{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q80VC9","secondaryAccessions":["E9Q5B0","Q5DTW9","Q8BUZ0","U5LGR7","U5LGS1","U5LGS5","U5LGT0","U5LHT8","U5LHU4","U5LHW1","U5LHW4","U5LHW9","U5LK15","U5LK19","U5LK24","U5LK70","U5LK74","U5LK79"],"uniProtkbId":"CAMP3_MOUSE","entryAudit":{"firstPublicDate":"2005-03-15","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2003-06-01","entryVersion":179,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Calmodulin-regulated spectrin-associated protein 3"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24244856"}],"value":"Marshalin"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"23169647"}],"value":"Protein Nezha"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1916947"}],"value":"Camsap3"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.6"}],"value":"Kiaa1543"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9P1Y5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23169647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26715742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28860385"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32482850"}],"value":"Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24706919, PubMed:26715742). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24706919). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (By similarity). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (PubMed:28860385). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (By similarity). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (By similarity). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (By similarity). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (By similarity). Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (PubMed:32482850)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9P1Y5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"23169647"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27349180"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30787442"}],"value":"Interacts with PLEKHA7 (By similarity). Interacts with CAMSAP2 (PubMed:23169647). Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP3-decorated microtubule stretches (By similarity). Interacts with AKAP9; regulating Golgi assembly in epithelial cells (By similarity). Interacts with MACF1 (By similarity). Interacts with isoform C of CDH23; leading to inhibit CAMSAP3 ability to induce microtubule bundle formation (PubMed:27349180). Interacts with AKNA (PubMed:30787442)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q80VC9","intActId":"EBI-2125556"},"interactantTwo":{"uniProtKBAccession":"Q8C1B1","geneName":"Camsap2","intActId":"EBI-8839434"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9P1Y5"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28860385"}],"value":"Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:24706919, PubMed:26715742). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (By similarity). Localizes along zonula adherens only at mature cell-cell contacts (By similarity). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (PubMed:28860385). This cytokinetic bridge does not undergo stereotypical abscission after cell division (PubMed:28860385). Accumulates to the pericentrosomal region following interaction with KATNA1 (By similarity)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24244856"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24706919"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26715742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28860385"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9P1Y5"}],"value":"Cell junction, adherens junction","id":"SL-0009"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9P1Y5"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32482850"}],"value":"Cytoplasm, cytoskeleton, cilium 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In cochlea, restricted to the organ of Corti and increases during development (at protein level) (PubMed:24244856). Highly expressed in both sensory hair cells and supporting cells (PubMed:24244856)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9P1Y5"},{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00841"}],"value":"The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26715742"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32482850"}],"value":"Mice are viable but show growth defects (PubMed:26715742). Disorganization of epithelial architecture, characterized by impaired apical-to-basal polarity of microtubules in epithelial cells (PubMed:26715742). Defects in the stereotypic positioning of the nucleus and Golgi apparatus (PubMed:26715742). Mice display subfertility in both sexes and severe nasal airway blockage leading to coughing, sneezing, hyposmia and rhinosinusitis (PubMed:32482850). Majority of cilia lack the central microtubule pair in their axoneme and display disorientated basal bodies and defects in ciliary motion, which is no longer synchronized (PubMed:32482850)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00841"}],"value":"Belongs to the CAMSAP1 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"Calmodulin-regulated spectrin-associated protein 3","featureId":"PRO_0000050800"},{"type":"Domain","location":{"start":{"value":203,"modifier":"EXACT"},"end":{"value":312,"modifier":"EXACT"}},"description":"Calponin-homology 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