.","Ellington A.E.","Evans K.A.","Faulkner L.","Francis M.D.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Ghori M.J.","Gilby L.M.","Gillson C.J.","Glithero R.J.","Grafham D.V.","Grant M.","Gribble S.","Griffiths C.","Griffiths M.N.D.","Hall R.","Halls K.S.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Heathcott R.","Holmes S.J.","Howden P.J.","Howe K.L.","Howell G.R.","Huckle E.","Humphray S.J.","Humphries M.D.","Hunt A.R.","Johnson C.M.","Joy A.A.","Kay M.","Keenan S.J.","Kimberley A.M.","King A.","Laird G.K.","Langford C.","Lawlor S.","Leongamornlert D.A.","Leversha M.","Lloyd C.R.","Lloyd D.M.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","Maslen G.L.","Matthews L.","McCann O.T.","McLaren S.J.","McLay K.","McMurray A.","Moore M.J.F.","Mullikin J.C.","Niblett D.","Nickerson T.","Novik K.L.","Oliver K.","Overton-Larty E.K.","Parker A.","Patel R.","Pearce A.V.","Peck A.I.","Phillimore B.J.C.T.","Phillips S.","Plumb R.W.","Porter K.M.","Ramsey Y.","Ranby S.A.","Rice C.M.","Ross M.T.","Searle S.M.","Sehra H.K.","Sheridan E.","Skuce C.D.","Smith S.","Smith M.","Spraggon L.","Squares S.L.","Steward C.A.","Sycamore N.","Tamlyn-Hall G.","Tester J.","Theaker A.J.","Thomas D.W.","Thorpe A.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","White S.S.","Whitehead S.L.","Whittaker H.","Wild A.","Willey D.J.","Wilmer T.E.","Wood J.M.","Wray P.W.","Wyatt J.C.","Young L.","Younger R.M.","Bentley D.R.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Dunham I.","Rogers J.","Beck S."],"citationCrossReferences":[{"database":"PubMed","id":"14574404"},{"database":"DOI","id":"10.1038/nature02055"}],"title":"The DNA sequence and analysis of human chromosome 6.","publicationDate":"2003","journal":"Nature","firstPage":"805","lastPage":"811","volume":"425"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"34255152","citationType":"journal article","authors":["Shen Q.","Martinez G.","Liu H.","Beurois J.","Wu H.","Amiri-Yekta A.","Liang D.","Kherraf Z.E.","Bidart M.","Cazin C.","Celse T.","Satre V.","Thierry-Mieg N.","Whitfield M.","Toure A.","Song B.","Lv M.","Li K.","Liu C.","Tao F.","He X.","Zhang F.","Arnoult C.","Ray P.F.","Cao Y.","Coutton C."],"citationCrossReferences":[{"database":"PubMed","id":"34255152"},{"database":"DOI","id":"10.1007/s00439-021-02313-z"}],"title":"Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse.","publicationDate":"2021","journal":"Hum. Genet.","firstPage":"1367","lastPage":"1377","volume":"140"},"referencePositions":["INVOLVEMENT IN SPGF102","TISSUE SPECIFICITY","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK093830","properties":[{"key":"ProteinId","value":"BAC04234.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292584","properties":[{"key":"ProteinId","value":"BAF85273.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL049697","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471051","properties":[{"key":"ProteinId","value":"EAW48594.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471051","properties":[{"key":"ProteinId","value":"EAW48596.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471051","properties":[{"key":"ProteinId","value":"EAW48598.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC035083","properties":[{"key":"ProteinId","value":"AAH35083.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS34498.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001026913.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001031743.3"}]},{"database":"AlphaFoldDB","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"127543","properties":[{"key":"Interactions","value":"68"}]},{"database":"ComplexPortal","id":"CPX-8163","properties":[{"key":"EntryName","value":"Radial spoke complex, ciliiar variant"}]},{"database":"ComplexPortal","id":"CPX-8164","properties":[{"key":"EntryName","value":"Radial spoke complex, flagellar variant"}]},{"database":"FunCoup","id":"Q8IYR0","properties":[{"key":"Number of interactors","value":"101"}]},{"database":"IntAct","id":"Q8IYR0","properties":[{"key":"Interactions","value":"59"}]},{"database":"MINT","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000358575","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8IYR0","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"CFAP206","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"34395551","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000358575","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71214","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"73997","properties":[{"key":"antibodies","value":"44 antibodies from 8 providers"}]},{"database":"DNASU","id":"154313","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000369562.9","properties":[{"key":"ProteinId","value":"ENSP00000358575.4"},{"key":"GeneId","value":"ENSG00000272514.7"}]},{"database":"Ensembl","id":"ENST00000507897.5","properties":[{"key":"ProteinId","value":"ENSP00000426769.1"},{"key":"GeneId","value":"ENSG00000213204.8"}]},{"database":"Ensembl","id":"ENST00000906987.1","properties":[{"key":"ProteinId","value":"ENSP00000577046.1"},{"key":"GeneId","value":"ENSG00000272514.7"}]},{"database":"Ensembl","id":"ENST00000918053.1","properties":[{"key":"ProteinId","value":"ENSP00000588112.1"},{"key":"GeneId","value":"ENSG00000272514.7"}]},{"database":"GeneID","id":"154313","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:154313","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000369562.9","properties":[{"key":"ProteinId","value":"ENSP00000358575.4"},{"key":"RefSeqNucleotideId","value":"NM_001031743.3"},{"key":"RefSeqProteinId","value":"NP_001026913.1"}]},{"database":"UCSC","id":"uc003plv.