{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q86TN4","secondaryAccessions":["A8MU17","A8MYC9","F5H2B2","Q9BSB9"],"uniProtkbId":"TRPT1_HUMAN","entryAudit":{"firstPublicDate":"2007-01-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-01-23","entryVersion":157,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"tRNA 2'-phosphotransferase 1"},"ecNumbers":[{"value":"2.7.1.160"}]}},"genes":[{"geneName":{"value":"TRPT1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"14504659"}],"value":"Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23324"},{"database":"Rhea","id":"RHEA-COMP:11106"},{"database":"Rhea","id":"RHEA-COMP:11107"},{"database":"ChEBI","id":"CHEBI:17154"},{"database":"ChEBI","id":"CHEBI:57540"},{"database":"ChEBI","id":"CHEBI:76596"},{"database":"ChEBI","id":"CHEBI:82883"},{"database":"ChEBI","id":"CHEBI:85027"}],"ecNumber":"2.7.1.160"}},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q86TN4-2","intActId":"EBI-12403619"},"interactantTwo":{"uniProtKBAccession":"Q9H8Y8","geneName":"GORASP2","intActId":"EBI-739467"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q86TN4-2","intActId":"EBI-12403619"},"interactantTwo":{"uniProtKBAccession":"Q12933","geneName":"TRAF2","intActId":"EBI-355744"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q86TN4-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q86TN4-2"],"sequenceIds":["VSP_022524"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q86TN4-3"],"sequenceIds":["VSP_045273"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q86TN4-4"],"sequenceIds":["VSP_045827"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14504659"}],"value":"Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the KptA/TPT1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"tRNA 2'-phosphotransferase 1","featureId":"PRO_0000273363"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":29,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":243,"modifier":"EXACT"},"end":{"value":253,"modifier":"EXACT"}},"description":"Basic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"N-acetylmethionine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"22814378"}]},{"type":"Modified residue","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":240,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"19690332"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":49,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_022524","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":109,"modifier":"EXACT"},"end":{"value":109,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000305"}],"featureId":"VSP_045827","alternativeSequence":{"originalSequence":"Q","alternativeSequences":["QVG"]}},{"type":"Alternative sequence","location":{"start":{"value":187,"modifier":"EXACT"},"end":{"value":224,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_045273","alternativeSequence":{"originalSequence":"DGIPFFRSANGVILTPGNTDGFLLPKYFKEALQLRPTR","alternativeSequences":["G"]}},{"type":"Natural variant","location":{"start":{"value":3,"modifier":"EXACT"},"end":{"value":3,"modifier":"EXACT"}},"description":"in dbSNP:rs12788168","featureCrossReferences":[{"database":"dbSNP","id":"rs12788168"}],"featureId":"VAR_030134","alternativeSequence":{"originalSequence":"F","alternativeSequences":["L"]}},{"type":"Natural variant","location":{"start":{"value":172,"modifier":"EXACT"},"end":{"value":172,"modifier":"EXACT"}},"description":"in dbSNP:rs1059440","featureCrossReferences":[{"database":"dbSNP","id":"rs1059440"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14504659"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15489334"}],"featureId":"VAR_030135","alternativeSequence":{"originalSequence":"H","alternativeSequences":["R"]}},{"type":"Natural variant","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":221,"modifier":"EXACT"}},"description":"in dbSNP:rs11549690","featureCrossReferences":[{"database":"dbSNP","id":"rs11549690"}],"featureId":"VAR_030136","alternativeSequence":{"originalSequence":"R","alternativeSequences":["C"]}},{"type":"Helix","location":{"start":{"value":26,"modifier":"EXACT"},"end":{"value":40,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Turn","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":47,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Helix","location":{"start":{"value":58,"modifier":"EXACT"},"end":{"value":62,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Turn","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":69,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Helix","location":{"start":{"value":72,"modifier":"EXACT"},"end":{"value":81,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":93,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Turn","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":104,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Helix","location":{"start