{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IXQ4","secondaryAccessions":["A8K8X8","Q05BX8","Q05D87","Q5T3Z3","Q5T3Z5","Q9C0F9","Q9H2R0","Q9P0W6"],"uniProtkbId":"GPAM1_HUMAN","entryAudit":{"firstPublicDate":"2007-07-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":153,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"GPALPP motifs-containing protein 1"}},"alternativeNames":[{"fullName":{"value":"Lipopolysaccharide-specific response protein 7"}}]},"genes":[{"geneName":{"value":"GPALPP1"},"synonyms":[{"value":"KIAA1704"},{"value":"LSR7"}],"orfNames":[{"value":"AD029"}]}],"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8IXQ4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8IXQ4-2"],"sequenceIds":["VSP_026568"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8IXQ4-3"],"sequenceIds":["VSP_026567"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8IXQ4-4"],"sequenceIds":["VSP_026569","VSP_026570"],"isoformSequenceStatus":"Described"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"AAH17776.1","note":"Contaminating sequence. Potential poly-A sequence.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB21795.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"GPALPP motifs-containing protein 1","featureId":"PRO_0000293714"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":7,"modifier":"EXACT"},"end":{"value":12,"modifier":"EXACT"}},"description":"GPALPP motif 1"},{"type":"Motif","location":{"start":{"value":32,"modifier":"EXACT"},"end":{"value":37,"modifier":"EXACT"}},"description":"GPALPP motif 2"},{"type":"Motif","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":97,"modifier":"EXACT"}},"description":"GPALPP motif 3"},{"type":"Motif","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"GPALPP motif 4"},{"type":"Compositional bias","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":116,"modifier":"EXACT"}},"description":"Pro residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":269,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19413330"}]},{"type":"Modified residue","location":{"start":{"value":28,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Modified residue","location":{"start":{"value":138,"modifier":"EXACT"},"end":{"value":138,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":140,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"}]},{"type":"Modified residue","location":{"start":{"value":141,"modifier":"EXACT"},"end":{"value":141,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17081983"}]},{"type":"Cross-link","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":308,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"featureId":"VSP_026567","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.3"}],"featureId":"VSP_026568","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":175,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_026569","alternativeSequence":{"originalSequence":"ETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKL","alternativeSequences":["VSSSHFNSKVWKVFIERIRCIVTNSKLYACSYYNHWTQL"]}},{"type":"Alternative sequence","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":340,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_026570","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":126,"modifier":"EXACT"},"end":{"value":126,"modifier":"EXACT"}},"description":"in Ref. 7; AAH32333","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["I"]}},{"type":"Sequence conflict","location":{"start":{"value":194,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"in Ref. 1; AAF70548","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["K"]}},{"type":"Sequence conflict","location":{"start":{"value":212,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"in Ref. 1; AAF70548","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"in Ref. 1; AAF70548","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":280,"modifier":"EXACT"}},"description":"in Ref. 7; AAH17776","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":295,"modifier":"EXACT"},"end":{"value":295,"modifier":"EXACT"}},"description":"in Ref. 7; AAH39586","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-DB2GEV7OM9QJV","citationType":"submission","authors":["Chai Y.B.","Zhao Z.L.","Zhu F.","Yan W.","Chen N.C.","Wang Q.","Yue L.","Chen S.M."],"title":"New gene from human dental pulp cells.","publicationDate":"APR-1999","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)"]},{"referenceNumber":2,"citation":{"id":"11214970","citationType":"journal article","authors":["Nagase T.","Kikuno R.","Hattori A.","Kondo Y.","Okumura K.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"11214970"},{"database":"DOI","id":"10.1093/dnares/7.6.347"}],"title":"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.","publicationDate":"2000","journal":"DNA Res.","firstPage":"347","lastPage":"355","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-75Q75FP73ERMM","citationType":"submission","authors":["Song H.","Gao G.","Peng Y.","Ren S.","Chen Z.","Han Z."],"publicationDate":"MAR-2000","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Adrenal gland","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15057823","citationType":"journal article","authors":["Dunham A.","Matthews L.H.","Burton J.","Ashurst J.L.","Howe K.L.","Ashcroft K.J.","Beare D.M.","Burford D.C.","Hunt S.E.","Griffiths-Jones S.","Jones M.C.","Keenan S.J.","Oliver K.","Scott C.E.