{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8CEL2","secondaryAccessions":["Q3KNX7","Q8R1E0"],"uniProtkbId":"CFA61_MOUSE","entryAudit":{"firstPublicDate":"2003-04-04","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2007-07-24","entryVersion":104,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1926024"}],"value":"Cilia- and flagella-associated protein 61"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1926024"}],"value":"Cfap61"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34792097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35387802"}],"value":"Involved in sperm flagellum assembly (PubMed:34792097, PubMed:35387802). Plays an essential role in the formation of the radial spokes in flagellum axoneme (PubMed:34792097, PubMed:35387802)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34792097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37352829"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"34792097"}],"value":"Component of axonemal radial spokes, the protein complexes that link the outer microtubule doublets with the central pair of microtubules (Probable). Interacts with CFAP91/MAATS1, ODAD2/ARMC4, RSPH3A, ROPN1, ROPN1L and RSPH9 (PubMed:34792097). Interacts with DYNLT1, DYNC1I2 and TUBB3 (PubMed:34792097). Interacts with WDR35, IFT22 and IFT81 (PubMed:34792097). Interacts with CFAP70 (PubMed:37352829)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37352829"}],"value":"Localizes to the manchette in elongating spermatids in a CFAP70-dependent manner"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34792097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35387802"}],"value":"Cytoplasm, cytoskeleton, flagellum axoneme","id":"SL-0114"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8NHU2"}],"value":"Cytoplasm, cytoskeleton, cilium axoneme","id":"SL-0304"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8NHU2"}],"value":"Cell projection, cilium","id":"SL-0066"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37352829"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8CEL2-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8CEL2-2"],"sequenceIds":["VSP_026930","VSP_026931"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34792097"}],"value":"Expressed in testis, brain and lung; the expression in testis is higher than that in other organs (PubMed:34792097). Detected in spermatozoa in seminiferous tubules (at protein level) (PubMed:34792097). Not detected in the respiratory tract cilia (PubMed:34792097)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34792097"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35387802"}],"value":"CFAP61-null male mice are infertile. The epididymis contains fewer spermatozoa in the cauda and caput regions compared to wild-type animals, and spermatozoa exhibit short, bent, curled, thick or missing flagella, and are immobile (PubMed:34792097, PubMed:35387802). Acrosome morphology is normal. The length and motility of respiratory tract cilia is also normal (PubMed:34792097)"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAC25604.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"Cilia- and flagella-associated protein 61","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"PRO_0000079418"},{"type":"Alternative sequence","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":237,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_026930","alternativeSequence":{"originalSequence":"EGK","alternativeSequences":["GDR"]}},{"type":"Alternative sequence","location":{"start":{"value":238,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_026931","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":287,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"in Ref. 3; BAC25604","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"EKHLKKCSTSLIIREMQIKTTLRFHLTPVRMAKIKNS","alternativeSequences":["DAESQGSPKVVEEQEMAPEITQEK"]}},{"type":"Sequence conflict","location":{"start":{"value":409,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"in Ref. 3; BAC25604","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":615,"modifier":"EXACT"},"end":{"value":616,"modifier":"EXACT"}},"description":"in Ref. 3; BAC25604","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"LQ","alternativeSequences":["VR"]}},{"type":"Sequence conflict","location":{"start":{"value":655,"modifier":"EXACT"},"end":{"value":659,"modifier":"EXACT"}},"description":"in Ref. 2; AAH24760","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"VSKDQ","alternativeSequences":["SDPRK"]}},{"type":"Sequence