":{"value":121,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Turn","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Helix","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":174,"modifier":"EXACT"},"end":{"value":179,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Helix","location":{"start":{"value":181,"modifier":"EXACT"},"end":{"value":186,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":192,"modifier":"EXACT"},"end":{"value":194,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":199,"modifier":"EXACT"},"end":{"value":201,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":204,"modifier":"EXACT"},"end":{"value":209,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Helix","location":{"start":{"value":211,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":219,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]},{"type":"Beta strand","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":223,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0007829","source":"PDB","id":"7YW3"}]}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0520","category":"Ligand","name":"NAD"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0819","category":"Biological process","name":"tRNA processing"}],"references":[{"referenceNumber":1,"citation":{"id":"14504659","citationType":"journal article","authors":["Hu Q.-D.","Lu H.","Huo K.","Ying K.","Li J.","Xie Y.","Mao Y.","Li Y.-Y."],"citationCrossReferences":[{"database":"PubMed","id":"14504659"},{"database":"DOI","id":"10.1007/s00018-003-3107-7"}],"title":"A human homolog of the yeast gene encoding tRNA 2'-phosphotransferase: cloning, characterization and complementation analysis.","publicationDate":"2003","journal":"Cell. Mol. Life Sci.","firstPage":"1725","lastPage":"1732","volume":"60"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","FUNCTION","TISSUE SPECIFICITY","VARIANT ARG-172"],"referenceComments":[{"value":"Fetal brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.-W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.-S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"CI-5GBDQ6B103N1E","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)","VARIANT ARG-172"],"referenceComments":[{"value":"Epidermal carcinoma","type":"TISSUE"},{"value":"Ovary","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"19413330","citationType":"journal article","authors":["Gauci S.","Helbig A.O.","Slijper M.","Krijgsveld J.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"19413330"},{"database":"DOI","id":"10.1021/ac9004309"}],"title":"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.","publicationDate":"2009","journal":"Anal. Chem.","firstPage":"4493","lastPage":"4501","volume":"81"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":7,"citation":{"id":"19690332","citationType":"journal article","authors":["Mayya V.","Lundgren D.H.","Hwang S.-I.","Rezaul K.","Wu L.","Eng J.K.","Rodionov V.","Han D.K."],"citationCrossReferences":[{"database":"PubMed","id":"19690332"},{"database":"DOI","id":"10.1126/scisignal.2000007"}],"title":"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.","publicationDate":"2009","journal":"Sci. Signal.","firstPage":"RA46","lastPage":"RA46","volume":"2"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Leukemic T-cell","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"22814378","citationType":"journal article","authors":["Van Damme P.","Lasa M.","Polevoda B.","Gazquez C.","Elosegui-Artola A.","Kim D.S.","De Juan-Pardo E.","Demeyer K.","Hole K.","Larrea E.","Timmerman E.","Prieto J.","Arnesen T.","Sherman F.","Gevaert K.","Aldabe R."],"citationCrossReferences":[{"database":"PubMed","id":"22814378"},{"database":"DOI","id":"10.1073/pnas.1210303109"}],"title":"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.","publicationDate":"2012","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"12449","lastPage":"12454","volume":"109"},"referencePositions":["ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"},{"value":"Erythroleukemia","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY211494","properties":[{"key":"ProteinId","value":"AAO62941.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AP005668","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP006334","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471076","properties":[{"key":"ProteinId","value":"EAW74202.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC005133","properties":[{"key":"ProteinId","value":"AAH05133.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BQ672032","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS31595.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q86TN4-1"},{"database":"CCDS","id":"CCDS44639.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q86TN4-2"},{"database":"CCDS","id":"CCDS53652.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q86TN4-4"},{"database":"CCDS","id":"CCDS53653.