{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7TLC7","uniProtkbId":"Y14_SARS","entryAudit":{"firstPublicDate":"2007-05-29","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2003-10-01","entryVersion":48,"sequenceVersion":1},"annotationScore":2.0,"organism":{"scientificName":"Severe acute respiratory syndrome coronavirus","commonName":"SARS-CoV","taxonId":694009,"lineage":["Viruses","Riboviria","Orthornavirae","Pisuviricota","Pisoniviricetes","Nidovirales","Cornidovirineae","Coronaviridae","Orthocoronavirinae","Betacoronavirus","Sarbecovirus","Betacoronavirus pandemicum"]},"organismHosts":[{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606},{"scientificName":"Paguma larvata","commonName":"Masked palm civet","taxonId":9675}],"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Uncharacterized protein 14"}}},"genes":[{"orfNames":[{"value":"ORF14"}]}],"comments":[{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q7TLC7","intActId":"EBI-25488942"},"interactantTwo":{"uniProtKBAccession":"P59636","geneName":"9b","intActId":"EBI-9021274"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7TLC7","intActId":"EBI-25488942"},"interactantTwo":{"uniProtKBAccession":"Q7TLC7","geneName":"ORF14","intActId":"EBI-25488942"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7TLC7","intActId":"EBI-25488942"},"interactantTwo":{"uniProtKBAccession":"Q13561","geneName":"DCTN2","intActId":"EBI-715074"},"numberOfExperiments":2,"organismDiffer":true},{"interactantOne":{"uniProtKBAccession":"Q7TLC7","intActId":"EBI-25488942"},"interactantTwo":{"uniProtKBAccession":"O14964","geneName":"HGS","intActId":"EBI-740220"},"numberOfExperiments":2,"organismDiffer":true}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":70,"modifier":"EXACT"}},"description":"Uncharacterized protein 14","featureId":"PRO_0000289937"}],"keywords":[{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"12730501","citationType":"journal article","authors":["Marra M.A.","Jones S.J.M.","Astell C.R.","Holt R.A.","Brooks-Wilson A.","Butterfield Y.S.N.","Khattra J.","Asano J.K.","Barber S.A.","Chan S.Y.","Cloutier A.","Coughlin S.M.","Freeman D.","Girn N.","Griffith O.L.","Leach S.R.","Mayo M.","McDonald H.","Montgomery S.B.","Pandoh P.K.","Petrescu A.S.","Robertson A.G.","Schein J.E.","Siddiqui A.","Smailus D.E.","Stott J.M.","Yang G.S.","Plummer F.","Andonov A.","Artsob H.","Bastien N.","Bernard K.","Booth T.F.","Bowness D.","Czub M.","Drebot M.","Fernando L.","Flick R.","Garbutt M.","Gray M.","Grolla A.","Jones S.","Feldmann H.","Meyers A.","Kabani A.","Li Y.","Normand S.","Stroher U.","Tipples G.A.","Tyler S.","Vogrig R.","Ward D.","Watson B.","Brunham R.C.","Krajden M.","Petric M.","Skowronski D.M.","Upton C.","Roper R.L."],"citationCrossReferences":[{"database":"PubMed","id":"12730501"},{"database":"DOI","id":"10.1126/science.1085953"}],"title":"The genome sequence of the SARS-associated coronavirus.","publicationDate":"2003","journal":"Science","firstPage":"1399","lastPage":"1404","volume":"300"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC RNA]"],"referenceComments":[{"value":"Isolate Tor2","type":"STRAIN"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY274119","properties":[{"key":"ProteinId","value":"AAP41049.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_RNA"}]},{"database":"AlphaFoldDB","id":"Q7TLC7","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"4383925","properties":[{"key":"Interactions","value":"11"}]},{"database":"IntAct","id":"Q7TLC7","properties":[{"key":"Interactions","value":"30"}]},{"database":"MINT","id":"Q7TLC7","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000354","properties":[{"key":"Component","value":"Segment"}]},{"database":"GO","id":"GO:0042802","properties":[{"key":"GoTerm","value":"F:identical protein binding"},{"key":"GoEvidenceType","value":"IPI:IntAct"}],"evidences":[{"evidenceCode":"ECO:0000353","source":"PubMed","id":"17520018"}]},{"database":"CDD","id":"cd21976","properties":[{"key":"EntryName","value":"SARS-CoV_ORF9c"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR035113","properties":[{"key":"EntryName","value":"Protein_14_SARS-like"}]},{"database":"Pfam","id":"PF17635","properties":[{"key":"EntryName","value":"bCoV_Orf14"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MLPPCYNFLKEQHCQKASTQREAEAAVKPLLAPHHVVAVIQEIQLLAAVGEILLLEWLAEVVKLPSRYCC","length":70,"molWeight":7852,"crc64":"9FCDB5ADCD6CF79A","md5":"C2E8B33AC99B9ED97BBFA325B749FE23"},"extraAttributes":{"countByCommentType":{"INTERACTION":4},"countByFeatureType":{"Chain":1},"uniParcId":"UPI000019AC3E"}}