{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IWI9","secondaryAccessions":["B9EGR5","E7ENI0","F5H7K2","Q9H8R3","Q9H9N7","Q9UG69","Q9Y4E9"],"uniProtkbId":"MGAP_HUMAN","entryAudit":{"firstPublicDate":"2008-07-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2019-06-05","entryVersion":181,"sequenceVersion":4},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"MAX gene-associated protein"}},"alternativeNames":[{"fullName":{"value":"MAX dimerization protein 5"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"39545409"}],"value":"MGA"},"synonyms":[{"value":"KIAA0518"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"value":"MAD5"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A2AWL7"}],"value":"Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15960975"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23372760"}],"value":"Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8IWI9","intActId":"EBI-2815196"},"interactantTwo":{"uniProtKBAccession":"Q13185","geneName":"CBX3","intActId":"EBI-78176"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IWI9","intActId":"EBI-2815196"},"interactantTwo":{"uniProtKBAccession":"P61244","geneName":"MAX","intActId":"EBI-751711"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IWI9","intActId":"EBI-2815196"},"interactantTwo":{"uniProtKBAccession":"Q9Y2K6","geneName":"USP20","intActId":"EBI-2511991"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8IWI9-4"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8IWI9-3"],"sequenceIds":["VSP_060177"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39545409"}],"value":"Highly expressed in germ cells and granulosa cells"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39545409"}],"value":"In germ cells and granulosa cells, expressed from early embryonic through adult developmental stages"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain"}],"commentType":"DOMAIN"},{"commentType":"DISEASE","disease":{"diseaseId":"Premature ovarian failure 26","diseaseAccession":"DI-06988","acronym":"POF26","description":"A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF26 inheritance is autosomal dominant.","diseaseCrossReference":{"database":"MIM","id":"621065"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39545409"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB14186.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAB14543.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":3065,"modifier":"EXACT"}},"description":"MAX gene-associated protein","featureId":"PRO_0000342692"},{"type":"Domain","location":{"start":{"value":2423,"modifier":"EXACT"},"end":{"value":2474,"modifier":"EXACT"}},"description":"bHLH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00981"}]},{"type":"DNA binding","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":260,"modifier":"EXACT"}},"description":"T-box","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00201"}]},{"type":"Region","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":604,"modifier":"EXACT"},"end":{"value":653,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":881,"modifier":"EXACT"},"end":{"value":911,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":971,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1246,"modifier":"EXACT"},"end":{"value":1332,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1380,"modifier":"EXACT"},"end":{"value":1429,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1488,"modifier":"EXACT"},"end":{"value":1517,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1905,"modifier":"EXACT"},"end":{"value":1927,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1967,"modifier":"EXACT"},"end":{"value":2029,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2258,"modifier":"EXACT"},"end":{"value":2316,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2576,"modifier":"EXACT"},"end":{"value":2595,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2668,"modifier":"EXACT"},"end":{"value":2709,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":2944,"modifier":"EXACT"},"end":{"value":2968,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1147,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":2817,"modifier":"EXACT"},"end":{"value":2841,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":277,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":278,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":624,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":632,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":901,"modifier":"EXACT"},"end":{"value":911,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":972,"modifier":"EXACT"},"end":{"value":981,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1253,"modifier":"EXACT"},"end":{"value":1269,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1310,"modifier