{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8C0T5","secondaryAccessions":["Q6PDI8","Q80U02","Q8C026"],"uniProtkbId":"SI1L1_MOUSE","entryAudit":{"firstPublicDate":"2004-07-19","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-19","entryVersion":182,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Signal-induced proliferation-associated 1-like protein 1"},"shortNames":[{"value":"SIPA1-like protein 1"}]}},"genes":[{"geneName":{"value":"Sipa1l1"},"synonyms":[{"value":"Kiaa0440"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18094260"}],"value":"Interacts with DLG4, PDLIM5, PDLIM7 and LZTS3. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Postsynaptic density","id":"SL-0297"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Synapse, synaptosome","id":"SL-0261"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"E6TP1 alpha"}],"isoformIds":["Q8C0T5-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8C0T5-2"],"sequenceIds":["VSP_010918","VSP_010919"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Phosphorylated at Ser-1328 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome (By similarity)"}],"commentType":"PTM"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1782,"modifier":"EXACT"}},"description":"Signal-induced proliferation-associated 1-like protein 1","featureId":"PRO_0000056747"},{"type":"Domain","location":{"start":{"value":599,"modifier":"EXACT"},"end":{"value":816,"modifier":"EXACT"}},"description":"Rap-GAP","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00165"}]},{"type":"Domain","location":{"start":{"value":953,"modifier":"EXACT"},"end":{"value":1031,"modifier":"EXACT"}},"description":"PDZ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00143"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":28,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":47,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":140,"modifier":"EXACT"},"end":{"value":171,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":277,"modifier":"EXACT"},"end":{"value":297,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1069,"modifier":"EXACT"},"end":{"value":1128,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1144,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1247,"modifier":"EXACT"},"end":{"value":1285,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1307,"modifier":"EXACT"},"end":{"value":1342,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1358,"modifier":"EXACT"},"end":{"value":1454,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1625,"modifier":"EXACT"},"end":{"value":1647,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1713,"modifier":"EXACT"},"end":{"value":1773,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":84,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":95,"modifier":"EXACT"},"end":{"value":125,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1080,"modifier":"EXACT"},"end":{"value":1093,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1159,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1186,"modifier":"EXACT"},"end":{"value":1205,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1261,"modifier":"EXACT"},"end":{"value":1276,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1315,"modifier":"EXACT"},"end":{"value":1328,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1358,"modifier":"EXACT"},"end":{"value":1368,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1378,"modifier":"EXACT"},"end":{"value":1410,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1432,"modifier":"EXACT"},"end":{"value":1447,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":162,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":187,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":193,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":288,"modifier":"EXACT"},"end":{"value":288,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1078,"modifier":"EXACT"},"end":{"value":1078,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1087,"modifier":"EXACT"},"end":{"value":1087,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1116,"modifier":"EXACT"},"end":{"value":1116,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1127,"modifier":"EXACT"},"end":{"value":1127,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1149,"modifier":"EXACT"},"end":{"value":1149,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1170,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1181,"modifier":"EXACT"},"end":{"value":1181,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1234,"modifier":"EXACT"},"end":{"value":1234,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1249,"modifier":"EXACT"},"end":{"value":1249,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1305,"modifier":"EXACT"},"end":{"value":1305,"modifier":"EXACT"}},"description":"Phosphoserine; by PLK2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35412"}]},{"type":"Modified residue","location":{"start":{"value":1309,"modifier":"EXACT"},"end":{"value":1309,"modifier":"EXACT"}},"description":"Phosphothreonine; by