{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q80TJ1","secondaryAccessions":["E9QN90","Q3TSP2","Q61374","Q6AXB4","Q6PGF0"],"uniProtkbId":"CAPS1_MOUSE","entryAudit":{"firstPublicDate":"2006-01-10","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2011-07-27","entryVersion":166,"sequenceVersion":3},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Calcium-dependent secretion activator 1"}},"alternativeNames":[{"fullName":{"value":"Calcium-dependent activator protein for secretion 1"},"shortNames":[{"value":"CAPS-1"}]}]},"genes":[{"geneName":{"value":"Cadps"},"synonyms":[{"value":"Caps"},{"value":"Caps1"},{"value":"Kiaa1121"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15820695"}],"value":"Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17984325"}],"value":"Homodimer. Interacts with the dopamine receptor DRD2 (By similarity). Interacts with RASL10B"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14530279"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15820695"}],"value":"Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14530279"}],"value":"Synapse","id":"SL-0258"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62717"}],"value":"Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane","id":"SL-0532"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62717"}],"value":"Peripheral membrane protein","id":"SL-9903"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q80TJ1-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q80TJ1-2"],"sequenceIds":["VSP_016809","VSP_016811","VSP_016813"],"isoformSequenceStatus":"Described"},{"name":{"value":"4"},"isoformIds":["Q80TJ1-4"],"sequenceIds":["VSP_016814"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14530279"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15820695"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17984325"}],"value":"Present in brain and adrenal glands (at protein level). Specifically expressed in neural and endocrine secretory tissues. Strongly expressed in almost all nerve cells of the brain, although it is absent from glial cells. Expressed in the cardiac atria, but not ventricles"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"value":"During brain development, its expression is similar to that of synaptic markers. Expression is first detectable late in embryogenesis (14 dpc) and increases to reach a plateau about 20 days after birth, when most synapses have been formed (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"17984325"}],"value":"In the heart, up-regulated by hypertrophic stimuli"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"The PH domain is essential for regulated exocytosis and binds phospholipids and plasma membrane. It however does not mediate binding to DCVs (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15820695"}],"value":"Mice die within 30 minutes after birth but do not display obvious developmental or biochemical abnormalities. They show a strong reduction in the frequency of amperometrically detectable release events of transmitter-filled vesicles, while the total number of fusing vesicles, as judged by capacitance recordings or total internal reflection microscopy, remains unchanged"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAA13044.1","note":"The sequence differs from that shown due to a duplication of 90 bp after position 107.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC65735.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1355,"modifier":"EXACT"}},"description":"Calcium-dependent secretion activator 1","featureId":"PRO_0000053865"},{"type":"Domain","location":{"start":{"value":378,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"C2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00041"}]},{"type":"Domain","location":{"start":{"value":519,"modifier":"EXACT"},"end":{"value":622,"modifier":"EXACT"}},"description":"PH","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00145"}]},{"type":"Domain","location":{"start":{"value":933,"modifier":"EXACT"},"end":{"value":1113,"modifier":"EXACT"}},"description":"MHD1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00587"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":792,"modifier":"EXACT"},"end":{"value":1131,"modifier":"EXACT"}},"description":"Interaction with DRD2","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":1179,"modifier":"EXACT"},"end":{"value":1355,"modifier":"EXACT"}},"description":"Mediates targeting and association with DCVs","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Region","location":{"start":{"value":1331,"modifier":"EXACT"},"end":{"value":1355,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":16,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":75,"modifier":"EXACT"}},"description":"Gly residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":34,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"21183079"}]},{"type":"Modified residue","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62717"}]},{"type":"Modified residue","location":{"start":{"value":96,"modifier":"EXACT"},"end":{"value":96,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62717"}]},{"type":"Modified residue","location":{"start":{"value":259,"modifier":"EXACT"},"end":{"value":259,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q62717"}]},{"type":"Alternative sequence","location":{"start":{"value":654,"modifier":"EXACT"},"end":{"value":658,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"featureId":"VSP_016809","alternativeSequence":{"originalSequence":"SGLKD","alternativeSequences":["Y"]}},{"type":"Alternative