{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8IVS8","secondaryAccessions":["Q0P630","Q2EZ43","Q6Y2K6","Q7Z6G5","Q86YR8","Q8TED2","Q8WTY2"],"uniProtkbId":"GLCTK_HUMAN","entryAudit":{"firstPublicDate":"2007-05-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":168,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20949620"}],"value":"Glycerate kinase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20949620"}],"value":"2.7.1.31"}]},"alternativeNames":[{"fullName":{"value":"HBeAg-binding protein 4"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20949620"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:24247"}],"value":"GLYCTK"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:24247"}],"value":"HBEBP4"}],"orfNames":[{"value":"LP5910"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20949620"},{"evidenceCode":"ECO:0000305"}],"value":"Catalyzes the conversion of glycerate to phosphoglycerate (PubMed:20949620). This conversion is an intermediary reaction found in several metabolic pathways (Probable)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23516"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:16659"},{"database":"ChEBI","id":"CHEBI:30616"},{"database":"ChEBI","id":"CHEBI:58272"},{"database":"ChEBI","id":"CHEBI:456216"}],"ecNumber":"2.7.1.31","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20949620"}]}},{"commentType":"BIOPHYSICOCHEMICAL PROPERTIES","kineticParameters":{"michaelisConstants":[{"constant":0.1,"unit":"mM","substrate":"D-glycerate","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20949620"}]}]}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q5BKX5-3","geneName":"ACTMAP","intActId":"EBI-11976299"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8N9V6-2","geneName":"ANKRD53","intActId":"EBI-13345447"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q96C12","geneName":"ARMC5","intActId":"EBI-6425121"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9Y6H3","geneName":"ATP23","intActId":"EBI-12811889"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q13137","geneName":"CALCOCO2","intActId":"EBI-739580"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8NHQ1","geneName":"CEP70","intActId":"EBI-739624"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q86UW9","geneName":"DTX2","intActId":"EBI-740376"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q5JST6","geneName":"EFHC2","intActId":"EBI-2349927"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9Y5P6","geneName":"GMPPB","intActId":"EBI-750945"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q08379","geneName":"GOLGA2","intActId":"EBI-618309"},"numberOfExperiments":6,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8IYA8","geneName":"IHO1","intActId":"EBI-8638439"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q53G59","geneName":"KLHL12","intActId":"EBI-740929"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P13646","geneName":"KRT13","intActId":"EBI-1223876"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P19012","geneName":"KRT15","intActId":"EBI-739566"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P08727","geneName":"KRT19","intActId":"EBI-742756"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"O76011","geneName":"KRT34","intActId":"EBI-1047093"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"O95678","geneName":"KRT75","intActId":"EBI-2949715"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q3LI72","geneName":"KRTAP19-5","intActId":"EBI-1048945"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q3LI66","geneName":"KRTAP6-2","intActId":"EBI-11962084"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q3LI67","geneName":"KRTAP6-3","intActId":"EBI-22311199"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9BRK4","geneName":"LZTS2","intActId":"EBI-741037"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9Y5V3","geneName":"MAGED1","intActId":"EBI-716006"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"A6NJ78-4","geneName":"METTL15","intActId":"EBI-10174029"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8N6F8","geneName":"METTL27","intActId":"EBI-8487781"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9NYP9","geneName":"MIS18A","intActId":"EBI-1104552"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q6PF18","geneName":"MORN3","intActId":"EBI-9675802"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8NI38","geneName":"NFKBID","intActId":"EBI-10271199"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"A8MTQ0","geneName":"NOTO","intActId":"EBI-17490746"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P49902","geneName":"NT5C2","intActId":"EBI-742084"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q99471","geneName":"PFDN5","intActId":"EBI-357275"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9NRD5","geneName":"PICK1","intActId":"EBI-79165"