{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7L1W4","secondaryAccessions":["D3DT29","Q6UWB2","Q9NVW3"],"uniProtkbId":"LRC8D_HUMAN","entryAudit":{"firstPublicDate":"2004-08-31","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":181,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BGR2"}],"value":"Volume-regulated anion channel subunit LRRC8D"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16992"}],"value":"Leucine-rich repeat-containing protein 5"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22532330"}],"value":"Leucine-rich repeat-containing protein 8D"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32415200"}],"value":"HsLRRC8D"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"22532330"},{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16992"}],"value":"LRRC8D"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:16992"}],"value":"LRRC5"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12975309"}],"value":"UNQ213/PRO239"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BGR2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24782309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24790029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26530471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26824658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28193731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"33171122"}],"value":"Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (By similarity). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"chloride(in) = chloride(out)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:29823"},{"database":"ChEBI","id":"CHEBI:17996"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"iodide(out) = iodide(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66324"},{"database":"ChEBI","id":"CHEBI:16382"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"taurine(out) = taurine(in)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:66328"},{"database":"ChEBI","id":"CHEBI:507393"}],"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8BGR2"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24782309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24790029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26530471"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26824658"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28193731"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"}],"value":"Heterohexamer; oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E) to form a heterohexamer (PubMed:24782309, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:32415200). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"INTERACTION","interactions":[{"interactantOne":{"uniProtKBAccession":"Q7L1W4","intActId":"EBI-861997"},"interactantTwo":{"uniProtKBAccession":"Q8IWT6","geneName":"LRRC8A","intActId":"EBI-10970086"},"numberOfExperiments":2,"organismDiffer":false}]},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24782309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24790029"}],"value":"In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029)"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24782309"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24790029"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28193731"}],"value":"Cell membrane","id":"SL-0039"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"}],"value":"Multi-pass membrane protein","id":"SL-9909"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24782309"},{"evidenceCode":"ECO:0000305","source":"PubMed","id":"24790029"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"}],"value":"The volume-regulated anion channel (VRAC) channel forms a trimer of dimers, with symmetry mismatch between the pore-forming domain and the cytosolic LRR repeats, a topology similar to gap junction proteins"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the LRRC8 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAQ89233.1","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"BAA91631.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":858,"modifier":"EXACT"}},"description":"Volume-regulated anion channel subunit LRRC8D","featureId":"PRO_0000084493"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":22,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Transmembrane","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":48,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Topological domain","location":{"start":{"value":49,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Transmembrane","location":{"start":{"value":164,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Topological domain","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Transmembrane","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":328,"modifier":"EXACT"}},"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Topological