{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8C119","secondaryAccessions":["Q80VN3","Q8BWV6"],"uniProtkbId":"NDNF_MOUSE","entryAudit":{"firstPublicDate":"2007-09-11","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-09-11","entryVersion":161,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein NDNF"}},"alternativeNames":[{"fullName":{"value":"Epidermacan"}},{"fullName":{"value":"Neuron-derived neurotrophic factor"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Ndnf"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8TB73"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706764"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"value":"Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (By similarity). Also regulates extracellular matrix assembly and cell adhesiveness (PubMed:18757743). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757743"}],"value":"Binds heparin and chondroitin sulfate"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757743"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"value":"Expressed in brain and spinal cord with no expression detected in heart, kidney or liver. Expressed by neurons but not by astrocytes. In the brain, detected in the cerebrum, cerebellum and olfactory bulbs. In the cerebral cortex, highly expressed in Cajal-Retzius cells. Also expressed in hippocampal neurons and in Purkinje and granule cells of the cerebellum (at protein level) (PubMed:20969804). Expressed in neurons along the GnRH migratory route"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757743"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"}],"value":"At 16.5 dpc, specifically expressed in the interfollicular basal cells of the epidermis (at protein level). Detected in the marginal cells and cortical plate of the brain cortex from 16 dpc to P90 with high levels between 16 dpc and P0 and lower levels from P7 to adulthood (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706764"}],"value":"Up-regulated in endothelial cells of muscles after hind limb ischemic surgery"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"}],"value":"O-glycosylated; contains heparan sulfate and chondroitin sulfate"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20969804"}],"value":"N-glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31883645"}],"value":"Knockout mice lacking Ndnf are grossly normal and able to produce viable pups (PubMed:31883645). Absence of Ndnf in 13.5 dpc embryos results in abnormal development of the olfactory system and defective gonadotropin-releasing hormone (GnRH) expressing neurons migration to the hypothalamus (PubMed:31883645)"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"BAC33925.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"Protein NDNF","featureId":"PRO_0000301966"},{"type":"Domain","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":331,"modifier":"EXACT"}},"description":"Fibronectin type-III 1"},{"type":"Domain","location":{"start":{"value":445,"modifier":"EXACT"},"end":{"value":564,"modifier":"EXACT"}},"description":"Fibronectin type-III 2"},{"type":"Glycosylation","location":{"start":{"value":322,"modifier":"EXACT"},"end":{"value":322,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":58,"modifier":"EXACT"}},"description":"in Ref. 1; BAC33925","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":425,"modifier":"EXACT"},"end":{"value":425,"modifier":"EXACT"}},"description":"in Ref. 1; BAC26349","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}}],"keywords":[{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0524","category":"Biological process","name":"Neurogenesis"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Head","type":"TISSUE"},{"value":"Spinal cord","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Eye","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"18757743","citationType":"journal article","authors":["Manabe R.","Tsutsui K.","Yamada T.","Kimura M.","Nakano I.","Shimono C.","Sanzen N.","Furutani Y.","Fukuda T.","Oguri Y.","Shimamoto K.","Kiyozumi D.","Sato Y.","Sado Y.","Senoo H.","Yamashina S.","Fukuda S.","Kawai J.","Sugiura N.","Kimata K.","Hayashizaki Y.","Sekiguchi K."],"citationCrossReferences":[{"database":"PubMed","id":"18757743"},{"database":"DOI","id":"10.1073/pnas.0803640105"}],"title":"Transcriptome-based systematic identification of extracellular matrix proteins.