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:21405","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134983540","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"154313","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"154313","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"CFAP206","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:21405","properties":[{"key":"GeneName","value":"CFAP206"}]},{"database":"HPA","id":"ENSG00000272514","properties":[{"key":"ExpressionPatterns","value":"Group enriched (fallopian tube, testis)"}]},{"database":"MIM","id":"621376","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"621387","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000213204","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000272514","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000272514","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QTGJ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000016036","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_030061_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"QLMELMC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10251073at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IYR0","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000272514","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"154313","properties":[{"key":"hits","value":"10 hits in 1107 CRISPR screens"}]},{"database":"ChiTaRS","id":"CFAP206","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"154313","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IYR0","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8IYR0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q8IYR0","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000272514","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 75 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8IYR0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0097729","properties":[{"key":"GoTerm","value":"C:9+2 motile cilium"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36417862"}]},{"database":"GO","id":"GO:0005930","properties":[{"key":"GoTerm","value":"C:axoneme"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005929","properties":[{"key":"GoTerm","value":"C:cilium"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36417862"}]},{"database":"GO","id":"GO:0031514","properties":[{"key":"GoTerm","value":"C:motile cilium"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001534","properties":[{"key":"GoTerm","value":"C:radial spoke"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036126","properties":[{"key":"GoTerm","value":"C:sperm flagellum"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36417862"}]},{"database":"GO","id":"GO:0035082","properties":[{"key":"GoTerm","value":"P:axoneme assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0003341","properties":[{"key":"GoTerm","value":"P:cilium movement"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030317","properties":[{"key":"GoTerm","value":"P:flagellated sperm motility"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"36417862"}]},{"database":"GO","id":"GO:0003356","properties":[{"key":"GoTerm","value":"P:regulation of cilium beat frequency"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:1901317","properties":[{"key":"GoTerm","value":"P:regulation of flagellated sperm motility"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007288","properties":[{"key":"GoTerm","value":"P:sperm axoneme assembly"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"34255152"}]},{"database":"InterPro","id":"IPR021897","properties":[{"key":"EntryName","value":"FAP206"}]},{"database":"PANTHER","id":"PTHR21442","properties":[{"key":"EntryName","value":"CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21442:SF0","properties":[{"key":"EntryName","value":"CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 206"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12018","properties":[{"key":"EntryName","value":"FAP206"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPPTQAESVIRSIIREIGQECAAHGEIVSETLIAFMVKAVVLDPSNGFNMDRTLMKSDVQNLVKLCMTRLLDTKNPSLDTIKMQVYFDMNYTNRVEFLEEHHRVLESRLGSVTREITDNRACAKEELESLYRKIISYVLLRSGLGSPTDIKTVREVTAALQSVFPQAELGTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAVLHVAIPATMQHIDYQLETARSQVYRYTAILEKAANDPLMRAELQPYMLKEALYNIRQYEVFLQIILSDIITGAQEVEMMTKQLGAHLEQLKMTIKSKIAVPTSQVFPIFIALSTLWTSLQDETIVVGVLSNLFTHIQPFLGAHELYFPERVMQCHLNGATVKTDVCRMKEHMEDRVNVADFRKLEWLFPETTANFDKLLIQYRGFCAYTFAATDGLLLPGNPAIGILKYKEKYYTFNSKDAAYSFAENPEHYIDIVREKAKKNTELIQLLELHQQFETFIPYSQMRDADKHYIKPITKCESSTQTNTHILPPTIVRSYEWNEWELRRKAIKLANLRQKVTHSVQTDLSHLRRENCSQVYPPKDTSTQSMREDSTGVPRPQIYLAGLRGGKSEITDEVKVNLTRDVDET","length":622,"molWeight":71193,"crc64":"EC3818B8596C0B1E","md5":"B556924F0AD78596F51734E565DE0997"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"INTERACTION":58,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DISEASE":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":1,"Natural variant":2,"Sequence conflict":1},"uniParcId":"UPI00001A3AA5"}}