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Andrews D.T.","Ashwell R.I.S.","Babbage A.K.","Bagguley C.L.","Bailey J.","Bannerjee R.","Barlow K.F.","Bates K.","Beasley H.","Bird C.P.","Bray-Allen S.","Brown A.J.","Brown J.Y.","Burrill W.","Carder C.","Carter N.P.","Chapman J.C.","Clamp M.E.","Clark S.Y.","Clarke G.","Clee C.M.","Clegg S.C.","Cobley V.","Collins J.E.","Corby N.","Coville G.J.","Deloukas P.","Dhami P.","Dunham I.","Dunn M.","Earthrowl M.E.","Ellington A.G.","Faulkner L.","Frankish A.G.","Frankland J.","French L.","Garner P.","Garnett J.","Gilbert J.G.R.","Gilson C.J.","Ghori J.","Grafham D.V.","Gribble S.M.","Griffiths C.","Hall R.E.","Hammond S.","Harley J.L.","Hart E.A.","Heath P.D.","Howden P.J.","Huckle E.J.","Hunt P.J.","Hunt A.R.","Johnson C.","Johnson D.","Kay M.","Kimberley A.M.","King A.","Laird G.K.","Langford C.J.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Lloyd C.","Loveland J.E.","Lovell J.","Martin S.","Mashreghi-Mohammadi M.","McLaren S.J.","McMurray A.","Milne S.","Moore M.J.F.","Nickerson T.","Palmer S.A.","Pearce A.V.","Peck A.I.","Pelan S.","Phillimore B.","Porter K.M.","Rice C.M.","Searle S.","Sehra H.K.","Shownkeen R.","Skuce C.D.","Smith M.","Steward C.A.","Sycamore N.","Tester J.","Thomas D.W.","Tracey A.","Tromans A.","Tubby B.","Wall M.","Wallis J.M.","West A.P.","Whitehead S.L.","Willey D.L.","Wilming L.","Wray P.W.","Wright M.W.","Young L.","Coulson A.","Durbin R.M.","Hubbard T.","Sulston J.E.","Beck S.","Bentley D.R.","Rogers J.","Ross M.T."],"citationCrossReferences":[{"database":"PubMed","id":"15057823"},{"database":"DOI","id":"10.1038/nature02379"}],"title":"The DNA sequence and analysis of human chromosome 13.","publicationDate":"2004","journal":"Nature","firstPage":"522","lastPage":"528","volume":"428"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":6,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":7,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"17081983","citationType":"journal article","authors":["Olsen J.V.","Blagoev B.","Gnad F.","Macek B.","Kumar C.","Mortensen P.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"17081983"},{"database":"DOI","id":"10.1016/j.cell.2006.09.026"}],"title":"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.","publicationDate":"2006","journal":"Cell","firstPage":"635","lastPage":"648","volume":"127"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105; THR-138; SER-140 AND SER-141","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2","CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":11,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105 AND THR-138","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":12,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-105","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":15,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-271 AND LYS-308","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF145122","properties":[{"key":"ProteinId","value":"AAF70548.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB051491","properties":[{"key":"ProteinId","value":"BAB21795.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF245045","properties":[{"key":"ProteinId","value":"AAG44482.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK292493","properties":[{"key":"ProteinId","value":"BAF85182.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL359706","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471075","properties":[{"key":"ProteinId","value":"EAX08720.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC017776","properties":[{"key":"ProteinId","value":"AAH17776.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC032333","properties":[{"key":"ProteinId","value":"AAH32333.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC039586","properties":[{"key":"ProteinId","value":"AAH39586.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS9394.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXQ4-1"},{"database":"RefSeq","id":"NP_001303880.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001316951.2"}],"isoformId":"Q8IXQ4-1"},{"database":"RefSeq","id":"NP_001303881.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001316952.2"}]},{"database":"RefSeq","id":"NP_061029.2","properties":[{"key":"NucleotideSequenceId","value":"NM_018559.5"}],"isoformId":"Q8IXQ4-1"},{"database":"RefSeq","id":"XP_005266501.1","properties":[{"key":"NucleotideSequenceId","value":"XM_005266444.4"}],"isoformId":"Q8IXQ4-1"},{"database":"RefSeq","id":"XP_047286392.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047430436.1"}],"isoformId":"Q8IXQ4-1"},{"database":"RefSeq","id":"XP_047286393.