{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7TPN3","secondaryAccessions":["Q8BGL2","Q8BJR5","Q8BWH9","Q8BXF5"],"uniProtkbId":"PIGV_MOUSE","entryAudit":{"firstPublicDate":"2006-07-25","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2006-07-25","entryVersion":140,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"GPI alpha-1,6-mannosyltransferase 2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"2.4.1.-"}]},"alternativeNames":[{"fullName":{"value":"GPI mannosyltransferase II"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"GPI-MT-II"}]},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"Phosphatidylinositol-glycan biosynthesis class V protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"PIG-V"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:2442480"}],"value":"Pigv"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A0A8C2M425"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"Alpha-1,6-mannosyltransferase that catalyzes the transfer of the second mannose, via an alpha-1,6 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) and participates in the seventh step of the glycosylphosphatidylinositol-anchor biosynthesis (By similarity). May also transfer the second mannose on a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H5), but less effectively (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60488"},{"database":"Rhea","id":"RHEA-COMP:19498"},{"database":"Rhea","id":"RHEA-COMP:19501"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57683"},{"database":"ChEBI","id":"CHEBI:58211"},{"database":"ChEBI","id":"CHEBI:143818"},{"database":"ChEBI","id":"CHEBI:144028"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60489"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]}]},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = a 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol + a di-trans,poly-cis-dolichyl phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:60992"},{"database":"Rhea","id":"RHEA-COMP:19498"},{"database":"Rhea","id":"RHEA-COMP:19501"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:57683"},{"database":"ChEBI","id":"CHEBI:58211"},{"database":"ChEBI","id":"CHEBI:144036"},{"database":"ChEBI","id":"CHEBI:144054"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:60993"},"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q7TPN3-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q7TPN3-2"],"sequenceIds":["VSP_019840"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}],"value":"Not N-glycosylated"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the PIGV family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAC33023.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"GPI alpha-1,6-mannosyltransferase 2","featureId":"PRO_0000246235"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":13,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":14,"modifier":"EXACT"},"end":{"value":34,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":35,"modifier":"EXACT"},"end":{"value":77,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":78,"modifier":"EXACT"},"end":{"value":98,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":114,"modifier":"EXACT"},"end":{"value":134,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":135,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":157,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":161,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":162,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":192,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":193,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":214,"modifier":"EXACT"},"end":{"value":234,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":235,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":256,"modifier":"EXACT"},"end":{"value":327,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":328,"modifier":"EXACT"},"end":{"value":348,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":349,"modifier":"EXACT"},"end":{"value":378,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":379,"modifier":"EXACT"},"end":{"value":399,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":469,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Transmembrane","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":490,"modifier":"EXACT"}},"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":491,"modifier":"EXACT"},"end":{"value":493,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9NUD9"}]},{"type":"Alternative sequence","location":{"start":{"value":27,"modifier":"EXACT"},"end":{"value":400,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_019840","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":218,"modifier":"EXACT"},"end":{"value":218,"modifier":"EXACT"}},"description":"in Ref. 1; BAC34995","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":460,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"in Ref. 2; AAH55060","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"D","alternativeSequences":["N"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"id":"KW-0337","category":"Biological process","name":"GPI-anchor biosynthesis"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Adrenal gland","type":"TISSUE"},{"value":"Cerebellum","type":"TISSUE"},{"value":"Corpora quadrigemina","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Colon","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK046527","properties":[{"key":"ProteinId","value":"BAC32773.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK047322","properties":[{"key":"ProteinId","value":"BAC33023.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK052446","properties":[{"key":"ProteinId","value":"BAC34995.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK080590","properties":[{"key":"ProteinId","value":"BAC37950.