sequence","location":{"start":{"value":863,"modifier":"EXACT"},"end":{"value":869,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"featureId":"VSP_016811","alternativeSequence":{"originalSequence":"ENQKDAE","alternativeSequences":["GKKREMYEHPVFCLASQVMDLTIQ"]}},{"type":"Alternative sequence","location":{"start":{"value":904,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.1"}],"featureId":"VSP_016813","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":905,"modifier":"EXACT"},"end":{"value":910,"modifier":"EXACT"}},"description":"in isoform 4","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"}],"featureId":"VSP_016814","alternativeSequence":{"originalSequence":"PHVDKG","alternativeSequences":["GK"]}},{"type":"Sequence conflict","location":{"start":{"value":19,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"in Ref. 1; BAA13044 and 2; BAC65735","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"in Ref. 2; BAC65735","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":908,"modifier":"EXACT"},"end":{"value":908,"modifier":"EXACT"}},"description":"in Ref. 4; BAE36633","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["V"]}},{"type":"Sequence conflict","location":{"start":{"value":1034,"modifier":"EXACT"},"end":{"value":1034,"modifier":"EXACT"}},"description":"in Ref. 4; BAE36633","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":1252,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"in Ref. 4; BAE36633","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"E","alternativeSequences":["G"]}},{"type":"Sequence conflict","location":{"start":{"value":1354,"modifier":"EXACT"},"end":{"value":1354,"modifier":"EXACT"}},"description":"in Ref. 1; BAA13044","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0106","category":"Ligand","name":"Calcium"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0268","category":"Biological process","name":"Exocytosis"},{"id":"KW-0446","category":"Ligand","name":"Lipid-binding"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-0653","category":"Biological process","name":"Protein transport"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0770","category":"Cellular component","name":"Synapse"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-AQ73J0UA53U0N","citationType":"submission","authors":["Namikawa K.","Su Q.N.","Toki H.","Kiyama H."],"title":"Down-regulation of CAPS (Ca(2+)-dependent activator for secretion) during nerve regeneration.","publicationDate":"JUN-1996","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"BALB/cJ","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"12693553","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Aizawa H.","Yuasa S.","Nakajima D.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"12693553"},{"database":"DOI","id":"10.1093/dnares/10.1.35"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"35","lastPage":"48","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"19468303","citationType":"journal article","authors":["Church D.M.","Goodstadt L.","Hillier L.W.","Zody M.C.","Goldstein S.","She X.","Bult C.J.","Agarwala R.","Cherry J.L.","DiCuccio M.","Hlavina W.","Kapustin Y.","Meric P.","Maglott D.","Birtle Z.","Marques A.C.","Graves T.","Zhou S.","Teague B.","Potamousis K.","Churas C.","Place M.","Herschleb J.","Runnheim R.","Forrest D.","Amos-Landgraf J.","Schwartz D.C.","Cheng Z.","Lindblad-Toh K.","Eichler E.E.","Ponting C.P."],"citationCrossReferences":[{"database":"PubMed","id":"19468303"},{"database":"DOI","id":"10.1371/journal.pbio.1000112"}],"title":"Lineage-specific biology revealed by a finished genome assembly of the mouse.","publicationDate":"2009","journal":"PLoS Biol.","firstPage":"E1000112","lastPage":"E1000112","volume":"7"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 693-1355"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Olfactory bulb","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 763-1355 (ISOFORM 4)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"14530279","citationType":"journal article","authors":["Speidel D.","Varoqueaux F.","Enk C.","Nojiri M.","Grishanin R.N.","Martin T.F.J.","Hofmann K.","Brose N.","Reim K."],"citationCrossReferences":[{"database":"PubMed","id":"14530279"},{"database":"DOI","id":"10.1074/jbc.m304727200"}],"title":"A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.","publicationDate":"2003","journal":"J. Biol. Chem.","firstPage":"52802","lastPage":"52809","volume":"278"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]},{"referenceNumber":7,"citation":{"id":"15820695","citationType":"journal article","authors":["Speidel D.","Bruederle C.E.","Enk C.","Voets T.","Varoqueaux F.","Reim K.","Becherer U.","Fornai F.","Ruggieri S.","Holighaus Y.","Weihe E.","Bruns D.","Brose N.","Rettig J."],"citationCrossReferences":[{"database":"PubMed","id":"15820695"},{"database":"DOI","id":"10.1016/j.neuron.2005.02.019"}],"title":"CAPS1 regulates catecholamine loading of large dense-core vesicles.","publicationDate":"2005","journal":"Neuron","firstPage":"75","lastPage":"88","volume":"46"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE"]},{"referenceNumber":8,"citation":{"id":"15820687","citationType":"journal article","authors":["Suedhof T.C."],"citationCrossReferences":[{"database":"PubMed","id":"15820687"},{"database":"DOI","id":"10.1016/j.neuron.2005.03.017"}],"title":"CAPS in search of a lost