PLK2","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35412"}]},{"type":"Modified residue","location":{"start":{"value":1328,"modifier":"EXACT"},"end":{"value":1328,"modifier":"EXACT"}},"description":"Phosphoserine; by CDK5","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O35412"}]},{"type":"Modified residue","location":{"start":{"value":1345,"modifier":"EXACT"},"end":{"value":1345,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1369,"modifier":"EXACT"},"end":{"value":1369,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1370,"modifier":"EXACT"},"end":{"value":1370,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1391,"modifier":"EXACT"},"end":{"value":1391,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1410,"modifier":"EXACT"},"end":{"value":1410,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1412,"modifier":"EXACT"},"end":{"value":1412,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1507,"modifier":"EXACT"},"end":{"value":1507,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1528,"modifier":"EXACT"},"end":{"value":1528,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19131326"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19144319"}]},{"type":"Modified residue","location":{"start":{"value":1530,"modifier":"EXACT"},"end":{"value":1530,"modifier":"EXACT"}},"description":"Phosphothreonine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1533,"modifier":"EXACT"},"end":{"value":1533,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1544,"modifier":"EXACT"},"end":{"value":1544,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1547,"modifier":"EXACT"},"end":{"value":1547,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"17242355"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1564,"modifier":"EXACT"},"end":{"value":1564,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1567,"modifier":"EXACT"},"end":{"value":1567,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"O43166"}]},{"type":"Modified residue","location":{"start":{"value":1580,"modifier":"EXACT"},"end":{"value":1580,"modifier":"EXACT"}},"description":"Asymmetric dimethylarginine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"24129315"}]},{"type":"Modified residue","location":{"start":{"value":1582,"modifier":"EXACT"},"end":{"value":1582,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1624,"modifier":"EXACT"},"end":{"value":1624,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1626,"modifier":"EXACT"},"end":{"value":1626,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1629,"modifier":"EXACT"},"end":{"value":1629,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1687,"modifier":"EXACT"},"end":{"value":1687,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1690,"modifier":"EXACT"},"end":{"value":1690,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1707,"modifier":"EXACT"},"end":{"value":1707,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1708,"modifier":"EXACT"},"end":{"value":1708,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":1712,"modifier":"EXACT"},"end":{"value":1712,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Alternative sequence","location":{"start":{"value":1736,"modifier":"EXACT"},"end":{"value":1751,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_010918","alternativeSequence":{"originalSequence":"EKEDKAQLQAEVEHLR","alternativeSequences":["VNALRKRRQGPAAGGS"]}},{"type":"Alternative sequence","location":{"start":{"value":1752,"modifier":"EXACT"},"end":{"value":1782,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_010919","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":855,"modifier":"EXACT"},"end":{"value":855,"modifier":"EXACT"}},"description":"in Ref. 1; BAC26660","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["N"]}},{"type":"Sequence conflict","location":{"start":{"value":1204,"modifier":"EXACT"},"end":{"value":1204,"modifier":"EXACT"}},"description":"in Ref. 1; BAC65566","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"W","alternativeSequences":["C"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0343","category":"Molecular function","name":"GTPase activation"},{"id":"KW-0488","category":"PTM","name":"Methylation"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0771","category":"Cellular component","name":"Synaptosome"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Olfactory bulb","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"CI-92NG82E19BM4T","citationType":"submission","authors":["Lubec G.","Kang S.U."],"publicationDate":"APR-2007","submissionDatabase":"UniProtKB"},"referencePositions":["PROTEIN SEQUENCE OF 18-28; 1379-1408 AND 1468-1482","IDENTIFICATION BY MASS SPECTROMETRY"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"12693553","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Aizawa H.","Yuasa S.","Nakajima D.