":"EXACT"},"end":{"value":1322,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1495,"modifier":"EXACT"},"end":{"value":1514,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1911,"modifier":"EXACT"},"end":{"value":1927,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1968,"modifier":"EXACT"},"end":{"value":1994,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2008,"modifier":"EXACT"},"end":{"value":2023,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2300,"modifier":"EXACT"},"end":{"value":2316,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2581,"modifier":"EXACT"},"end":{"value":2595,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":2671,"modifier":"EXACT"},"end":{"value":2709,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":534,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":645,"modifier":"EXACT"},"end":{"value":645,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":851,"modifier":"EXACT"},"end":{"value":851,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":924,"modifier":"EXACT"},"end":{"value":924,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1208,"modifier":"EXACT"},"end":{"value":1208,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":1430,"modifier":"EXACT"},"end":{"value":1430,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"}]},{"type":"Modified residue","location":{"start":{"value":1457,"modifier":"EXACT"},"end":{"value":1457,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2265,"modifier":"EXACT"},"end":{"value":2265,"modifier":"EXACT"}},"description":"Omega-N-methylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":2541,"modifier":"EXACT"},"end":{"value":2541,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2910,"modifier":"EXACT"},"end":{"value":2910,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"}]},{"type":"Modified residue","location":{"start":{"value":2921,"modifier":"EXACT"},"end":{"value":2921,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21406692"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Modified residue","location":{"start":{"value":2978,"modifier":"EXACT"},"end":{"value":2978,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Cross-link","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":323,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":329,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":349,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":432,"modifier":"EXACT"},"end":{"value":432,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":465,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":482,"modifier":"EXACT"},"end":{"value":482,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":570,"modifier":"EXACT"},"end":{"value":570,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":613,"modifier":"EXACT"},"end":{"value":613,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":785,"modifier":"EXACT"},"end":{"value":785,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":791,"modifier":"EXACT"},"end":{"value":791,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":817,"modifier":"EXACT"},"end":{"value":817,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":826,"modifier":"EXACT"},"end":{"value":826,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":928,"modifier":"EXACT"},"end":{"value":928,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":990,"modifier":"EXACT"},"end":{"value":990,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1091,"modifier":"EXACT"},"end":{"value":1091,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1140,"modifier":"EXACT"},"end":{"value":1140,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1162,"modifier":"EXACT"},"end":{"value":1162,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1199,"modifier":"EXACT"},"end":{"value":1199,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1207,"modifier":"EXACT"},"end":{"value":1207,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1461,"modifier":"EXACT"},"end":{"value":1461,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1502,"modifier":"EXACT"},"end":{"value":1502,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1985,"modifier":"EXACT"},"end":{"value":1985,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":1992,"modifier":"EXACT"},"end":{"value":1992,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2103,"modifier":"EXACT"},"end":{"value":2103,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2113,"modifier":"EXACT"},"end":{"value":2113,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2135,"modifier":"EXACT"},"end":{"value":2135,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2139,"modifier":"EXACT"},"end":{"value":2139,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2146,"modifier":"EXACT"},"end":{"value":2146,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