domain","location":{"start":{"value":329,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Transmembrane","location":{"start":{"value":361,"modifier":"EXACT"},"end":{"value":386,"modifier":"EXACT"}},"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Topological domain","location":{"start":{"value":387,"modifier":"EXACT"},"end":{"value":858,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Repeat","location":{"start":{"value":514,"modifier":"EXACT"},"end":{"value":534,"modifier":"EXACT"}},"description":"LRR 1"},{"type":"Repeat","location":{"start":{"value":538,"modifier":"EXACT"},"end":{"value":559,"modifier":"EXACT"}},"description":"LRR 2"},{"type":"Repeat","location":{"start":{"value":561,"modifier":"EXACT"},"end":{"value":582,"modifier":"EXACT"}},"description":"LRR 3"},{"type":"Repeat","location":{"start":{"value":589,"modifier":"EXACT"},"end":{"value":609,"modifier":"EXACT"}},"description":"LRR 4"},{"type":"Repeat","location":{"start":{"value":612,"modifier":"EXACT"},"end":{"value":632,"modifier":"EXACT"}},"description":"LRR 5"},{"type":"Repeat","location":{"start":{"value":636,"modifier":"EXACT"},"end":{"value":657,"modifier":"EXACT"}},"description":"LRR 6"},{"type":"Repeat","location":{"start":{"value":659,"modifier":"EXACT"},"end":{"value":680,"modifier":"EXACT"}},"description":"LRR 7"},{"type":"Repeat","location":{"start":{"value":684,"modifier":"EXACT"},"end":{"value":705,"modifier":"EXACT"}},"description":"LRR 8"},{"type":"Repeat","location":{"start":{"value":707,"modifier":"EXACT"},"end":{"value":728,"modifier":"EXACT"}},"description":"LRR 9"},{"type":"Repeat","location":{"start":{"value":730,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"LRR 10"},{"type":"Repeat","location":{"start":{"value":753,"modifier":"EXACT"},"end":{"value":774,"modifier":"EXACT"}},"description":"LRR 11"},{"type":"Repeat","location":{"start":{"value":776,"modifier":"EXACT"},"end":{"value":797,"modifier":"EXACT"}},"description":"LRR 12"},{"type":"Repeat","location":{"start":{"value":799,"modifier":"EXACT"},"end":{"value":820,"modifier":"EXACT"}},"description":"LRR 13"},{"type":"Region","location":{"start":{"value":221,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":227,"modifier":"EXACT"},"end":{"value":251,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Modified residue","location":{"start":{"value":241,"modifier":"EXACT"},"end":{"value":241,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":242,"modifier":"EXACT"},"end":{"value":242,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"18669648"}]},{"type":"Modified residue","location":{"start":{"value":246,"modifier":"EXACT"},"end":{"value":246,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0007744","source":"PubMed","id":"20068231"},{"evidenceCode":"ECO:0007744","source":"PubMed","id":"23186163"}]},{"type":"Disulfide bond","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":354,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"},{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]},{"type":"Natural variant","location":{"start":{"value":371,"modifier":"EXACT"},"end":{"value":371,"modifier":"EXACT"}},"description":"in dbSNP:rs11552246","featureCrossReferences":[{"database":"dbSNP","id":"rs11552246"}],"featureId":"VAR_051132","alternativeSequence":{"originalSequence":"S","alternativeSequences":["Y"]}},{"type":"Mutagenesis","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":44,"modifier":"EXACT"}},"description":"Alters channel anion selectivity.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"26824658"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["C"]}},{"type":"Mutagenesis","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"Affects ion selectivity of the channel. Reduced permeability to negatively charged glutamate and gluconate.","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32415200"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-0002","category":"Technical term","name":"3D-structure"},{"id":"KW-1003","category":"Cellular component","name":"Cell membrane"},{"id":"KW-1015","category":"PTM","name":"Disulfide bond"},{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0407","category":"Molecular function","name":"Ion channel"},{"id":"KW-0406","category":"Biological process","name":"Ion transport"},{"id":"KW-0433","category":"Domain","name":"Leucine-rich repeat"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"},{"id":"KW-0813","category":"Biological process","name":"Transport"}],"references":[{"referenceNumber":1,"citation":{"id":"16710414","citationType":"journal article","authors":["Gregory S.G.","Barlow K.F.","McLay K.E.","Kaul R.","Swarbreck D.","Dunham A.","Scott C.E.","Howe K.L.","Woodfine K.","Spencer C.C.A.","Jones M.C.","Gillson C.","Searle S.","Zhou Y.","Kokocinski F.","McDonald L.","Evans R.","Phillips K.","Atkinson A.","Cooper R.","Jones C.","Hall R.E.","Andrews T.D.","Lloyd C.","Ainscough R.","Almeida