{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8H0W0","secondaryAccessions":["Q8LFG2","Q9SSM1"],"uniProtkbId":"LPA3_ARATH","entryAudit":{"firstPublicDate":"2014-01-22","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":116,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Arabidopsis thaliana","commonName":"Mouse-ear cress","taxonId":3702,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","eudicotyledons","Gunneridae","Pentapetalae","rosids","malvids","Brassicales","Brassicaceae","Camelineae","Arabidopsis"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein LPA3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20605914"}],"value":"Protein LOW PSII ACCUMULATION 3, chloroplastic"}}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20605914"}],"value":"LPA3"},"orderedLocusNames":[{"value":"At1g73060"}],"orfNames":[{"value":"F3N23.26"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8H0W0","intActId":"EBI-25519598"},"interactantTwo":{"uniProtKBAccession":"Q84MB2","geneName":"TIFY8","intActId":"EBI-4426557"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"22223895"}],"value":"Plastid, chloroplast","id":"SL-0049"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"20605914"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"28154118"}],"value":"An article reported a role in essential for photosystem II assembly; however, this paper was later retracted"}],"commentType":"CAUTION"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"AAD55653.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Transit peptide","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":24,"modifier":"EXACT"}},"description":"Chloroplast","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"}]},{"type":"Chain","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":358,"modifier":"EXACT"}},"description":"Protein LPA3","featureId":"PRO_0000425144"},{"type":"Modified residue","location":{"start":{"value":25,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"N-acetylglycine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22223895"}]},{"type":"Sequence conflict","location":{"start":{"value":178,"modifier":"EXACT"},"end":{"value":178,"modifier":"EXACT"}},"description":"in Ref. 5; AAM61432","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0150","category":"Cellular component","name":"Chloroplast"},{"id":"KW-0934","category":"Cellular component","name":"Plastid"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0809","category":"Domain","name":"Transit peptide"}],"references":[{"referenceNumber":1,"citation":{"id":"11130712","citationType":"journal article","authors":["Theologis A.","Ecker J.R.","Palm C.J.","Federspiel N.A.","Kaul S.","White O.","Alonso J.","Altafi H.","Araujo R.","Bowman C.L.","Brooks S.Y.","Buehler E.","Chan A.","Chao Q.","Chen H.","Cheuk R.F.","Chin C.W.","Chung M.K.","Conn L.","Conway A.B.","Conway A.R.","Creasy T.H.","Dewar K.","Dunn P.","Etgu P.","Feldblyum T.V.","Feng J.-D.","Fong B.","Fujii C.Y.","Gill J.E.","Goldsmith A.D.","Haas B.","Hansen N.F.","Hughes B.","Huizar L.","Hunter J.L.","Jenkins J.","Johnson-Hopson C.","Khan S.","Khaykin E.","Kim C.J.","Koo H.L.","Kremenetskaia I.","Kurtz D.B.","Kwan A.","Lam B.","Langin-Hooper S.","Lee A.","Lee J.M.","Lenz C.A.","Li J.H.","Li Y.-P.","Lin X.","Liu S.X.","Liu Z.A.","Luros J.S.","Maiti R.","Marziali A.","Militscher J.","Miranda M.","Nguyen M.","Nierman W.C.","Osborne B.I.","Pai G.","Peterson J.","Pham P.K.","Rizzo M.","Rooney T.","Rowley D.","Sakano H.","Salzberg S.L.","Schwartz J.R.","Shinn P.","Southwick A.M.","Sun H.","Tallon L.J.","Tambunga G.","Toriumi M.J.","Town C.D.","Utterback T.","Van Aken S.","Vaysberg M.","Vysotskaia V.S.","Walker M.","Wu D.","Yu G.","Fraser C.M.","Venter J.C.","Davis R.W."],"citationCrossReferences":[{"database":"PubMed","id":"11130712"},{"database":"DOI","id":"10.1038/35048500"}],"title":"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.","publicationDate":"2000","journal":"Nature","firstPage":"816","lastPage":"820","volume":"408"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"27862469","citationType":"journal