{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8BP22","secondaryAccessions":["A2AVA5","A2AVA6","A2AVA7","Q7TNQ9","Q8C2F8","Q8VDU6","Q9D2J3"],"uniProtkbId":"CBAR1_MOUSE","entryAudit":{"firstPublicDate":"2007-05-15","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2022-02-23","entryVersion":130,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1915349"}],"value":"CBY1-interacting BAR domain-containing protein 1"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1915349"}],"value":"Cibar1"},"synonyms":[{"value":"Fam92a"},{"value":"Fam92a1"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29459677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30395363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38197861"}],"value":"Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (By similarity). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (PubMed:29459677). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (PubMed:38197861). This positioning is essential for proper sperm motility and function (PubMed:38197861). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (PubMed:38197861). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (PubMed:38197861). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (PubMed:38197861)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38197861"}],"value":"Homodimer (via BAR-like domain). Heterodimer with FAM92B (via BAR-like domains). Interacts (via BAR-like domain) with CBY1; this interaction is required for targeting FAM92A to centriole and cilium basal body (By similarity). Interacts (via BAR-like domain) with CBY3; both proteins form a ninefold symmetric structure at the flagellar base; are recruited to the annulus in a mutually dependent manner and regulate annulus positioning (PubMed:38197861)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q8BP22","intActId":"EBI-646638"},"interactantTwo":{"uniProtKBAccession":"Q60680-1","geneName":"Chuk","intActId":"EBI-646260"},"numberOfExperiments":4,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27528616"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29459677"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38197861"}],"value":"Weak punctate vesicular distribution throughout the cytoplasm. Localizes at the distal end of mother centrioles. Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:29459677). Localizes to the annulus at the junction between the midpiece (MP) and principal piece (PP) of the sperm flagellum (PubMed:38197861)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"}],"value":"Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole","id":"SL-0046"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27528616"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29459677"}],"value":"Cell projection, cilium","id":"SL-0066"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"30404948"}],"value":"Mitochondrion inner membrane","id":"SL-0168"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"}],"value":"Peripheral membrane protein","id":"SL-9903"},"orientation":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"}],"value":"Matrix side","id":"SL-9913"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38197861"}],"value":"Cell projection, cilium, flagellum","id":"SL-0117"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30395363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30404948"}],"value":"Expressed in the heart, liver, spleen, lung, kidney, brain and muscle (at protein level) (PubMed:30404948). Strongly expressed throughout the developing limb bud, including the progress zone and the apical ectodermal ridge (PubMed:30395363)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30395363"}],"value":"High and steady expression is observed in the developing limb throughout embryonic stages 11.5-15.5 dpc"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A1XBS5"}],"value":"The BAR-like domain displays limited similarity to other BAR domains"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30395363"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38197861"}],"value":"Knockout homozygous mice show uni- or bilateral abnormal bone growth or exostosis on the deltoid tuberosity of the humerus, abnormalities at the left stifle consistent with a tendon calcification, and abnormal digit morphology including polysyndactyly and osteomas on the hind paw metatarsals (PubMed:30395363). Exhibit male fertility defects, caused by kinked sperm flagella with the annulus mispositioned in the principal piece of the sperm (PubMed:38197861)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the CIBAR family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC37273.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC40516.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Transit 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