J.P.","Ambrose K.D.","Anderson F.","Andrew R.W.","Ashwell R.I.S.","Aubin K.","Babbage A.K.","Bagguley C.L.","Bailey J.","Beasley H.","Bethel G.","Bird C.P.","Bray-Allen S.","Brown J.Y.","Brown A.J.","Buckley D.","Burton J.","Bye J.","Carder C.","Chapman J.C.","Clark S.Y.","Clarke G.","Clee C.","Cobley V.","Collier R.E.","Corby N.","Coville G.J.","Davies J.","Deadman R.","Dunn M.","Earthrowl M.","Ellington A.G.","Errington H.","Frankish A.","Frankland J.","French L.","Garner P.","Garnett J.","Gay L.","Ghori M.R.J.","Gibson R.","Gilby L.M.","Gillett W.","Glithero R.J.","Grafham D.V.","Griffiths C.","Griffiths-Jones S.","Grocock R.","Hammond S.","Harrison E.S.I.","Hart E.","Haugen E.","Heath P.D.","Holmes S.","Holt K.","Howden P.J.","Hunt A.R.","Hunt S.E.","Hunter G.","Isherwood J.","James R.","Johnson C.","Johnson D.","Joy A.","Kay M.","Kershaw J.K.","Kibukawa M.","Kimberley A.M.","King A.","Knights A.J.","Lad H.","Laird G.","Lawlor S.","Leongamornlert D.A.","Lloyd D.M.","Loveland J.","Lovell J.","Lush M.J.","Lyne R.","Martin S.","Mashreghi-Mohammadi M.","Matthews L.","Matthews N.S.W.","McLaren S.","Milne S.","Mistry S.","Moore M.J.F.","Nickerson T.","O'Dell C.N.","Oliver K.","Palmeiri A.","Palmer S.A.","Parker A.","Patel D.","Pearce A.V.","Peck A.I.","Pelan S.","Phelps K.","Phillimore B.J.","Plumb R.","Rajan J.","Raymond C.","Rouse G.","Saenphimmachak C.","Sehra H.K.","Sheridan E.","Shownkeen R.","Sims S.","Skuce C.D.","Smith M.","Steward C.","Subramanian S.","Sycamore N.","Tracey A.","Tromans A.","Van Helmond Z.","Wall M.","Wallis J.M.","White S.","Whitehead S.L.","Wilkinson J.E.","Willey D.L.","Williams H.","Wilming L.","Wray P.W.","Wu Z.","Coulson A.","Vaudin M.","Sulston J.E.","Durbin R.M.","Hubbard T.","Wooster R.","Dunham I.","Carter N.P.","McVean G.","Ross M.T.","Harrow J.","Olson M.V.","Beck S.","Rogers J.","Bentley D.R."],"citationCrossReferences":[{"database":"PubMed","id":"16710414"},{"database":"DOI","id":"10.1038/nature04727"}],"title":"The DNA sequence and biological annotation of human chromosome 1.","publicationDate":"2006","journal":"Nature","firstPage":"315","lastPage":"321","volume":"441"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":2,"citation":{"id":"CI-5GBD0VIIJ7C63","citationType":"submission","authors":["Mural R.J.","Istrail S.","Sutton G.G.","Florea L.","Halpern A.L.","Mobarry C.M.","Lippert R.","Walenz B.","Shatkay H.","Dew I.","Miller J.R.","Flanigan M.J.","Edwards N.J.","Bolanos R.","Fasulo D.","Halldorsson B.V.","Hannenhalli S.","Turner R.","Yooseph S.","Lu F.","Nusskern D.R.","Shue B.C.","Zheng X.H.","Zhong F.","Delcher A.L.","Huson D.H.","Kravitz S.A.","Mouchard L.","Reinert K.","Remington K.A.","Clark A.G.","Waterman M.S.","Eichler E.E.","Adams M.D.","Hunkapiller M.W.","Myers E.W.","Venter J.C."],"publicationDate":"SEP-2005","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"Placenta","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-858"]},{"referenceNumber":5,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 335-858"]},{"referenceNumber":6,"citation":{"id":"22532330","citationType":"journal article","authors":["Abascal F.","Zardoya R."],"citationCrossReferences":[{"database":"PubMed","id":"22532330"},{"database":"DOI","id":"10.1002/bies.201100173"}],"title":"LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication.","publicationDate":"2012","journal":"Bioessays","firstPage":"551","lastPage":"560","volume":"34"},"referencePositions":["IDENTIFICATION"]},{"referenceNumber":7,"citation":{"id":"18669648","citationType":"journal article","authors":["Dephoure N.","Zhou C.","Villen J.","Beausoleil S.A.","Bakalarski C.E.","Elledge S.J.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"18669648"},{"database":"DOI","id":"10.1073/pnas.0805139105"}],"title":"A quantitative atlas of mitotic phosphorylation.","publicationDate":"2008","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"10762","lastPage":"10767","volume":"105"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241 AND SER-242","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":8,"citation":{"id":"20068231","citationType":"journal article","authors":["Olsen J.V.","Vermeulen M.","Santamaria A.","Kumar C.","Miller M.L.","Jensen L.J.","Gnad F.","Cox J.","Jensen T.S.","Nigg E.A.","Brunak S.","Mann M."],"citationCrossReferences":[{"database":"PubMed","id":"20068231"},{"database":"DOI","id":"10.1126/scisignal.2000475"}],"title":"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.","publicationDate":"2010","journal":"Sci. Signal.","firstPage":"RA3","lastPage":"RA3","volume":"3"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":9,"citation":{"id":"23186163","citationType":"journal article","authors":["Zhou H.","Di Palma S.","Preisinger C.","Peng M.","Polat A.N.","Heck A.J.","Mohammed S."],"citationCrossReferences":[{"database":"PubMed","id":"23186163"},{"database":"DOI","id":"10.1021/pr300630k"}],"title":"Toward