2159,"modifier":"EXACT"},"end":{"value":2159,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2194,"modifier":"EXACT"},"end":{"value":2194,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2206,"modifier":"EXACT"},"end":{"value":2206,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2238,"modifier":"EXACT"},"end":{"value":2238,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25218447"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25772364"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2284,"modifier":"EXACT"},"end":{"value":2284,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2378,"modifier":"EXACT"},"end":{"value":2378,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2413,"modifier":"EXACT"},"end":{"value":2413,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"25755297"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2457,"modifier":"EXACT"},"end":{"value":2457,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2532,"modifier":"EXACT"},"end":{"value":2532,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2546,"modifier":"EXACT"},"end":{"value":2546,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2629,"modifier":"EXACT"},"end":{"value":2629,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2679,"modifier":"EXACT"},"end":{"value":2679,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2698,"modifier":"EXACT"},"end":{"value":2698,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":2784,"modifier":"EXACT"},"end":{"value":2784,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Cross-link","location":{"start":{"value":3041,"modifier":"EXACT"},"end":{"value":3041,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"28112733"}]},{"type":"Alternative sequence","location":{"start":{"value":1529,"modifier":"EXACT"},"end":{"value":1737,"modifier":"EXACT"}},"description":"in isoform 2","featureId":"VSP_060177","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"in dbSNP:rs3803348","featureCrossReferences":[{"database":"dbSNP","id":"rs3803348"}],"featureId":"VAR_044341","alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Natural variant","location":{"start":{"value":716,"modifier":"EXACT"},"end":{"value":716,"modifier":"EXACT"}},"description":"in dbSNP:rs2178004","featureCrossReferences":[{"database":"dbSNP","id":"rs2178004"}],"featureId":"VAR_044342","alternativeSequence":{"originalSequence":"T","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":896,"modifier":"EXACT"},"end":{"value":3065,"modifier":"EXACT"}},"description":"in POF26; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39545409"}],"featureId":"VAR_090383","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":910,"modifier":"EXACT"},"end":{"value":3065,"modifier":"EXACT"}},"description":"in POF26; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39545409"}],"featureId":"VAR_090384","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1073,"modifier":"EXACT"},"end":{"value":3065,"modifier":"EXACT"}},"description":"in POF26; likely pathogenic","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39545409"}],"featureId":"VAR_090385","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":1270,"modifier":"EXACT"},"end":{"value":1270,"modifier":"EXACT"}},"description":"in dbSNP:rs17677811","featureCrossReferences":[{"database":"dbSNP","id":"rs17677811"}],"featureId":"VAR_044343","alternativeSequence":{"originalSequence":"C","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":1523,"modifier":"EXACT"},"end":{"value":1523,"modifier":"EXACT"}},"description":"in dbSNP:rs17677991","featureCrossReferences":[{"database":"dbSNP","id":"rs17677991"}],"featureId":"VAR_057268","alternativeSequence":{"originalSequence":"P","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":266,"modifier":"EXACT"},"end":{"value":266,"modifier":"EXACT"}},"description":"in Ref. 3; BAB14186","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"K","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":742,"modifier":"EXACT"},"end":{"value":742,"modifier":"EXACT"}},"description":"in Ref. 3; BAB14186","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":1383,"modifier":"EXACT"},"end":{"value":1383,"modifier":"EXACT"}},"description":"in Ref. 2; AAI36660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":2230,"modifier":"EXACT"},"end":{"value":2230,"modifier":"EXACT"}},"description":"in Ref. 3; BAB14543","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":2365,"modifier":"EXACT"},"end":{"value":2365,"modifier":"EXACT"}},"description":"in Ref. 3; BAB14543","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":2744,"modifier":"EXACT"},"end":{"value":2744,"modifier":"EXACT"}},"description":"in Ref. 2; AAI36660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1066","category":"Disease","name":"Premature ovarian