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9UPG8","geneName":"PLAGL2","intActId":"EBI-2876622"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P01189","geneName":"POMC","intActId":"EBI-12219503"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9GZV8","geneName":"PRDM14","intActId":"EBI-3957793"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q08623","geneName":"PUDP","intActId":"EBI-12807240"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9BYM8","geneName":"RBCK1","intActId":"EBI-2340624"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q93062","geneName":"RBPMS","intActId":"EBI-740322"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q04864","geneName":"REL","intActId":"EBI-307352"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q04864-2","geneName":"REL","intActId":"EBI-10829018"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8IYX7","geneName":"SAXO1","intActId":"EBI-3957636"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9UHV2","geneName":"SERTAD1","intActId":"EBI-748601"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q53HV7-2","geneName":"SMUG1","intActId":"EBI-12275818"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q96H20","geneName":"SNF8","intActId":"EBI-747719"},"numberOfExperiments":5,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q99932-2","geneName":"SPAG8","intActId":"EBI-11959123"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q7Z699","geneName":"SPRED1","intActId":"EBI-5235340"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P14373","geneName":"TRIM27","intActId":"EBI-719493"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8IWZ5","geneName":"TRIM42","intActId":"EBI-5235829"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q15645","geneName":"TRIP13","intActId":"EBI-358993"},"numberOfExperiments":9,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9UGJ1","geneName":"TUBGCP4","intActId":"EBI-1052544"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q6NVU6","geneName":"UFSP1","intActId":"EBI-12068150"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q8TF47","geneName":"ZFP90","intActId":"EBI-11419867"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"O60844","geneName":"ZG16","intActId":"EBI-746479"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q9NZV7","geneName":"ZIM2","intActId":"EBI-11962760"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"Q6ZNG0","geneName":"ZNF620","intActId":"EBI-4395669"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q8IVS8","intActId":"EBI-748515"},"interactantTwo":{"uniProtKBAccession":"P0C7X2","geneName":"ZNF688","intActId":"EBI-4395732"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","molecule":"Isoform 1","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41330740"}],"value":"Mitochondrion matrix","id":"SL-0170"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"}],"value":"Glycerate kinase 1"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"}],"value":"GLYCTK1"}],"isoformIds":["Q8IVS8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"}],"value":"Glycerate kinase 2"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"}],"value":"GLYCTK2"}],"isoformIds":["Q8IVS8-2"],"sequenceIds":["VSP_025360","VSP_025362"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8IVS8-3"],"sequenceIds":["VSP_025358"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q8IVS8-4"],"sequenceIds":["VSP_025363","VSP_025365"],"isoformSequenceStatus":"Described"},{"name":{"value":"5"},"isoformIds":["Q8IVS8-5"],"sequenceIds":["VSP_025357","VSP_025364","VSP_025365"],"isoformSequenceStatus":"Described"},{"name":{"value":"6"},"isoformIds":["Q8IVS8-6"],"sequenceIds":["VSP_025356"],"isoformSequenceStatus":"Described"},{"name":{"value":"7"},"isoformIds":["Q8IVS8-7"],"sequenceIds":["VSP_025359","VSP_025361"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16753811"}],"value":"Widely expressed"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41330740"}],"value":"Expressed at highest levels in the liver, followed by testis and kidney"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 1"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41330740"}],"value":"Expressed at highest levels in the liver, followed by testis and kidney"}],"commentType":"TISSUE SPECIFICITY","molecule":"Isoform 2"},{"commentType":"DISEASE","disease":{"diseaseId":"D-glyceric aciduria","diseaseAccession":"DI-03131","acronym":"D-GA","description":"A rare metabolic disease characterized by chronic metabolic acidosis and a highly variable clinical phenotype. Clinical features range from an encephalopathic presentation with seizures, microcephaly, severe intellectual disability and early death, to milder manifestations with only speech delay or even normal