{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IWE4","secondaryAccessions":["B3KVY4"],"uniProtkbId":"DCNL3_HUMAN","entryAudit":{"firstPublicDate":"2008-02-26","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2003-03-01","entryVersion":148,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"DCN1-like protein 3"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23201271"}],"value":"DCNL3"}]},"alternativeNames":[{"fullName":{"value":"DCUN1 domain-containing protein 3"}},{"fullName":{"value":"Defective in cullin neddylation protein 1-like protein 3"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25349211"}],"value":"Squamous cell carcinoma-related oncogene 3"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:28734"}],"value":"DCUN1D3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25349211"}],"value":"SCCRO3"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23201271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27542266"}],"value":"Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes and may play a role in the cell cycle progression by regulating the SCF ubiquitin E3 ligase complex, after UV damage (PubMed:18823379, PubMed:19617556, PubMed:23201271, PubMed:27542266). At the cell membrane, can promote and as well inhibit cullins neddylation (PubMed:19617556, PubMed:25349211, PubMed:26906416)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23201271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27542266"}],"value":"Part of a complex containing DCUN1D3, CUL3 and RBX1 (PubMed:19617556). Interacts (via the DCUN1 domain) with the unneddylated cullins: interacts with CUL1, CUL2, CUL3, CUL4A, CUL4B and CUL5; these interactions promote the cullin neddylation and the identity of the cullin dictates the affinity of the interaction (PubMed:23201271, PubMed:26906416, PubMed:27542266). Interacts preferentially with CUL3; this interaction triggers the relocalization of CUL3 to the cell membrane where CUL3 is neddylated (PubMed:19617556). Interacts (via DCUN1 domain) with RBX1 (PubMed:25349211, PubMed:26906416). May also interact with regulators or subunits of cullin-RING ligases such as RNF7, ELOB and DDB1; these interactions are bridged by cullins (PubMed:26906416). Interacts (via DCUN1 domain) with CAND1; this interaction is bridged by cullins and strongly inhibits cullin neddylation (PubMed:26906416, PubMed:27542266). These CAND-cullin-DCNL complexes can only be neddylated in the presence of a substrate adapter (PubMed:26906416). Interacts (via DCUN1 domain) with the N-terminally acetylated form of UBE2M and UBE2F (PubMed:19617556, PubMed:23201271, PubMed:25349211)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8IWE4","intActId":"EBI-15794102"},"interactantTwo":{"uniProtKBAccession":"Q13618","geneName":"CUL3","intActId":"EBI-456129"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IWE4","intActId":"EBI-15794102"},"interactantTwo":{"uniProtKBAccession":"Q13618-1","geneName":"CUL3","intActId":"EBI-15794202"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"}],"value":"After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"value":"Cell membrane","id":"SL-0039"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"}],"value":"Cytoplasm, perinuclear region","id":"SL-0198"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"value":"Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18823379"}],"value":"Increases by UVC treatment"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23201271"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"value":"The DCUN1 domain, also known as PONY domain, mediates the interaction with different cullins (PubMed:19617556, PubMed:23201271). The DCUN1 domain mediates the interaction with the N-terminally acetylated NEDD8-conjugating E2s enzyme leading to the NEDD8 transfer from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes; the neddylation efficiency correlates with the DCUN1D5-cullin and DCUN1D5-E2 interaction affinities (PubMed:23201271). This domain is also involved in CAND1-, cullins- and RBX1-binding (PubMed:25349211, PubMed:26906416)"}],"commentType":"DOMAIN"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"DCN1-like protein 3","featureId":"PRO_0000320048"},{"type":"Domain","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":278,"modifier":"EXACT"}},"description":"DCUN1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00574"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":284,"modifier":"EXACT"},"end":{"value":304,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Lipidation","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-myristoyl glycine","evidences":[{"evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"}]},{"type":"Natural variant","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"in a cancer; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"}],"featureId":"VAR_072689","alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}},{"type":"Natural variant","location":{"start":{"value":239,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"in a cancer; uncertain significance","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"}],"featureId":"VAR_072690","alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Mutagenesis","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":26,"modifier":"EXACT"}},"description":"No effect on CAND1-, CUL1-, CUL3- and RBX1-binding.