article","authors":["Cheng C.Y.","Krishnakumar V.","Chan A.P.","Thibaud-Nissen F.","Schobel S.","Town C.D."],"citationCrossReferences":[{"database":"PubMed","id":"27862469"},{"database":"DOI","id":"10.1111/tpj.13415"}],"title":"Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.","publicationDate":"2017","journal":"Plant J.","firstPage":"789","lastPage":"804","volume":"89"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"CI-CI4AM1G71UC0S","citationType":"submission","authoringGroup":["The Arabidopsis Information Resource (TAIR)"],"title":"Community-consensus reference genome of Arabidopsis thaliana Col-0.","publicationDate":"FEB-2026","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"14593172","citationType":"journal article","authors":["Yamada K.","Lim J.","Dale J.M.","Chen H.","Shinn P.","Palm C.J.","Southwick A.M.","Wu H.C.","Kim C.J.","Nguyen M.","Pham P.K.","Cheuk R.F.","Karlin-Newmann G.","Liu S.X.","Lam B.","Sakano H.","Wu T.","Yu G.","Miranda M.","Quach H.L.","Tripp M.","Chang C.H.","Lee J.M.","Toriumi M.J.","Chan M.M.","Tang C.C.","Onodera C.S.","Deng J.M.","Akiyama K.","Ansari Y.","Arakawa T.","Banh J.","Banno F.","Bowser L.","Brooks S.Y.","Carninci P.","Chao Q.","Choy N.","Enju A.","Goldsmith A.D.","Gurjal M.","Hansen N.F.","Hayashizaki Y.","Johnson-Hopson C.","Hsuan V.W.","Iida K.","Karnes M.","Khan S.","Koesema E.","Ishida J.","Jiang P.X.","Jones T.","Kawai J.","Kamiya A.","Meyers C.","Nakajima M.","Narusaka M.","Seki M.","Sakurai T.","Satou M.","Tamse R.","Vaysberg M.","Wallender E.K.","Wong C.","Yamamura Y.","Yuan S.","Shinozaki K.","Davis R.W.","Theologis A.","Ecker J.R."],"citationCrossReferences":[{"database":"PubMed","id":"14593172"},{"database":"DOI","id":"10.1126/science.1088305"}],"title":"Empirical analysis of transcriptional activity in the Arabidopsis genome.","publicationDate":"2003","journal":"Science","firstPage":"842","lastPage":"846","volume":"302"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"cv. Columbia","type":"STRAIN"}]},{"referenceNumber":5,"citation":{"id":"CI-3TH3AFLAVIRO9","citationType":"submission","authors":["Brover V.V.","Troukhan M.E.","Alexandrov N.A.","Lu Y.-P.","Flavell R.B.","Feldmann K.A."],"title":"Full-length cDNA from Arabidopsis thaliana.","publicationDate":"MAR-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":6,"citation":{"id":"20605914","citationType":"journal article","authors":["Cai W.","Ma J.","Chi W.","Zou M.","Guo J.","Lu C.","Zhang L."],"citationCrossReferences":[{"database":"PubMed","id":"20605914"},{"database":"DOI","id":"10.1104/pp.110.159558"}],"title":"Cooperation of LPA3 and LPA2 is essential for photosystem II assembly in Arabidopsis.","publicationDate":"2010","journal":"Plant Physiol.","firstPage":"109","lastPage":"120","volume":"154"},"referencePositions":["RETRACTED PAPER"]},{"referenceNumber":7,"citation":{"id":"28154118","citationType":"journal article","authors":["Cai W.","Ma J.","Chi W.","Zou M.","Guo J.","Lu C.","Zhang L."],"citationCrossReferences":[{"database":"PubMed","id":"28154118"},{"database":"DOI","id":"10.1104/pp.16.01908"}],"publicationDate":"2017","journal":"Plant Physiol.","firstPage":"1526","lastPage":"1526","volume":"173"},"referencePositions":["RETRACTION NOTICE OF PUBMED:20605914"]},{"referenceNumber":8,"citation":{"id":"22223895","citationType":"journal article","authors":["Bienvenut W.V.","Sumpton D.","Martinez A.","Lilla S.","Espagne C.","Meinnel T.","Giglione C."],"citationCrossReferences":[{"database":"PubMed","id":"22223895"},{"database":"DOI","id":"10.1074/mcp.m111.015131"}],"title":"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.","publicationDate":"2012","journal":"Mol. Cell. Proteomics","firstPage":"M111.015131","lastPage":"M111.015131","volume":"11"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-25","CLEAVAGE OF TRANSIT PEPTIDE [LARGE SCALE ANALYSIS] AFTER CYS-24","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC008017","properties":[{"key":"ProteinId","value":"AAD55653.