development.","diseaseCrossReference":{"database":"MIM","id":"220120"},"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20949620"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28190537"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30637540"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31837836"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39619776"}]},"note":{"texts":[{"value":"The disease is caused by variants affecting the gene represented in this entry"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the glycerate kinase type-2 family"}],"commentType":"SIMILARITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16753811"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"41330740"}],"value":"Isoform 1 was reported to localize to the cytoplasm and isoform 2 to both the cytoplasm and mitochondria (Ref. 1). However, a more recent study found isoform 1 in the mitochondria and suggested that isoform 2 is likely non-functional, as it was not detected at the protein level (Ref. 9)"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAH36862.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"Glycerate kinase","featureId":"PRO_0000287192"},{"type":"Modified residue","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24275569"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"in isoform 6","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15498874"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.5"}],"featureId":"VSP_025356","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_025357","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_025358","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"in isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"featureId":"VSP_025359","alternativeSequence":{"originalSequence":"GGSALLPAPIPPVTLEEKQTLTRLLAAR","alternativeSequences":["WGTPAAHRDDRYQCHGHPPLVPAASVMA"]}},{"type":"Alternative sequence","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"}],"featureId":"VSP_025360","alternativeSequence":{"originalSequence":"GSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKALSQLKGGGLAQAAYPA","alternativeSequences":["EPHPVRCGGGPCGGDCQWPHRGQFPQCARLPAYPQSLRPPCSPATFCEDCAVSGRL"]}},{"type":"Alternative sequence","location":{"start":{"value":206,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"in isoform 7","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.2"}],"featureId":"VSP_025361","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16753811"}],"featureId":"VSP_025362","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.5"}],"featureId":"VSP_025363","alternativeSequence":{"originalSequence":"DVKSMAQFYGLLAHVARTRLTPSMAGAS","alternativeSequences":["WGTPAAHRDDRYQCHGHPPLVPAASVMA"]}},{"type":"Alternative sequence","location":{"start":{"value":340,"modifier":"EXACT"},"end":{"value":367,"modifier":"EXACT"}},"description":"in isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_025364","alternativeSequence":{"originalSequence":"DVKSMAQFYGLLAHVARTRLTPSMAGAS","alternativeSequences":["WGTPAAHRDDRYQCHGHPPIVPAASVMA"]}},{"type":"Alternative sequence","location":{"start":{"value":368,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"in isoform 4 and isoform 5","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.5"}],"featureId":"VSP_025365","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":27,"modifier":"EXACT"}},"description":"in dbSNP:rs34502608","featureCrossReferences":[{"database":"dbSNP","id":"rs34502608"}],"featureId":"VAR_061205","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Natural variant","location":{"start":{"value":152,"modifier":"EXACT"},"end":{"value":152,"modifier":"EXACT"}},"description":"in D-GA; uncertain significance; dbSNP:rs2471080344","featureCrossReferences":[{"database":"dbSNP","id":"rs2471080344"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30637540"}],"featureId":"VAR_091118","alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Natural variant","location":{"start":{"value":170,"modifier":"EXACT"},"end":{"value":170,"modifier":"EXACT"}},"description":"in dbSNP:rs35130772","featureCrossReferences":[{"database":"dbSNP","id":"rs35130772"}],"featureId":"VAR_032285","alternativeSequence":{"originalSequence":"L","alternativeSequences":["V"]}},{"type":"Natural variant","location":{"start":{"value":173,"modifier":"EXACT"},"end":{"value":173,"modifier":"EXACT"}},"description":"in D-GA; uncertain significance; dbSNP:rs755417656","featureCrossReferences":[{"database":"dbSNP","id":"rs755417656"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31837836"}],"featureId":"VAR_091119","alternativeSequence":{"originalSequence":"V","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"in D-GA; uncertain significance; dbSNP:rs758174758","featureCrossReferences":[{"database":"dbSNP","id":"rs758174758"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28190537"}],"featureId":"VAR_091120","alternativeSequence":{"originalSequence":"P","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":285,"modifier":"EXACT"},"end":{"value":523,"modifier":"EXACT"}},"description":"in