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q86TN4-3"},{"database":"RefSeq","id":"NP_001028850.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001033678.4"}],"isoformId":"Q86TN4-1"},{"database":"RefSeq","id":"NP_001153861.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160389.2"}],"isoformId":"Q86TN4-4"},{"database":"RefSeq","id":"NP_001153862.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160390.2"}],"isoformId":"Q86TN4-1"},{"database":"RefSeq","id":"NP_001153864.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160392.2"}],"isoformId":"Q86TN4-3"},{"database":"RefSeq","id":"NP_001153865.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001160393.1"}]},{"database":"RefSeq","id":"NP_001317227.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001330298.2"}]},{"database":"RefSeq","id":"NP_113660.1","properties":[{"key":"NucleotideSequenceId","value":"NM_031472.4"}],"isoformId":"Q86TN4-2"},{"database":"RefSeq","id":"XP_024304476.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024448708.2"}],"isoformId":"Q86TN4-1"},{"database":"RefSeq","id":"XP_024304477.1","properties":[{"key":"NucleotideSequenceId","value":"XM_024448709.2"}],"isoformId":"Q86TN4-1"},{"database":"RefSeq","id":"XP_047283635.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047427679.1"}],"isoformId":"Q86TN4-3"},{"database":"RefSeq","id":"XP_047283636.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047427680.1"}],"isoformId":"Q86TN4-3"},{"database":"RefSeq","id":"XP_047283637.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047427681.1"}],"isoformId":"Q86TN4-2"},{"database":"RefSeq","id":"XP_054226109.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054370134.1"}],"isoformId":"Q86TN4-1"},{"database":"RefSeq","id":"XP_054226111.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054370136.1"}],"isoformId":"Q86TN4-1"},{"database":"RefSeq","id":"XP_054226112.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054370137.1"}],"isoformId":"Q86TN4-3"},{"database":"RefSeq","id":"XP_054226114.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054370139.1"}],"isoformId":"Q86TN4-3"},{"database":"RefSeq","id":"XP_054226117.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054370142.1"}],"isoformId":"Q86TN4-2"},{"database":"PDB","id":"7YW3","properties":[{"key":"Method","value":"X-ray"},{"key":"Resolution","value":"2.50 A"},{"key":"Chains","value":"A=1-253"}]},{"database":"PDBsum","id":"7YW3","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"123736","properties":[{"key":"Interactions","value":"17"}]},{"database":"FunCoup","id":"Q86TN4","properties":[{"key":"Number of interactors","value":"157"}]},{"database":"IntAct","id":"Q86TN4","properties":[{"key":"Interactions","value":"12"}]},{"database":"MINT","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"9606.ENSP00000378050","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q86TN4","properties":[{"key":"glycosylation","value":"1 site, 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"TRPT1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"124053420","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000378050","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"2072","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"25919","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"69716","properties":[{"key":"Description","value":"-"}],"isoformId":"Q86TN4-1"},{"database":"ProteomicsDB","id":"69717","properties":[{"key":"Description","value":"-"}],"isoformId":"Q86TN4-2"},{"database":"Pumba","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"51851","properties":[{"key":"antibodies","value":"34 antibodies from 14 providers"}]},{"database":"DNASU","id":"83707","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000317459.11","properties":[{"key":"ProteinId","value":"ENSP00000314073.6"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-1"},{"database":"Ensembl","id":"ENST00000394546.6","properties":[{"key":"ProteinId","value":"ENSP00000378050.2"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-4"},{"database":"Ensembl","id":"ENST00000394547.7","properties":[{"key":"ProteinId","value":"ENSP00000378051.3"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-2"},{"database":"Ensembl","id":"ENST00000541278.5","properties":[{"key":"ProteinId","value":"ENSP00000438683.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-3"},{"database":"Ensembl","id":"ENST00000877499.1","properties":[{"key":"ProteinId","value":"ENSP00000547558.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-1"},{"database":"Ensembl","id":"ENST00000877505.1","properties":[{"key":"ProteinId","value":"ENSP00000547564.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-4"},{"database":"Ensembl","id":"ENST00000877507.1","properties":[{"key":"ProteinId","value":"ENSP00000547566.