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047430437.1"}],"isoformId":"Q8IXQ4-2"},{"database":"AlphaFoldDB","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120665","properties":[{"key":"Interactions","value":"80"}]},{"database":"FunCoup","id":"Q8IXQ4","properties":[{"key":"Number of interactors","value":"3889"}]},{"database":"IntAct","id":"Q8IXQ4","properties":[{"key":"Interactions","value":"44"}]},{"database":"MINT","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000368447","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8IXQ4","properties":[{"key":"glycosylation","value":"5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GPALPP1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74728222","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000368447","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"71037","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXQ4-1"},{"database":"ProteomicsDB","id":"71038","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXQ4-2"},{"database":"ProteomicsDB","id":"71039","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXQ4-3"},{"database":"ProteomicsDB","id":"71040","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IXQ4-4"},{"database":"Pumba","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"42228","properties":[{"key":"antibodies","value":"39 antibodies from 12 providers"}]},{"database":"DNASU","id":"55425","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000357537.4","properties":[{"key":"ProteinId","value":"ENSP00000350145.3"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-3"},{"database":"Ensembl","id":"ENST00000379151.9","properties":[{"key":"ProteinId","value":"ENSP00000368447.4"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"Ensembl","id":"ENST00000497558.5","properties":[{"key":"ProteinId","value":"ENSP00000432500.1"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"Ensembl","id":"ENST00000904226.1","properties":[{"key":"ProteinId","value":"ENSP00000574285.1"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"Ensembl","id":"ENST00000904227.1","properties":[{"key":"ProteinId","value":"ENSP00000574286.1"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"Ensembl","id":"ENST00000923874.1","properties":[{"key":"ProteinId","value":"ENSP00000593933.1"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"Ensembl","id":"ENST00000923875.1","properties":[{"key":"ProteinId","value":"ENSP00000593934.1"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"Ensembl","id":"ENST00000955038.1","properties":[{"key":"ProteinId","value":"ENSP00000625097.1"},{"key":"GeneId","value":"ENSG00000133114.19"}],"isoformId":"Q8IXQ4-1"},{"database":"GeneID","id":"55425","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:55425","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000379151.9","properties":[{"key":"ProteinId","value":"ENSP00000368447.4"},{"key":"RefSeqNucleotideId","value":"NM_018559.5"},{"key":"RefSeqProteinId","value":"NP_061029.2"}]},{"database":"UCSC","id":"uc001uzq.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8IXQ4-1"},{"database":"AGR","id":"HGNC:20298","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134943194","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55425","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"55425","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GPALPP1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:20298","properties":[{"key":"GeneName","value":"GPALPP1"}]},{"database":"HPA","id":"ENSG00000133114","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"OpenTargets","id":"ENSG00000133114","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000133114","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4188","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000163575","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_029231_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NKAADFG","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"73491at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IXQ4","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000133114","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"55425","properties":[{"key":"hits","value":"21 hits in 1148 CRISPR screens"}]},{"database":"ChiTaRS","id":"GPALPP1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"KIAA1704","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"55425","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IXQ4","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q8IXQ4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 13"}]},{"database":"RNAct","id":"Q8IXQ4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000133114","properties":[{"key":"ExpressionPatterns","value":"Expressed in endothelial cell and 180 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8IXQ4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR022226","properties":[{"key":"EntryName","value":"DUF3752"}]},{"database":"InterPro","id":"IPR046331","properties":[{"key":"EntryName","value":"GPAM1-like"}]},{"database":"PANTHER","id":"PTHR46370","properties":[{"key":"EntryName","value":"GPALPP MOTIFS-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR46370:SF1","properties":[{"key":"EntryName","value":"GPALPP MOTIFS-CONTAINING PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12572","properties":[{"key":"EntryName","value":"DUF3752"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MARDLIGPALPPGFKARGTAEDEERDPSPVAGPALPPNYKSSSSDSSDSDEDSSSLYEEGNQESEEDDSGPTARKQRKNQDDDDDDDDGFFGPALPPGFKKQDDSPPRPIIGPALPPGFIKSTQKSDKGRDDPGQQETDSSEDEDIIGPMPAKGPVNYNVTTEFEKRAQRMKEKLTKGDDDSSKPIVRESWMTELPPEMKDFGLGPRTFKRRADDTSGDRSIWTDTPADRERKAKETQEARKSSSKKDEEHILSGRDKRLAEQVSSYNESKRSESLMDIHHKKLKSKAAEDKNKPQERIPFDRDKDLKVNRFDEAQKKALIKKSRELNTRFSHGKGNMFL","length":340,"molWeight":38142,"crc64":"F752A6A2917132E6","md5":"F62FC835E3D2437DA9B7444F357A6F18"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":4,"SEQUENCE CAUTION":2},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Region":1,"Motif":4,"Compositional bias":7,"Modified residue":6,"Cross-link":2,"Alternative sequence":4,"Sequence conflict":6},"uniParcId":"UPI000007435F"}}