{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7TPM5","secondaryAccessions":["Q3TTJ0","Q3U293","Q9D9W4"],"uniProtkbId":"SACA9_MOUSE","entryAudit":{"firstPublicDate":"2005-07-05","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2003-10-01","entryVersion":124,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Sperm acrosome-associated protein 9"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24256100"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"Acrosome and sperm tail protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"24256100"},{"evidenceCode":"ECO:0000303","source":"Reference","id":"Ref.4"}],"value":"MAST"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1917237"}],"value":"Spaca9"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37865089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37989994"}],"value":"Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) of multiciliated respiratory cells and the distal singlet microtubules of monoflagellated spermatozoa (PubMed:37865089, PubMed:37989994). Forms an extensive interaction network cross-linking the lumen of axonemal doublet microtubules (PubMed:37865089)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"},{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96E40"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24256100"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37865089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37989994"}],"value":"Microtubule inner protein component of sperm flagellar doublet microtubules (PubMed:37865089, PubMed:37989994). Interacts with CABP1 and CALR (PubMed:24256100). Interacts with INCA1 (By similarity). Interacts with microtubules (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24256100"}],"value":"In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24256100"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24256100"}],"value":"Cytoplasmic vesicle, secretory vesicle, acrosome","id":"SL-0007"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27914912"}],"value":"Cytoplasm, cytoskeleton, cilium basal body","id":"SL-0087"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27914912"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37865089"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"37989994"}],"value":"Cytoplasm, cytoskeleton, flagellum axoneme","id":"SL-0114"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q96E40"}],"value":"Cytoplasm, cytoskeleton, cilium axoneme","id":"SL-0304"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"}],"value":"Nucleus","id":"SL-0191"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q7TPM5-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q7TPM5-2"],"sequenceIds":["VSP_046487","VSP_046488"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24256100"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27914912"},{"evidenceCode":"ECO:0000269","source":"Reference","id":"Ref.4"}],"value":"Expressed in sperm (at protein level) (Ref.4). Expressed from almost all the cell types of testis, with abundant expression in round and elongated spermatids (at protein level) (PubMed:24256100). Predominantly expressed in tissues containing motile cilia (PubMed:27914912)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27914912"}],"value":"Expressed in the developing fetal lung epithelium (at protein level)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"27914912"}],"value":"Expression is activated by FOXJ1 and NOTO"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34471926"}],"value":"Deficient mice are viable, fertile, and have no clear phenotypic differences from wild-type mice"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"Sperm acrosome-associated protein 9","featureId":"PRO_0000089674"},{"type":"Site","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":117,"modifier":"EXACT"}},"description":"Essential for interaction with INCA1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"}]},{"type":"Site","location":{"start":{"value":119,"modifier":"EXACT"},"end":{"value":119,"modifier":"EXACT"}},"description":"Essential for interaction with INCA1","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q4V8P4"}]},{"type":"Alternative sequence","location":{"start":{"value":117,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_046487","alternativeSequence":{"originalSequence":"YPHEVVNHLSCDEARNH","alternativeSequences":["GRHSFCTVASSGGDIQE"]}},{"type":"Alternative sequence","location":{"start":{"value":134,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_046488","alternativeSequence":{}},{"type":"Sequence conflict","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"in Ref. 1; BAB24565","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["D"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0969","category":"Cellular component","name":"Cilium"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0968","category":"Cellular component","name":"Cytoplasmic vesicle"},{"id":"KW-0206","category":"Cellular component","name":"Cytoskeleton"},{"id":"KW-0282","category":"Cellular component","name":"Flagellum"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"NOD","type":"STRAIN"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"CI-70VOHH7BF94TO","citationType":"submission","authors":["Mural R.J.","Adams M.D.","Myers E.W.","Smith H.O.","Venter J.C."],"publicationDate":"JUL-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"CI-DQS4OQ05D77K","citationType":"submission","authors":["Bhattacharya R.","Dhople V.M.","Jesudasan R.A."],"title":"Novel miRNA cluster generated by