{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7Z6M3","secondaryAccessions":["A1L458","B4DUS1","B7ZM50","B9EGN0","D6RUW6","D6RUW8"],"uniProtkbId":"MILR1_HUMAN","entryAudit":{"firstPublicDate":"2007-10-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-10-23","entryVersion":145,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Allergin-1"}},"alternativeNames":[{"fullName":{"value":"Allergy inhibitory receptor 1"}},{"fullName":{"value":"Mast cell antigen 32"},"shortNames":[{"value":"MCA-32"}]},{"fullName":{"value":"Mast cell immunoglobulin-like receptor 1"}}],"flag":"Precursor"},"genes":[{"geneName":{"value":"MILR1"},"synonyms":[{"value":"C17orf60"},{"value":"MCA32"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Monomer. Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q7Z6M3","intActId":"EBI-18391669"},"interactantTwo":{"uniProtKBAccession":"Q8WVX3-2","geneName":"ARLN","intActId":"EBI-12003442"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z6M3","intActId":"EBI-18391669"},"interactantTwo":{"uniProtKBAccession":"Q6UX41-6","geneName":"BTNL8","intActId":"EBI-17442596"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z6M3","intActId":"EBI-18391669"},"interactantTwo":{"uniProtKBAccession":"Q96F15","geneName":"GIMAP5","intActId":"EBI-6166686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z6M3","intActId":"EBI-18391669"},"interactantTwo":{"uniProtKBAccession":"Q9HCP6","geneName":"HHATL","intActId":"EBI-5916693"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z6M3","intActId":"EBI-18391669"},"interactantTwo":{"uniProtKBAccession":"O75425","geneName":"MOSPD3","intActId":"EBI-12179105"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z6M3","intActId":"EBI-18391669"},"interactantTwo":{"uniProtKBAccession":"Q9NV12","geneName":"TMEM140","intActId":"EBI-2844246"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20526344"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20526344"}],"value":"Single-pass type I membrane protein","id":"SL-9905"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"L"}],"isoformIds":["Q7Z6M3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"S1"}],"isoformIds":["Q7Z6M3-2"],"sequenceIds":["VSP_040766"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"synonyms":[{"value":"S2"}],"isoformIds":["Q7Z6M3-3"],"sequenceIds":["VSP_040765"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20526344"}],"value":"Expressed in myeloid cells (dendritic cells, macrophages and neutrophils, weak expression on B-cells but not in T-cells or natural killer cells), peripheral blood basophils and mast cells (at protein level)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20526344"}],"value":"N-glycosylated"}],"commentType":"PTM"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAI36595.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAG62433.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":19,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Chain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Allergin-1","featureId":"PRO_0000307364"},{"type":"Topological domain","location":{"start":{"value":20,"modifier":"EXACT"},"end":{"value":227,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Transmembrane","location":{"start":{"value":228,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":249,"modifier":"EXACT"},"end":{"value":343,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"Ig-like C2-type 1"},{"type":"Domain","location":{"start":{"value":128,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Ig-like C2-type 2"},{"type":"Motif","location":{"start":{"value":311,"modifier":"EXACT"},"end":{"value":316,"modifier":"EXACT"}},"description":"ITIM motif"},{"type":"Motif","location":{"start":{"value":336,"modifier":"EXACT"},"end":{"value":341,"modifier":"EXACT"}},"description":"ITIM motif"},{"type":"Modified residue","location":{"start":{"value":313,"modifier":"EXACT"},"end":{"value":313,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TB92"}]},{"type":"Modified residue","location":{"start":{"value":338,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3TB92"}]},{"type":"Glycosylation","location":{"start":{"value":51,"modifier":"EXACT"},"end":{"value":51,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":60,"modifier":"EXACT"},"end":{"value":60,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":89,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":157,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":182,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Disulfide bond","location":{"start":{"value":56,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Disulfide bond","location":{"start":{"value":147,"modifier":"EXACT"},"end":{"value":196,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Alternative sequence","location":{"start":{"value":33,"modifier":"EXACT"},"end":{"value":122,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20526344"}],"featureId":"VSP_040765","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":217,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15489334"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20526344"}],"featureId":"VSP_040766","alternativeSequence":{}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0393","category":"Domain","name":"Immunoglobulin