a comprehensive characterization of a human cancer cell phosphoproteome.","publicationDate":"2013","journal":"J. Proteome Res.","firstPage":"260","lastPage":"271","volume":"12"},"referencePositions":["PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246","IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Cervix carcinoma","type":"TISSUE"}]},{"referenceNumber":10,"citation":{"id":"24782309","citationType":"journal article","authors":["Lee C.C.","Freinkman E.","Sabatini D.M.","Ploegh H.L."],"citationCrossReferences":[{"database":"PubMed","id":"24782309"},{"database":"DOI","id":"10.1074/jbc.m114.571257"}],"title":"The protein synthesis inhibitor blasticidin S enters mammalian cells via leucine-rich repeat-containing protein 8D.","publicationDate":"2014","journal":"J. Biol. Chem.","firstPage":"17124","lastPage":"17131","volume":"289"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","TOPOLOGY","INTERACTION WITH LRRC8A; LRRC8B AND LRRC8C"]},{"referenceNumber":11,"citation":{"id":"24790029","citationType":"journal article","authors":["Voss F.K.","Ullrich F.","Muench J.","Lazarow K.","Lutter D.","Mah N.","Andrade-Navarro M.A.","von Kries J.P.","Stauber T.","Jentsch T.J."],"citationCrossReferences":[{"database":"PubMed","id":"24790029"},{"database":"DOI","id":"10.1126/science.1252826"}],"title":"Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.","publicationDate":"2014","journal":"Science","firstPage":"634","lastPage":"638","volume":"344"},"referencePositions":["FUNCTION","TRANSPORTER ACTIVITY","INTERACTION WITH LRRC8A","SUBCELLULAR LOCATION"]},{"referenceNumber":12,"citation":{"id":"26530471","citationType":"journal article","authors":["Planells-Cases R.","Lutter D.","Guyader C.","Gerhards N.M.","Ullrich F.","Elger D.A.","Kucukosmanoglu A.","Xu G.","Voss F.K.","Reincke S.M.","Stauber T.","Blomen V.A.","Vis D.J.","Wessels L.F.","Brummelkamp T.R.","Borst P.","Rottenberg S.","Jentsch T.J."],"citationCrossReferences":[{"database":"PubMed","id":"26530471"},{"database":"DOI","id":"10.15252/embj.201592409"}],"title":"Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs.","publicationDate":"2015","journal":"EMBO J.","firstPage":"2993","lastPage":"3008","volume":"34"},"referencePositions":["FUNCTION"]},{"referenceNumber":13,"citation":{"id":"26824658","citationType":"journal article","authors":["Syeda R.","Qiu Z.","Dubin A.E.","Murthy S.E.","Florendo M.N.","Mason D.E.","Mathur J.","Cahalan S.M.","Peters E.C.","Montal M.","Patapoutian A."],"citationCrossReferences":[{"database":"PubMed","id":"26824658"},{"database":"DOI","id":"10.1016/j.cell.2015.12.031"}],"title":"LRRC8 proteins form volume-regulated anion channels that sense ionic strength.","publicationDate":"2016","journal":"Cell","firstPage":"499","lastPage":"511","volume":"164"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","SUBUNIT","IDENTIFICATION BY MASS SPECTROMETRY","MUTAGENESIS OF THR-44"]},{"referenceNumber":14,"citation":{"id":"28193731","citationType":"journal article","authors":["Lutter D.","Ullrich F.","Lueck J.C.","Kempa S.","Jentsch T.J."],"citationCrossReferences":[{"database":"PubMed","id":"28193731"},{"database":"DOI","id":"10.1242/jcs.196253"}],"title":"Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.","publicationDate":"2017","journal":"J. Cell Sci.","firstPage":"1122","lastPage":"1133","volume":"130"},"referencePositions":["FUNCTION","SUBUNIT","SUBCELLULAR LOCATION"]},{"referenceNumber":15,"citation":{"id":"33171122","citationType":"journal article","authors":["Lahey L.J.","Mardjuki R.E.","Wen X.","Hess G.T.","Ritchie C.","Carozza J.A.","Boehnert V.","Maduke M.","Bassik M.C.","Li L."],"citationCrossReferences":[{"database":"PubMed","id":"33171122"},{"database":"DOI","id":"10.1016/j.molcel.2020.10.021"}],"title":"LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP.","publicationDate":"2020","journal":"Mol. Cell","firstPage":"578","lastPage":"591.e5","volume":"80"},"referencePositions":["FUNCTION"]},{"referenceNumber":16,"citation":{"id":"32415200","citationType":"journal article","authors":["Nakamura R.","Numata T.","Kasuya G.","Yokoyama T.","Nishizawa T.","Kusakizako T.","Kato T.","Hagino T.","Dohmae N.","Inoue M.","Watanabe K.","Ichijo H.","Kikkawa M.","Shirouzu M.","Jentsch T.J.","Ishitani R.","Okada Y.","Nureki O."],"citationCrossReferences":[{"database":"PubMed","id":"32415200"},{"database":"DOI","id":"10.1038/s42003-020-0951-z"}],"title":"Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.","publicationDate":"2020","journal":"Commun. Biol.","firstPage":"240","lastPage":"240","volume":"3"},"referencePositions":["STRUCTURE BY ELECTRON MICROSCOPY (4.36 ANGSTROMS)","FUNCTION","SUBUNIT","TOPOLOGY","DISULFIDE BOND","DOMAIN","MUTAGENESIS OF PHE-143"],"evidences":[{"evidenceCode":"ECO:0007744","source":"PDB","id":"6M04"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL391497","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471097","properties":[{"key":"ProteinId","value":"EAW73130.