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As part of the Shu complex, promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:34253720). The Shu complex is essential during meiosis by stabilizing DMC1 filaments (PubMed:34253720, PubMed:36938872). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q14159"}],"value":"Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR (By similarity). Interacts (via C-terminal region) with BLM; the interaction is direct (By similarity). Interacts with RAD51; the interaction is direct (By similarity). Interacts (via the C-terminal region) with FIGNL1 (via N-terminal one-half region); the interaction is direct (By similarity). Component of the Shu complex, composed of the SWSAP1-ZSWIM7/SWS1 heterodimer and SPIDR (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q14159"}],"value":"Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q14159"}],"value":"Chromosome","id":"SL-0468"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q14159"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q8BGX7-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q8BGX7-2"],"sequenceIds":["VSP_020769"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q8BGX7-3"],"sequenceIds":["VSP_020767","VSP_020768"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34253720"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36938872"}],"value":"Mice are viable but display sterility in both males and females due to defects in meiotic homologous recombination (PubMed:34253720, PubMed:36938872). 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SPIDR"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14950","properties":[{"key":"EntryName","value":"DUF4502"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF14951","properties":[{"key":"EntryName","value":"DUF4503"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSGARRPGTSKRKRNWHIEHPSFREERSQQLRRGNFKTVEAADSLSKAWLKCGEGFQDTSEILSLASEKTGITEKHLELSPKPKTETTSKNASELPNIIWSSSESDFSDEDKTLPALQRDGRHGPRADRLGDRTISCPEDEDIEDELQVIDWEVNSDKEDPGGPSECEDDKGTLDISDCDSCASLTSDDRLCEPSEPISTEILEYSSDSEKEEDPEHSLFIDSESPHKYQADFKSDARWCLVSQTDSEANSAEPTLTPQKYTVKFPKTPEYSVTKKKLLRGGLAERLQELQNRKRSAISLWRHRCVSYQMTPLGRKSGVLTVKILELHEECSMQVAVCEQLAGPPITSPPGGLAPRPGAYLKVLFTRETADHLMGHPQDIIYIFPPWQKLLIPNGSCSIILNTYFCQKAIAKETVREDLYSPDISLSRRNITLAQTFRIKDITDNSSINQTTYDSLATPGTGWTHGHEKAEQHLIVAAPLRNSLLDIVESQRAGLWSGVRVQVVVQRVYSLLSRDGARSQQGHTVGHADASGAWSCLLVQDACGMFGEVFLNSTLWKSRQLEGKSCSMSGVKVLQKATRGRTPGLFSLIDSLWPPVISLTEPSCGQPSGETKTYLPPPIFCYIFSAHPTLGQIDAIEDHISKLYQPPVVRCLKEILQTNECSTRCSFYARVIYQKPQLKNLLAQKEIWLLVTDITLQTQDERDHSLPKTLPVYIAPSCVLGPEVVEELALLVSYNLLFRDAFKDNGQIVCIERTVILPQKPLLCVPSASCDLPSPVTLDELSALTPVNSICSVQGTVVDVDESTAFSWPVCDRCGNGRLEQKPEDGGTFSCGDCSQLVLSPLQERHLHVFLDCPTRPESTVKVKLLESSISLLLMSAASEDGSYEVESVLGKEMGPLLCFVQSITTQQSSCVVTLEEIELLSTEGATAAQPPP","length":933,"molWeight":103297,"crc64":"64EC6762D3332474","md5":"E0889DF5FD11C9653204979312681E8C"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Chain":1,"Region":4,"Compositional bias":5,"Alternative sequence":3,"Sequence conflict":3},"uniParcId":"UPI00000EB9A0"}}