D-GA; likely pathogenic; dbSNP:rs1700505486","featureCrossReferences":[{"database":"dbSNP","id":"rs1700505486"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"39619776"}],"featureId":"VAR_091121","alternativeSequence":{}},{"type":"Natural variant","location":{"start":{"value":394,"modifier":"EXACT"},"end":{"value":394,"modifier":"EXACT"}},"description":"in dbSNP:rs9813489","featureCrossReferences":[{"database":"dbSNP","id":"rs9813489"}],"featureId":"VAR_032286","alternativeSequence":{"originalSequence":"T","alternativeSequences":["I"]}},{"type":"Natural variant","location":{"start":{"value":493,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"in D-GA; loss of glycerate kinase activity; dbSNP:rs121909448","featureCrossReferences":[{"database":"dbSNP","id":"rs121909448"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20949620"}],"featureId":"VAR_065909","alternativeSequence":{"originalSequence":"F","alternativeSequences":["C"]}},{"type":"Sequence conflict","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":144,"modifier":"EXACT"}},"description":"in Ref. 1; AAP51132","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["Y"]}},{"type":"Sequence conflict","location":{"start":{"value":245,"modifier":"EXACT"},"end":{"value":245,"modifier":"EXACT"}},"description":"in Ref. 4; BAB85018","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0225","category":"Disease","name":"Disease variant"},{"id":"KW-0418","category":"Molecular function","name":"Kinase"},{"id":"KW-0496","category":"Cellular component","name":"Mitochondrion"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"}],"references":[{"referenceNumber":1,"citation":{"id":"16753811","citationType":"journal article","authors":["Guo J.-H.","Hexige S.","Chen L.","Zhou G.-J.","Wang X.","Jiang J.-M.","Kong Y.-H.","Ji G.-Q.","Wu C.-Q.","Zhao S.-Y.","Yu L."],"citationCrossReferences":[{"database":"PubMed","id":"16753811"},{"database":"DOI","id":"10.1080/10425170500476665"}],"title":"Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.","publicationDate":"2006","journal":"DNA Seq.","firstPage":"1","lastPage":"7","volume":"17"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)","TISSUE SPECIFICITY","CAUTION"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-8NDM3SJCJEHMC","citationType":"submission","authors":["Guo J.H."],"title":"Cloning of HCG9886S gene and identification of a novel domain.","publicationDate":"NOV-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)"],"referenceComments":[{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15498874","citationType":"journal article","authors":["Wan D.","Gong Y.","Qin W.","Zhang P.","Li J.","Wei L.","Zhou X.","Li H.","Qiu X.","Zhong F.","He L.","Yu J.","Yao G.","Jiang H.","Qian L.","Yu Y.","Shu H.","Chen X.","Xu H.","Guo M.","Pan Z.","Chen Y.","Ge C.","Yang S.","Gu J."],"citationCrossReferences":[{"database":"PubMed","id":"15498874"},{"database":"DOI","id":"10.1073/pnas.0404089101"}],"title":"Large-scale cDNA transfection screening for genes related to cancer development and progression.","publicationDate":"2004","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"15724","lastPage":"15729","volume":"101"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6)"]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)"]},{"referenceNumber":5,"citation":{"id":"CI-5166CTTJ2T8LQ","citationType":"submission","authors":["Zhang J.-K.","Cheng J.","Lan X.-Y.","Guo J.","Zhang L.-Y."],"title":"Screening and cloning of HBeAg binding protein 4.","publicationDate":"JAN-2006","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6)"]},{"referenceNumber":6,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)"],"referenceComments":[{"value":"Lung","type":"TISSUE"},{"value":"Skin","type":"TISSUE"}]},{"referenceNumber":7,"citation":{"id":"20949620","citationType":"journal article","authors":["Sass J.O.","Fischer K.","Wang R.","Christensen E.","Scholl-Burgi S.","Chang R.","Kapelari K.","Walter M."],"citationCrossReferences":[{"database":"PubMed","id":"20949620"},{"database":"DOI","id":"10.1002/humu.21375"}],"title":"D-glyceric aciduria is caused by genetic deficiency of D-glycerate kinase (GLYCTK).","publicationDate":"2010","journal":"Hum. Mutat.","firstPage":"1280","lastPage":"1285","volume":"31"},"referencePositions":["FUNCTION","BIOPHYSICOCHEMICAL PROPERTIES","CATALYTIC ACTIVITY","VARIANT D-GA CYS-493","CHARACTERIZATION OF VARIANT D-GA CYS-493"]},{"referenceNumber":8,"citation":{"id":"24275569","citationType":"journal article","authors":["Bian Y.","Song C.","Cheng K.","Dong M.","Wang F.","Huang J.","Sun D.","Wang L.","Ye M.","Zou