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This splicing event yields the active XBP1s transcription factor, which induces genes required to resolve protein folding defects in the endoplasmic reticulum (PubMed:25378478, PubMed:26483401, PubMed:38493148)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-histidyl-[RNA ligase] + GTP = N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] + diphosphate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:68084"},{"database":"Rhea","id":"RHEA-COMP:17425"},{"database":"Rhea","id":"RHEA-COMP:17427"},{"database":"ChEBI","id":"CHEBI:29979"},{"database":"ChEBI","id":"CHEBI:33019"},{"database":"ChEBI","id":"CHEBI:37565"},{"database":"ChEBI","id":"CHEBI:176906"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24870230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38493148"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:68085"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24870230"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38493148"}]}]},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38493148"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38493148"}],"value":"Binds 1 Mn(2+) ion per subunit. 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