{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q8A1F9","uniProtkbId":"SUSR_BACTN","entryAudit":{"firstPublicDate":"2026-06-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-06-01","entryVersion":101,"sequenceVersion":1},"annotationScore":3.0,"organism":{"scientificName":"Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)","taxonId":226186,"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000001414"}],"lineage":["Bacteria","Pseudomonadati","Bacteroidota","Bacteroidia","Bacteroidales","Bacteroidaceae","Bacteroides"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8955400"}],"value":"Starch utilization system regulator SusR"}},"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8955400"}],"value":"susR"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"AAO78810.1"}],"value":"BT_3705"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"11717279"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8955400"}],"value":"Transcriptional activator which regulates the maltose-dependent expression of starch utilization system (sus) genes (PubMed:8955400). Activates transcription from two promoters: one controlling susA, which codes for an neopullulanase, and another controlling susB and susC, which code for an alpha-glucosidase and an outer membrane receptor, respectively (PubMed:8955400). Works in conjunction with MalR to provide coordinate regulation of the starch utilization system (PubMed:11717279)"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Cell inner membrane","id":"SL-0037"},"topology":{"evidences":[{"evidenceCode":"ECO:0000255"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8955400"}],"value":"Constitutively expressed; expression is not affected by growth on glucose, maltose or chondroitin sulfate and is not autoregulated"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"8955400"}],"value":"The cellular level of SusR is a limiting factor for starch utilization; increasing the number of copies of the susR gene increases the rate of growth on starch (PubMed:8955400). susA expression is more sensitive to susR gene dosage than susBC operon expression, indicating differential regulation of the two transcriptional units (PubMed:8955400)"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the SusR transcriptional regulator family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":25,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"Starch utilization system regulator SusR","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":"PRO_0000463748"},{"type":"Topological domain","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":380,"modifier":"EXACT"}},"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"Transmembrane","location":{"start":{"value":381,"modifier":"EXACT"},"end":{"value":401,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":402,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]},{"type":"DNA binding","location":{"start":{"value":543,"modifier":"EXACT"},"end":{"value":562,"modifier":"EXACT"}},"description":"H-T-H motif","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"8955400"}]}],"keywords":[{"id":"KW-0010","category":"Molecular function","name":"Activator"},{"id":"KW-0997","category":"Cellular component","name":"Cell inner membrane"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-0238","category":"Molecular function","name":"DNA-binding"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0804","category":"Biological process","name":"Transcription"},{"id":"KW-0805","category":"Biological process","name":"Transcription regulation"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"12663928","citationType":"journal article","authors":["Xu J.","Bjursell M.K.","Himrod J.","Deng S.","Carmichael L.K.","Chiang H.C.","Hooper L.V.","Gordon J.I."],"citationCrossReferences":[{"database":"PubMed","id":"12663928"},{"database":"DOI","id":"10.1126/science.1080029"}],"title":"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.","publicationDate":"2003","journal":"Science","firstPage":"2074","lastPage":"2076","volume":"299"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000001414"}],"value":"ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50","type":"STRAIN"}],"evidences":[{"evidenceCode":"ECO:0000312","source":"Proteomes","id":"UP000001414"}]},{"referenceNumber":2,"citation":{"id":"8955400","citationType":"journal article","authors":["D'Elia J.N.","Salyers A.A."],"citationCrossReferences":[{"database":"PubMed","id":"8955400"},{"database":"DOI","id":"10.1128/jb.178.24.7180-7186.1996"}],"title":"Effect of regulatory protein levels on utilization of starch by Bacteroides thetaiotaomicron.","publicationDate":"1996","journal":"J. 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