domain"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0732","category":"Domain","name":"Signal"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"20526344","citationType":"journal article","authors":["Hitomi K.","Tahara-Hanaoka S.","Someya S.","Fujiki A.","Tada H.","Sugiyama T.","Shibayama S.","Shibuya K.","Shibuya A."],"citationCrossReferences":[{"database":"PubMed","id":"20526344"},{"database":"DOI","id":"10.1038/ni.1886"}],"title":"An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.","publicationDate":"2010","journal":"Nat. Immunol.","firstPage":"601","lastPage":"607","volume":"11"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","GLYCOSYLATION"]},{"referenceNumber":2,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"Prostate","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AB542950","properties":[{"key":"ProteinId","value":"BAJ08251.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB542951","properties":[{"key":"ProteinId","value":"BAJ08252.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AB542952","properties":[{"key":"ProteinId","value":"BAJ08253.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK300768","properties":[{"key":"ProteinId","value":"BAG62433.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC053534","properties":[{"key":"ProteinId","value":"AAH53534.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC130406","properties":[{"key":"ProteinId","value":"AAI30407.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC136594","properties":[{"key":"ProteinId","value":"AAI36595.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC144272","properties":[{"key":"ProteinId","value":"AAI44273.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS74133.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7Z6M3-1"},{"database":"CCDS","id":"CCDS77087.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7Z6M3-2"},{"database":"CCDS","id":"CCDS77088.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7Z6M3-3"},{"database":"RefSeq","id":"NP_001078892.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001085423.2"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"NP_001278245.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001291316.2"}],"isoformId":"Q7Z6M3-2"},{"database":"RefSeq","id":"NP_001278246.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001291317.2"}],"isoformId":"Q7Z6M3-3"},{"database":"RefSeq","id":"NP_001356422.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001369493.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"NP_001425762.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001438833.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_024306476.2","properties":[{"key":"NucleotideSequenceId","value":"XM_024450708.2"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_047291746.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047435790.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_047291747.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047435791.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_047291749.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047435793.1"}],"isoformId":"Q7Z6M3-2"},{"database":"RefSeq","id":"XP_054171742.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054315767.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_054171744.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054315769.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_054171745.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054315770.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_054171746.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054315771.1"}],"isoformId":"Q7Z6M3-1"},{"database":"RefSeq","id":"XP_054171748.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054315773.1"}],"isoformId":"Q7Z6M3-2"},{"database":"AlphaFoldDB","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"129734","properties":[{"key":"Interactions","value":"77"}]},{"database":"FunCoup","id":"Q7Z6M3","properties":[{"key":"Number of interactors","value":"362"}]},{"database":"IntAct","id":"Q7Z6M3","properties":[{"key":"Interactions","value":"73"}]},{"database":"STRING","id":"9606.ENSP00000482801","properties":[{"key":"Description","value":"-"}]},{"database":"GlyCosmos","id":"Q7Z6M3","properties":[{"key":"glycosylation","value":"6 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q7Z6M3","properties":[{"key":"glycosylation","value":"6 sites, 10 N-linked glycans (3 sites)"}]},{"database":"iPTMnet","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"MILR1","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"160013631","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000482801","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"69447","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7Z6M3-1"},{"database":"ProteomicsDB","id":"69448","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7Z6M3-2"},{"database":"ProteomicsDB","id":"69449","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7Z6M3-3"},{"database":"Antibodypedia","id":"68852","properties":[{"key":"antibodies","value":"101 antibodies from 14 providers"}]},{"database":"DNASU","id":"284021","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000612535.4","properties":[{"key":"ProteinId","value":"ENSP00000477504.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-3"},{"database":"Ensembl","id":"ENST00000615220.4","properties":[{"key":"ProteinId","value":"ENSP00000480749.