ID   PODN_HUMAN              Reviewed;         613 AA.
AC   Q7Z5L7; B4DKN5; B4E373; Q5VVZ2; Q5VVZ3; Q6PIR3; Q6UXL8; Q8N641;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   27-MAR-2024, entry version 174.
DE   RecName: Full=Podocan;
DE   Flags: Precursor;
GN   Name=PODN; Synonyms=SLRR5A; ORFNames=UNQ293/PRO332;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS
RP   MET-444 AND ALA-472.
RC   TISSUE=Kidney;
RX   PubMed=12796502; DOI=10.1074/jbc.m301299200;
RA   Ross M.D., Bruggeman L.A., Hanss B., Sunamoto M., Marras D., Klotman M.E.,
RA   Klotman P.E.;
RT   "Podocan, a novel small leucine-rich repeat protein expressed in the
RT   sclerotic glomerular lesion of experimental HIV-associated nephropathy.";
RL   J. Biol. Chem. 278:33248-33255(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-472.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP   ALA-472.
RC   TISSUE=Colon, Tongue, and Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ALA-472.
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, AND
RP   INTERACTION WITH TYPE I COLLAGEN.
RX   PubMed=15063725; DOI=10.1016/s0014-5793(04)00250-9;
RA   Shimizu-Hirota R., Sasamura H., Kuroda M., Kobayashi E., Saruta T.;
RT   "Functional characterization of podocan, a member of a new class in the
RT   small leucine-rich repeat protein family.";
RL   FEBS Lett. 563:69-74(2004).
RN   [7]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-281 AND ASN-299.
RC   TISSUE=Liver;
RX   PubMed=19159218; DOI=10.1021/pr8008012;
RA   Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT   "Glycoproteomics analysis of human liver tissue by combination of multiple
RT   enzyme digestion and hydrazide chemistry.";
RL   J. Proteome Res. 8:651-661(2009).
RN   [8]
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=20551380; DOI=10.1074/mcp.m110.001693;
RA   Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M.;
RT   "Proteomics characterization of extracellular space components in the human
RT   aorta.";
RL   Mol. Cell. Proteomics 9:2048-2062(2010).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- FUNCTION: Negatively regulates cell proliferation and cell migration.
CC       {ECO:0000269|PubMed:15063725}.
CC   -!- SUBUNIT: Binds to type I collagen.
CC   -!- INTERACTION:
CC       Q7Z5L7-3; Q86X45: DNAAF11; NbExp=3; IntAct=EBI-23806733, EBI-9379658;
CC   -!- SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space,
CC       extracellular matrix.
CC   -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q7Z5L7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q7Z5L7-2; Sequence=VSP_037827;
CC       Name=3;
CC         IsoId=Q7Z5L7-3; Sequence=VSP_021784;
CC       Name=4;
CC         IsoId=Q7Z5L7-4; Sequence=VSP_021784, VSP_039064;
CC   -!- TISSUE SPECIFICITY: Kidney, heart, liver, pancreas and vascular smooth
CC       muscle cells. Also detected in aortic intima (at protein level).
CC       {ECO:0000269|PubMed:12796502, ECO:0000269|PubMed:15063725,
CC       ECO:0000269|PubMed:20551380}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:15063725,
CC       ECO:0000269|PubMed:19159218}.
CC   -!- MISCELLANEOUS: [Isoform 2]: No signal peptide. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform 3]: No signal peptide. {ECO:0000305}.
CC   -!- MISCELLANEOUS: [Isoform 4]: No signal peptide. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class V subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH28292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY313607; AAP79898.1; -; mRNA.
DR   EMBL; AY358294; AAQ88661.1; -; mRNA.
DR   EMBL; AK296649; BAG59247.1; -; mRNA.
DR   EMBL; AK299375; BAG61365.1; -; mRNA.
DR   EMBL; AK304599; BAG65385.1; -; mRNA.
DR   EMBL; AL445183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC028292; AAH28292.1; ALT_INIT; mRNA.
DR   EMBL; BC030608; AAH30608.1; -; mRNA.