H."],"citationCrossReferences":[{"database":"PubMed","id":"24275569"},{"database":"DOI","id":"10.1016/j.jprot.2013.11.014"}],"title":"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.","publicationDate":"2014","journal":"J. Proteomics","firstPage":"253","lastPage":"262","volume":"96"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"41330740","citationType":"journal article","authors":["Korwitz-Reichelt A.","Schulke D.","Walter M.","Sass J.O."],"citationCrossReferences":[{"database":"PubMed","id":"41330740"},{"database":"DOI","id":"10.1002/jimd.70119"}],"title":"Human d-Glycerate Kinase, Encoded by GLYCTK and Deficient in d-Glyceric Aciduria, Is a Mitochondrial Enzyme.","publicationDate":"2026","journal":"J. Inherit. Metab. Dis.","firstPage":"e70119","lastPage":"e70119","volume":"49"},"referencePositions":["SUBCELLULAR LOCATION (ISOFORM 1)","TISSUE SPECIFICITY (ISOFORMS 1 AND 2)","CAUTION"]},{"referenceNumber":10,"citation":{"id":"28190537","citationType":"journal article","authors":["Kalim A.","Fitzsimons P.","Till C.","Fernando M.","Mayne P.","Sass J.O.","Crushell E."],"citationCrossReferences":[{"database":"PubMed","id":"28190537"},{"database":"DOI","id":"10.1016/j.braindev.2017.01.005"}],"title":"Further evidence that d-glycerate kinase (GK) deficiency is a benign disorder.","publicationDate":"2017","journal":"Brain Dev.","firstPage":"536","lastPage":"538","volume":"39"},"referencePositions":["VARIANT D-GA ARG-256","INVOLVEMENT IN D-GA"]},{"referenceNumber":11,"citation":{"id":"30637540","citationType":"journal article","authors":["Zehavi Y.","Mandel H.","Eran A.","Ravid S.","Abu Rashid M.","Jansen E.E.W.","Wamelink M.M.C.","Saada A.","Shaag A.","Elpeleg O.","Spiegel R."],"citationCrossReferences":[{"database":"PubMed","id":"30637540"},{"database":"DOI","id":"10.1007/s11011-019-0384-x"}],"title":"Severe infantile epileptic encephalopathy associated with D-glyceric aciduria: report of a novel case and review.","publicationDate":"2019","journal":"Metab. Brain Dis.","firstPage":"557","lastPage":"563","volume":"34"},"referencePositions":["VARIANT D-GA PRO-152","INVOLVEMENT IN D-GA"]},{"referenceNumber":12,"citation":{"id":"31837836","citationType":"journal article","authors":["Sass J.O.","Behringer S.","Fernando M.","Cesaroni E.","Cursio I.","Volpini A.","Till C."],"citationCrossReferences":[{"database":"PubMed","id":"31837836"},{"database":"DOI","id":"10.1016/j.braindev.2019.11.008"}],"title":"d-Glycerate kinase deficiency in a neuropediatric patient.","publicationDate":"2020","journal":"Brain Dev.","firstPage":"226","lastPage":"230","volume":"42"},"referencePositions":["VARIANT D-GA LEU-173","INVOLVEMENT IN D-GA"]},{"referenceNumber":13,"citation":{"id":"39619776","citationType":"journal article","authors":["Kingma S.D.K.","Steinbusch L.K.M.","Aukema S.M.","Sinnema M.","Panis B.","Nicolai J.","Rubio-Gozalbo E."],"citationCrossReferences":[{"database":"PubMed","id":"39619776"},{"database":"DOI","id":"10.1016/j.ymgmr.2024.101159"}],"title":"D-glyceric aciduria due to GLYCTK mutation: Disease or non-disease?","publicationDate":"2024","journal":"Mol. Genet. Metab. Rep.","firstPage":"101159","lastPage":"101159","volume":"41"},"referencePositions":["VARIANT D-GA 285-LYS--ARG-523 DEL","INVOLVEMENT IN D-GA"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY295075","properties":[{"key":"ProteinId","value":"AAP51132.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AF448855","properties":[{"key":"ProteinId","value":"AAP41923.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY172690","properties":[{"key":"ProteinId","value":"AAO17719.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY189286","properties":[{"key":"ProteinId","value":"AAO86730.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK074215","properties":[{"key":"ProteinId","value":"BAB85018.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY134474","properties":[{"key":"ProteinId","value":"AAM95456.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"DQ352863","properties":[{"key":"ProteinId","value":"ABD22985.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC021896","properties":[{"key":"ProteinId","value":"AAH21896.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC036862","properties":[{"key":"ProteinId","value":"AAH36862.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC042151","properties":[{"key":"ProteinId","value":"AAH42151.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS2852.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-1"},{"database":"CCDS","id":"CCDS46841.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-2"},{"database":"RefSeq","id":"NP_001138423.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001144951.2"}],"isoformId":"Q8IVS8-2"},{"database":"RefSeq","id":"NP_001424550.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001437621.1"}],"isoformId":"Q8IVS8-1"},{"database":"RefSeq","id":"NP_001424551.