{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8BVF4","secondaryAccessions":["Q14CD0","Q3TR07","Q9D9N6"],"uniProtkbId":"CCD30_MOUSE","entryAudit":{"firstPublicDate":"2008-05-20","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2003-03-01","entryVersion":130,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Coiled-coil domain-containing protein 30"}},"alternativeNames":[{"fullName":{"value":"Prefoldin subunit 6-like protein"}}]},"genes":[{"geneName":{"value":"Ccdc30"},"synonyms":[{"value":"Pfdn6l"}]}],"comments":[{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8BVF4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8BVF4-2"],"sequenceIds":["VSP_033800"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8BVF4-3"],"sequenceIds":["VSP_033798","VSP_033799","VSP_033801","VSP_033802"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the prefoldin subunit beta family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Coiled-coil domain-containing protein 30","featureId":"PRO_0000336046"},{"type":"Region","location":{"start":{"value":38,"modifier":"EXACT"},"end":{"value":65,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":614,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":244,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Coiled coil","location":{"start":{"value":276,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":53,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":625,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_033798","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":68,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_033799","alternativeSequence":{"originalSequence":"QDCLLRDVECIAQKLEASLEEIHRGAREPREEREQRTLGDALENARLEIEKLKDNLMKLKESGTTDLQRAREHNQRLDEEILALRNRVRSLDSEKKVLGEM","alternativeSequences":["MTSENACEDLVSKGPLLEVEAVSPSEDRQALCSELGESKQEETPDESVKAATFPRERQESQQMRGHEQPLAVEPKEVGRLEEEASLQSQSCGGSSDDSSTK"]}},{"type":"Alternative sequence","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_033800","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":351,"modifier":"EXACT"},"end":{"value":376,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_033801","alternativeSequence":{"originalSequence":"ILLDQDINELQTQVRALQDKEEQQEA","alternativeSequences":["GLGFAPQHCTNTAIFPGPPLFLSESC"]}},{"type":"Alternative sequence","location":{"start":{"value":377,"modifier":"EXACT"},"end":{"value":654,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_033802","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":66,"modifier":"EXACT"},"end":{"value":66,"modifier":"EXACT"}},"description":"in Ref. 3; AAI14437","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":412,"modifier":"EXACT"},"end":{"value":412,"modifier":"EXACT"}},"description":"in Ref. 3; AAI14437","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"N","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Cerebellum","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":4,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK006668","properties":[{"key":"ProteinId","value":"BAB24696.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK078362","properties":[{"key":"ProteinId","value":"BAC37237.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK163185","properties":[{"key":"ProteinId","value":"BAE37224.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BX470216","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC114436","properties":[{"key":"ProteinId","value":"AAI14437.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS38861.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8BVF4-1"},{"database":"CCDS","id":"CCDS89822.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8BVF4-2"},{"database":"RefSeq","id":"NP_001257364.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001270435.2"}],"isoformId":"Q8BVF4-2"},{"database":"RefSeq","id":"NP_083562.1","properties":[{"key":"NucleotideSequenceId","value":"NM_029286.3"}],"isoformId":"Q8BVF4-1"},{"database":"AlphaFoldDB","id":"Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q8BVF4","properties":[{"key":"Number of interactors","value":"28"}]},{"database":"STRING","id":"10090.ENSMUSP00000158825","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000158825","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"281305","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8BVF4-1"},{"database":"ProteomicsDB","id":"281306","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8BVF4-2"},{"database":"ProteomicsDB","id":"281307","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8BVF4-3"},{"database":"Antibodypedia","id":"52243","properties":[{"key":"antibodies","value":"62 antibodies from 10 providers"}]},{"database":"Ensembl","id":"ENSMUST00000044781.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000047534.3"},{"key":"GeneId","value":"ENSMUSG00000028637.17"}],"isoformId":"Q8BVF4-3"},{"database":"Ensembl","id":"ENSMUST00000238293.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000158680.2"},{"key":"GeneId","value":"ENSMUSG00000028637.17"}],"isoformId":"Q8BVF4-2"},{"database":"Ensembl","id":"ENSMUST00000238759.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000158825.2"},{"key":"GeneId","value":"ENSMUSG00000028637.17"}],"isoformId":"Q8BVF4-1"},{"database":"GeneID","id":"73332","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:73332","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008umc.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8BVF4-1"},{"database":"UCSC","id":"uc008umd.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8BVF4-2"},{"database":"UCSC","id":"uc008ume.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8BVF4-3"},{"database":"AGR","id":"MGI:1920582","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"728621","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1920582","properties":[{"key":"GeneName","value":"Ccdc30"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000028637","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QWNQ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007816","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_035106_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EREQHEC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"PhylomeDB","id":"Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"73332","properties":[{"key":"hits","value":"1 hit in 73 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8BVF4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"Q8BVF4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000028637","properties":[{"key":"ExpressionPatterns","value":"Expressed in spermatid and 176 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8BVF4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"InterPro","id":"IPR052825","properties":[{"key":"EntryName","value":"CCD-Prefoldin_beta-like"}]},{"database":"InterPro","id":"IPR031476","properties":[{"key":"EntryName","value":"DUF4686"}]},{"database":"PANTHER","id":"PTHR34479","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 30"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR34479:SF1","properties":[{"key":"EntryName","value":"COILED-COIL DOMAIN-CONTAINING PROTEIN 30"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15742","properties":[{"key":"EntryName","value":"DUF4686"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MCQEGLFRLALSSPRKQTACSLGERRTLAEALGLVDSTLESRRDPNSSLQKEFPQHQDEDQSRAAAPQDCLLRDVECIAQKLEASLEEIHRGAREPREEREQRTLGDALENARLEIEKLKDNLMKLKESGTTDLQRAREHNQRLDEEILALRNRVRSLDSEKKVLGEMYLTSGEKTSCQHQGELRELRQNLRRLQILCNSAEKELRYERGRSLDLKQHNSLLQEENIKIKIELKQAQEKLLDNARLHSSLTAEWKHCQQKVKELELEGLRQTQSLKSQQGLQEKLAREKSKAAEAQEKILDLQQKLDHGRQVCLSDVCILRKKQLEEEIKEAKSIEARLQQQCQEEQQRRILLDQDINELQTQVRALQDKEEQQEAVNSQQQEALRKQLERERRKCEEYVKSNQELSEKLSNLQQEKEALWQEHGRFLEQLGDHVRNYKDKHHCHKAKLQKVKDRLTHELEIRNKRIKELEDETGKLQQKIEMEKVFQGQIMAQNDILLLEKRKLLEQVTDQEELICSSKCTISAFQSKASLLDKENQQLQENCLRLMQQIGLLEQIIRSIQIRREEETVITDNAAFEILKKILPLQNSSFSGTGFVLSAENLQETELHKWEGAAAIPKSPEPLSRSQDSESGYINVTSLKETHNTQGDQKPEL","length":654,"molWeight":76048,"crc64":"06279678033AC5E9","md5":"C43F5E13EEDE89C092069E149F10ADCB"},"extraAttributes":{"countByCommentType":{"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Coiled coil":2,"Compositional bias":2,"Alternative sequence":5,"Sequence conflict":2},"uniParcId":"UPI00000EA907"}}