{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IXR9","uniProtkbId":"CL056_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2013-02-06","entryVersion":126,"sequenceVersion":3},"annotationScore":2.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein C12orf56"}}},"genes":[{"geneName":{"value":"C12orf56"}}],"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8IXR9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8IXR9-2"],"sequenceIds":["VSP_031745"],"isoformSequenceStatus":"Described"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"Uncharacterized protein C12orf56","featureId":"PRO_0000320926"},{"type":"Region","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":238,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_031745","alternativeSequence":{}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16541075","citationType":"journal article","authors":["Scherer S.E.","Muzny D.M.","Buhay C.J.","Chen R.","Cree A.","Ding Y.","Dugan-Rocha S.","Gill R.","Gunaratne P.","Harris R.A.","Hawes A.C.","Hernandez J.","Hodgson A.V.","Hume J.","Jackson A.","Khan Z.M.","Kovar-Smith C.","Lewis L.R.","Lozado R.J.","Metzker M.L.","Milosavljevic A.","Miner G.R.","Montgomery K.T.","Morgan M.B.","Nazareth L.V.","Scott G.","Sodergren E.","Song X.-Z.","Steffen D.","Lovering R.C.","Wheeler D.A.","Worley K.C.","Yuan Y.","Zhang Z.","Adams C.Q.","Ansari-Lari M.A.","Ayele M.","Brown M.J.","Chen G.","Chen Z.","Clerc-Blankenburg K.P.","Davis C.","Delgado O.","Dinh H.H.","Draper H.","Gonzalez-Garay M.L.","Havlak P.","Jackson L.R.","Jacob L.S.","Kelly S.H.","Li L.","Li Z.","Liu J.","Liu W.","Lu J.","Maheshwari M.","Nguyen B.-V.","Okwuonu G.O.","Pasternak S.","Perez L.M.","Plopper F.J.H.","Santibanez J.","Shen H.","Tabor P.E.","Verduzco D.","Waldron L.","Wang Q.","Williams G.A.","Zhang J.","Zhou J.","Allen C.C.","Amin A.G.","Anyalebechi V.","Bailey M.","Barbaria J.A.","Bimage K.E.","Bryant N.P.","Burch P.E.","Burkett C.E.","Burrell K.L.","Calderon E.","Cardenas V.","Carter K.","Casias K.","Cavazos I.","Cavazos S.R.","Ceasar H.","Chacko J.","Chan S.N.","Chavez D.","Christopoulos C.","Chu J.","Cockrell R.","Cox C.D.","Dang M.","Dathorne S.R.","David R.","Davis C.M.","Davy-Carroll L.","Deshazo D.R.","Donlin J.E.","D'Souza L.","Eaves K.A.","Egan A.","Emery-Cohen A.J.","Escotto M.","Flagg N.","Forbes L.D.","Gabisi A.M.","Garza M.","Hamilton C.","Henderson N.","Hernandez O.","Hines S.","Hogues M.E.","Huang M.","Idlebird D.G.","Johnson R.","Jolivet A.","Jones S.","Kagan R.","King L.M.","Leal B.","Lebow H.","Lee S.","LeVan J.M.","Lewis L.C.","London P.","Lorensuhewa L.M.","Loulseged H.","Lovett D.A.","Lucier A.","Lucier R.L.","Ma J.","Madu R.C.","Mapua P.","Martindale A.D.","Martinez E.","Massey E.","Mawhiney S.","Meador M.G.","Mendez S.","Mercado C.","Mercado I.C.","Merritt C.E.","Miner Z.L.","Minja E.","Mitchell T.","Mohabbat F.","Mohabbat K.","Montgomery B.","Moore N.","Morris S.","Munidasa M.","Ngo R.N.","Nguyen N.B.","Nickerson E.","Nwaokelemeh O.O.","Nwokenkwo S.","Obregon M.","Oguh M.","Oragunye N.","Oviedo R.J.","Parish B.J.","Parker D.N.","Parrish J.","Parks K.L.","Paul H.A.","Payton B.A.","Perez A.","Perrin W.","Pickens A.","Primus E.L.","Pu L.-L.","Puazo M.","Quiles M.M.","Quiroz J.B.","Rabata D.","Reeves K.","Ruiz S.J.","Shao H.","Sisson I.","Sonaike T.","Sorelle R.P.","Sutton A.E.","Svatek A.F.","Svetz L.A.","Tamerisa K.S.","Taylor T.R.","Teague B.","Thomas N.","Thorn R.D.","Trejos Z.Y.","Trevino B.K.","Ukegbu O.N.","Urban J.B.","Vasquez L.I.","Vera V.A.","Villasana D.M.","Wang L.","Ward-Moore S.","Warren J.T.","Wei X.","White F.","Williamson A.L.","Wleczyk R.","Wooden H.S.","Wooden S.H.","Yen J.","Yoon L.","Yoon V.","Zorrilla S.E.","Nelson D.","Kucherlapati R.","Weinstock G.","Gibbs R.A."],"citationCrossReferences":[{"database":"PubMed","id":"16541075"},{"database":"DOI","id":"10.1038/nature04569"}],"title":"The finished DNA sequence of human chromosome 12.","publicationDate":"2006","journal":"Nature","firstPage":"346","lastPage":"351","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-622 (ISOFORM 2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC012158","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC135279","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC039369","properties":[{"key":"ProteinId","value":"AAH39369.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS44935.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXR9-2"},{"database":"CCDS","id":"CCDS61182.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXR9-1"},{"database":"RefSeq","id":"NP_001093146.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001099676.3"}],"isoformId":"Q8IXR9-2"},{"database":"RefSeq","id":"NP_001164104.