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-1"},{"database":"Ensembl","id":"ENST00000616498.4","properties":[{"key":"ProteinId","value":"ENSP00000481318.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-2"},{"database":"Ensembl","id":"ENST00000619286.5","properties":[{"key":"ProteinId","value":"ENSP00000482801.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-1"},{"database":"Ensembl","id":"ENST00000718366.1","properties":[{"key":"ProteinId","value":"ENSP00000520795.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-1"},{"database":"Ensembl","id":"ENST00000718367.1","properties":[{"key":"ProteinId","value":"ENSP00000520797.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-1"},{"database":"Ensembl","id":"ENST00000718368.1","properties":[{"key":"ProteinId","value":"ENSP00000520798.1"},{"key":"GeneId","value":"ENSG00000271605.7"}],"isoformId":"Q7Z6M3-1"},{"database":"GeneID","id":"284021","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:284021","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000619286.5","properties":[{"key":"ProteinId","value":"ENSP00000482801.1"},{"key":"RefSeqNucleotideId","value":"NM_001085423.2"},{"key":"RefSeqProteinId","value":"NP_001078892.1"}]},{"database":"UCSC","id":"uc010wpz.4","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q7Z6M3-1"},{"database":"AGR","id":"HGNC:27570","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA142672243","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"284021","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"284021","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"MILR1","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:27570","properties":[{"key":"GeneName","value":"MILR1"}]},{"database":"HPA","id":"ENSG00000271605","properties":[{"key":"ExpressionPatterns","value":"Tissue enhanced (lymphoid)"}]},{"database":"MalaCards","id":"MILR1","properties":[{"key":"Description","value":"-"}]},{"database":"OpenTargets","id":"ENSG00000271605","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000271605","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502S5BW","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244808","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_069833_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HEIHYAT","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9947088at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q7Z6M3","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000271605","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"284021","properties":[{"key":"hits","value":"6 hits in 276 CRISPR screens"}]},{"database":"ChiTaRS","id":"MILR1","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"284021","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q7Z6M3","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q7Z6M3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q7Z6M3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000271605","properties":[{"key":"ExpressionPatterns","value":"Expressed in monocyte and 121 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q7Z6M3","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"NAS:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"20526344"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0043303","properties":[{"key":"GoTerm","value":"P:mast cell degranulation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0033004","properties":[{"key":"GoTerm","value":"P:negative regulation of mast cell activation"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"FunFam","id":"2.60.40.10:FF:001338","properties":[{"key":"EntryName","value":"MILR1 isoform 7"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.60.40.10","properties":[{"key":"EntryName","value":"Immunoglobulins"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR036179","properties":[{"key":"EntryName","value":"Ig-like_dom_sf"}]},{"database":"InterPro","id":"IPR013783","properties":[{"key":"EntryName","value":"Ig-like_fold"}]},{"database":"InterPro","id":"IPR040878","properties":[{"key":"EntryName","value":"IL-40-like_Ig"}]},{"database":"Pfam","id":"PF13895","properties":[{"key":"EntryName","value":"Ig_2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17736","properties":[{"key":"EntryName","value":"Ig_C17orf99"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48726","properties":[{"key":"EntryName","value":"Immunoglobulin"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MWSHLNRLLFWSIFSSVTCRKAVLDCEAMKTNEFPSPCLDSKTKVVMKGQNVSMFCSHKNKSLQITYSLFRRKTHLGTQDGKGEPAIFNLSITEAHESGPYKCKAQVTSCSKYSRDFSFTIVDPVTSPVLNIMVIQTETDRHITLHCLSVNGSLPINYTFFENHVAISPAISKYDREPAEFNLTKKNPGEEEEYRCEAKNRLPNYATYSHPVTMPSTGGDSCPFCLKLLLPGLLLLLVVIILILAFWVLPKYKTRKAMRNNVPRDRGDTAMEVGIYANILEKQAKEESVPEVGSRPCVSTAQDEAKHSQELQYATPVFQEVAPREQEACDSYKSGYVYSELNF","length":343,"molWeight":38735,"crc64":"DCD1E784D40885C5","md5":"81471B4DD5009D3908183158ED0570F9"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"INTERACTION":6,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"PTM":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Signal":1,"Chain":1,"Topological domain":2,"Transmembrane":1,"Domain":2,"Motif":2,"Modified residue":2,"Glycosylation":6,"Disulfide bond":2,"Alternative sequence":2},"uniParcId":"UPI0000158625"}}