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"}],"alternativeSequence":{}},{"type":"Mutagenesis","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"No effect on CAND1-, CUL1-, CUL3- and RBX1-binding. Loss of localization at the cell membrane. Loss of function of inhibition of DCUN1D1-mediated CUL1 neddylation. Loss of myristoylation. Loss of myristoylation; when associated with A-4. Loss of myristoylation; when associated with A-8. Loss of palmitoylation. Affects cell membrane localization, and localizes throughout the cytoplasm. Does not relocalizes CUL3 to the cell membrane.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":4,"modifier":"EXACT"},"end":{"value":4,"modifier":"EXACT"}},"description":"Does not affect myristoylation; when associated with A-8. Loss of myristoylation; when associated with A-2. Loss of palmitoylation; when associated with A-8. Reduces cell membrane localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":8,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"Does not affect myristoylation; when associated with A-4. Loss of myristoylation; when associated with A-2. Loss of palmitoylation; when associated with A-4. Reduces cell membrane localization.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Loss of interaction with CUL1, CUL2, CUL3, CULA4, CULA5, CAND1 and RBX1; when associated with R-265 and A-271. Does not affect both nucleus and cytoplasm localization; when associated with R-265 and A-271. Loss of interaction with CUL3; when associated with R-265 and A-271.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Loss of CAND1-, CUL1-, CUL3- and RBX1-binding. Loss of function of inhibition of DCUN1D1-mediated CUL1 neddylation, but no effect on localization at the cell membrane; when associated with R-265 and N-271.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Mutagenesis","location":{"start":{"value":265,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Loss of CAND1-, CUL1-, CUL3- and RBX1-binding. Loss of function of inhibition of DCUN1D1-mediated CUL1 neddylation, but no effect on localization at the cell membrane; when associated with N-241 and N-271. Loss of interaction with CUL1, CUL2, CUL3, CULA4, CULA5, CAND1 and RBX1; when associated with A-241 and A-271. Does not affect both nucleus and cytoplasm localization; when associated with A-241 and A-271. Loss of interaction with CUL3; when associated with A-241 and A-271.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["R"]}},{"type":"Mutagenesis","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Loss of interaction with CUL1, CUL2, CUL3, CULA4, CULA5 CALD1 and RBX1; when associated with A-241 and R-265. Does not affect both nucleus and cytoplasm localization; when associated with A-241 and R-265. Loss of interaction with CUL3; when associated with A-241 and A-271.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19617556"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26906416"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["A"]}},{"type":"Mutagenesis","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"Loss of CAND1-, CUL1-, CUL3- and RBX1-binding. Loss of function of inhibition of DCUN1D1-mediated CUL1 neddylation, but no effect on localization at the cell membrane; when associated with N-241 and R-265.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25349211"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}},{"type":"Helix","location":{"start":{"value":90,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Beta strand","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":106,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":108,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":125,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":176,"modifier":"EXACT"},"end":{"value":190,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Turn","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Beta strand","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":202,"modifier":"EXACT"},"end":{"value":212,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Turn","location":{"start":{"value":213,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":252,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]},{"type":"Helix","location":{"start":{"value":268,"modifier":"EXACT"},"end":{"value":282,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"4GBA"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0449","category":"PTM","name":"Lipoprotein"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0519","category":"PTM","name":"Myristate"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0564","category":"PTM","name":"Palmitate"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16533400","citationType":"journal