failure"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0678","category":"Molecular function","name":"Repressor"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"16572171","citationType":"journal article","authors":["Zody M.C.","Garber M.","Sharpe T.","Young S.K.","Rowen L.","O'Neill K.","Whittaker C.A.","Kamal M.","Chang J.L.","Cuomo C.A.","Dewar K.","FitzGerald M.G.","Kodira C.D.","Madan A.","Qin S.","Yang X.","Abbasi N.","Abouelleil A.","Arachchi H.M.","Baradarani L.","Birditt B.","Bloom S.","Bloom T.","Borowsky M.L.","Burke J.","Butler J.","Cook A.","DeArellano K.","DeCaprio D.","Dorris L. III","Dors M.","Eichler E.E.","Engels R.","Fahey J.","Fleetwood P.","Friedman C.","Gearin G.","Hall J.L.","Hensley G.","Johnson E.","Jones C.","Kamat A.","Kaur A.","Locke D.P.","Madan A.","Munson G.","Jaffe D.B.","Lui A.","Macdonald P.","Mauceli E.","Naylor J.W.","Nesbitt R.","Nicol R.","O'Leary S.B.","Ratcliffe A.","Rounsley S.","She X.","Sneddon K.M.B.","Stewart S.","Sougnez C.","Stone S.M.","Topham K.","Vincent D.","Wang S.","Zimmer A.R.","Birren B.W.","Hood L.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16572171"},{"database":"DOI","id":"10.1038/nature04601"}],"title":"Analysis of the DNA sequence and duplication history of human chromosome 15.","publicationDate":"2006","journal":"Nature","firstPage":"671","lastPage":"675","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","VARIANTS SER-716 AND ALA-1523"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 183-1134 AND 1800-2526 (ISOFORM 1)","VARIANT SER-716"],"referenceComments":[{"value":"Ovary","type":"TISSUE"},{"value":"Teratocarcinoma","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"9628581","citationType":"journal article","authors":["Nagase T.","Ishikawa K.","Miyajima N.","Tanaka A.","Kotani H.","Nomura N.","Ohara O."],"citationCrossReferences":[{"database":"PubMed","id":"9628581"},{"database":"DOI","id":"10.1093/dnares/5.1.31"}],"title":"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.","publicationDate":"1998","journal":"DNA Res.","firstPage":"31","lastPage":"39","volume":"5"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2416-3065 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"17974005","citationType":"journal article","authors":["Bechtel S.","Rosenfelder H.","Duda A.","Schmidt C.P.","Ernst U.","Wellenreuther R.","Mehrle A.","Schuster C.","Bahr A.","Bloecker H.","Heubner D.","Hoerlein A.","Michel G.","Wedler H.","Koehrer K.","Ottenwaelder B.","Poustka A.","Wiemann S.","Schupp I."],"citationCrossReferences":[{"database":"PubMed","id":"17974005"},{"database":"DOI","id":"10.1186/1471-2164-8-399"}],"title":"The full-ORF clone resource of the German cDNA consortium.","publicationDate":"2007","journal":"BMC Genomics","firstPage":"399","lastPage":"399","volume":"8"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2817-3065 (ISOFORM 1)"],"referenceComments":[{"value":"Uterus","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"15960975","citationType":"journal article","authors":["Dou Y.","Milne T.A.","Tackett A.J.","Smith E.R.","Fukuda A.","Wysocka J.","Allis C.D.","Chait B.T.","Hess J.L.","Roeder R.G."],"citationCrossReferences":[{"database":"PubMed","id":"15960975"},{"database":"DOI","id":"10.1016/j.cell.2005.04.031"}],"title":"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.","publicationDate":"2005","journal":"Cell","firstPage":"873","lastPage":"885","volume":"121"},"referencePositions":["IDENTIFICATION IN THE MLL1/MLL COMPLEX"]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-924; SER-1208 AND SER-1457","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645 AND SER-2910","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-534; SER-1208; SER-1430; SER-1457 AND SER-2541","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"21269460","citationType":"journal article","authors":["Burkard T.R.","Planyavsky M.","Kaupe I.","Breitwieser F.P.","Buerckstuemmer T.","Bennett K.L.","Superti-Furga G.","Colinge J."],"citationCrossReferences":[{"database":"PubMed","id":"21269460"},{"database":"DOI","id":"10.1186/1752-0509-5-17"}],"title":"Initial characterization of the human central proteome.","publicationDate":"2011","journal":"BMC Syst. Biol.","firstPage":"17","lastPage":"17","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":12,"citation":{"id":"21406692","citationType":"journal article","authors":["Rigbolt K.T.","Prokhorova T.A.","Akimov V.","Henningsen J.","Johansen P.T.","Kratchmarova I.","Kassem M.","Mann M.","Olsen J.V.","Blagoev B."],"citationCrossReferences":[{"database":"PubMed","id":"21406692"},{"database":"DOI","id":"10.1126/scisignal.2001570"}],"title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.","publicationDate":"2011","journal":"Sci. Signal.","firstPage":"RS3","lastPage":"RS3","volume":"4"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2921","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":13,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-607; SER-851; SER-924; SER-1208; SER-1457; SER-2541; SER-2921 