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001437622.1"}],"isoformId":"Q8IVS8-2"},{"database":"RefSeq","id":"NP_660305.2","properties":[{"key":"NucleotideSequenceId","value":"NM_145262.4"}],"isoformId":"Q8IVS8-1"},{"database":"RefSeq","id":"XP_047303421.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047447465.1"}],"isoformId":"Q8IVS8-4"},{"database":"RefSeq","id":"XP_047303422.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047447466.1"}],"isoformId":"Q8IVS8-4"},{"database":"RefSeq","id":"XP_054201255.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054345280.1"}],"isoformId":"Q8IVS8-1"},{"database":"RefSeq","id":"XP_054201256.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054345281.1"}],"isoformId":"Q8IVS8-4"},{"database":"AlphaFoldDB","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"126307","properties":[{"key":"Interactions","value":"63"}]},{"database":"FunCoup","id":"Q8IVS8","properties":[{"key":"Number of interactors","value":"804"}]},{"database":"IntAct","id":"Q8IVS8","properties":[{"key":"Interactions","value":"59"}]},{"database":"MINT","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-GLYCTK","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000389175","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8IVS8","properties":[{"key":"glycosylation","value":"1 site"}]},{"database":"iPTMnet","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"GLYCTK","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"74728080","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000389175","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"70758","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-1"},{"database":"ProteomicsDB","id":"70759","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-2"},{"database":"ProteomicsDB","id":"70760","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-3"},{"database":"ProteomicsDB","id":"70761","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-4"},{"database":"ProteomicsDB","id":"70762","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-5"},{"database":"ProteomicsDB","id":"70763","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-6"},{"database":"ProteomicsDB","id":"70764","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8IVS8-7"},{"database":"Antibodypedia","id":"1847","properties":[{"key":"antibodies","value":"271 antibodies from 31 providers"}]},{"database":"DNASU","id":"132158","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000436784.7","properties":[{"key":"ProteinId","value":"ENSP00000389175.2"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-1"},{"database":"Ensembl","id":"ENST00000473032.5","properties":[{"key":"ProteinId","value":"ENSP00000418951.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-7"},{"database":"Ensembl","id":"ENST00000477382.2","properties":[{"key":"ProteinId","value":"ENSP00000419008.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-2"},{"database":"Ensembl","id":"ENST00000863513.1","properties":[{"key":"ProteinId","value":"ENSP00000533572.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-1"},{"database":"Ensembl","id":"ENST00000863514.1","properties":[{"key":"ProteinId","value":"ENSP00000533573.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-1"},{"database":"Ensembl","id":"ENST00000863515.1","properties":[{"key":"ProteinId","value":"ENSP00000533574.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-1"},{"database":"Ensembl","id":"ENST00000863516.1","properties":[{"key":"ProteinId","value":"ENSP00000533575.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-1"},{"database":"Ensembl","id":"ENST00000863517.1","properties":[{"key":"ProteinId","value":"ENSP00000533576.1"},{"key":"GeneId","value":"ENSG00000168237.19"}],"isoformId":"Q8IVS8-1"},{"database":"GeneID","id":"132158","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:132158","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000436784.7","properties":[{"key":"ProteinId","value":"ENSP00000389175.2"},{"key":"RefSeqNucleotideId","value":"NM_145262.4"},{"key":"RefSeqProteinId","value":"NP_660305.2"}]},{"database":"UCSC","id":"uc003ddo.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q8IVS8-1"},{"database":"AGR","id":"HGNC:24247","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162389865","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"132158","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"132158","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"GLYCTK","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:24247","properties":[{"key":"GeneName","value":"GLYCTK"}]},{"database":"HPA","id":"ENSG00000168237","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (liver)"}]},{"database":"MalaCards","id":"GLYCTK","properties":[{"key":"Description","value":"-"}]},{"database":"MIM","id":"220120","properties":[{"key":"Type","value":"phenotype"}]},{"database":"MIM","id":"610516","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000168237","properties":[{"key":"Description","value":"-"}]},{"database":"Orphanet","id":"941","properties":[{"key":"Disease","value":"D-glyceric