DR   CCDS; CCDS573.2; -. [Q7Z5L7-1]
DR   RefSeq; NP_001186009.1; NM_001199080.2. [Q7Z5L7-1]
DR   RefSeq; NP_001186010.1; NM_001199081.2. [Q7Z5L7-1]
DR   RefSeq; NP_714914.2; NM_153703.4. [Q7Z5L7-1]
DR   RefSeq; XP_005270514.1; XM_005270457.3. [Q7Z5L7-1]
DR   AlphaFoldDB; Q7Z5L7; -.
DR   SMR; Q7Z5L7; -.
DR   BioGRID; 126059; 21.
DR   IntAct; Q7Z5L7; 8.
DR   STRING; 9606.ENSP00000379212; -.
DR   GlyConnect; 1618; 7 N-Linked glycans (2 sites).
DR   GlyCosmos; Q7Z5L7; 4 sites, 6 glycans.
DR   GlyGen; Q7Z5L7; 4 sites, 6 N-linked glycans (2 sites).
DR   iPTMnet; Q7Z5L7; -.
DR   PhosphoSitePlus; Q7Z5L7; -.
DR   BioMuta; PODN; -.
DR   DMDM; 118573110; -.
DR   EPD; Q7Z5L7; -.
DR   jPOST; Q7Z5L7; -.
DR   MassIVE; Q7Z5L7; -.
DR   PaxDb; 9606-ENSP00000308315; -.
DR   PeptideAtlas; Q7Z5L7; -.
DR   ProteomicsDB; 69321; -. [Q7Z5L7-1]
DR   ProteomicsDB; 69322; -. [Q7Z5L7-2]
DR   ProteomicsDB; 69323; -. [Q7Z5L7-3]
DR   ProteomicsDB; 69324; -. [Q7Z5L7-4]
DR   Antibodypedia; 2151; 140 antibodies from 29 providers.
DR   DNASU; 127435; -.
DR   Ensembl; ENST00000312553.10; ENSP00000308315.6; ENSG00000174348.14. [Q7Z5L7-1]
DR   Ensembl; ENST00000371500.8; ENSP00000360555.3; ENSG00000174348.14. [Q7Z5L7-2]
DR   Ensembl; ENST00000395871.7; ENSP00000379212.3; ENSG00000174348.14. [Q7Z5L7-3]
DR   Ensembl; ENST00000618387.1; ENSP00000479233.1; ENSG00000174348.14. [Q7Z5L7-2]
DR   GeneID; 127435; -.
DR   KEGG; hsa:127435; -.
DR   MANE-Select; ENST00000312553.10; ENSP00000308315.6; NM_153703.5; NP_714914.3.
DR   UCSC; uc001cuv.4; human. [Q7Z5L7-1]
DR   AGR; HGNC:23174; -.
DR   CTD; 127435; -.
DR   DisGeNET; 127435; -.
DR   GeneCards; PODN; -.
DR   HGNC; HGNC:23174; PODN.
DR   HPA; ENSG00000174348; Low tissue specificity.
DR   MIM; 608661; gene.
DR   neXtProt; NX_Q7Z5L7; -.
DR   OpenTargets; ENSG00000174348; -.
DR   PharmGKB; PA134980106; -.
DR   VEuPathDB; HostDB:ENSG00000174348; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000160740; -.
DR   HOGENOM; CLU_000288_186_3_1; -.
DR   InParanoid; Q7Z5L7; -.
DR   OrthoDB; 1005434at2759; -.
DR   PhylomeDB; Q7Z5L7; -.
DR   TreeFam; TF336377; -.
DR   PathwayCommons; Q7Z5L7; -.
DR   SignaLink; Q7Z5L7; -.
DR   BioGRID-ORCS; 127435; 12 hits in 1146 CRISPR screens.
DR   ChiTaRS; PODN; human.
DR   GenomeRNAi; 127435; -.
DR   Pharos; Q7Z5L7; Tbio.
DR   PRO; PR:Q7Z5L7; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q7Z5L7; Protein.
DR   Bgee; ENSG00000174348; Expressed in right ovary and 136 other cell types or tissues.
DR   ExpressionAtlas; Q7Z5L7; baseline and differential.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005518; F:collagen binding; IDA:UniProtKB.
DR   GO; GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR45712; AGAP008170-PA; 1.
DR   PANTHER; PTHR45712:SF22; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 4.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00364; LRR_BAC; 6.
DR   SMART; SM00368; LRR_RI; 6.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 13.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   PROSITE; PS51450; LRR; 17.