AND SER-2978","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]},{"referenceNumber":14,"citation":{"id":"23372760","citationType":"journal article","authors":["Kateb F.","Perrin H.","Tripsianes K.","Zou P.","Spadaccini R.","Bottomley M.","Franzmann T.M.","Buchner J.","Ansieau S.","Sattler M."],"citationCrossReferences":[{"database":"PubMed","id":"23372760"},{"database":"DOI","id":"10.1371/journal.pone.0054715"}],"title":"Structural and functional analysis of the DEAF-1 and BS69 MYND domains.","publicationDate":"2013","journal":"PLoS ONE","firstPage":"E54715","lastPage":"E54715","volume":"8"},"referencePositions":["INTERACTION WITH ZMYND11"]},{"referenceNumber":15,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-2265","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Colon carcinoma","type":"TISSUE"}]},{"referenceNumber":16,"citation":{"id":"25218447","citationType":"journal article","authors":["Hendriks I.A.","D'Souza R.C.","Yang B.","Verlaan-de Vries M.","Mann M.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25218447"},{"database":"DOI","id":"10.1038/nsmb.2890"}],"title":"Uncovering global SUMOylation signaling networks in a site-specific manner.","publicationDate":"2014","journal":"Nat. Struct. Mol. Biol.","firstPage":"927","lastPage":"936","volume":"21"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-460; LYS-570; LYS-1985; LYS-2113; LYS-2135 AND LYS-2238","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":17,"citation":{"id":"25772364","citationType":"journal article","authors":["Hendriks I.A.","Treffers L.W.","Verlaan-de Vries M.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25772364"},{"database":"DOI","id":"10.1016/j.celrep.2015.02.033"}],"title":"SUMO-2 orchestrates chromatin modifiers in response to DNA damage.","publicationDate":"2015","journal":"Cell Rep.","firstPage":"1778","lastPage":"1791","volume":"10"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-2113; LYS-2135 AND LYS-2238","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":18,"citation":{"id":"25755297","citationType":"journal article","authors":["Xiao Z.","Chang J.G.","Hendriks I.A.","Sigurdsson J.O.","Olsen J.V.","Vertegaal A.C."],"citationCrossReferences":[{"database":"PubMed","id":"25755297"},{"database":"DOI","id":"10.1074/mcp.o114.044792"}],"title":"System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.","publicationDate":"2015","journal":"Mol. Cell. Proteomics","firstPage":"1419","lastPage":"1434","volume":"14"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-329; LYS-1207; LYS-1985; LYS-2113; LYS-2135; LYS-2194; LYS-2238; LYS-2284 AND LYS-2413","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":19,"citation":{"id":"28112733","citationType":"journal article","authors":["Hendriks I.A.","Lyon D.","Young C.","Jensen L.J.","Vertegaal A.C.","Nielsen M.L."],"citationCrossReferences":[{"database":"PubMed","id":"28112733"},{"database":"DOI","id":"10.1038/nsmb.3366"}],"title":"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.","publicationDate":"2017","journal":"Nat. Struct. Mol. Biol.","firstPage":"325","lastPage":"336","volume":"24"},"referencePositions":["SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-4; LYS-178; LYS-323; LYS-329; LYS-349; LYS-432; LYS-460; LYS-465; LYS-482; LYS-570; LYS-613; LYS-654; LYS-785; LYS-791; LYS-817; LYS-826; LYS-928; LYS-990; LYS-1091; LYS-1140; LYS-1162; LYS-1199; LYS-1207; LYS-1461; LYS-1502; LYS-1985; LYS-1992; LYS-2103; LYS-2113; LYS-2135; LYS-2139; LYS-2146; LYS-2159; LYS-2194; LYS-2206; LYS-2238; LYS-2284; LYS-2378; LYS-2413; LYS-2457; LYS-2532; LYS-2546; LYS-2629; LYS-2679; LYS-2698; LYS-2784 AND LYS-3041","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":20,"citation":{"id":"39545409","citationType":"journal article","authors":["Tang S.","Guo T.","Song C.","Wang L.","Zhang J.","Rajkovic A.","Lin X.","Chen S.","Liu Y.","Tian W.","Wu B.","Wang S.","Wang W.","Lai Y.","Wang A.","Xu S.","Jin L.","Ke H.","Zhao S.","Li Y.","Qin Y.","Zhang F.","Chen Z.J."],"citationCrossReferences":[{"database":"PubMed","id":"39545409"},{"database":"DOI","id":"10.1172/jci183758"}],"title":"MGA loss-of-function variants cause premature ovarian insufficiency.","publicationDate":"2024","journal":"J. Clin. Invest.","firstPage":"0","lastPage":"0","volume":"134"},"referencePositions":["INVOLVEMENT IN POF26","VARIANTS POF26 896-ARG--LYS-3065 DEL; 910-ARG--LYS-3065 DEL AND 1073-ARG--LYS-3065 DEL","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC016134","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC073657","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC136659","properties":[{"key":"ProteinId","value":"AAI36660.