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK080858","properties":[{"key":"ProteinId","value":"BAC38047.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK148285","properties":[{"key":"ProteinId","value":"BAE28458.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC055060","properties":[{"key":"ProteinId","value":"AAH55060.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS18755.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPN3-1"},{"database":"CCDS","id":"CCDS51322.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPN3-2"},{"database":"RefSeq","id":"NP_001139427.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001145955.1"}]},{"database":"RefSeq","id":"NP_001139428.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001145956.1"}],"isoformId":"Q7TPN3-2"},{"database":"RefSeq","id":"NP_001343395.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001356466.1"}],"isoformId":"Q7TPN3-1"},{"database":"RefSeq","id":"NP_848813.3","properties":[{"key":"NucleotideSequenceId","value":"NM_178698.5"}],"isoformId":"Q7TPN3-1"},{"database":"AlphaFoldDB","id":"Q7TPN3","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q7TPN3","properties":[{"key":"Number of interactors","value":"604"}]},{"database":"STRING","id":"10090.ENSMUSP00000050647","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q7TPN3","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000050647","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"288160","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPN3-1"},{"database":"ProteomicsDB","id":"288161","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPN3-2"},{"database":"Antibodypedia","id":"30687","properties":[{"key":"antibodies","value":"102 antibodies from 18 providers"}]},{"database":"Ensembl","id":"ENSMUST00000062118.11","properties":[{"key":"ProteinId","value":"ENSMUSP00000050647.5"},{"key":"GeneId","value":"ENSMUSG00000043257.16"}],"isoformId":"Q7TPN3-1"},{"database":"Ensembl","id":"ENSMUST00000067902.13","properties":[{"key":"ProteinId","value":"ENSMUSP00000065601.7"},{"key":"GeneId","value":"ENSMUSG00000043257.16"}],"isoformId":"Q7TPN3-2"},{"database":"GeneID","id":"230801","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:230801","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008vdf.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q7TPN3-1"},{"database":"UCSC","id":"uc008vdg.2","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q7TPN3-2"},{"database":"AGR","id":"MGI:2442480","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55650","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2442480","properties":[{"key":"GeneName","value":"Pigv"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000043257","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG2647","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000013174","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_029048_3_2_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q7TPN3","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GALFIWC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10252502at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q7TPN3","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-162710","properties":[{"key":"PathwayName","value":"Synthesis of glycosylphosphatidylinositol (GPI)"}]},{"database":"UniPathway","id":"UPA00196","properties":[{"key":"RectionId","value":"-"}]},{"database":"BioGRID-ORCS","id":"230801","properties":[{"key":"hits","value":"11 hits in 76 CRISPR screens"}]},{"database":"PRO","id":"PR:Q7TPN3","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 4"}]},{"database":"RNAct","id":"Q7TPN3","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000043257","properties":[{"key":"ExpressionPatterns","value":"Expressed in ear vesicle and 200 other cell types or tissues"}]},{"database":"GO","id":"GO:0005783","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031501","properties":[{"key":"GoTerm","value":"C:mannosyltransferase complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0000009","properties":[{"key":"GoTerm","value":"F:alpha-1,6-mannosyltransferase activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0120563","properties":[{"key":"GoTerm","value":"F:dol-P-Man:Man(1)GlcN-acyl-PI alpha-1,6-mannosyltransferase activity"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0000030","properties":[{"key":"GoTerm","value":"F:mannosyltransferase activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006506","properties":[{"key":"GoTerm","value":"P:GPI anchor biosynthetic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"InterPro","id":"IPR007315","properties":[{"key":"EntryName","value":"PIG-V/Gpi18"}]},{"database":"PANTHER","id":"PTHR12468","properties":[{"key":"EntryName","value":"GPI MANNOSYLTRANSFERASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12468:SF2","properties":[{"key":"EntryName","value":"GPI MANNOSYLTRANSFERASE 2"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04188","properties":[{"key":"EntryName","value":"Mannosyl_trans2"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGLLDPSQKEVLRFAVNCRILTLVLQALFNLIIPDHHADAFCPPRLAPSGSADQLVEGLLGGLSRWDAEHFLFIAEHGYLYEHNFAFFPGFPLALLMGTELLRPLQGLLSQRSCLLVSVALLNLLFSVLAAVALHDLGCLVLHCPRQALCAALLFCISPANVFLAAGYSEALFAFLTFSAMGQLERGRGWASGLLFALAAGVRSNGLVSLGFLLHSQCRGFCSSLAVLSPWKPLVKLMASVCLSVLIVSLPFALFQYRAYIQFCSPGSAPSIPEPLLQLAADKGYRLAGENAPPWCSWDLPLIYNYIQDVYWNVGLLRYYELKQVPNFLLATPVTVLVVWATWTYVTTHPWLCLTLGLQRTKDRENPEKPHRGFLSPKVFVYLVHAAALLVFGGLCMHVQVLTRFLASSTPIMYWFPAHLLQDQEPLLRCVDTEPGKLPQEKSPPGQKAPRNCLMKLFYDWKRCSPVTRCVLVYFLTYWLLGLILHCNFLPWT","length":493,"molWeight":55026,"crc64":"8A176D43F3CB7F4C","md5":"10CFC56D75E7B7EF04CF0C472A2E7D08"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"PTM":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":11,"Transmembrane":10,"Alternative sequence":1,"Sequence conflict":2},"uniParcId":"UPI00000EB9E9"}}