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Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3KP66"}],"value":"Interacts with IRAK1, NOD2 and RIPK2; the interaction takes place upon PRR stimulation. Interacts with YWHAQ/14-3-3T; the interaction increases upon PRR stimulation and is required for cellular signaling pathway activation and cytokine secretion. Interacts (via N-terminal domain) with CYTH1 and CYTH2 (via their N-terminal domains). Interacts with FBXW11 and BTRC; associates with SCF E3 ubiquitin-protein ligase complexes (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3KP66"}],"value":"Translocates to the nucleus upon NOD2 stimulation"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3KP66"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q3KP66"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29420262"}],"value":"After infection with Citrobacter rodentium, mutants show significantly increased bacterial loads at day 5 compared to wild-types. They are able to control the infection by day 12 post-infection, they exhibit significantly shortened colon length. They don't have impaired cytokine response (PubMed:29420262). Mutants also exhibit impaired recovery from dextran sodium sulfate-induces colitis, they show increased body weight loss and reduced colon length (PubMed:29420262)"}],"commentType":"DISRUPTION PHENOTYPE"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":663,"modifier":"EXACT"}},"description":"Innate immunity activator 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