{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8CD15","secondaryAccessions":["Q8QZX1","Q9CQ03"],"uniProtkbId":"RIOX2_MOUSE","entryAudit":{"firstPublicDate":"2007-10-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-10-23","entryVersion":151,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1914264"}],"value":"Ribosomal oxygenase 2"}},"alternativeNames":[{"fullName":{"value":"Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IUF8"}],"value":"1.14.11.79"}]},{"fullName":{"value":"Histone lysine demethylase MINA"}},{"fullName":{"value":"MYC-induced nuclear antigen"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1914264"}],"value":"Riox2"},"synonyms":[{"value":"Mina"},{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16533354"}],"value":"Mina53"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16533354"}],"value":"Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-histidyl-[ribosomal protein uL15] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + succinate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54024"},{"database":"Rhea","id":"RHEA-COMP:13760"},{"database":"Rhea","id":"RHEA-COMP:13761"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:29979"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:138021"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IUF8"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:54256"},{"database":"Rhea","id":"RHEA-COMP:9745"},{"database":"Rhea","id":"RHEA-COMP:13840"},{"database":"ChEBI","id":"CHEBI:15379"},{"database":"ChEBI","id":"CHEBI:16526"},{"database":"ChEBI","id":"CHEBI:16810"},{"database":"ChEBI","id":"CHEBI:29979"},{"database":"ChEBI","id":"CHEBI:30031"},{"database":"ChEBI","id":"CHEBI:138021"}],"ecNumber":"1.14.11.79","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IUF8"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Fe(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29033"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Binds 1 Fe(2+) ion per subunit."}]}},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16533354"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16533354"}],"value":"Nucleus, nucleolus","id":"SL-0188"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16533354"}],"value":"Predominantly expressed in testis. Expressed at high levels in spleen, thymus, and colon, but barely detectable in brain, skeletal muscle, and seminal vesicle (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16533354"}],"value":"In testis, expressed in the nuclei of spermatogonia at all stages of the seminiferous epithelial cycle, and in meiotic prophase cells such as preleptotene, leptotene and zygotene, and weakly in early pachytene spermatocytes, but is absent in late pachytene spermatocytes, spermatids and mature sperm (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16533354"}],"value":"Up-regulated in experimentally-induced cryptorchid testis"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the ROX family. MINA53 subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"Ribosomal oxygenase 2","featureId":"PRO_0000308378"},{"type":"Domain","location":{"start":{"value":139,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"JmjC","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00538"}]},{"type":"Binding site","location":{"start":{"value":179,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00538"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":181,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00538"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","note":"catalytic"}},{"type":"Binding site","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:24875"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00538"}],"ligand":{"name":"Fe cation","id":"ChEBI:CHEBI:24875","note":"catalytic"}},{"type":"Modified residue","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":309,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IUF8"}]},{"type":"Sequence conflict","location":{"start":{"value":15,"modifier":"EXACT"},"end":{"value":15,"modifier":"EXACT"}},"description":"in Ref. 3; AAH25109/AAH23462","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["E"]}},{"type":"Sequence conflict","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"in Ref. 2; BAC27503","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":440,"modifier":"EXACT"},"end":{"value":440,"modifier":"EXACT"}},"description":"in Ref. 3; AAH25109/AAH23462","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0223","category":"Molecular function","name":"Dioxygenase"},{"id":"KW-0408","category":"Ligand","name":"Iron"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0560","category":"Molecular function","name":"Oxidoreductase"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0690","category":"Biological process","name":"Ribosome biogenesis"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"}],"references":[{"referenceNumber":1,"citation":{"id":"16533354","citationType":"journal article","authors":["Tsuneoka M.","Nishimune Y.","Ohta K.","Teye K.","Tanaka H.","Soejima M.","Iida H.","Inokuchi T.","Kimura H.","Koda Y."],"citationCrossReferences":[{"database":"PubMed","id":"16533354"},{"database":"DOI","id":"10.1111/j.1365-2605.2005.00572.x"}],"title":"Expression of Mina53, a product of a Myc target gene in mouse testis.","publicationDate":"2006","journal":"Int. J. Androl.","firstPage":"323","lastPage":"330","volume":"29"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]","FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE","INDUCTION"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAD60965.1"}],"value":"Stomach","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000305"},{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAD60965.1"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAC27503.1"}],"value":"C57BL/6J","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAB28860.1"}],"value":"Embryo","type":"TISSUE"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAC27503.1"}],"value":"Embryonic testis","type":"TISSUE"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAB25275.1"}],"value":"Pancreas","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAC27503.1"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAH58242.1"}],"value":"C57BL/6J","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAH23462.1"}],"value":"FVB/N","type":"STRAIN"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAH23462.1"}],"value":"Kidney","type":"TISSUE"},{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAH58242.1"}],"value":"Olfactory epithelium","type":"TISSUE"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAH23462.1"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB177385","properties":[{"key":"ProteinId","value":"BAD60965.