ID   Q88FV8_PSEPK            Unreviewed;       400 AA.
AC   Q88FV8;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   28-JAN-2026, entry version 135.
DE   SubName: Full=Oxidoreductase, Zn-dependent and NAD(P)-binding {ECO:0000313|EMBL:AAN69564.1};
GN   Name=ybdR {ECO:0000313|EMBL:AAN69564.1};
GN   OrderedLocusNames=PP_3970 {ECO:0000313|EMBL:AAN69564.1};
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC   Pseudomonadales; Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488 {ECO:0000313|EMBL:AAN69564.1, ECO:0000313|Proteomes:UP000000556};
RN   [1] {ECO:0000313|EMBL:AAN69564.1, ECO:0000313|Proteomes:UP000000556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440
RC   {ECO:0000313|Proteomes:UP000000556};
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L., Beanan M., DeBoy R.T., Daugherty S., Kolonay J., Madupu R.,
RA   Nelson W., White O., Peterson J., Khouri H., Hance I., Chris Lee P.,
RA   Holtzapple E., Scanlan D., Tran K., Moazzez A., Utterback T., Rizzo M.,
RA   Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D.,
RA   Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N.,
RA   Dusterhoft A., Tummler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
RN   [2] {ECO:0000313|EMBL:AAN69564.1, ECO:0000313|Proteomes:UP000000556}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440
RC   {ECO:0000313|Proteomes:UP000000556};
RX   PubMed=26913973; DOI=10.1111/1462-2920.13230;
RA   Belda E., van Heck R.G., Lopez-Sanchez M.J., Cruveiller S., Barbe V.,
RA   Fraser C., Klenk H.P., Petersen J., Morgat A., Nikel P.I., Vallenet D.,
RA   Rouy Z., Sekowska A., Martins Dos Santos V.A., de Lorenzo V., Danchin A.,
RA   Medigue C.;
RT   "The revisited genome of Pseudomonas putida KT2440 enlightens its value as
RT   a robust metabolic chassis.";
RL   Environ. Microbiol. 18:3403-3424(2016).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; AE015451; AAN69564.1; -; Genomic_DNA.
DR   RefSeq; WP_010954785.1; NC_002947.4.
DR   AlphaFoldDB; Q88FV8; -.
DR   STRING; 160488.PP_3970; -.
DR   PaxDb; 160488-PP_3970; -.
DR   KEGG; ppu:PP_3970; -.
DR   PATRIC; fig|160488.4.peg.4228; -.
DR   eggNOG; COG1063; Bacteria.
DR   HOGENOM; CLU_026673_11_3_6; -.
DR   OrthoDB; 9773078at2; -.
DR   PhylomeDB; Q88FV8; -.
DR   BioCyc; PPUT160488:G1G01-4235-MONOMER; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProtKB-ARBA.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR020843; ER.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000556};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          8..386
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   400 AA;  42747 MW;  716BB15D58C62DB9 CRC64;
     MRAVSYHGAN DVRVDSVPDP ILQDADDIIL RVTATAICGS DLHLYRGKIP ETEQGDIFGH
     EFMGIVEEVG RDVTTLQVGD RVVIPFVIAC GSCFFCQQDL FAACETTNTG RGSIINKKGI
     PPGAALFGYS HLYGGIPGGQ ADYVRVPKGN VGPFKVPTTL ADDKVLFLSD ILPTAWQAVI
     NAEIGEGSSV AIYGAGPVGL LSAACARMLG AHTVFMVDDN DYRLAYAQEA YGVIPINFEK
     DDDPADSIIR QTPGMRGVDA VIDAVGFEAK GSTTETVMTA LKLEGSSGKA LRQSIAAVRR
     GGVVSVPGVY AGFIHGFMFG DAFDKGLTFK MGQTHVQKYL PELLEHIEAG RLQPELIVTH
     RLALEEAAMG YKMFDQKQDN CRKVILVPGA APGTLGPDHL
//