{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8BR90","secondaryAccessions":["Q91YM1"],"uniProtkbId":"RIMC1_MOUSE","entryAudit":{"firstPublicDate":"2008-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":116,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2146232"}],"value":"RAB7A-interacting MON1-CCZ1 complex subunit 1"}},"alternativeNames":[{"fullName":{"value":"UPF0600 protein C5orf51 homolog"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2146232"}],"value":"Rimoc1"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2146232"}],"value":"AW549877"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6NDU8"}],"value":"Plays an important role in the removal of damaged mitochondria via mitophagy by controlling the stability and localization of RAB7A (By similarity). Required for the recruitment of RAB7A and ATG9A vesicles to damaged mitochondria and promotes the stability of RAB7A by inhibiting its proteasomal degradation during mitophagy (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6NDU8"}],"value":"Interacts with the MON1A-CCZ1B complex. Interacts with GDP-bound RAB7A and promotes its interaction with the MON1A-CCZ1B complex"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6NDU8"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8BR90-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8BR90-2"],"sequenceIds":["VSP_034224","VSP_034225"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the RIMOC1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6NDU8"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":294,"modifier":"EXACT"}},"description":"RAB7A-interacting MON1-CCZ1 complex subunit 1","featureId":"PRO_0000341215"},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A6NDU8"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":68,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034224","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":69,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_034225","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["M"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0072","category":"Biological process","name":"Autophagy"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Corpora quadrigemina","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Mammary tumor","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK045350","properties":[{"key":"ProteinId","value":"BAC32323.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK154940","properties":[{"key":"ProteinId","value":"BAE32940.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC016504","properties":[{"key":"ProteinId","value":"AAH16504.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS27360.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q8BR90-1"},{"database":"RefSeq","id":"NP_666042.2","properties":[{"key":"NucleotideSequenceId","value":"NM_145930.3"}],"isoformId":"Q8BR90-1"},{"database":"AlphaFoldDB","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"222985","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q8BR90","properties":[{"key":"Number of interactors","value":"3786"}]},{"database":"STRING","id":"10090.ENSMUSP00000038476","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000038476","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"23213","properties":[{"key":"antibodies","value":"63 antibodies from 13 providers"}]},{"database":"DNASU","id":"106064","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000046633.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000038476.9"},{"key":"GeneId","value":"ENSMUSG00000041935.11"}],"isoformId":"Q8BR90-1"},{"database":"GeneID","id":"106064","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:106064","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007vcg.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8BR90-2"},{"database":"UCSC","id":"uc007vch.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q8BR90-1"},{"database":"AGR","id":"MGI:2146232","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"285636","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2146232","properties":[{"key":"GeneName","value":"Rimoc1"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000041935","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QW9A","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000011383","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_082742_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"NEGKEHP","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6135810at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"106064","properties":[{"key":"hits","value":"2 hits in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8BR90","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 15"}]},{"database":"RNAct","id":"Q8BR90","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000041935","properties":[{"key":"ExpressionPatterns","value":"Expressed in parotid gland and 259 other cell types or tissues"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000423","properties":[{"key":"GoTerm","value":"P:mitophagy"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR037657","properties":[{"key":"EntryName","value":"RIMC1"}]},{"database":"PANTHER","id":"PTHR28494:SF1","properties":[{"key":"EntryName","value":"RAB7A-INTERACTING MON1-CCZ1 COMPLEX SUBUNIT 1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR28494","properties":[{"key":"EntryName","value":"UPF0600 PROTEIN C5ORF51"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17716","properties":[{"key":"EntryName","value":"RIMC1"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MAAAVSGVVRRVEELGDLAQAHIQHLSEAAGEDDHFLIRASAALEKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDCSPQKVKELLAFLSEPEILAKESNMHPKLCGLLGAELLECLSWRRGALLYMYCHSLTKRREWLLRKSNLLQKYLVDGINYLLQMLNYRCPVQLNEGVSFQDLDTAKLLSTGVFSDIHVLAMMYSGEMCYWGLKHCTDQQSENHEVDTDVFGASCTTHKETLDFREVGEKILKKYVSVCEGPLKEQEWNTANAKQILSFFQQRCS","length":294,"molWeight":33471,"crc64":"C5E91D1163CB71C7","md5":"6353244C0860D16FBDE07FF700EF1BF2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"SIMILARITY":1},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Modified residue":1,"Alternative sequence":2},"uniParcId":"UPI00000EAE54"}}