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK022696","properties":[{"key":"ProteinId","value":"BAB14186.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK023360","properties":[{"key":"ProteinId","value":"BAB14543.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB011090","properties":[{"key":"ProteinId","value":"BAA25444.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AL050181","properties":[{"key":"ProteinId","value":"CAB43310.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS55959.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IWI9-4"},{"database":"CCDS","id":"CCDS55960.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IWI9-3"},{"database":"PIR","id":"T00081","properties":[{"key":"EntryName","value":"T00081"}]},{"database":"RefSeq","id":"NP_001074010.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001080541.3"}],"isoformId":"Q8IWI9-3"},{"database":"RefSeq","id":"NP_001157745.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001164273.2"}],"isoformId":"Q8IWI9-4"},{"database":"RefSeq","id":"XP_047288236.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047432280.1"}],"isoformId":"Q8IWI9-4"},{"database":"RefSeq","id":"XP_047288247.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047432291.1"}],"isoformId":"Q8IWI9-3"},{"database":"SMR","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"116870","properties":[{"key":"Interactions","value":"267"}]},{"database":"ComplexPortal","id":"CPX-2551","properties":[{"key":"EntryName","value":"MGA-MAX transcriptional repressor complex"}]},{"database":"CORUM","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-57615N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8IWI9","properties":[{"key":"Number of interactors","value":"3726"}]},{"database":"IntAct","id":"Q8IWI9","properties":[{"key":"Interactions","value":"134"}]},{"database":"MINT","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-MGA","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000219905","properties":[{"key":"Description","value":"-"}]},{"database":"CarbonylDB","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"GlyConnect","id":"Q8IWI9","properties":[{"key":"glycosylation","value":"1 O-GlcNAc glycan (1 site)"}]},{"database":"GlyCosmos","id":"Q8IWI9","properties":[{"key":"glycosylation","value":"6 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q8IWI9","properties":[{"key":"glycosylation","value":"20 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (19 sites)"}]},{"database":"iPTMnet","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MGA","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"527504082","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000219905","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"17160","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"27509","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"6067","properties":[{"key":"antibodies","value":"88 antibodies from 16 providers"}]},{"database":"Ensembl","id":"ENST00000219905.13","properties":[{"key":"ProteinId","value":"ENSP00000219905.7"},{"key":"GeneId","value":"ENSG00000174197.20"}],"isoformId":"Q8IWI9-4"},{"database":"Ensembl","id":"ENST00000566586.6","properties":[{"key":"ProteinId","value":"ENSP00000456141.1"},{"key":"GeneId","value":"ENSG00000174197.20"}],"isoformId":"Q8IWI9-3"},{"database":"Ensembl","id":"ENST00000916428.1","properties":[{"key":"ProteinId","value":"ENSP00000586487.1"},{"key":"GeneId","value":"ENSG00000174197.20"}],"isoformId":"Q8IWI9-3"},{"database":"GeneID","id":"23269","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:23269","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc010ucy.2","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8IWI9-4"},{"database":"AGR","id":"HGNC:14010","properties":[{"key":"Description","value":"-"}]},{"database":"CIViC","id":"23269","properties":[{"key":"Number of evidences","value":"1 evidence item across 1 molecular profile"}]},{"database":"ClinPGx","id":"PA134976336","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23269","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"23269","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MGA","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:14010","properties":[{"key":"GeneName","value":"MGA"}]},{"database":"HPA","id":"ENSG00000174197","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MalaCards","id":"MGA","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"616061","properties":[{"key":"Type","value":"gene"}]},{"database":"MIM","id":"621065","properties":[{"key":"Type","value":"phenotype"}]},{"database":"OpenTargets","id":"ENSG00000174197","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000174197","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3585","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156269","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000469_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FQRKATH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6119313at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IWI9","properties":[{"key":"Number