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The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:25535373, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20676083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21636303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25535373"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29042515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34887561"}],"value":"Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and localizes BAG6 to the cytosol (PubMed:21636303, PubMed:25535373, PubMed:29042515). Interacts with GET3 (PubMed:34887561)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"Q9NX04","geneName":"AIRIM","intActId":"EBI-8643161"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"P46379-2","geneName":"BAG6","intActId":"EBI-10988864"},"numberOfExperiments":4,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"Q9H596","geneName":"DUSP21","intActId":"EBI-7357329"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"Q9H0I2","geneName":"ENKD1","intActId":"EBI-744099"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"P35555","geneName":"FBN1","intActId":"EBI-2505934"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"O43681","geneName":"GET3","intActId":"EBI-2515857"},"numberOfExperiments":7,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"Q14161-11","geneName":"GIT2","intActId":"EBI-12028686"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"Q9BYQ3","geneName":"KRTAP9-3","intActId":"EBI-1043191"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"P69849","geneName":"NOMO3","intActId":"EBI-947048"},"numberOfExperiments":2,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"Q9BW27","geneName":"NUP85","intActId":"EBI-716392"},"numberOfExperiments":3,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"O43741","geneName":"PRKAB2","intActId":"EBI-1053424"},"numberOfExperiments":8,"organismDiffer":false},{"interactantOne":{"uniProtKBAccession":"Q7L5D6","intActId":"EBI-711823"},"interactantTwo":{"uniProtKBAccession":"O00560","geneName":"SDCBP","intActId":"EBI-727004"},"numberOfExperiments":3,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20676083"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21636303"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29042515"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32395830"}],"value":"Cytoplasm, cytosol","id":"SL-0091"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q7L5D6-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q7L5D6-2"],"sequenceIds":["VSP_017652"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"29042515"}],"value":"Ubiquitinated by RNF12, leading to proteasomal degradation. 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CDG2Y is an autosomal recessive form characterized by poor overall growth and global developmental delay with impaired intellectual development. 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