function.","publicationDate":"2005","journal":"Neuron","firstPage":"2","lastPage":"4","volume":"46"},"referencePositions":["REVIEW"]},{"referenceNumber":9,"citation":{"id":"17984325","citationType":"journal article","authors":["Rybkin I.I.","Kim M.S.","Bezprozvannaya S.","Qi X.","Richardson J.A.","Plato C.F.","Hill J.A.","Bassel-Duby R.","Olson E.N."],"citationCrossReferences":[{"database":"PubMed","id":"17984325"},{"database":"DOI","id":"10.1083/jcb.200707101"}],"title":"Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein.","publicationDate":"2007","journal":"J. Cell Biol.","firstPage":"527","lastPage":"537","volume":"179"},"referencePositions":["INTERACTION WITH RASL10B","INDUCTION","TISSUE SPECIFICITY"]},{"referenceNumber":10,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Brown adipose tissue","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"D86214","properties":[{"key":"ProteinId","value":"BAA13044.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK122453","properties":[{"key":"ProteinId","value":"BAC65735.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC116395","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC154250","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC154592","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AC156025","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AK161919","properties":[{"key":"ProteinId","value":"BAE36633.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC057065","properties":[{"key":"ProteinId","value":"AAH57065.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS36806.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q80TJ1-2"},{"database":"CCDS","id":"CCDS36807.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q80TJ1-1"},{"database":"RefSeq","id":"NP_001036082.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001042617.1"}],"isoformId":"Q80TJ1-1"},{"database":"RefSeq","id":"NP_001346848.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001359919.1"}],"isoformId":"Q80TJ1-4"},{"database":"RefSeq","id":"NP_036191.2","properties":[{"key":"NucleotideSequenceId","value":"NM_012061.3"}],"isoformId":"Q80TJ1-2"},{"database":"AlphaFoldDB","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"205117","properties":[{"key":"Interactions","value":"11"}]},{"database":"FunCoup","id":"Q80TJ1","properties":[{"key":"Number of interactors","value":"484"}]},{"database":"IntAct","id":"Q80TJ1","properties":[{"key":"Interactions","value":"4"}]},{"database":"MINT","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"STRING","id":"10090.ENSMUSP00000064706","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q80TJ1","properties":[{"key":"glycosylation","value":"4 sites, 1 O-linked glycan (4 sites)"}]},{"database":"iPTMnet","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"MetOSite","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000064706","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"265528","properties":[{"key":"Description","value":"-"}],"isoformId":"Q80TJ1-1"},{"database":"ProteomicsDB","id":"265529","properties":[{"key":"Description","value":"-"}],"isoformId":"Q80TJ1-2"},{"database":"ProteomicsDB","id":"265530","properties":[{"key":"Description","value":"-"}],"isoformId":"Q80TJ1-4"},{"database":"Pumba","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"DNASU","id":"27062","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000067491.14","properties":[{"key":"ProteinId","value":"ENSMUSP00000064706.7"},{"key":"GeneId","value":"ENSMUSG00000054423.16"}],"isoformId":"Q80TJ1-2"},{"database":"Ensembl","id":"ENSMUST00000112658.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000108277.2"},{"key":"GeneId","value":"ENSMUSG00000054423.16"}],"isoformId":"Q80TJ1-1"},{"database":"GeneID","id":"27062","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:27062","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc007sfu.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q80TJ1-1"},{"database":"UCSC","id":"uc007sfv.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q80TJ1-2"},{"database":"AGR","id":"MGI:1350922","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"8618","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1350922","properties":[{"key":"GeneName","value":"Cadps"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000054423","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG3543","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00590000083094","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_007068_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FAFCATH","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"BioGRID-ORCS","id":"27062","properties":[{"key":"hits","value":"3 hits in 77 CRISPR screens"}]},{"database":"CD-CODE","id":"CE726F99","properties":[{"key":"EntryName","value":"Postsynaptic density"}]},{"database":"PRO","id":"PR:Q80TJ1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 14"}]},{"database":"RNAct","id":"Q80TJ1","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000054423","properties":[{"key":"ExpressionPatterns","value":"Expressed in pontine nuclear group and 174 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q80TJ1","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0031410","properties":[{"key":"GoTerm","value":"C:cytoplasmic vesicle"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"15820695"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0031045","properties":[{"key":"GoTerm","value":"C:dense core