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12849","lastPage":"12854","volume":"105"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION","GLYCOSYLATION","DEVELOPMENTAL STAGE"]},{"referenceNumber":4,"citation":{"id":"20969804","citationType":"journal article","authors":["Kuang X.L.","Zhao X.M.","Xu H.F.","Shi Y.Y.","Deng J.B.","Sun G.T."],"citationCrossReferences":[{"database":"PubMed","id":"20969804"},{"database":"DOI","id":"10.1186/1471-2202-11-137"}],"title":"Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development.","publicationDate":"2010","journal":"BMC Neurosci.","firstPage":"137","lastPage":"137","volume":"11"},"referencePositions":["TISSUE SPECIFICITY","DEVELOPMENTAL STAGE","GLYCOSYLATION"]},{"referenceNumber":5,"citation":{"id":"24706764","citationType":"journal article","authors":["Ohashi K.","Enomoto T.","Joki Y.","Shibata R.","Ogura Y.","Kataoka Y.","Shimizu Y.","Kambara T.","Uemura Y.","Yuasa D.","Matsuo K.","Hayakawa S.","Hiramatsu-Ito M.","Murohara T.","Ouchi N."],"citationCrossReferences":[{"database":"PubMed","id":"24706764"},{"database":"DOI","id":"10.1074/jbc.m114.555789"}],"title":"Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"14132","lastPage":"14144","volume":"289"},"referencePositions":["INDUCTION","FUNCTION"]},{"referenceNumber":6,"citation":{"id":"31883645","citationType":"journal article","authors":["Messina A.","Pulli K.","Santini S.","Acierno J.","Kaensaekoski J.","Cassatella D.","Xu C.","Casoni F.","Malone S.A.","Ternier G.","Conte D.","Sidis Y.","Tommiska J.","Vaaralahti K.","Dwyer A.","Gothilf Y.","Merlo G.R.","Santoni F.","Niederlaender N.J.","Giacobini P.","Raivio T.","Pitteloud N."],"citationCrossReferences":[{"database":"PubMed","id":"31883645"},{"database":"DOI","id":"10.1016/j.ajhg.2019.12.003"}],"title":"Neuron-derived neurotrophic factor is mutated in congenital hypogonadotropic hypogonadism.","publicationDate":"2020","journal":"Am. J. Hum. Genet.","firstPage":"58","lastPage":"70","volume":"106"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK029210","properties":[{"key":"ProteinId","value":"BAC26349.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK049802","properties":[{"key":"ProteinId","value":"BAC33925.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC047154","properties":[{"key":"ProteinId","value":"AAH47154.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS20207.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_765987.2","properties":[{"key":"NucleotideSequenceId","value":"NM_172399.3"}]},{"database":"RefSeq","id":"XP_006506591.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006506528.5"}]},{"database":"AlphaFoldDB","id":"Q8C119","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8C119","properties":[{"key":"Number of interactors","value":"305"}]},{"database":"IntAct","id":"Q8C119","properties":[{"key":"Interactions","value":"1"}]},{"database":"STRING","id":"10090.ENSMUSP00000051297","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q8C119","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q8C119","properties":[{"key":"glycosylation","value":"3 sites"}]},{"database":"PhosphoSitePlus","id":"Q8C119","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8C119","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000051297","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"287461","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"52933","properties":[{"key":"antibodies","value":"89 antibodies from 17 providers"}]},{"database":"DNASU","id":"68169","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000054351.6","properties":[{"key":"ProteinId","value":"ENSMUSP00000051297.5"},{"key":"GeneId","value":"ENSMUSG00000049001.6"}]},{"database":"GeneID","id":"68169","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:68169","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009cei.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:1915419","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"79625","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1915419","properties":[{"key":"GeneName","value":"Ndnf"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000049001","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4806","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007586","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_041753_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8C119","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"YLFRDTS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9872501at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8C119","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"68169","properties":[{"key":"hits","value":"2 hits in 80 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8C119","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 6"}]},{"database":"RNAct","id":"Q8C119","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000049001","properties":[{"key":"ExpressionPatterns","value":"Expressed in vault of skull and 187 other cell types or tissues"}]},{"database":"GO","id":"GO:0031012","properties":[{"key":"GoTerm","value":"C:extracellular matrix"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18757743"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18757743"}]},{"database":"GO","id":"GO:0140144","properties":[{"key":"GoTerm","value":"C:non-collagenous