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"12693553"},{"database":"DOI","id":"10.1093/dnares/10.1.35"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"35","lastPage":"48","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 273-1782 (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16452087","citationType":"journal article","authors":["Trinidad J.C.","Specht C.G.","Thalhammer A.","Schoepfer R.","Burlingame A.L."],"citationCrossReferences":[{"database":"PubMed","id":"16452087"},{"database":"DOI","id":"10.1074/mcp.t500041-mcp200"}],"title":"Comprehensive identification of phosphorylation sites in postsynaptic density preparations.","publicationDate":"2006","journal":"Mol. Cell. Proteomics","firstPage":"914","lastPage":"922","volume":"5"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"18094260","citationType":"journal article","authors":["Richter M.","Murai K.K.","Bourgin C.","Pak D.T.","Pasquale E.B."],"citationCrossReferences":[{"database":"PubMed","id":"18094260"},{"database":"DOI","id":"10.1523/jneurosci.2746-07.2007"}],"title":"The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.","publicationDate":"2007","journal":"J. Neurosci.","firstPage":"14205","lastPage":"14215","volume":"27"},"referencePositions":["INTERACTION WITH EPHA4"]},{"referenceNumber":7,"citation":{"id":"17242355","citationType":"journal article","authors":["Villen J.","Beausoleil S.A.","Gerber S.A.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"17242355"},{"database":"DOI","id":"10.1073/pnas.0609836104"}],"title":"Large-scale phosphorylation analysis of mouse liver.","publicationDate":"2007","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1488","lastPage":"1493","volume":"104"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1547","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Liver","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"19144319","citationType":"journal article","authors":["Trost M.","English L.","Lemieux S.","Courcelles M.","Desjardins M.","Thibault P."],"citationCrossReferences":[{"database":"PubMed","id":"19144319"},{"database":"DOI","id":"10.1016/j.immuni.2008.11.006"}],"title":"The phagosomal proteome in interferon-gamma-activated macrophages.","publicationDate":"2009","journal":"Immunity","firstPage":"143","lastPage":"154","volume":"30"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1528","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"19131326","citationType":"journal article","authors":["Sweet S.M.","Bailey C.M.","Cunningham D.L.","Heath J.K.","Cooper H.J."],"citationCrossReferences":[{"database":"PubMed","id":"19131326"},{"database":"DOI","id":"10.1074/mcp.m800451-mcp200"}],"title":"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.","publicationDate":"2009","journal":"Mol. Cell. Proteomics","firstPage":"904","lastPage":"912","volume":"8"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1528","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Embryonic fibroblast","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255; SER-288; SER-1127; SER-1410; SER-1412; SER-1547; SER-1564; SER-1582; SER-1624; SER-1626; SER-1629; SER-1687; SER-1690; SER-1707; SER-1708 AND SER-1712","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"24129315","citationType":"journal article","authors":["Guo A.","Gu H.","Zhou J.","Mulhern D.","Wang Y.","Lee K.A.","Yang V.","Aguiar M.","Kornhauser J.","Jia X.","Ren J.","Beausoleil S.A.","Silva J.C.","Vemulapalli V.","Bedford M.T.","Comb M.J."],"citationCrossReferences":[{"database":"PubMed","id":"24129315"},{"database":"DOI","id":"10.1074/mcp.o113.027870"}],"title":"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.","publicationDate":"2014","journal":"Mol. Cell. Proteomics","firstPage":"372","lastPage":"387","volume":"13"},"referencePositions":["METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1580","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK029889","properties":[{"key":"ProteinId","value":"BAC26660.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK032493","properties":[{"key":"ProteinId","value":"BAC27896.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC058681","properties":[{"key":"ProteinId","value":"AAH58681.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK122284","properties":[{"key":"ProteinId","value":"BAC65566.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS26026.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8C0T5-1"},{"database":"CCDS","id":"CCDS49105.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8C0T5-2"},{"database":"RefSeq","id":"NP_001161455.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001167983.1"}],"isoformId":"Q8C0T5-2"},{"database":"RefSeq","id":"NP_001394332.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407403.1"}],"isoformId":"Q8C0T5-1"},{"database":"RefSeq","id":"NP_001394333.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407404.1"}],"isoformId":"Q8C0T5-1"},{"database":"RefSeq","id":"NP_001394334.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407405.1"}],"isoformId":"Q8C0T5-1"},{"database":"RefSeq","id":"NP_001394335.