conflict","location":{"start":{"value":1223,"modifier":"EXACT"},"end":{"value":1223,"modifier":"EXACT"}},"description":"in Ref. 2; AAH24760","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["L"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0282","category":"Cellular component","name":"Flagellum"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 655-1252 (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-616 (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"34792097","citationType":"journal article","authors":["Liu S.","Zhang J.","Kherraf Z.E.","Sun S.","Zhang X.","Cazin C.","Coutton C.","Zouari R.","Zhao S.","Hu F.","Fourati Ben Mustapha S.","Arnoult C.","Ray P.F.","Liu M."],"citationCrossReferences":[{"database":"PubMed","id":"34792097"},{"database":"DOI","id":"10.1242/dev.199805"}],"title":"CFAP61 is required for sperm flagellum formation and male fertility in human and mouse.","publicationDate":"2021","journal":"Development","firstPage":"0","lastPage":"0","volume":"148"},"referencePositions":["FUNCTION","TISSUE SPECIFICITY","SUBUNIT","INTERACTION WITH CFAP91; ODAD2; RSPH3A; ROPN1; ROPN1L; RSPH9; DYNLT1; DYNC1I2; TUBB3; WDR35; IFT22 AND IFT81","SUBCELLULAR LOCATION","DISRUPTION PHENOTYPE"]},{"referenceNumber":6,"citation":{"id":"35387802","citationType":"journal article","authors":["Hu T.","Meng L.","Tan C.","Luo C.","He W.B.","Tu C.","Zhang H.","Du J.","Nie H.","Lu G.X.","Lin G.","Tan Y.Q."],"citationCrossReferences":[{"database":"PubMed","id":"35387802"},{"database":"DOI","id":"10.1136/jmedgenet-2021-108249"}],"title":"Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia.","publicationDate":"2023","journal":"J. Med. Genet.","firstPage":"144","lastPage":"153","volume":"60"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","DISRUPTION PHENOTYPE"]},{"referenceNumber":7,"citation":{"id":"37352829","citationType":"journal article","authors":["Jin H.J.","Wang J.L.","Geng X.Y.","Wang C.Y.","Wang B.B.","Chen S.R."],"citationCrossReferences":[{"database":"PubMed","id":"37352829"},{"database":"DOI","id":"10.1016/j.ebiom.2023.104675"}],"title":"CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men.","publicationDate":"2023","journal":"EBioMedicine","firstPage":"104675","lastPage":"104675","volume":"93"},"referencePositions":["INTERACTION WITH CFAP70","SUBCELLULAR LOCATION"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL672100","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL732467","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL935056","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC024760","properties":[{"key":"ProteinId","value":"AAH24760.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC107030","properties":[{"key":"ProteinId","value":"AAI07031.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC107031","properties":[{"key":"ProteinId","value":"AAI07032.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK019712","properties":[{"key":"ProteinId","value":"BAC25604.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"PDB","id":"9D2F","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.70 A"},{"key":"Chains","value":"J=1-1252"}]},{"database":"PDBsum","id":"9D2F","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q8CEL2","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-46494","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8CEL2","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8CEL2","properties":[{"key":"Number of interactors","value":"15"}]},{"database":"STRING","id":"10090.ENSMUSP00000112099","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8CEL2","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8CEL2","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000112099","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"281650","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8CEL2-1"},{"database":"ProteomicsDB","id":"281651","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8CEL2-2"},{"database":"AGR","id":"MGI:1926024","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1926024","properties":[{"key":"GeneName","value":"Cfap61"}]},{"database":"eggNOG","id":"ENOG502QSEC","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q8CEL2","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q8CEL2","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Unplaced"}]},{"database":"RNAct","id":"Q8CEL2","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"GO","id":"GO:0005930","properties":[{"key":"GoTerm","value":"C:axoneme"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35387802"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36659204"}]},{"database":"GO","id":"GO:0002177","properties":[{"key":"GoTerm","value":"C:manchette"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37352829"}]},{"database":"GO","id":"GO:0031514","properties":[{"key":"GoTerm","value":"C:motile