extensive alternate splicing of a multicopy non-coding RNA from mouse Y-heterochromatin.","publicationDate":"JUN-2009","submissionDatabase":"UniProtKB"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","TISSUE SPECIFICITY"],"referenceComments":[{"value":"RIII","type":"STRAIN"},{"value":"Sperm","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"24256100","citationType":"journal article","authors":["Bhattacharya R.","Devi M.S.","Dhople V.M.","Jesudasan R.A."],"citationCrossReferences":[{"database":"PubMed","id":"24256100"},{"database":"DOI","id":"10.1186/1471-2121-14-50"}],"title":"A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome.","publicationDate":"2013","journal":"BMC Cell Biol.","firstPage":"50","lastPage":"50","volume":"14"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY","TISSUE SPECIFICITY","SUBCELLULAR LOCATION","INTERACTION WITH CABP1 AND CALR"]},{"referenceNumber":7,"citation":{"id":"27914912","citationType":"journal article","authors":["Stauber M.","Weidemann M.","Dittrich-Breiholz O.","Lobschat K.","Alten L.","Mai M.","Beckers A.","Kracht M.","Gossler A."],"citationCrossReferences":[{"database":"PubMed","id":"27914912"},{"database":"DOI","id":"10.1016/j.ydbio.2016.11.019"}],"title":"Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.","publicationDate":"2017","journal":"Dev. Biol.","firstPage":"170","lastPage":"188","volume":"423"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DEVELOPMENTAL STAGE","INDUCTION"]},{"referenceNumber":8,"citation":{"id":"34471926","citationType":"journal article","authors":["Castaneda J.M.","Shimada K.","Satouh Y.","Yu Z.","Devlin D.J.","Ikawa M.","Matzuk M.M."],"citationCrossReferences":[{"database":"PubMed","id":"34471926"},{"database":"DOI","id":"10.1242/jcs.259206"}],"title":"FAM209 associates with DPY19L2, and is required for sperm acrosome biogenesis and fertility in mice.","publicationDate":"2021","journal":"J. Cell Sci.","firstPage":"0","lastPage":"0","volume":"134"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":9,"citation":{"id":"37865089","citationType":"journal article","authors":["Chen Z.","Shiozaki M.","Haas K.M.","Skinner W.M.","Zhao S.","Guo C.","Polacco B.J.","Yu Z.","Krogan N.J.","Lishko P.V.","Kaake R.M.","Vale R.D.","Agard D.A."],"citationCrossReferences":[{"database":"PubMed","id":"37865089"},{"database":"DOI","id":"10.1016/j.cell.2023.09.017"}],"title":"De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking.","publicationDate":"2023","journal":"Cell","firstPage":"5041","lastPage":"5053","volume":"186"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (7.70 ANGSTROMS) OF SPERM FLAGELLAR DOUBLET MICROTUBULES","FUNCTION","SUBCELLULAR LOCATION","SUBUNIT"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8TO0"}]},{"referenceNumber":10,"citation":{"id":"37989994","citationType":"journal article","authors":["Tai L.","Yin G.","Huang X.","Sun F.","Zhu Y."],"citationCrossReferences":[{"database":"PubMed","id":"37989994"},{"database":"DOI","id":"10.1038/s41421-023-00606-3"}],"title":"In-cell structural insight into the stability of sperm microtubule doublet.","publicationDate":"2023","journal":"Cell Discov.","firstPage":"116","lastPage":"116","volume":"9"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (4.50 ANGSTROMS)","FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"8I7O"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"8I7R"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK006393","properties":[{"key":"ProteinId","value":"BAB24565.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK155408","properties":[{"key":"ProteinId","value":"BAE33249.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK161340","properties":[{"key":"ProteinId","value":"BAE36335.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"CH466542","properties":[{"key":"ProteinId","value":"EDL08395.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC055108","properties":[{"key":"ProteinId","value":"AAH55108.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS15845.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPM5-1"},{"database":"RefSeq","id":"NP_081559.1","properties":[{"key":"NucleotideSequenceId","value":"NM_027283.1"}],"isoformId":"Q7TPM5-1"},{"database":"PDB","id":"8I7O","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.50 A"},{"key":"Chains","value":"YI/YJ/YK/YL/YM/YN=1-168"}]},{"database":"PDB","id":"8I7R","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"6.50 A"},{"key":"Chains","value":"YA/YB/YC/YD/YE/YF/YG/YH/YI/YJ/YK/YL/YM/YN/YO/YP/YQ/YR/YS/YT/YU/YV/YW=1-168"}]},{"database":"PDB","id":"8TO0","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.70 A"},{"key":"Chains","value":"F0/F1/F2/F3/F4/F5/F6/F7/F8/F9/GA/GB/GC/GD/GE/GF/GG/GH/GI/GJ/GK/GL/GM/GN/GO/GP/GQ=1-168"}]},{"database":"PDB","id":"9IJJ","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"7.70 A"},{"key":"Chains","value":"1A/1B/1C/1D/1E/1F/1G/1I/1J/1K/1L/1M/1N/1O/1P/1Q/1R/1S/1T/1U/1V/1W/1X/1Y/1Z/1a/1b/1c/1d/1e=1-168"}]},{"database":"PDBsum","id":"8I7O","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8I7R","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"8TO0","properties":[{"key":"Description","value":"-"}]},{"database":"PDBsum","id":"9IJJ","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35229","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-35230","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-41431","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-60633","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q7TPM5","properties":[{"key":"Number of