granule"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0098674","properties":[{"key":"GoTerm","value":"C:extrinsic component of neuronal dense core vesicle membrane"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0098978","properties":[{"key":"GoTerm","value":"C:glutamatergic synapse"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18022372"}]},{"database":"GO","id":"GO:0098793","properties":[{"key":"GoTerm","value":"C:presynapse"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045202","properties":[{"key":"GoTerm","value":"C:synapse"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14530279"}]},{"database":"GO","id":"GO:0005509","properties":[{"key":"GoTerm","value":"F:calcium ion binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005546","properties":[{"key":"GoTerm","value":"F:phosphatidylinositol-4,5-bisphosphate binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0019901","properties":[{"key":"GoTerm","value":"F:protein kinase binding"},{"key":"GoEvidenceType","value":"IPI:ParkinsonsUK-UCL"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"21307259"}]},{"database":"GO","id":"GO:0017156","properties":[{"key":"GoTerm","value":"P:calcium-ion regulated exocytosis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0050432","properties":[{"key":"GoTerm","value":"P:catecholamine secretion"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15820695"}]},{"database":"GO","id":"GO:0006887","properties":[{"key":"GoTerm","value":"P:exocytosis"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0099011","properties":[{"key":"GoTerm","value":"P:neuronal dense core vesicle exocytosis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:1905415","properties":[{"key":"GoTerm","value":"P:positive regulation of dense core granule exocytosis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0045921","properties":[{"key":"GoTerm","value":"P:positive regulation of exocytosis"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0099525","properties":[{"key":"GoTerm","value":"P:presynaptic dense core vesicle exocytosis"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"25719439"}]},{"database":"GO","id":"GO:0016082","properties":[{"key":"GoTerm","value":"P:synaptic vesicle priming"},{"key":"GoEvidenceType","value":"IDA:SynGO"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"18022372"}]},{"database":"GO","id":"GO:0016050","properties":[{"key":"GoTerm","value":"P:vesicle organization"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"15820695"}]},{"database":"CDD","id":"cd01234","properties":[{"key":"EntryName","value":"PH_CADPS"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.30.29.30:FF:000007","properties":[{"key":"EntryName","value":"Calcium-dependent secretion activator 2 isoform B"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.30.29.30","properties":[{"key":"EntryName","value":"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR000008","properties":[{"key":"EntryName","value":"C2_dom"}]},{"database":"InterPro","id":"IPR033227","properties":[{"key":"EntryName","value":"CAPS"}]},{"database":"InterPro","id":"IPR057457","properties":[{"key":"EntryName","value":"CAPS_C2"}]},{"database":"InterPro","id":"IPR010439","properties":[{"key":"EntryName","value":"MUN_dom"}]},{"database":"InterPro","id":"IPR014770","properties":[{"key":"EntryName","value":"Munc13_1"}]},{"database":"InterPro","id":"IPR011993","properties":[{"key":"EntryName","value":"PH-like_dom_sf"}]},{"database":"InterPro","id":"IPR001849","properties":[{"key":"EntryName","value":"PH_domain"}]},{"database":"PANTHER","id":"PTHR12166","properties":[{"key":"EntryName","value":"CALCIUM-DEPENDENT SECRETION ACTIVATOR"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12166:SF6","properties":[{"key":"EntryName","value":"CALCIUM-DEPENDENT SECRETION ACTIVATOR 1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF25341","properties":[{"key":"EntryName","value":"C2_CAPS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF06292","properties":[{"key":"EntryName","value":"MUN"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF00169","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM01145","properties":[{"key":"EntryName","value":"DUF1041"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00233","properties":[{"key":"EntryName","value":"PH"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF50729","properties":[{"key":"EntryName","value":"PH domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50004","properties":[{"key":"EntryName","value":"C2"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51258","properties":[{"key":"EntryName","value":"MHD1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50003","properties":[{"key":"EntryName","value":"PH_DOMAIN"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLDPSSSEEESDEILEEERGKDVLGSAASGARLSPSRTSEGSAGSAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQAFLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLNAKGGNVPQLDAPISQFSGLKDADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKVPNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNIICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEEATASVSEGGGLQGISMKDSDEEDEEDD","length":1355,"molWeight":153113,"crc64":"59596BAD74C6AE56","md5":"7F339C61CC0C9DC02284202D012DD8AA"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"DOMAIN":1,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Domain":3,"Region":4,"Compositional bias":3,"Modified residue":4,"Alternative sequence":4,"Sequence conflict":6},"uniParcId":"UPI0000DB8415"}}