{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8BLI4","secondaryAccessions":["Q3U620"],"uniProtkbId":"DSE_MOUSE","entryAudit":{"firstPublicDate":"2006-02-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-03-01","entryVersion":143,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Dermatan-sulfate epimerase"},"shortNames":[{"value":"DS epimerase"}],"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"5.1.3.19"}]},"alternativeNames":[{"fullName":{"value":"Chondroitin-glucuronate 5-epimerase"}},{"fullName":{"value":"Squamous cell carcinoma antigen recognized by T-cells 2"},"shortNames":[{"value":"SART-2"}]}],"flag":"Precursor"},"genes":[{"geneName":{"value":"Dse"},"synonyms":[{"value":"Sart2"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"chondroitin 4'-sulfate = dermatan 4'-sulfate","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:21084"},{"database":"Rhea","id":"RHEA-COMP:9829"},{"database":"Rhea","id":"RHEA-COMP:9965"},{"database":"ChEBI","id":"CHEBI:58422"},{"database":"ChEBI","id":"CHEBI:58465"}],"ecNumber":"5.1.3.19","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Also has weak activity in the presence of Mg(2+) or Ca(2+) ions."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Glycan metabolism; chondroitin sulfate biosynthesis"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Glycan metabolism; heparan sulfate biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Golgi apparatus membrane","id":"SL-0134"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Cytoplasmic vesicle membrane","id":"SL-0089"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Microsome membrane","id":"SL-0165"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"value":"N-glycosylated. Glycosylation is important for enzymatic activity"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the dermatan-sulfate isomerase family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAE31905.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":958,"modifier":"EXACT"}},"description":"Dermatan-sulfate epimerase","featureId":"PRO_0000223312"},{"type":"Topological domain","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":902,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":903,"modifier":"EXACT"},"end":{"value":923,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":924,"modifier":"EXACT"},"end":{"value":933,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":934,"modifier":"EXACT"},"end":{"value":954,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":955,"modifier":"EXACT"},"end":{"value":958,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Active site","location":{"start":{"value":205,"modifier":"EXACT"},"end":{"value":205,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}]},{"type":"Active site","location":{"start":{"value":261,"modifier":"EXACT"},"end":{"value":261,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}]},{"type":"Active site","location":{"start":{"value":473,"modifier":"EXACT"},"end":{"value":473,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}]},{"type":"Binding site","location":{"start":{"value":452,"modifier":"EXACT"},"end":{"value":452,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29035"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"ligand":{"name":"Mn(2+)","id":"ChEBI:CHEBI:29035"}},{"type":"Binding site","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29035"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"ligand":{"name":"Mn(2+)","id":"ChEBI:CHEBI:29035"}},{"type":"Binding site","location":{"start":{"value":481,"modifier":"EXACT"},"end":{"value":481,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29035"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}],"ligand":{"name":"Mn(2+)","id":"ChEBI:CHEBI:29035"}},{"type":"Site","location":{"start":{"value":450,"modifier":"EXACT"},"end":{"value":450,"modifier":"EXACT"}},"description":"Critical for catalysis","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9UL01"}]},{"type":"Glycosylation","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":183,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":336,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":411,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":642,"modifier":"EXACT"},"end":{"value":642,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":648,"modifier":"EXACT"},"end":{"value":648,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":420,"modifier":"EXACT"},"end":{"value":420,"modifier":"EXACT"}},"description":"in Ref. 1; BAE31905","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":732,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"in Ref. 1; BAE31905","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"V","alternativeSequences":["I"]}}],"keywords":[{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0333","category":"Cellular component","name":"Golgi apparatus"},{"id":"KW-0413","category":"Molecular function","name":"Isomerase"},{"id":"KW-0464","category":"Ligand","name":"Manganese"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0492","category":"Cellular component","name":"Microsome"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Bone marrow","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK045065","properties":[{"key":"ProteinId","value":"BAC32205.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK153326","properties":[{"key":"ProteinId","value":"BAE31905.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC053095","properties":[{"key":"ProteinId","value":"AAH53095.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS23776.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_766096.1","properties":[{"key":"NucleotideSequenceId","value":"NM_172508.3"}]},{"database":"RefSeq","id":"XP_006512714.1","properties":[{"key":"NucleotideSequenceId","value":"XM_006512651.5"}]},{"database":"RefSeq","id":"XP_011241458.