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001170633.2"}],"isoformId":"Q8IXR9-1"},{"database":"AlphaFoldDB","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125452","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"Q8IXR9","properties":[{"key":"Number of interactors","value":"1"}]},{"database":"STRING","id":"9606.ENSP00000446101","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C12orf56","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"449081294","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000446101","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"66385","properties":[{"key":"antibodies","value":"26 antibodies from 8 providers"}]},{"database":"DNASU","id":"115749","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000333722.9","properties":[{"key":"ProteinId","value":"ENSP00000329698.5"},{"key":"GeneId","value":"ENSG00000185306.14"}],"isoformId":"Q8IXR9-2"},{"database":"Ensembl","id":"ENST00000543942.7","properties":[{"key":"ProteinId","value":"ENSP00000446101.2"},{"key":"GeneId","value":"ENSG00000185306.14"}],"isoformId":"Q8IXR9-1"},{"database":"GeneID","id":"115749","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:115749","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000543942.7","properties":[{"key":"ProteinId","value":"ENSP00000446101.2"},{"key":"RefSeqNucleotideId","value":"NM_001170633.2"},{"key":"RefSeqProteinId","value":"NP_001164104.1"}]},{"database":"UCSC","id":"uc001ssa.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8IXR9-1"},{"database":"AGR","id":"HGNC:26967","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA143485385","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"115749","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"115749","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C12orf56","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:26967","properties":[{"key":"GeneName","value":"C12orf56"}]},{"database":"HPA","id":"ENSG00000185306","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (choroid plexus, testis)"}]},{"database":"OpenTargets","id":"ENSG00000185306","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000185306","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QVPD","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000018424","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_032455_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"LFWRSSE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6022562at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IXR9","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000185306","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"115749","properties":[{"key":"hits","value":"52 hits in 1118 CRISPR screens"}]},{"database":"ChiTaRS","id":"C12orf56","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"115749","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IXR9","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8IXR9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"Q8IXR9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000185306","properties":[{"key":"ExpressionPatterns","value":"Expressed in sperm and 111 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8IXR9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR027878","properties":[{"key":"EntryName","value":"DUF4551"}]},{"database":"PANTHER","id":"PTHR35354","properties":[{"key":"EntryName","value":"RGD1561648"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR35354:SF1","properties":[{"key":"EntryName","value":"RGD1561648"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15087","properties":[{"key":"EntryName","value":"DUF4551"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASPLPSGFPARRNSRLDVFLRRHLPPEVYDAVRAYEPCIVVSNSENHILKYVVLSDRLVYLTENPPKSIRRVVALRDVVAIDLIDDYPEFLSSPDREISQHIRIIYSSTVLKKECKKSNSVRKFLFPFHHTKANNKKVKEEKNGLAFWRSKESRSLKESPLRDQQESSTPSKDSTLCPRPGLKKLSLHGQGAFRPLPSPSRRSSQSAPTTGKAVSEPSCTTNTKEPQGLPDHNSISEIPFKCNGNGNEFYLGNSLLDSPSQSNSNLEKKESELHLYVISTTSSIFLHLKSSWNNYIIKATLLQDPFYASEFSPAIGSQKPYRSEEKIKHFSQLKSELFLKDNSLRRILSLLMELKVAAQKNFILKRLFWKTSDLFYFIVNKLHEYLPESRDKNALQNQSQRVDELVACIEIIQTLVLMFRETETESSRLNTLAAKKGALFNLLVILISEPQIPKSCPVFDIQLVADSALVRMSFDAELQKLILEYTNTATALLYEILLVFQQGNLGLGSTKFAISWIMSFLQSCPPIITFVASIVKQVVRGLSASFQLLSPCQAVLLYQQFYILKSCLRHSRTLAEYIRNNYREEFRYFIHMPALQKRLPLCYPITQPTIQLFHEVLKLVE","length":622,"molWeight":71046,"crc64":"35E0DC70E2A6A354","md5":"230C9A8F7972C610F76E29E006650D4D"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":2},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Alternative sequence":1},"uniParcId":"UPI0001C0B37D"}}