article","authors":["Kemmer D.","Podowski R.M.","Arenillas D.","Lim J.","Hodges E.","Roth P.","Sonnhammer E.L.L.","Hoeoeg C.","Wasserman W.W."],"citationCrossReferences":[{"database":"PubMed","id":"16533400"},{"database":"DOI","id":"10.1186/1471-2164-7-48"}],"title":"NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.","publicationDate":"2006","journal":"BMC Genomics","firstPage":"48","lastPage":"48","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"]},{"referenceNumber":2,"citation":{"id":"18823379","citationType":"journal article","authors":["Ma T.","Shi T.","Huang J.","Wu L.","Hu F.","He P.","Deng W.","Gao P.","Zhang Y.","Song Q.","Ma D.","Qiu X."],"citationCrossReferences":[{"database":"PubMed","id":"18823379"},{"database":"DOI","id":"10.1111/j.1349-7006.2008.00929.x"}],"title":"DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth.","publicationDate":"2008","journal":"Cancer Sci.","firstPage":"2128","lastPage":"2135","volume":"99"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","TISSUE SPECIFICITY","INDUCTION","FUNCTION"]},{"referenceNumber":3,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"19617556","citationType":"journal article","authors":["Meyer-Schaller N.","Chou Y.C.","Sumara I.","Martin D.D.","Kurz T.","Katheder N.","Hofmann K.","Berthiaume L.G.","Sicheri F.","Peter M."],"citationCrossReferences":[{"database":"PubMed","id":"19617556"},{"database":"DOI","id":"10.1073/pnas.0812528106"}],"title":"The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.","publicationDate":"2009","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12365","lastPage":"12370","volume":"106"},"referencePositions":["FUNCTION","INTERACTION WITH CUL1; CUL2; CUL3 AND UBE2M","MUTAGENESIS OF GLY-2; CYS-4; CYS-8; ASP-241; ALA-265 AND ASP-271","DOMAIN","MYRISTOYLATION AT GLY-2","SUBCELLULAR LOCATION"]},{"referenceNumber":7,"citation":{"id":"25349211","citationType":"journal article","authors":["Huang G.","Stock C.","Bommelje C.C.","Weeda V.B.","Shah K.","Bains S.","Buss E.","Shaha M.","Rechler W.","Ramanathan S.Y.","Singh B."],"citationCrossReferences":[{"database":"PubMed","id":"25349211"},{"database":"DOI","id":"10.1074/jbc.m114.585505"}],"title":"SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1).","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"34728","lastPage":"34742","volume":"289"},"referencePositions":["FUNCTION","INTERACTION WITH CAND1; CUL1; CUL3 AND RBX1","LACK OF INTERACTION WITH UBE2M","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","MUTAGENESIS OF 1-MET--ASN-26; GLY-2; ASP-241; ALA-265 AND ASP-271","VARIANTS SER-2 AND PHE-239"]},{"referenceNumber":8,"citation":{"id":"26906416","citationType":"journal article","authors":["Keuss M.J.","Thomas Y.","Mcarthur R.","Wood N.T.","Knebel A.","Kurz T."],"citationCrossReferences":[{"database":"PubMed","id":"26906416"},{"database":"DOI","id":"10.1242/jcs.181784"}],"title":"Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.","publicationDate":"2016","journal":"J. Cell Sci.","firstPage":"1441","lastPage":"1454","volume":"129"},"referencePositions":["INTERACTION WITH CUL1; CUL2; CUL3; CUL4A; CUL4B; CUL5; CAND1; RBX1; RNF7; ELOB AND DDB1","SUBCELLULAR LOCATION","FUNCTION","TISSUE SPECIFICITY","MUTAGENESIS OF ASP-241; ALA-265 AND ASP-271"]},{"referenceNumber":9,"citation":{"id":"27542266","citationType":"journal article","authors":["Zhang S.","Huang J.","Shi T.","Hu F.","Zhang L.","Zhou P.K.","Ma D.","Ma T.","Qiu X."],"citationCrossReferences":[{"database":"PubMed","id":"27542266"},{"database":"DOI","id":"10.18632/oncotarget.11302"}],"title":"DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.","publicationDate":"2016","journal":"Oncotarget","firstPage":"58483","lastPage":"58491","volume":"7"},"referencePositions":["INTERACTION WITH CAND1 AND CUL1","FUNCTION"]},{"referenceNumber":10,"citation":{"id":"23201271","citationType":"journal article","authors":["Monda J.K.","Scott D.C.","Miller D.J.","Lydeard J.","King D.","Harper J.W.","Bennett E.J.","Schulman B.A."],"citationCrossReferences":[{"database":"PubMed","id":"23201271"},{"database":"DOI","id":"10.1016/j.str.2012.10.013"}],"title":"Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.","publicationDate":"2013","journal":"Structure","firstPage":"42","lastPage":"53","volume":"21"},"referencePositions":["X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 86-304 IN COMPLEX WITH UBE2F PEPTIDE","INTERACTION OF THE DCUN1 DOMAIN WITH CUL1; CUL2; CUL3; CUL4A; CUL4B; CUL5; UBE2F AND UBE2M","FUNCTION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY364247","properties":[{"key":"ProteinId","value":"AAQ76806.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK123719","properties":[{"key":"ProteinId","value":"BAG53946.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH471228","properties":[{"key":"ProteinId","value":"EAW66842.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC040442","properties":[{"key":"ProteinId","value":"AAH40442.