cilium"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001534","properties":[{"key":"GoTerm","value":"C:radial spoke"},{"key":"GoEvidenceType","value":"ISA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000247","source":"PubMed","id":"34792097"}]},{"database":"GO","id":"GO:0001536","properties":[{"key":"GoTerm","value":"C:radial spoke stalk"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"34792097"}]},{"database":"GO","id":"GO:0036126","properties":[{"key":"GoTerm","value":"C:sperm flagellum"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"34792097"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"35387802"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"36659204"}]},{"database":"GO","id":"GO:0003341","properties":[{"key":"GoTerm","value":"P:cilium movement"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0044782","properties":[{"key":"GoTerm","value":"P:cilium organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030317","properties":[{"key":"GoTerm","value":"P:flagellated sperm motility"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"36659204"}]},{"database":"GO","id":"GO:0120316","properties":[{"key":"GoTerm","value":"P:sperm flagellum assembly"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"35387802"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"36659204"}]},{"database":"GO","id":"GO:0007290","properties":[{"key":"GoTerm","value":"P:spermatid nucleus elongation"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"36659204"}]},{"database":"Gene3D","id":"3.40.630.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.50.50.60","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR016181","properties":[{"key":"EntryName","value":"Acyl_CoA_acyltransferase"}]},{"database":"InterPro","id":"IPR038884","properties":[{"key":"EntryName","value":"CFAP61"}]},{"database":"InterPro","id":"IPR056299","properties":[{"key":"EntryName","value":"CFAP61_dimer"}]},{"database":"InterPro","id":"IPR032151","properties":[{"key":"EntryName","value":"CFAP61_N"}]},{"database":"InterPro","id":"IPR036188","properties":[{"key":"EntryName","value":"FAD/NAD-bd_sf"}]},{"database":"PANTHER","id":"PTHR21178","properties":[{"key":"EntryName","value":"CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21178:SF8","properties":[{"key":"EntryName","value":"CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 61"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF23150","properties":[{"key":"EntryName","value":"CFAP61_dimer"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16092","properties":[{"key":"EntryName","value":"CFAP61_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF55729","properties":[{"key":"EntryName","value":"Acyl-CoA N-acyltransferases (Nat)"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51905","properties":[{"key":"EntryName","value":"FAD/NAD(P)-binding domain"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSILTSPRGKVEVVHCRRTESQDIFCIKNLVRKFTQKLFGRLNIIYLLEKANLAVTVCNDKEEIMAHSIFLDYPNWNVAKQDNWIPLFRELDKEIPCTPLNTLFMHFFVAVDEYATGCLKEIIRTVFKAVPELYFIFLIVPTYLSLGSTLITVFDQVGNIPCLNYNEDFAVHICHRHNHYPQLHIRKARVEDHDDLMPIFMHYDNTLKEIYGEYFLAELIEAQDKDHHAVVCEVEGKAVGFMSVCTSVNLPLLHECFDLGPFHGFCTPHPDDILKPSREPSLEEGEEKHLKKCSTSLIIREMQIKTTLRFHLTPVRMAKIKNSETETSASCEEALPTVLGLVSEERLKQDMEKNLSILSLVDEEDVASSLSSSLLLSVESSHFRPLYLGDPIAFCIQLFCIDERYEARQVLISNVSLSLDFMSFVFSLFPGKNFCLISVPHLTPEFVLIQNFVKVVPFNNCTLDHDLYVFHRAGLLRSITIRLAKFLDTAGVEKLVSTLLLSTKILDDLAQYNEAGRDPDGTALQVFVAEVADQIVGIAVIRKEMDIEYIRSHYNIEDFIYFSHHQQEEHGRLNHFALNPIFRHYTKFFLKEILRLGYKSCLYYPVYPQTREGKLQSSYSHSLTSALHYLVPVRPRRQIVYPLEKLGINAPSKEVSKDQVSFALNHTNRKLTLEPKVTVNARIVVVGASSVGISFLETLVFCSHLKFNNLTLISTHGLPGKRLLHNEQRKFLASDHCFNDKDYALMSLCSWVNVVVGRMTAIDRAAKQVVVSKSEIVFYDHLILCTGLQYQVPCPTGADTEQHLTNREVLELSKQRYTGTVPSNLFILNDEEDCVRMLCWLRNSSILTEGKVIVYGNTLDAYTTVETLLNIGMKGSGIYFVHPPTESNITCINNNDVESAVEDALSAAGVTVFHDALLAQWNHGQHPDPIYNACFTTSTKPIRLECSAFFSFYKKNVDYETFKAFNDACLVYDGRLVIDTTFHTNDIAIRAAGSLTKFSNRYYSNEWTHSNFSSKEIGFQLAAAMLSLFDPTLEPVTEPPADLDRLIPMYKGAKIQGGILPGSYHYLHISKPAIPTPLNLQRSQPDFGSDVVTGNAKKGTYFRLYINNYKLVEAITCFSKEPFPSSNYIRLFGQHEQVLNNLCTRFDDKLIPDLYSYFTEPWCMALFHDRFIDLKKELRQILISKQEEDKPTMEEIAYRLEEEEINLNEKPQKYLQRVFEDSIYKSLLEKSILDYLHYNQYHLPMYAWPGII","length":1252,"molWeight":143289,"crc64":"C7C9E79DC4153CD4","md5":"F84CF56AB66C7D8EEFBECC5285C7FEFF"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Alternative sequence":2,"Sequence conflict":5},"uniParcId":"UPI00015887A8"}}