{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8C5T8","uniProtkbId":"CF263_MOUSE","entryAudit":{"firstPublicDate":"2007-03-06","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":120,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Cilia- and flagella-associated protein 263"}}},"genes":[{"geneName":{"value":"Cfap263"},"synonyms":[{"value":"Ccdc113"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q22KK0"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H0I3"}],"value":"Component of centriolar satellites contributing to primary cilium formation (By similarity). In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q22KK0"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H0I3"}],"value":"Forms a complex with CFAP184; the interaction is required for functional activity in cilia (By similarity). Interacts with HAP1 and PCM1 (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q22KK0"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H0I3"}],"value":"Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1 (By similarity). Localizes at cilium but not at the ciliary tips (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9H0I3"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite","id":"SL-0485"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q22KK0"}],"value":"Cell projection, cilium","id":"SL-0066"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CFAP263 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":377,"modifier":"EXACT"}},"description":"Cilia- and flagella-associated protein 263","featureId":"PRO_0000279400"},{"type":"Coiled coil","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":139,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":169,"modifier":"EXACT"},"end":{"value":355,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]}],"keywords":[{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0970","category":"Biological process","name":"Cilium biogenesis/degradation"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK077130","properties":[{"key":"ProteinId","value":"BAC36633.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC060957","properties":[{"key":"ProteinId","value":"AAH60957.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS22563.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_766502.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172914.2"}]},{"database":"AlphaFoldDB","id":"Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8C5T8","properties":[{"key":"Number of interactors","value":"104"}]},{"database":"STRING","id":"10090.ENSMUSP00000049497","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000049497","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"265575","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"54998","properties":[{"key":"antibodies","value":"83 antibodies from 14 providers"}]},{"database":"DNASU","id":"244608","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000041569.5","properties":[{"key":"ProteinId","value":"ENSMUSP00000049497.4"},{"key":"GeneId","value":"ENSMUSG00000036598.5"}]},{"database":"GeneID","id":"244608","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:244608","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009myn.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:3606076","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"244608","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:3606076","properties":[{"key":"GeneName","value":"Ccdc113"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000036598","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QU7J","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154521","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_046867_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TCQQHRA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10259713at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"244608","properties":[{"key":"hits","value":"1 hit in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8C5T8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 8"}]},{"database":"RNAct","id":"Q8C5T8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000036598","properties":[{"key":"ExpressionPatterns","value":"Expressed in ventricular system choroidal fissure and 54 other cell types or tissues"}]},{"database":"GO","id":"GO:0005930","properties":[{"key":"GoTerm","value":"C:axoneme"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0034451","properties":[{"key":"GoTerm","value":"C:centriolar satellite"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25074808"}]},{"database":"InterPro","id":"IPR051885","properties":[{"key":"EntryName","value":"CC_CF"}]},{"database":"InterPro","id":"IPR025254","properties":[{"key":"EntryName","value":"CCDC113/CCDC96_CC"}]},{"database":"PANTHER","id":"PTHR15654:SF2","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 113"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15654","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13870","properties":[{"key":"EntryName","value":"CCDC113_CCDC96_CC"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSEEDSDSVITDSQAEEEGELPVIQLCGLVEELSYGNSALKTETEMFEKYYSRLEPRDHRMTRLSDIKITAAEFSQLRSRRKSKARGGLDRTLGLTVEQKLELVQKELEDTRDEIRHMRANAERDLQHHEAIIEEADIRWNEVQKAVHEFEKDILKTISKKKGSILATQKVMKYIEDMNRRRDNIKDKLCLKNVSLKVQRKKMLSQLRQKEEVGEALHDVDFQQLKIENAQFLETIEARNKELIQLKLASGNTLQVLNTYKNKLHRAMEIYVNLDKEILLRNELLGKIEKETIQAEEDRAKAHILNDKLRKQLAEFRAPQVMMYVKEKILNGELEKTIKMWERKVEIAEMSLKGYRKAWNKMKTSDEQLQIIRPPGK","length":377,"molWeight":44215,"crc64":"CC8F7AD15821CB72","md5":"CEE5463D67F5E18C5D3A46A067F32475"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Coiled coil":2},"uniParcId":"UPI00000276D0"}}