interactors","value":"155"}]},{"database":"STRING","id":"10090.ENSMUSP00000121846","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000121846","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"256584","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPM5-1"},{"database":"ProteomicsDB","id":"256585","properties":[{"key":"Description","value":"-"}],"isoformId":"Q7TPM5-2"},{"database":"Antibodypedia","id":"18219","properties":[{"key":"antibodies","value":"54 antibodies from 14 providers"}]},{"database":"DNASU","id":"69987","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000102877.8","properties":[{"key":"ProteinId","value":"ENSMUSP00000099941.2"},{"key":"GeneId","value":"ENSMUSG00000026809.16"}],"isoformId":"Q7TPM5-1"},{"database":"Ensembl","id":"ENSMUST00000124840.2","properties":[{"key":"ProteinId","value":"ENSMUSP00000121846.2"},{"key":"GeneId","value":"ENSMUSG00000026809.16"}],"isoformId":"Q7TPM5-1"},{"database":"GeneID","id":"69987","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:69987","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc008iza.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q7TPM5-1"},{"database":"UCSC","id":"uc008izc.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q7TPM5-2"},{"database":"AGR","id":"MGI:1917237","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"11092","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1917237","properties":[{"key":"GeneName","value":"Spaca9"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000026809","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QQV9","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00390000007746","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_100443_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"EHHCYNS","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9999829at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID-ORCS","id":"69987","properties":[{"key":"hits","value":"0 hits in 78 CRISPR screens"}]},{"database":"PRO","id":"PR:Q7TPM5","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 2"}]},{"database":"RNAct","id":"Q7TPM5","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000026809","properties":[{"key":"ExpressionPatterns","value":"Expressed in seminiferous tubule of testis and 89 other cell types or tissues"}]},{"database":"GO","id":"GO:0001669","properties":[{"key":"GoTerm","value":"C:acrosomal vesicle"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24256100"}]},{"database":"GO","id":"GO:0005879","properties":[{"key":"GoTerm","value":"C:axonemal microtubule"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0160110","properties":[{"key":"GoTerm","value":"C:axonemal microtubule doublet inner sheath"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37865089"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37989994"}]},{"database":"GO","id":"GO:0005930","properties":[{"key":"GoTerm","value":"C:axoneme"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0036064","properties":[{"key":"GoTerm","value":"C:ciliary basal body"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27914912"}]},{"database":"GO","id":"GO:0097546","properties":[{"key":"GoTerm","value":"C:ciliary base"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"27914912"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24256100"}]},{"database":"GO","id":"GO:0005881","properties":[{"key":"GoTerm","value":"C:cytoplasmic microtubule"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005829","properties":[{"key":"GoTerm","value":"C:cytosol"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0097229","properties":[{"key":"GoTerm","value":"C:sperm end piece"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0036126","properties":[{"key":"GoTerm","value":"C:sperm flagellum"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37865089"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37989994"}]},{"database":"GO","id":"GO:0048306","properties":[{"key":"GoTerm","value":"F:calcium-dependent protein binding"},{"key":"GoEvidenceType","value":"IPI:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"24256100"}]},{"database":"GO","id":"GO:0008017","properties":[{"key":"GoTerm","value":"F:microtubule binding"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035082","properties":[{"key":"GoTerm","value":"P:axoneme assembly"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0030317","properties":[{"key":"GoTerm","value":"P:flagellated sperm motility"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37865089"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"37989994"}]},{"database":"InterPro","id":"IPR027818","properties":[{"key":"EntryName","value":"SPACA9"}]},{"database":"PANTHER","id":"PTHR32455","properties":[{"key":"EntryName","value":"SPERM ACROSOME-ASSOCIATED PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR32455:SF1","properties":[{"key":"EntryName","value":"SPERM ACROSOME-ASSOCIATED PROTEIN 9"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF15120","properties":[{"key":"EntryName","value":"SPACA9"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MNEVKESLRSIEQKYKLFQQQQFTFIAALEHCRENAHDKIRPISSIEQVQSYMEHYCNNSTHRRILIMFMDICSELSKLCQHFEALHSGTPVTNSLLEKCKTLVSQSNDLSSLRAKYPHEVVNHLSCDEARNHYGGVVSLIPIVLDFMKEWIAHSEKLPRKVLQHGTT","length":168,"molWeight":19482,"crc64":"650C8FE0B6BA325E","md5":"CDFEB770C417B30279153CB7962558D2"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":2,"TISSUE SPECIFICITY":1,"DEVELOPMENTAL STAGE":1,"INDUCTION":1,"DISRUPTION PHENOTYPE":1},"countByFeatureType":{"Chain":1,"Site":2,"Alternative sequence":2,"Sequence conflict":1},"uniParcId":"UPI00001B2CC4"}}