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-1"},{"database":"Ensembl","id":"ENST00000935365.1","properties":[{"key":"ProteinId","value":"ENSP00000605424.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-1"},{"database":"Ensembl","id":"ENST00000935367.1","properties":[{"key":"ProteinId","value":"ENSP00000605426.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-3"},{"database":"Ensembl","id":"ENST00000962780.1","properties":[{"key":"ProteinId","value":"ENSP00000632839.1"},{"key":"GeneId","value":"ENSG00000149743.15"}],"isoformId":"Q86TN4-1"},{"database":"GeneID","id":"83707","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:83707","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000317459.11","properties":[{"key":"ProteinId","value":"ENSP00000314073.6"},{"key":"RefSeqNucleotideId","value":"NM_001033678.4"},{"key":"RefSeqProteinId","value":"NP_001028850.2"}]},{"database":"UCSC","id":"uc001nyn.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q86TN4-1"},{"database":"AGR","id":"HGNC:20316","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA134964265","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"83707","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"TRPT1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:20316","properties":[{"key":"GeneName","value":"TRPT1"}]},{"database":"HPA","id":"ENSG00000149743","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (skeletal)"}]},{"database":"MIM","id":"610470","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000149743","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000149743","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2278","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000002731","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"RHGASQM","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"419694at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q86TN4","properties":[{"key":"Number of GO annotations","value":"2 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.7.1.160","properties":[{"key":"OrganismId","value":"2681"}]},{"database":"PathwayCommons","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000149743","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"83707","properties":[{"key":"hits","value":"21 hits in 1155 CRISPR screens"}]},{"database":"ChiTaRS","id":"TRPT1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"TRPT1","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"83707","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q86TN4","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q86TN4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q86TN4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000149743","properties":[{"key":"ExpressionPatterns","value":"Expressed in gastrocnemius and 175 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q86TN4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000215","properties":[{"key":"GoTerm","value":"F:tRNA 2'-phosphotransferase activity"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"37334830"}]},{"database":"GO","id":"GO:0006388","properties":[{"key":"GoTerm","value":"P:tRNA splicing, via endonucleolytic cleavage and ligation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"Gene3D","id":"3.20.170.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.970","properties":[{"key":"EntryName","value":"RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR002745","properties":[{"key":"EntryName","value":"Ptrans_KptA/Tpt1"}]},{"database":"InterPro","id":"IPR042081","properties":[{"key":"EntryName","value":"RNA_2'-PTrans_C"}]},{"database":"InterPro","id":"IPR042080","properties":[{"key":"EntryName","value":"RNA_2'-PTrans_N"}]},{"database":"PANTHER","id":"PTHR12684","properties":[{"key":"EntryName","value":"PUTATIVE PHOSPHOTRANSFERASE"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12684:SF2","properties":[{"key":"EntryName","value":"TRNA 2'-PHOSPHOTRANSFERASE 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF01885","properties":[{"key":"EntryName","value":"PTS_2-RNA"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF56399","properties":[{"key":"EntryName","value":"ADP-ribosylation"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNFSGGGRQEAAGSRGRRAPRPREQDRDVQLSKALSYALRHGALKLGLPMGADGFVPLGTLLQLPQFRGFSAEDVQRVVDTNRKQRFALQLGDPSTGLLIRANQGHSLQVPKLELMPLETPQALPPMLVHGTFWKHWPSILLKGLSCQGRTHIHLAPGLPGDPGIISGMRSHCEIAVFIDGPLALADGIPFFRSANGVILTPGNTDGFLLPKYFKEALQLRPTRKPLSLAGDEETECQSSPKHSSRERRRIQQ","length":253,"molWeight":27742,"crc64":"6209F45DC3DB5CBF","md5":"42F71760CE7F2E74765063FF138318B7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"INTERACTION":2,"ALTERNATIVE PRODUCTS":4,"TISSUE SPECIFICITY":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Region":2,"Compositional bias":1,"Modified residue":2,"Alternative sequence":3,"Natural variant":3,"Helix":7,"Turn":4,"Beta strand":11},"uniParcId":"UPI0000246DFD"}}