DR   Genevisible; Q7Z5L7; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasm; Extracellular matrix; Glycoprotein;
KW   Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..613
FT                   /note="Podocan"
FT                   /id="PRO_0000262524"
FT   DOMAIN          59..96
FT                   /note="LRRNT"
FT   REPEAT          97..118
FT                   /note="LRR 1"
FT   REPEAT          121..141
FT                   /note="LRR 2"
FT   REPEAT          147..168
FT                   /note="LRR 3"
FT   REPEAT          169..189
FT                   /note="LRR 4"
FT   REPEAT          192..212
FT                   /note="LRR 5"
FT   REPEAT          218..238
FT                   /note="LRR 6"
FT   REPEAT          239..260
FT                   /note="LRR 7"
FT   REPEAT          263..283
FT                   /note="LRR 8"
FT   REPEAT          289..310
FT                   /note="LRR 9"
FT   REPEAT          311..331
FT                   /note="LRR 10"
FT   REPEAT          334..357
FT                   /note="LRR 11"
FT   REPEAT          360..380
FT                   /note="LRR 12"
FT   REPEAT          381..402
FT                   /note="LRR 13"
FT   REPEAT          405..426
FT                   /note="LRR 14"
FT   REPEAT          431..452
FT                   /note="LRR 15"
FT   REPEAT          476..489
FT                   /note="LRR 16"
FT   REPEAT          502..522
FT                   /note="LRR 17"
FT   REPEAT          523..544
FT                   /note="LRR 18"
FT   REPEAT          547..568
FT                   /note="LRR 19"
FT   REPEAT          573..595
FT                   /note="LRR 20"
FT   REGION          588..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        214
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        281
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   CARBOHYD        299
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:19159218"
FT   CARBOHYD        410
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MEGEEAEQPAWFRQPWRPGASDSAPPAGTM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:12975309,
FT                   ECO:0000303|PubMed:14702039"
FT                   /id="VSP_037827"
FT   VAR_SEQ         1
FT                   /note="M -> MEGARARGAQLRLGERVRPVGRRSAPGRSRFRQPWRPGASDSAPPAG
FT                   TM (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_021784"
FT   VAR_SEQ         105..246
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_039064"
FT   VARIANT         444
FT                   /note="T -> M (in dbSNP:rs12567021)"
FT                   /evidence="ECO:0000269|PubMed:12796502"
FT                   /id="VAR_029497"
FT   VARIANT         472
FT                   /note="V -> A (in dbSNP:rs1288389)"
FT                   /evidence="ECO:0000269|PubMed:12796502,
FT                   ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_029498"
FT   CONFLICT        Q7Z5L7-3:32
FT                   /note="R -> H (in Ref. 5; AAH30608)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   613 AA;  68976 MW;  DA574FC77CCDAC91 CRC64;
     MAQSRVLLLL LLLPPQLHLG PVLAVRAPGF GRSGGHSLSP EENEFAEEEP VLVLSPEEPG
     PGPAAVSCPR DCACSQEGVV DCGGIDLREF PGDLPEHTNH LSLQNNQLEK IYPEELSRLH
     RLETLNLQNN RLTSRGLPEK AFEHLTNLNY LYLANNKLTL APRFLPNALI SVDFAANYLT
     KIYGLTFGQK PNLRSVYLHN NKLADAGLPD NMFNGSSNVE VLILSSNFLR HVPKHLPPAL
     YKLHLKNNKL EKIPPGAFSE LSSLRELYLQ NNYLTDEGLD NETFWKLSSL EYLDLSSNNL
     SRVPAGLPRS LVLLHLEKNA IRSVDANVLT PIRSLEYLLL HSNQLREQGI HPLAFQGLKR
     LHTVHLYNNA LERVPSGLPR RVRTLMILHN QITGIGREDF ATTYFLEELN LSYNRITSPQ
     VHRDAFRKLR LLRSLDLSGN RLHTLPPGLP RNVHVLKVKR NELAALARGA LVGMAQLREL
     YLTSNRLRSR ALGPRAWVDL AHLQLLDIAG NQLTEIPEGL PESLEYLYLQ NNKISAVPAN
     AFDSTPNLKG IFLRFNKLAV GSVVDSAFRR LKHLQVLDIE GNLEFGDISK DRGRLGKEKE
     EEEEEEEEEE ETR
//