{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7Z699","secondaryAccessions":["B2RPJ8","Q05D53","Q8N256"],"uniProtkbId":"SPRE1_HUMAN","entryAudit":{"firstPublicDate":"2005-01-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-01-04","entryVersion":181,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sprouty-related, EVH1 domain-containing protein 1"},"shortNames":[{"value":"Spred-1"},{"value":"hSpred1"}]}},"genes":[{"geneName":{"value":"SPRED1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q924S8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18216281"}],"value":"Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Negatively regulates hematopoiesis of bone marrow (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q924S8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15683364"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16115197"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"18216281"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24705354"}],"value":"Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED2 to form heterodimers (PubMed:15683364). Interacts (via C-terminus) with TAOK1/MARKK (via C-terminus); the interaction does not affect TAOK1 kinase activity (PubMed:18216281). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:18216281). Interacts with CAV1 (PubMed:16115197). Interacts with RAS (By similarity). Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of SPRED1 (PubMed:24705354)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q6H8Q1-8","geneName":"ABLIM2","intActId":"EBI-16436655"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q8NC06-3","geneName":"ACBD4","intActId":"EBI-12811089"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"P26436","geneName":"ACRV1","intActId":"EBI-25884472"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q6UY14-3","geneName":"ADAMTSL4","intActId":"EBI-10173507"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q7Z6V5","geneName":"ADAT2","intActId":"EBI-2809203"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q9UKV8","geneName":"AGO2","intActId":"EBI-528269"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q04828","geneName":"AKR1C1","intActId":"EBI-2116455"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"P09917","geneName":"ALOX5","intActId":"EBI-79934"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q6ZTN6-2","geneName":"ANKRD13D","intActId":"EBI-25840993"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q86SG2","geneName":"ANKRD23","intActId":"EBI-5661893"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q49AR9","geneName":"ANKS1A","intActId":"EBI-11954519"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"P53677-2","geneName":"AP3M2","intActId":"EBI-12177015"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"P07741","geneName":"APRT","intActId":"EBI-1047565"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"P29972","geneName":"AQP1","intActId":"EBI-745213"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q9NXL2-1","geneName":"ARHGEF38","intActId":"EBI-18172597"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q9UBL0-2","geneName":"ARPP21","intActId":"EBI-25931672"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q8WXK3","geneName":"ASB13","intActId":"EBI-707573"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q8WXK3-2","geneName":"ASB13","intActId":"EBI-12015080"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q9Y575-3","geneName":"ASB3","intActId":"EBI-14199987"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q96DX5-3","geneName":"ASB9","intActId":"EBI-25843552"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q6XD76","geneName":"ASCL4","intActId":"EBI-10254793"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q96FT7-4","geneName":"ASIC4","intActId":"EBI-9089489"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7Z699","intActId":"EBI-5235340"},"interactantTwo":{"uniProtKBAccession":"Q8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