{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8CGA4","uniProtkbId":"MTURN_MOUSE","entryAudit":{"firstPublicDate":"2007-07-10","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2003-03-01","entryVersion":97,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Maturin"}},"alternativeNames":[{"fullName":{"value":"Maturin neural progenitor differentiation regulator protein homolog"}}]},"genes":[{"geneName":{"value":"Mturn"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q7ZX36"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24681962"}],"value":"Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser- 536' (By similarity). May be involved in early neuronal development (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8N3F0"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24681962"}],"value":"Expressed in the thymus, bone marrow and spleen"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24095902"}],"value":"Expressed in embryo throughout the early nervous system. Strongly expressed in differentiating neurons in the brain, spinal cord and retina. Not detected in the lens at any developmental stage tested"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8N3F0"}],"value":"Phosphorylation at Tyr-34 is essential for its ability to promote megakaryocyte differentiation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the MTURN family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Maturin","featureId":"PRO_0000294234"},{"type":"Region","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":131,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8N3F0"}]}],"keywords":[{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"FVB/N","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"24095902","citationType":"journal article","authors":["Martinez-De Luna R.I.","Ku R.Y.","Lyou Y.","Zuber M.E."],"citationCrossReferences":[{"database":"PubMed","id":"24095902"},{"database":"DOI","id":"10.1016/j.ydbio.2013.09.028"}],"title":"Maturin is a novel protein required for differentiation during primary neurogenesis.","publicationDate":"2013","journal":"Dev. Biol.","firstPage":"26","lastPage":"40","volume":"384"},"referencePositions":["DEVELOPMENTAL STAGE"]},{"referenceNumber":4,"citation":{"id":"24681962","citationType":"journal article","authors":["Sun X.","Lu B.","Hu B.","Xiao W.","Li W.","Huang Z."],"citationCrossReferences":[{"database":"PubMed","id":"24681962"},{"database":"DOI","id":"10.1038/bcj.2014.18"}],"title":"Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling.","publicationDate":"2014","journal":"Blood Cancer J.","firstPage":"E198","lastPage":"E198","volume":"4"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"BC042507","properties":[{"key":"ProteinId","value":"AAH42507.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC052467","properties":[{"key":"ProteinId","value":"AAH52467.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS20158.2","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001276669.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289740.1"}]},{"database":"RefSeq","id":"NP_001276670.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001289741.1"}]},{"database":"AlphaFoldDB","id":"Q8CGA4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"212752","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q8CGA4","properties":[{"key":"Number of interactors","value":"683"}]},{"database":"STRING","id":"10090.ENSMUSP00000140358","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8CGA4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8CGA4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000140358","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"287639","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8CGA4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"35235","properties":[{"key":"antibodies","value":"8 antibodies from 7 providers"}]},{"database":"Ensembl","id":"ENSMUST00000190641.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000140586.2"},{"key":"GeneId","value":"ENSMUSG00000038065.14"}]},{"database":"GeneID","id":"68235","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:68235","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009cad.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1915485","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"222166","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1915485","properties":[{"key":"GeneName","value":"Mturn"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000038065","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502RXQA","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00500000045044","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_163056_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8CGA4","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"9922400at2759","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"68235","properties":[{"key":"hits","value":"0 hits in 60 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8CGA4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q8CGA4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000038065","properties":[{"key":"ExpressionPatterns","value":"Expressed in cortical plate and 218 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8CGA4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048666","properties":[{"key":"GoTerm","value":"P:neuron development"},{"key":"GoEvidenceType","value":"ISS:MGI"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"PubMed","id":"24095902"}]},{"database":"GO","id":"GO:0070374","properties":[{"key":"GoTerm","value":"P:positive regulation of ERK1 and ERK2 cascade"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0046330","properties":[{"key":"GoTerm","value":"P:positive regulation of JNK cascade"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0045654","properties":[{"key":"GoTerm","value":"P:positive regulation of megakaryocyte differentiation"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24681962"}]},{"database":"GO","id":"GO:0023051","properties":[{"key":"GoTerm","value":"P:regulation of signaling"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"InterPro","id":"IPR027892","properties":[{"key":"EntryName","value":"Maturin"}]},{"database":"PANTHER","id":"PTHR32008","properties":[{"key":"EntryName","value":"MATURIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32008:SF2","properties":[{"key":"EntryName","value":"MATURIN"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15167","properties":[{"key":"EntryName","value":"DUF4581"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MDFQQLADVAEKWCSSTPFELIAAEETERRMDFYADPGVSFYVLCPDNGCGDSFHVWSESEDCLPFLQLAQDYISSCGKKTLHEVLEKVFKSFRPLLGLPDADDDAFEEYSADVEEEEPEADHPQMGVSQQ","length":131,"molWeight":14841,"crc64":"D7424C3DBB06F0B1","md5":"87BC461305846A9EC8024F21542081AA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"PTM":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Modified residue":1},"uniParcId":"UPI00000E8EF3"}}