component of basement membrane"},{"key":"GoEvidenceType","value":"TAS:GO_Central"}],"evidences":[{"evidenceCode":"ECO:0000304","source":"PubMed","id":"36399478"}]},{"database":"GO","id":"GO:0005539","properties":[{"key":"GoTerm","value":"F:glycosaminoglycan binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18757743"}]},{"database":"GO","id":"GO:0008201","properties":[{"key":"GoTerm","value":"F:heparin binding"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18757743"}]},{"database":"GO","id":"GO:0001525","properties":[{"key":"GoTerm","value":"P:angiogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0044344","properties":[{"key":"GoTerm","value":"P:cellular response to fibroblast growth factor stimulus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0071456","properties":[{"key":"GoTerm","value":"P:cellular response to hypoxia"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030198","properties":[{"key":"GoTerm","value":"P:extracellular matrix organization"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18757743"}]},{"database":"GO","id":"GO:0021828","properties":[{"key":"GoTerm","value":"P:gonadotrophin-releasing hormone neuronal migration to the hypothalamus"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"31883645"}]},{"database":"GO","id":"GO:2000352","properties":[{"key":"GoTerm","value":"P:negative regulation of endothelial cell apoptotic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043524","properties":[{"key":"GoTerm","value":"P:negative regulation of neuron apoptotic process"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0001764","properties":[{"key":"GoTerm","value":"P:neuron migration"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0010811","properties":[{"key":"GoTerm","value":"P:positive regulation of cell-substrate adhesion"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18757743"}]},{"database":"GO","id":"GO:0010976","properties":[{"key":"GoTerm","value":"P:positive regulation of neuron projection development"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0002931","properties":[{"key":"GoTerm","value":"P:response to ischemia"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24706764"}]},{"database":"GO","id":"GO:0007165","properties":[{"key":"GoTerm","value":"P:signal transduction"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0061042","properties":[{"key":"GoTerm","value":"P:vascular wound healing"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"24706764"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR003961","properties":[{"key":"EntryName","value":"FN3_dom"}]},{"database":"InterPro","id":"IPR036116","properties":[{"key":"EntryName","value":"FN3_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR019326","properties":[{"key":"EntryName","value":"NDNF"}]},{"database":"InterPro","id":"IPR045805","properties":[{"key":"EntryName","value":"NDNF_C"}]},{"database":"InterPro","id":"IPR055271","properties":[{"key":"EntryName","value":"NDNF_Fn(III)_1"}]},{"database":"InterPro","id":"IPR056225","properties":[{"key":"EntryName","value":"NDNF_N"}]},{"database":"PANTHER","id":"PTHR14619","properties":[{"key":"EntryName","value":"NEURON-DERIVED NEUROTROPHIC FACTOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14619:SF1","properties":[{"key":"EntryName","value":"PROTEIN NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10179","properties":[{"key":"EntryName","value":"NDNF"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF19433","properties":[{"key":"EntryName","value":"NDNF_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF24354","properties":[{"key":"EntryName","value":"NDNF_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00060","properties":[{"key":"EntryName","value":"FN3"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF49265","properties":[{"key":"EntryName","value":"Fibronectin type III"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MELFYWCLLCLLLPLTSRTQKLPTRDEELFQMQIRDKEFFHDSSVIPDGAEVSSYLFRDTPRRYFFMVEEDNTPLSVTVTPCDAPLEWKLSLQELHEGSSADGSGDPELLDQQKQQMTDVEGTELFSYKGNDVEYFLSSSSPSGLYQLELLSTEKDTHFKVYATTTPESDQPYPELPYDPRVDVTSFGRTTVTLAWKPSPTASILKQPIEYCVVINKEHNFKSLCAAETKMNADDAFMVAPKPGLDFNPFDFAHFGFPTDNLGKDRSLLAKPSPKVGRHVYWRPKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTKEEAKQKTVELKDGRVTDVFVKRKGKKFLRFAPVSSHQKVTFFIHSCMDAVQVQVRRDGRLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQERRKFCIYRKEVDGNYSEDQKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGHSVKYQSKIVKTRKVC","length":568,"molWeight":65027,"crc64":"3928EAA45CA8DE4B","md5":"7C2FAB84C15065DAB022CB91434CEE0A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"PTM":2,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Domain":2,"Glycosylation":2,"Sequence conflict":2},"uniParcId":"UPI000000BB75"}}