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011243156.4"}]},{"database":"RefSeq","id":"XP_036011615.1","properties":[{"key":"NucleotideSequenceId","value":"XM_036155722.1"}]},{"database":"AlphaFoldDB","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"229367","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q8BLI4","properties":[{"key":"Number of interactors","value":"898"}]},{"database":"STRING","id":"10090.ENSMUSP00000040074","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q8BLI4","properties":[{"key":"glycosylation","value":"5 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q8BLI4","properties":[{"key":"glycosylation","value":"5 sites"}]},{"database":"iPTMnet","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000040074","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"277411","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"212898","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000048010.9","properties":[{"key":"ProteinId","value":"ENSMUSP00000040074.8"},{"key":"GeneId","value":"ENSMUSG00000039497.9"}]},{"database":"GeneID","id":"212898","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:212898","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007eus.1","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2443455","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"29940","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2443455","properties":[{"key":"GeneName","value":"Dse"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000039497","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QPWZ","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000006522","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_308813_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FFIHAVC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"5946629at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"5.1.3.19","properties":[{"key":"OrganismId","value":"3474"}]},{"database":"Reactome","id":"R-MMU-2022923","properties":[{"key":"PathwayName","value":"DS-GAG biosynthesis"}]},{"database":"UniPathway","id":"UPA00755","properties":[{"key":"RectionId","value":"-"}]},{"database":"UniPathway","id":"UPA00756","properties":[{"key":"RectionId","value":"-"}]},{"database":"BioGRID-ORCS","id":"212898","properties":[{"key":"hits","value":"4 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q8BLI4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 10"}]},{"database":"RNAct","id":"Q8BLI4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000039497","properties":[{"key":"ExpressionPatterns","value":"Expressed in manus and 209 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q8BLI4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0030659","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005794","properties":[{"key":"GoTerm","value":"C:Golgi apparatus"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000139","properties":[{"key":"GoTerm","value":"C:Golgi membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0047757","properties":[{"key":"GoTerm","value":"F:chondroitin-glucuronate 5-epimerase activity"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050654","properties":[{"key":"GoTerm","value":"P:chondroitin sulfate proteoglycan metabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0050651","properties":[{"key":"GoTerm","value":"P:dermatan sulfate proteoglycan biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0050655","properties":[{"key":"GoTerm","value":"P:dermatan sulfate proteoglycan metabolic process"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0015012","properties":[{"key":"GoTerm","value":"P:heparan sulfate proteoglycan biosynthetic process"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniPathway"}]},{"database":"FunFam","id":"1.50.10.100:FF:000001","properties":[{"key":"EntryName","value":"dermatan-sulfate epimerase isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.70.98.70:FF:000001","properties":[{"key":"EntryName","value":"dermatan-sulfate epimerase isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.70.98.70","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.50.10.100","properties":[{"key":"EntryName","value":"Chondroitin AC/alginate lyase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR008929","properties":[{"key":"EntryName","value":"Chondroitin_lyas"}]},{"database":"InterPro","id":"IPR052447","properties":[{"key":"EntryName","value":"Dermatan-Sulfate_Isomerase"}]},{"database":"InterPro","id":"IPR032518","properties":[{"key":"EntryName","value":"DSE-like_N"}]},{"database":"PANTHER","id":"PTHR15532","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR15532:SF3","properties":[{"key":"EntryName","value":"DERMATAN-SULFATE EPIMERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF16332","properties":[{"key":"EntryName","value":"DSE-like_N"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48230","properties":[{"key":"EntryName","value":"Chondroitin AC/alginate lyase"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MRTHTRGAPSVFFICLLCCVSAFITDENPEVMIPFTNANYDSHPMLYFSRKDVAELQLRAASSHEHIAARLTEAVHTMLTNPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENTEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQETFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLILMNQGYLQEAYLWTKQVLSIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKPVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTYFNNVLMFSPAVSKSCFSPWEGQVTEDCSSKWSKYKHDLAASCQGRVIAADEKDGVVFIRGEGVGAYNPMLNLKHIQRNLILLHPQLLLLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKANFASVMYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSVDVQSFSIHGDPQRLDVFIATSEHAYATYLWTGENTGHSAFAQVIADHQKILFDQSSAIKSTAVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVQNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQRQQRGKSKKSRKAGKHYKFVDAVPDIFAQIEVNEKKIRQKAQVLAQREQPIDEDEEMKDLLDFADVTYEKHKNEGSVKGGFGQVRMVTSHNRAPSLSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCVLLWLYSSCSQSQC","length":958,"molWeight":109755,"crc64":"6C7D18A2F2BBBBE8","md5":"BE875D201DFED039219DD06E14FE3574"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"PATHWAY":2,"SUBCELLULAR LOCATION":1,"PTM":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":3,"Transmembrane":2,"Active site":3,"Binding site":3,"Site":1,"Glycosylation":5,"Sequence conflict":2},"uniParcId":"UPI00000269ED"}}