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CP002684","properties":[{"key":"ProteinId","value":"AEE35409.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"OZ408683","properties":[{"key":"ProteinId","value":"CAO7033124.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BT002009","properties":[{"key":"ProteinId","value":"AAN72020.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BT008843","properties":[{"key":"ProteinId","value":"AAP68282.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY084869","properties":[{"key":"ProteinId","value":"AAM61432.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PIR","id":"B96756","properties":[{"key":"EntryName","value":"B96756"}]},{"database":"RefSeq","id":"NP_565054.1","properties":[{"key":"NucleotideSequenceId","value":"NM_105964.5"}]},{"database":"AlphaFoldDB","id":"Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"28856","properties":[{"key":"Interactions","value":"3"}]},{"database":"FunCoup","id":"Q8H0W0","properties":[{"key":"Number of interactors","value":"1506"}]},{"database":"IntAct","id":"Q8H0W0","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"3702.Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"3702-Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"238631","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"843637","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ath:AT1G73060","properties":[{"key":"Description","value":"-"}]},{"database":"Araport","id":"AT1G73060","properties":[{"key":"Description","value":"-"}]},{"database":"TAIR","id":"AT1G73060","properties":[{"key":"GeneName","value":"LPA3"}]},{"database":"eggNOG","id":"ENOG502QW2X","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"HOGENOM","id":"CLU_052261_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"KSATWWE","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2082at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8H0W0","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000006548","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"ExpressionAtlas","id":"Q8H0W0","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009507","properties":[{"key":"GoTerm","value":"C:chloroplast"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"18431481"}]},{"database":"GO","id":"GO:0009570","properties":[{"key":"GoTerm","value":"C:chloroplast stroma"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"18633119"}]},{"database":"GO","id":"GO:0005739","properties":[{"key":"GoTerm","value":"C:mitochondrion"},{"key":"GoEvidenceType","value":"HDA:TAIR"}],"evidences":[{"evidenceCode":"ECO:0007005","source":"PubMed","id":"28887381"}]},{"database":"InterPro","id":"IPR018962","properties":[{"key":"EntryName","value":"DUF1995"}]},{"database":"InterPro","id":"IPR044687","properties":[{"key":"EntryName","value":"LPA3"}]},{"database":"PANTHER","id":"PTHR34051","properties":[{"key":"EntryName","value":"PROTEIN LOW PSII ACCUMULATION 3, CHLOROPLASTIC"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34051:SF2","properties":[{"key":"EntryName","value":"PROTEIN LPA3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF09353","properties":[{"key":"EntryName","value":"DUF1995"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAMAIAMLPALFSSPSILTSRIRCGATANSGGAISSTSSNSDPRRGVPLYKPKSYEVLATDAANSLAFALQDSKSRLEIDFPPLPSSISSYKGSSDDFIDANIQLAVTVVRKLQEKIETRACIVFPDKPEKRRASQRFKAAFDSVDGISIGSLDDIPGTSVTNFFRSIRSTLDFDFEDENEGTWEPKEPPTLYIFINCSTRELSFIEKFVETFASSTPALLFNLELDTLRADLGLLGFPPKDLHYRFLSQFIPVFYIRTREYSKTVAVAPFVLNYNGALFRQYPGPWQVMLKQTDGSFACVAESPTRFTLGETKEELLQVLGLQEEKGSSLEFLRRGYKSATWWEEDVELEASSNWRN","length":358,"molWeight":40029,"crc64":"003D4CA23B63DA13","md5":"70117B07229A96AFA309D5DF1BD378F9"},"extraAttributes":{"countByCommentType":{"INTERACTION":1,"SUBCELLULAR LOCATION":1,"CAUTION":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Transit peptide":1,"Chain":1,"Modified residue":1,"Sequence conflict":1},"uniParcId":"UPI00000ADB44"}}