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001407406.1"}],"isoformId":"Q8C0T5-1"},{"database":"RefSeq","id":"NP_766167.2","properties":[{"key":"NucleotideSequenceId","value":"NM_172579.4"}],"isoformId":"Q8C0T5-1"},{"database":"RefSeq","id":"XP_017170514.1","properties":[{"key":"NucleotideSequenceId","value":"XM_017315025.2"}],"isoformId":"Q8C0T5-1"},{"database":"AlphaFoldDB","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"229945","properties":[{"key":"Interactions","value":"21"}]},{"database":"FunCoup","id":"Q8C0T5","properties":[{"key":"Number of interactors","value":"746"}]},{"database":"IntAct","id":"Q8C0T5","properties":[{"key":"Interactions","value":"6"}]},{"database":"MINT","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000131030","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q8C0T5","properties":[{"key":"glycosylation","value":"20 sites, 3 N-linked glycans (4 sites), 1 O-linked glycan (13 sites)"}]},{"database":"iPTMnet","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000131030","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"261033","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8C0T5-1"},{"database":"ProteomicsDB","id":"261034","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8C0T5-2"},{"database":"Pumba","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"132","properties":[{"key":"antibodies","value":"52 antibodies from 25 providers"}]},{"database":"DNASU","id":"217692","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000053969.7","properties":[{"key":"ProteinId","value":"ENSMUSP00000061014.7"},{"key":"GeneId","value":"ENSMUSG00000042700.17"}],"isoformId":"Q8C0T5-1"},{"database":"Ensembl","id":"ENSMUST00000166429.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000131030.3"},{"key":"GeneId","value":"ENSMUSG00000042700.17"}],"isoformId":"Q8C0T5-1"},{"database":"Ensembl","id":"ENSMUST00000222298.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000152356.2"},{"key":"GeneId","value":"ENSMUSG00000042700.17"}],"isoformId":"Q8C0T5-2"},{"database":"Ensembl","id":"ENSMUST00000222714.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000152212.2"},{"key":"GeneId","value":"ENSMUSG00000042700.17"}],"isoformId":"Q8C0T5-1"},{"database":"GeneID","id":"217692","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:217692","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007ocu.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8C0T5-1"},{"database":"UCSC","id":"uc007ocw.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8C0T5-2"},{"database":"AGR","id":"MGI:2443679","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"26037","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2443679","properties":[{"key":"GeneName","value":"Sipa1l1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000042700","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3686","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000155944","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_002127_0_1_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"VWAIRAK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"2499658at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"217692","properties":[{"key":"hits","value":"3 hits in 77 CRISPR screens"}]},{"database":"CD-CODE","id":"CE726F99","properties":[{"key":"EntryName","value":"Postsynaptic density"}]},{"database":"PRO","id":"PR:Q8C0T5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 12"}]},{"database":"RNAct","id":"Q8C0T5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000042700","properties":[{"key":"ExpressionPatterns","value":"Expressed in olfactory tubercle and 235 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8C0T5","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0015629","properties":[{"key":"GoTerm","value":"C:actin cytoskeleton"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043197","properties":[{"key":"GoTerm","value":"C:dendritic spine"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043025","properties":[{"key":"GoTerm","value":"C:neuronal cell body"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0098794","properties":[{"key":"GoTerm","value":"C:postsynapse"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0014069","properties":[{"key":"GoTerm","value":"C:postsynaptic density"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0032991","properties":[{"key":"GoTerm","value":"C:protein-containing complex"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0051015","properties":[{"key":"GoTerm","value":"F:actin filament binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0046875","properties":[{"key":"GoTerm","value":"F:ephrin receptor binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"18094260"}]},{"database":"GO","id":"GO:0005096","properties":[{"key":"GoTerm","value":"F:GTPase activator activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0044877","properties":[{"key":"GoTerm","value":"F:protein-containing complex binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031625","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030036","properties":[{"key":"GoTerm","value":"P:actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0090630","properties":[{"key":"GoTerm","value":"P:activation of GTPase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0048013","properties":[{"key":"GoTerm","value":"P:ephrin