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To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms (PubMed:36293380). Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination (PubMed:36607699)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).","ecNumber":"3.4.19.12","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16214042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34445214"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35913642"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"36607699"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16214042"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"35913642"}],"value":"Interacts with TRAF2 and RELA. 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