of GO annotations","value":"7 GO annotations based on evolutionary models"}]},{"database":"PathwayCommons","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8953750","properties":[{"key":"PathwayName","value":"Transcriptional Regulation by E2F6"}]},{"database":"SignaLink","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000174197","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"23269","properties":[{"key":"hits","value":"48 hits in 1182 CRISPR screens"}]},{"database":"ChiTaRS","id":"MGA","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"23269","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IWI9","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8IWI9","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"Q8IWI9","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000174197","properties":[{"key":"ExpressionPatterns","value":"Expressed in calcaneal tendon and 208 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8IWI9","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0071339","properties":[{"key":"GoTerm","value":"C:MLL1 complex"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15960975"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035102","properties":[{"key":"GoTerm","value":"C:PRC1 complex"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0090571","properties":[{"key":"GoTerm","value":"C:RNA polymerase II transcription repressor complex"},{"key":"GoEvidenceType","value":"EXP:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"10601024"}]},{"database":"GO","id":"GO:0000981","properties":[{"key":"GoTerm","value":"F:DNA-binding transcription factor activity, RNA polymerase II-specific"},{"key":"GoEvidenceType","value":"ISA:NTNU_SB"}]},{"database":"GO","id":"GO:0046983","properties":[{"key":"GoTerm","value":"F:protein dimerization activity"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0000978","properties":[{"key":"GoTerm","value":"F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0001708","properties":[{"key":"GoTerm","value":"P:cell fate specification"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0031507","properties":[{"key":"GoTerm","value":"P:heterochromatin formation"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0045892","properties":[{"key":"GoTerm","value":"P:negative regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22325352"}]},{"database":"GO","id":"GO:0000122","properties":[{"key":"GoTerm","value":"P:negative regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"NAS:ComplexPortal"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"10601024"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"CDD","id":"cd18911","properties":[{"key":"EntryName","value":"bHLHzip_MGA"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd20195","properties":[{"key":"EntryName","value":"T-box_MGA-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.60.40.820:FF:000009","properties":[{"key":"EntryName","value":"MAX gene-associated protein isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"4.10.280.10:FF:000040","properties":[{"key":"EntryName","value":"MAX gene-associated protein isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"4.10.280.10","properties":[{"key":"EntryName","value":"Helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.820","properties":[{"key":"EntryName","value":"Transcription factor, T-box"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011598","properties":[{"key":"EntryName","value":"bHLH_dom"}]},{"database":"InterPro","id":"IPR036638","properties":[{"key":"EntryName","value":"HLH_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR037935","properties":[{"key":"EntryName","value":"MAX_gene-associated_bHLHzip"}]},{"database":"InterPro","id":"IPR032060","properties":[{"key":"EntryName","value":"MGA_dom"}]},{"database":"InterPro","id":"IPR008967","properties":[{"key":"EntryName","value":"p53-like_TF_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR046360","properties":[{"key":"EntryName","value":"T-box_DNA-bd"}]},{"database":"InterPro","id":"IPR036960","properties":[{"key":"EntryName","value":"T-box_sf"}]},{"database":"InterPro","id":"IPR001699","properties":[{"key":"EntryName","value":"TF_T-box"}]},{"database":"InterPro","id":"IPR018186","properties":[{"key":"EntryName","value":"TF_T-box_CS"}]},{"database":"PANTHER","id":"PTHR11267:SF32","properties":[{"key":"EntryName","value":"MAX GENE-ASSOCIATED PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR11267","properties":[{"key":"EntryName","value":"T-BOX PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00010","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16059","properties":[{"key":"EntryName","value":"MGA_dom"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00907","properties":[{"key":"EntryName","value":"T-box"},{"key":"MatchStatus","value":"1"}]},{"database":"PRINTS","id":"PR00937","properties":[{"key":"EntryName","value":"TBOX"}]},{"database":"SMART","id":"SM00353","properties":[{"key":"EntryName","value":"HLH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00425","properties":[{"key":"EntryName","value":"TBOX"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF47459","properties":[{"key":"EntryName","value":"HLH, helix-loop-helix DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF49417","properties":[{"key":"EntryName","value":"p53-like transcription factors"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50888","properties":[{"key":"EntryName","value":"BHLH"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS01264","properties":[{"key":"EntryName","value":"TBOX_2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50252","properties":[{"key":"EntryName","value":"TBOX_3"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MEEKQQIILANQDGGTVAGAAPTFFVILKQPGNGKTDQGILVTNQDACALASSVSSPVKSKGKICLPADCTVGGITVTLDNNSMWNEFYHRSTEMILTKQGRRMFPYCRYWITGLDSNLKYILVMDISPVDNHRYKWNGRWWEPSGKAEPHVLGRVFIHPESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKAVEVIQLNGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLNNKPQRDGKQKNSSDQEGNNISSSSGHRVRLTEGQGSEIQPGDLDPLSRGHETSGKGLEKTSLNIKRDFLGFMDTDSALSEVPQLKQEISECLIASSFEDDSRVASPLDQNGSFNVVIKEEPLDDYDYELGECPEGVTVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNPEADHLSSKWLPSSPSGVAKAKMFKLDTGKMPVVYLEPCAVTRSTVKISELPDNMLSTSRKDKSSMLAELEYLPTYIENSNETAFCLGKESENGLRKHSPDLRVVQKYPLLKEPQWKYPDISDSISTERILDDSKDSVGDSLSGKEDLGRKRTTMLKIATAAKVVNANQNASPNVPGKRGRPRKLKLCKAGRPPKNTGKSLISTKNTPVSPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTTEESSSLQASTTNDSGYRARISQLEKELIEDLKTLRHKQVIHPGLQEVGLKLNSVDPTMSIDLKYLGVQLPLAPATSFPFWNLTGTNPASPDAGFPFVSRTGKTNDFTKIKGWRGKFHSASASRNEGGNSESSLKNRSAFCSDKLDEYLENEGKLMETSMGFSSNAPTSPVVYQLPTKSTSYVRTLDSVLKKQSTISPSTSYSLKPHSVPPVSRKAKSQNRQATFSGRTKSSYKSILPYPVSPKQKYSHVILGDKVTKNSSGIISENQANNFVVPTLDENIFPKQISLRQAQQQQQQQQGSRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKTKPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVKGGSKTKHFQRKAAHRDPVFYDTLGEEAREEEEGIREEEEQLKEKKKRKKLEYTICETEPEQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPMKPLLLPQPEVLSPTVKGKLLTGIKSPRSYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEDQRQPSSSSSPSPSFQQQTSCHSSPENHNNAKEPDSEQQPLKQLTCDLEDDSDKLQEKSWKSSCNEGESSSTSYMHQRSPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKSRGEKNPPVYSSRVKISMPSCQDQDDMAEKSGSETPDGPLSPGKMEDISPVQTDALDSVRERLHGGKGLPFYAGLSPAGKLVAYKRKPSSSTSGLIQVASNAKVAASRKPRTLLPSTSNSKMASSSGTATNRPGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVSTPQTLAGTQKFSIRPSPVMVVTPVVSSEPVQVCSPVTAAVTTTTPQVFLENTTAVTPMTAISDVETKETTYSSGATTTGVVEVSETNTSTSVTSTQSTATVNLTKTTGITTPVASVAFPKSLVASPSTITLPVASTASTSLVVVTAAASSSMVTTPTSSLGSVPIILSGINGSPPVSQRPENAAQIPVATPQVSPNTVKRAGPRLLLIPVQQGSPTLRPVSNTQLQGHRMVLQPVRSPSGMNLFRHPNGQIVQLLPLHQLRGSNTQPNLQPVMFRNPGSVMGIRLPAPSKPSETPPSSTSSSAFSVMNPVIQAVGSSSAVNVITQAPSLLSSGASFVSQAGTLTLRISPPEPQSFASKTGSETKITYSSGGQPVGTASLIPLQSGSFALLQLPGQKPVPSSILQHVASLQMKRESQNPDQKDETNSIKREQETKKVLQSEGEAVDPEANVIKQNSGAATSEETLNDSLEDRGDHLDEECLPEEGCATVKPSEHSCITGSHTDQDYKDVNEEYGARNRKSSKEKVAVLEVRTISEKASNKTVQNLSKVQHQKLGDVKVEQQKGFDNPEENSSEFPVTFKEESKFELSGSKVMEQQSNLQPEAKEKECGDSLEKDRERWRKHLKGPLTRKCVGASQECKKEADEQLIKETKTCQENSDVFQQEQGISDLLGKSGITEDARVLKTECDSWSRISNPSAFSIVPRRAAKSSRGNGHFQGHLLLPGEQIQPKQEKKGGRSSADFTVLDLEEDDEDDNEKTDDSIDEIVDVVSDYQSEEVDDVEKNNCVEYIEDDEEHVDIETVEELSEEINVAHLKTTAAHTQSFKQPSCTHISADEKAAERSRKAPPIPLKLKPDYWSDKLQKEAEAFAYYRRTHTANERRRRGEMRDLFEKLKITLGLLHSSKVSKSLILTRAFSEIQGLTDQADKLIGQKNLLTRKRNILIRKVSSLSGKTEEVVLKKLEYIYAKQQALEAQKRKKKMGSDEFDISPRISKQQEGSSASSVDLGQMFINNRRGKPLILSRKKDQATENTSPLNTPHTSANLVMTPQGQLLTLKGPLFSGPVVAVSPDLLESDLKPQVAGSAVALPENDDLFMMPRIVNVTSLATEGGLVDMGGSKYPHEVPDSKPSDHLKDTVRNEDNSLEDKGRISSRGNRDGRVTLGPTQVFLANKDSGYPQIVDVSNMQKAQEFLPKKISGDMRGIQYKWKESESRGERVKSKDSSFHKLKMKDLKDSSIEMELRKVTSAIEEAALDSSELLTNMEDEDDTDETLTSLLNEIAFLNQQLNDDSVGLAELPSSMDTEFPGDARRAFISKVPPGSRATFQVEHLGTGLKELPDVQGESDSISPLLLHLEDDDFSENEKQLAEPASEPDVLKIVIDSEIKDSLLSNKKAIDGGKNTSGLPAEPESVSSPPTLHMKTGLENSNSTDTLWRPMPKLAPLGLKVANPSSDADGQSLKVMPCLAPIAAKVGSVGHKMNLTGNDQEGRESKVMPTLAPVVAKLGNSGASPSSAGK","length":3065,"molWeight":336159,"crc64":"430B04B7ED92B4A8","md5":"057E3CA6057584C1730ED9111E9CA0C5"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":3,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"DOMAIN":1,"DISEASE":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":1,"DNA binding":1,"Region":13,"Coiled coil":2,"Compositional bias":16,"Modified residue":13,"Cross-link":47,"Alternative sequence":1,"Natural variant":7,"Sequence conflict":6},"uniParcId":"UPI0001B2337E"}}