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK007810","properties":[{"key":"ProteinId","value":"BAB25275.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK013451","properties":[{"key":"ProteinId","value":"BAB28860.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK031671","properties":[{"key":"ProteinId","value":"BAC27503.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC023462","properties":[{"key":"ProteinId","value":"AAH23462.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC025109","properties":[{"key":"ProteinId","value":"AAH25109.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058242","properties":[{"key":"ProteinId","value":"AAH58242.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS28257.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_080186.3","properties":[{"key":"NucleotideSequenceId","value":"NM_025910.3"}]},{"database":"RefSeq","id":"XP_006522542.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006522479.5"}]},{"database":"AlphaFoldDB","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"211876","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q8CD15","properties":[{"key":"Number of interactors","value":"1757"}]},{"database":"STRING","id":"10090.ENSMUSP00000125297","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000125297","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"253245","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2005","properties":[{"key":"antibodies","value":"388 antibodies from 40 providers"}]},{"database":"DNASU","id":"67014","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000023407.12","properties":[{"key":"ProteinId","value":"ENSMUSP00000023407.6"},{"key":"GeneId","value":"ENSMUSG00000022724.16"}]},{"database":"Ensembl","id":"ENSMUST00000160571.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000125297.2"},{"key":"GeneId","value":"ENSMUSG00000022724.16"}]},{"database":"GeneID","id":"67014","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:67014","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007zph.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1914264","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"84864","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1914264","properties":[{"key":"GeneName","value":"Riox2"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000022724","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3706","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000000083","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_013645_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"IRREMVY","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"425950at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-3214842","properties":[{"key":"PathwayName","value":"HDMs demethylate histones"}]},{"database":"Reactome","id":"R-MMU-9629569","properties":[{"key":"PathwayName","value":"Protein hydroxylation"}]},{"database":"BioGRID-ORCS","id":"67014","properties":[{"key":"hits","value":"4 hits in 82 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8CD15","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 16"}]},{"database":"RNAct","id":"Q8CD15","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000022724","properties":[{"key":"ExpressionPatterns","value":"Expressed in otic placode and 258 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8CD15","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19561615"}]},{"database":"GO","id":"GO:0005730","properties":[{"key":"GoTerm","value":"C:nucleolus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"12091391"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19561615"}]},{"database":"GO","id":"GO:0005667","properties":[{"key":"GoTerm","value":"C:transcription regulator complex"},{"key":"GoEvidenceType","value":"IPI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"19561615"}]},{"database":"GO","id":"GO:0051864","properties":[{"key":"GoTerm","value":"F:histone H3K36 demethylase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032453","properties":[{"key":"GoTerm","value":"F:histone H3K4 demethylase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0036139","properties":[{"key":"GoTerm","value":"F:peptidyl-histidine dioxygenase activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0003714","properties":[{"key":"GoTerm","value":"F:transcription corepressor activity"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"19561615"}]},{"database":"GO","id":"GO:0042127","properties":[{"key":"GoTerm","value":"P:regulation of cell population proliferation"},{"key":"GoEvidenceType","value":"ISO:MGI"}],"evidences":[{"evidenceCode":"ECO:0000266","source":"PubMed","id":"12091391"}]},{"database":"Gene3D","id":"3.90.930.40","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.120.650","properties":[{"key":"EntryName","value":"Cupin"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.1500","properties":[{"key":"EntryName","value":"JmjC domain-containing ribosomal oxygenase (ROX), dimer domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003347","properties":[{"key":"EntryName","value":"JmjC_dom"}]},{"database":"InterPro","id":"IPR039994","properties":[{"key":"EntryName","value":"NO66-like"}]},{"database":"InterPro","id":"IPR046799","properties":[{"key":"EntryName","value":"ROXA-like_wH"}]},{"database":"PANTHER","id":"PTHR13096","properties":[{"key":"EntryName","value":"MINA53 MYC INDUCED NUCLEAR ANTIGEN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR13096:SF7","properties":[{"key":"EntryName","value":"RIBOSOMAL OXYGENASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF08007","properties":[{"key":"EntryName","value":"JmjC_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20514","properties":[{"key":"EntryName","value":"WHD_ROXA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF51197","properties":[{"key":"EntryName","value":"Clavaminate synthase-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51184","properties":[{"key":"EntryName","value":"JMJC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MPKKVQPTGDENEEASVPCKRVKEELPETLSVLNFDSPSSFFESLISPIKVETFFKEFWEQKPLLIQRDDPVLAKYYQSLFSLSDLKRLCKKGVYYGRDVNVCRSISGKKKVLNKDGRAHFLQLRKDFDQKRATIQFHQPQRYKDELWRIQEKLECYFGSLVGSNVYMTPAGSQGLPPHYDDVEVFILQLEGTKHWRLYSPTVPLAHEYSVESEDRIGTPTHDFLLKPGDLLYFPRGTIHQAETPSGLAYSIHLTISTYQNNSWGDCLLDSISGFVFDIAKEDVALRSGMPRRMLLNVETPADVTRKLSGFLRTLADQLEGREELLSSDMKKDFVKHRLPPFFEGNGTETMDPGKQLPRLDNIIRLQFKDHIVLTVGPDKNPFDEAQQKVVYIYHSLKNVRQMHMIGEEEESEIFGLRFPLSHVDALKQIWCGSPIRVKDLKLDTDEEKENLALSLWSESLIQVL","length":465,"molWeight":53517,"crc64":"E0504FE459FFC47A","md5":"4573A32B2255BB09358FA39D12706556"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":1,"Binding site":3,"Modified residue":1,"Sequence conflict":3},"uniParcId":"UPI0000021FC0"}}