{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8CDM8","secondaryAccessions":["Q3T9P9","Q68FM8","Q6P5D5","Q80TB5","Q8C8M2","Q8R1V3"],"uniProtkbId":"FHI2A_MOUSE","entryAudit":{"firstPublicDate":"2007-04-17","lastAnnotationUpdateDate":"2026-01-28","lastSequenceUpdateDate":"2007-04-17","entryVersion":136,"sequenceVersion":2},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2147545"}],"value":"FHF complex subunit HOOK interacting protein 2A"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2147545"}],"value":"Fhip2a"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2147545"}],"value":"Fam160b1"},{"value":"Kiaa1600"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q5W0V3"}],"value":"May be required for proper functioning of the nervous system"}],"commentType":"FUNCTION"},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8CDM8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8CDM8-2"],"sequenceIds":["VSP_024592"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the FHIP family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAC32767.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BC079562","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":764,"modifier":"EXACT"}},"description":"FHF complex subunit HOOK interacting protein 2A","featureId":"PRO_0000284649"},{"type":"Region","location":{"start":{"value":190,"modifier":"EXACT"},"end":{"value":236,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":214,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":524,"modifier":"EXACT"},"end":{"value":764,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_024592","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":95,"modifier":"EXACT"}},"description":"in Ref. 1; BAC32767","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":477,"modifier":"EXACT"},"end":{"value":477,"modifier":"EXACT"}},"description":"in Ref. 1; BAE42971","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"H","alternativeSequences":["Y"]}},{"type":"Sequence conflict","location":{"start":{"value":492,"modifier":"EXACT"},"end":{"value":492,"modifier":"EXACT"}},"description":"in Ref. 1; BAC32767","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":518,"modifier":"EXACT"},"end":{"value":518,"modifier":"EXACT"}},"description":"in Ref. 1; BAC26638","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":548,"modifier":"EXACT"},"end":{"value":548,"modifier":"EXACT"}},"description":"in Ref. 1; BAE42971","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":578,"modifier":"EXACT"},"end":{"value":578,"modifier":"EXACT"}},"description":"in Ref. 1; BAE42971","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":607,"modifier":"EXACT"},"end":{"value":607,"modifier":"EXACT"}},"description":"in Ref. 1; BAE42971","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":680,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"in Ref. 1; BAE42971","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"I","alternativeSequences":["V"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Adrenal gland","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)","NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 365-764 (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"12693553","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Aizawa H.","Yuasa S.","Nakajima D.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"12693553"},{"database":"DOI","id":"10.1093/dnares/10.1.35"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"35","lastPage":"48","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 69-764 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK029835","properties":[{"key":"ProteinId","value":"BAC26638.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK046518","properties":[{"key":"ProteinId","value":"BAC32767.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK172373","properties":[{"key":"ProteinId","value":"BAE42971.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC023048","properties":[{"key":"ProteinId","value":"AAH23048.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC062949","properties":[{"key":"ProteinId","value":"AAH62949.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC079562","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK122530","properties":[{"key":"ProteinId","value":"BAC65812.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS29925.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8CDM8-1"},{"database":"RefSeq","id":"NP_663480.3","properties":[{"key":"NucleotideSequenceId","value":"NM_145505.4"}],"isoformId":"Q8CDM8-1"},{"database":"AlphaFoldDB","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"230493","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q8CDM8","properties":[{"key":"Number of interactors","value":"335"}]},{"database":"STRING","id":"10090.ENSMUSP00000048903","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8CDM8","properties":[{"key":"glycosylation","value":"3 sites, 1 O-linked glycan (2 sites)"}]},{"database":"iPTMnet","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000048903","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"271529","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8CDM8-1"},{"database":"ProteomicsDB","id":"271530","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8CDM8-2"},{"database":"Pumba","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"52360","properties":[{"key":"antibodies","value":"111 antibodies from 19 providers"}]},{"database":"DNASU","id":"226252","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000036407.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000048903.5"},{"key":"GeneId","value":"ENSMUSG00000033478.7"}],"isoformId":"Q8CDM8-1"},{"database":"GeneID","id":"226252","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:226252","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008iac.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8CDM8-1"},{"database":"AGR","id":"MGI:2147545","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"57700","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2147545","properties":[{"key":"GeneName","value":"Fhip2a"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000033478","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3695","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000182936","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_023718_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VQTEFFF","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5350595at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"226252","properties":[{"key":"hits","value":"0 hits in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8CDM8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 19"}]},{"database":"RNAct","id":"Q8CDM8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000033478","properties":[{"key":"ExpressionPatterns","value":"Expressed in humerus cartilage element and 241 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8CDM8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR019384","properties":[{"key":"EntryName","value":"FHIP"}]},{"database":"InterPro","id":"IPR045669","properties":[{"key":"EntryName","value":"FHIP_C"}]},{"database":"InterPro","id":"IPR045668","properties":[{"key":"EntryName","value":"FHIP_KELAA_motif"}]},{"database":"PANTHER","id":"PTHR21705:SF10","properties":[{"key":"EntryName","value":"FHF COMPLEX SUBUNIT HOOK INTERACTING PROTEIN 2A"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21705","properties":[{"key":"EntryName","value":"RAI16 PROTEIN-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19314","properties":[{"key":"EntryName","value":"DUF5917"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19311","properties":[{"key":"EntryName","value":"KELAA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10257","properties":[{"key":"EntryName","value":"RAI16-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MFSKLTSILQHAVEALAPSLPLQEDFVYHWKAITHYYIETSDDKAPVTDTNIPSHLEQMLDILVQEENERESGETGPCMEYLLHHKILETLYTLGKADCPPGMKQQVLVFYTKLLGRIRQPLLPHINVHRPVQKLIRLCGEVLATPTENEEIQFLCIVCAKLKQDPYLVNFFLENKSKSLVSRGALSVISEDGPKGQDPGSGDVSQCQQPQELSGATGVEPTESEEEPPHQMDDLSASLDDLNVTSLPEASAVRPNQDYNLVNSLLNLTRSPDGRIAVKACEGLMLLVSLPEPAAAKCLAQSTCLCELLTGRLTSLYKALPQSVDPLDIETVEAVNWGLDSYSHKEDASAFPGKRALISFLSWFDYCDQLIKEAQKTAAVALAKAIHERFFVGVMEPQLMQTSEMGILTSTALLHRIVRQVTSDVLLQEMVVFILGEQREPETLSEISRHPLRHRLIEHCDHISDEISIMTLRMFEHLLQKPNEHILYNLVLRNLEERNYTENKPSCPEDKDVVENGLIAGAVDLEEDPLFTDISPDNTLPNQEWICSPRTSPDHPKNDGKTEVHKVVNSFLCLVPDDAKSSYHVEGTGYDTYLRDAHRQFRDYCAICSRWEWPGAPKPLEKCDLEAAFFEGHFLKVLFDRMGRILDQPYDVNLQVTSVLSRLSLFPHPHTHEYLLDPYINLASGCRSLFSVIVRVVGDLMVRIQRIQDFTPKLLLVRKRLLGLEPEGPIVDHITLLEGVIVLEEFCKELAAIAFVKYHASATP","length":764,"molWeight":86017,"crc64":"90D4F625C02DD286","md5":"53066793B127CDB616C9BA8E0622B52E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"ALTERNATIVE PRODUCTS":2,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Region":1,"Compositional bias":1,"Alternative sequence":1,"Sequence conflict":8},"uniParcId":"UPI000024E0C1"}}