receptor signaling pathway"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"17785183"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18094260"}]},{"database":"GO","id":"GO:0098974","properties":[{"key":"GoTerm","value":"P:postsynaptic actin cytoskeleton organization"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0050770","properties":[{"key":"GoTerm","value":"P:regulation of axonogenesis"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18094260"}]},{"database":"GO","id":"GO:0048814","properties":[{"key":"GoTerm","value":"P:regulation of dendrite morphogenesis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0061001","properties":[{"key":"GoTerm","value":"P:regulation of dendritic spine morphogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0043087","properties":[{"key":"GoTerm","value":"P:regulation of GTPase activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"18094260"}]},{"database":"GO","id":"GO:0099151","properties":[{"key":"GoTerm","value":"P:regulation of postsynaptic density assembly"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0051056","properties":[{"key":"GoTerm","value":"P:regulation of small GTPase mediated signal transduction"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0048167","properties":[{"key":"GoTerm","value":"P:regulation of synaptic plasticity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"CDD","id":"cd06745","properties":[{"key":"EntryName","value":"PDZ_SIPA1-like"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.11210:FF:000002","properties":[{"key":"EntryName","value":"Signal-induced proliferation-associated 1-like protein 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.42.10:FF:000027","properties":[{"key":"EntryName","value":"Signal-induced proliferation-associated 1-like protein 1 isoform 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.42.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"6.10.140.210","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.11210","properties":[{"key":"EntryName","value":"Rap/Ran-GAP"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR001478","properties":[{"key":"EntryName","value":"PDZ"}]},{"database":"InterPro","id":"IPR036034","properties":[{"key":"EntryName","value":"PDZ_sf"}]},{"database":"InterPro","id":"IPR035974","properties":[{"key":"EntryName","value":"Rap/Ran-GAP_sf"}]},{"database":"InterPro","id":"IPR000331","properties":[{"key":"EntryName","value":"Rap/Ran_GAP_dom"}]},{"database":"InterPro","id":"IPR050989","properties":[{"key":"EntryName","value":"Rap1_Ran_GAP"}]},{"database":"InterPro","id":"IPR021818","properties":[{"key":"EntryName","value":"SIPA1L_C"}]},{"database":"PANTHER","id":"PTHR15711","properties":[{"key":"EntryName","value":"RAP GTPASE-ACTIVATING PROTEIN"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15711:SF10","properties":[{"key":"EntryName","value":"SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00595","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF21022","properties":[{"key":"EntryName","value":"Rap-GAP_dimer"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02145","properties":[{"key":"EntryName","value":"Rap_GAP"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF11881","properties":[{"key":"EntryName","value":"SPAR_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00228","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50156","properties":[{"key":"EntryName","value":"PDZ domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF111347","properties":[{"key":"EntryName","value":"Rap/Ran-GAP"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50106","properties":[{"key":"EntryName","value":"PDZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50085","properties":[{"key":"EntryName","value":"RAPGAP"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MTSLKRSQTERPVTADRASVVSTDGAPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGDSFFDLLKGYKDDRSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVKRYTVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISSEFIVLIEQETKSVAFNCSCRDVIGWTSSDTSLKIFYERGECVSVESFISGEDIKEIVRRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYQMNEGISYEFKFPFRNNNKWQRNASKGAHSPQVPSQLQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDISGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGPSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKAESSLSLDIHSKSQGGSSPLSRENSTFSINDAASHTSTMSSRHSASPVVFSSARSSPKEELHPTASSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLQASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHALSSPQSPFPTTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDAASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSKDPSPTLASKVDQLEGMLKMLREDLKKEKEDKAQLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS","length":1782,"molWeight":197031,"crc64":"A5BBD8CD69A481FC","md5":"E18E92853E0E68978A0DC737A5E6F6CE"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"PTM":2},"countByFeatureType":{"Chain":1,"Domain":2,"Region":10,"Coiled coil":1,"Compositional bias":10,"Modified residue":42,"Alternative sequence":2,"Sequence conflict":2},"uniParcId":"UPI000024E72A"}}