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Mediates early complex III biogenesis (PubMed:35977508). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (PubMed:35977508). Also required for cytochrome c oxidase complex (complex IV) assembly (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69YU5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32161263"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35977508"}],"value":"Interacts with UQCRC1 (PubMed:32161263). Interacts with UQCRQ (PubMed:32161263). Interacts with UQCC5 (By similarity). Forms a complex, named COMB/coordinator of mitochondrial CYTB biogenesis, composed of UQCC1, UQCC2, UQCC4, UQCC5 and UQCC6; stabilizes nascent cytochrome b/MT-CYB and promotes its membrane insertion (PubMed:35977508). Forms a complex, named COMA, composed of UQCC1, UQCC2 and UQCC4; activates MT-CYB translation (PubMed:35977508). Forms a complex, named COMC, composed of UQCC1, UQCC2; UQCC3 and UQCC4; mediates MT-CYB hemylation and association with the first nuclear-encoded complex III subunit UQCRQ (PubMed:35977508). Interacts with MT-CYB (PubMed:35977508)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32161263"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69YU5"}],"value":"Single-pass type II membrane protein","id":"SL-9906"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32161263"}],"value":"Highly expressed in brown adipose, cardiac and skeletal muscle (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35977508"}],"value":"Uqcc6 deficiency leads to complete loss of mitochondrial respiratory chain complex III, resulting in growth retardation and a mild increase in blood lactate levels and significantly decreased exercise tolerance. The subunits of mitochondrial respiratory chain complex I, II, IV, and V are not affected"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the UQCC6 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":67,"modifier":"EXACT"}},"description":"Ubiquinol-cytochrome c reductase complex assembly factor 6","featureId":"PRO_0000340274"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":8,"modifier":"EXACT"}},"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q69YU5"}]},{"type":"Transmembrane","location":{"start":{"value":9,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological 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