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS10592.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_775746.1","properties":[{"key":"NucleotideSequenceId","value":"NM_173475.4"}]},{"database":"PDB","id":"4GBA","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.40 A"},{"key":"Chains","value":"A/B=86-304"}]},{"database":"PDBsum","id":"4GBA","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"125841","properties":[{"key":"Interactions","value":"29"}]},{"database":"DIP","id":"DIP-60769N","properties":[{"key":"Description","value":"-"}]},{"database":"ELM","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8IWE4","properties":[{"key":"Number of interactors","value":"2123"}]},{"database":"IntAct","id":"Q8IWE4","properties":[{"key":"Interactions","value":"11"}]},{"database":"MINT","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000319482","properties":[{"key":"Description","value":"-"}]},{"database":"BindingDB","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"ChEMBL","id":"CHEMBL4295894","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"DCUN1D3","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74728175","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000319482","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"70849","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"25634","properties":[{"key":"antibodies","value":"62 antibodies from 18 providers"}]},{"database":"DNASU","id":"123879","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000324344.9","properties":[{"key":"ProteinId","value":"ENSP00000319482.3"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000563934.1","properties":[{"key":"ProteinId","value":"ENSP00000454762.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000900856.1","properties":[{"key":"ProteinId","value":"ENSP00000570915.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000900857.1","properties":[{"key":"ProteinId","value":"ENSP00000570916.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000917271.1","properties":[{"key":"ProteinId","value":"ENSP00000587330.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000917272.1","properties":[{"key":"ProteinId","value":"ENSP00000587331.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000917273.1","properties":[{"key":"ProteinId","value":"ENSP00000587332.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000917274.1","properties":[{"key":"ProteinId","value":"ENSP00000587333.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000917275.1","properties":[{"key":"ProteinId","value":"ENSP00000587334.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000917276.1","properties":[{"key":"ProteinId","value":"ENSP00000587335.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000947782.1","properties":[{"key":"ProteinId","value":"ENSP00000617841.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000947783.1","properties":[{"key":"ProteinId","value":"ENSP00000617842.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000947784.1","properties":[{"key":"ProteinId","value":"ENSP00000617843.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"Ensembl","id":"ENST00000947785.1","properties":[{"key":"ProteinId","value":"ENSP00000617844.1"},{"key":"GeneId","value":"ENSG00000188215.11"}]},{"database":"GeneID","id":"123879","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:123879","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000324344.9","properties":[{"key":"ProteinId","value":"ENSP00000319482.3"},{"key":"RefSeqNucleotideId","value":"NM_173475.4"},{"key":"RefSeqProteinId","value":"NP_775746.1"}]},{"database":"UCSC","id":"uc002dhz.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:28734","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672009","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"123879","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"DCUN1D3","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:28734","properties":[{"key":"GeneName","value":"DCUN1D3"}]},{"database":"HPA","id":"ENSG00000188215","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"616167","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000188215","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000188215","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3077","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154944","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_047042_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"DQMNQNI","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"27198at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IWE4","properties":[{"key":"Number of GO annotations","value":"5 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-8951664","properties":[{"key":"PathwayName","value":"Neddylation"}]},{"database":"SignaLink","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000188215","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"123879","properties":[{"key":"hits","value":"28 hits in 1165 CRISPR