{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8FFJ2","uniProtkbId":"YFBV_ECOL6","entryAudit":{"firstPublicDate":"2003-06-06","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2003-03-01","entryVersion":87,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)","taxonId":199310,"lineage":["Bacteria","Pseudomonadati","Pseudomonadota","Gammaproteobacteria","Enterobacterales","Enterobacteriaceae","Escherichia"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"value":"UPF0208 membrane protein YfbV"}}},"genes":[{"geneName":{"value":"yfbV"},"orderedLocusNames":[{"value":"c2836"}]}],"comments":[{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cell inner membrane","id":"SL-0037"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UPF0208 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"UPF0208 membrane protein YfbV","featureId":"PRO_0000080811"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":45,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":46,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":91,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":92,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"12471157","citationType":"journal article","authors":["Welch R.A.","Burland V.","Plunkett G. III","Redford P.","Roesch P.","Rasko D.","Buckles E.L.","Liou S.-R.","Boutin A.","Hackett J.","Stroud D.","Mayhew G.F.","Rose D.J.","Zhou S.","Schwartz D.C.","Perna N.T.","Mobley H.L.T.","Donnenberg M.S.","Blattner F.R."],"citationCrossReferences":[{"database":"PubMed","id":"12471157"},{"database":"DOI","id":"10.1073/pnas.252529799"}],"title":"Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli.","publicationDate":"2002","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"17020","lastPage":"17024","volume":"99"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"CFT073 / ATCC 700928 / UPEC","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AE014075","properties":[{"key":"ProteinId","value":"AAN81290.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"RefSeq","id":"WP_000106615.1","properties":[{"key":"NucleotideSequenceId","value":"NC_004431.1"}]},{"database":"AlphaFoldDB","id":"Q8FFJ2","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"199310.c2836","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"ecc:c2836","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"COG3092","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"HOGENOM","id":"CLU_128746_0_0_6","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"ECOL199310:C2836-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001410","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-SubCell"}]},{"database":"HAMAP","id":"MF_01101","properties":[{"key":"EntryName","value":"UPF0208"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007334","properties":[{"key":"EntryName","value":"UPF0208"}]},{"database":"NCBIfam","id":"NF002493","properties":[{"key":"EntryName","value":"PRK01816.1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04217","properties":[{"key":"EntryName","value":"DUF412"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSTPDNRSVNFFSLFCRGQHYSKTWPLEKRLAPVFVENRVIKMTRYAIRFMPPIAVFTLCWQIALGGQLGPAVATALFALSLPMQGLWWLGKRSVTPLPPAILNWFYEVRGKLQESGQVLAPVEGKPDYQALADTLKRAFKQLDKTFLDDL","length":151,"molWeight":17160,"crc64":"D17DC538EBE3165B","md5":"B701DCF5FE1427625CC5649839C19376"},"extraAttributes":{"countByCommentType":{"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Topological domain":3,"Transmembrane":2},"uniParcId":"UPI00000DEE08"}}