aciduria"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000168237","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3935","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000014365","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_112512_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GKAAWRM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"44918at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q8IVS8","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.1.31","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-70350","properties":[{"key":"PathwayName","value":"Fructose catabolism"}]},{"database":"SABIO-RK","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"SIGNOR","id":"Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000168237","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"132158","properties":[{"key":"hits","value":"14 hits in 1158 CRISPR screens"}]},{"database":"ChiTaRS","id":"GLYCTK","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"132158","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q8IVS8","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q8IVS8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 3"}]},{"database":"RNAct","id":"Q8IVS8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000168237","properties":[{"key":"ExpressionPatterns","value":"Expressed in right lobe of liver and 110 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8IVS8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16753811"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:HPA"}]},{"database":"GO","id":"GO:0005759","properties":[{"key":"GoTerm","value":"C:mitochondrial matrix"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16753811"}]},{"database":"GO","id":"GO:0008887","properties":[{"key":"GoTerm","value":"F:glycerate kinase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16753811"}]},{"database":"GO","id":"GO:0061624","properties":[{"key":"GoTerm","value":"P:fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate"},{"key":"GoEvidenceType","value":"TAS:Reactome"}]},{"database":"GO","id":"GO:0006468","properties":[{"key":"GoTerm","value":"P:protein phosphorylation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"16753811"}]},{"database":"FunFam","id":"3.40.50.10180:FF:000003","properties":[{"key":"EntryName","value":"GLYCTK isoform 4"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.10180","properties":[{"key":"EntryName","value":"Glycerate kinase, MOFRL-like N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.1480.10","properties":[{"key":"EntryName","value":"MOFRL domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR037035","properties":[{"key":"EntryName","value":"GK-like_C_sf"}]},{"database":"InterPro","id":"IPR038614","properties":[{"key":"EntryName","value":"GK_N_sf"}]},{"database":"InterPro","id":"IPR007835","properties":[{"key":"EntryName","value":"MOFRL"}]},{"database":"InterPro","id":"IPR025286","properties":[{"key":"EntryName","value":"MOFRL_assoc_dom"}]},{"database":"InterPro","id":"IPR039760","properties":[{"key":"EntryName","value":"MOFRL_protein"}]},{"database":"PANTHER","id":"PTHR12227","properties":[{"key":"EntryName","value":"GLYCERATE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12227:SF0","properties":[{"key":"EntryName","value":"GLYCERATE KINASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13660","properties":[{"key":"EntryName","value":"DUF4147"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF05161","properties":[{"key":"EntryName","value":"MOFRL"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF82544","properties":[{"key":"EntryName","value":"GckA/TtuD-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAALQVLPRLARAPLHPLLWRGSVARLASSMALAEQARQLFESAVGAVLPGPMLHRALSLDPGGRQLKVRDRNFQLRQNLYLVGFGKAVLGMAAAAEELLGQHLVQGVISVPKGIRAAMERAGKQEMLLKPHSRVQVFEGAEDNLPDRDALRAALAIQQLAEGLTADDLLLVLISGGGSALLPAPIPPVTLEEKQTLTRLLAARGATIQELNTIRKALSQLKGGGLAQAAYPAQVVSLILSDVVGDPVEVIASGPTVASSHNVQDCLHILNRYGLRAALPRSVKTVLSRADSDPHGPHTCGHVLNVIIGSNVLALAEAQRQAEALGYQAVVLSAAMQGDVKSMAQFYGLLAHVARTRLTPSMAGASVEEDAQLHELAAELQIPDLQLEEALETMAWGRGPVCLLAGGEPTVQLQGSGRGGRNQELALRVGAELRRWPLGPIDVLFLSGGTDGQDGPTEAAGAWVTPELASQAAAEGLDIATFLAHNDSHTFFCCLQGGAHLLHTGMTGTNVMDTHLLFLRPR","length":523,"molWeight":55253,"crc64":"CCBEC88E8850FC11","md5":"1D7479E7C5EF2F34E808A97088BB0EE2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"BIOPHYSICOCHEMICAL PROPERTIES":1,"INTERACTION":56,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":7,"TISSUE SPECIFICITY":3,"DISEASE":1,"SIMILARITY":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Modified residue":1,"Alternative sequence":10,"Natural variant":8,"Sequence conflict":2},"uniParcId":"UPI000004FD5A"}}