screens"}]},{"database":"EvolutionaryTrace","id":"Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"123879","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IWE4","properties":[{"key":"DevelopmentLevel","value":"Tchem"}]},{"database":"PRO","id":"PR:Q8IWE4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q8IWE4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000188215","properties":[{"key":"ExpressionPatterns","value":"Expressed in secondary oocyte and 173 other cell types or tissues"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26906416"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26906416"}]},{"database":"GO","id":"GO:0048471","properties":[{"key":"GoTerm","value":"C:perinuclear region of cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18823379"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19617556"}]},{"database":"GO","id":"GO:0000151","properties":[{"key":"GoTerm","value":"C:ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0097602","properties":[{"key":"GoTerm","value":"F:cullin family protein binding"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23201271"}]},{"database":"GO","id":"GO:0031624","properties":[{"key":"GoTerm","value":"F:ubiquitin conjugating enzyme binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032182","properties":[{"key":"GoTerm","value":"F:ubiquitin-like protein binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0030308","properties":[{"key":"GoTerm","value":"P:negative regulation of cell growth"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18823379"}]},{"database":"GO","id":"GO:2000134","properties":[{"key":"GoTerm","value":"P:negative regulation of G1/S transition of mitotic cell cycle"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18823379"}]},{"database":"GO","id":"GO:2000435","properties":[{"key":"GoTerm","value":"P:negative regulation of protein neddylation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"26906416"}]},{"database":"GO","id":"GO:0043065","properties":[{"key":"GoTerm","value":"P:positive regulation of apoptotic process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18823379"}]},{"database":"GO","id":"GO:2000436","properties":[{"key":"GoTerm","value":"P:positive regulation of protein neddylation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"23201271"}]},{"database":"GO","id":"GO:0045116","properties":[{"key":"GoTerm","value":"P:protein neddylation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0010564","properties":[{"key":"GoTerm","value":"P:regulation of cell cycle process"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"27542266"}]},{"database":"GO","id":"GO:2000434","properties":[{"key":"GoTerm","value":"P:regulation of protein neddylation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"19617556"}]},{"database":"GO","id":"GO:0010332","properties":[{"key":"GoTerm","value":"P:response to gamma radiation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18823379"}]},{"database":"GO","id":"GO:0010225","properties":[{"key":"GoTerm","value":"P:response to UV-C"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18823379"}]},{"database":"FunFam","id":"1.10.238.10:FF:000126","properties":[{"key":"EntryName","value":"DCN1-like protein"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.238.200:FF:000003","properties":[{"key":"EntryName","value":"DCN1-like protein 3"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.200","properties":[{"key":"EntryName","value":"Cullin, PONY binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.238.10","properties":[{"key":"EntryName","value":"EF-hand"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR014764","properties":[{"key":"EntryName","value":"DCN-prot"}]},{"database":"InterPro","id":"IPR042460","properties":[{"key":"EntryName","value":"DCN1-like_PONY"}]},{"database":"InterPro","id":"IPR005176","properties":[{"key":"EntryName","value":"PONY_dom"}]},{"database":"PANTHER","id":"PTHR12281:SF31","properties":[{"key":"EntryName","value":"DCN1-LIKE PROTEIN 3"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12281","properties":[{"key":"EntryName","value":"RP42 RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03556","properties":[{"key":"EntryName","value":"Cullin_binding"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51229","properties":[{"key":"EntryName","value":"DCUN1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGQCVTKCKNPSSTLGSKNGDREPSNKSHSRRGAGHREEQVPPCGKPGGDILVNGTKKAEAATEACQLPTSSGDAGRESKSNAEESSLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDKFKDLYRFTFQFGLDSEEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENPSGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLFDTFVEWEMERRKREGEGRGALSSGPEGLCPEEQT","length":304,"molWeight":34291,"crc64":"4B190AEAE7557A78","md5":"C3AC878DA9B2F472CE0D72BA09AF609F"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":2,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Domain":1,"Region":2,"Lipidation":1,"Natural variant":2,"Mutagenesis":9,"Helix":10,"Beta strand":2,"Turn":2},"uniParcId":"UPI000005032C"}}