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471097","properties":[{"key":"ProteinId","value":"EAW73131.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"CH471097","properties":[{"key":"ProteinId","value":"EAW73132.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC024159","properties":[{"key":"ProteinId","value":"AAH24159.2"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK001332","properties":[{"key":"ProteinId","value":"BAA91631.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY358874","properties":[{"key":"ProteinId","value":"AAQ89233.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS726.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001127951.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001134479.2"}]},{"database":"RefSeq","id":"NP_060573.2","properties":[{"key":"NucleotideSequenceId","value":"NM_018103.5"}]},{"database":"RefSeq","id":"XP_011539991.1","properties":[{"key":"NucleotideSequenceId","value":"XM_011541689.2"}]},{"database":"RefSeq","id":"XP_047279896.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423940.1"}]},{"database":"RefSeq","id":"XP_047279899.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423943.1"}]},{"database":"RefSeq","id":"XP_047279900.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423944.1"}]},{"database":"RefSeq","id":"XP_047279902.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423946.1"}]},{"database":"RefSeq","id":"XP_047279903.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423947.1"}]},{"database":"RefSeq","id":"XP_047279906.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423950.1"}]},{"database":"RefSeq","id":"XP_047279909.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423953.1"}]},{"database":"RefSeq","id":"XP_047279910.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423954.1"}]},{"database":"RefSeq","id":"XP_047279912.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423956.1"}]},{"database":"RefSeq","id":"XP_047279917.1","properties":[{"key":"NucleotideSequenceId","value":"XM_047423961.1"}]},{"database":"RefSeq","id":"XP_054193319.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337344.1"}]},{"database":"RefSeq","id":"XP_054193320.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337345.1"}]},{"database":"RefSeq","id":"XP_054193321.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337346.1"}]},{"database":"RefSeq","id":"XP_054193322.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337347.1"}]},{"database":"RefSeq","id":"XP_054193323.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337348.1"}]},{"database":"RefSeq","id":"XP_054193324.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337349.1"}]},{"database":"RefSeq","id":"XP_054193325.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337350.1"}]},{"database":"RefSeq","id":"XP_054193326.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337351.1"}]},{"database":"RefSeq","id":"XP_054193327.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337352.1"}]},{"database":"RefSeq","id":"XP_054193328.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337353.1"}]},{"database":"RefSeq","id":"XP_054193329.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337354.1"}]},{"database":"RefSeq","id":"XP_054193330.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337355.1"}]},{"database":"RefSeq","id":"XP_054193331.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337356.1"}]},{"database":"RefSeq","id":"XP_054193332.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337357.1"}]},{"database":"RefSeq","id":"XP_054193333.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337358.1"}]},{"database":"RefSeq","id":"XP_054193334.1","properties":[{"key":"NucleotideSequenceId","value":"XM_054337359.1"}]},{"database":"PDB","id":"6M04","properties":[{"key":"Method","value":"EM"},{"key":"Resolution","value":"4.36 A"},{"key":"Chains","value":"A/B/C/D/E/F=1-858"}]},{"database":"PDBsum","id":"6M04","properties":[{"key":"Description","value":"-"}]},{"database":"AlphaFoldDB","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"EMDB","id":"EMD-30029","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"120447","properties":[{"key":"Interactions","value":"47"}]},{"database":"CORUM","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"DIP","id":"DIP-31280N","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q7L1W4","properties":[{"key":"Number of interactors","value":"622"}]},{"database":"IntAct","id":"Q7L1W4","properties":[{"key":"Interactions","value":"22"}]},{"database":"MINT","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"NDEx","id":"IQUERY-CP-LRRC8D","properties":[{"key":"Evidences","value":"1 NDEx IQuery Curated Pathway"}]},{"database":"STRING","id":"9606.ENSP00000338887","properties":[{"key":"Description","value":"-"}]},{"database":"TCDB","id":"1.A.25.3.1","properties":[{"key":"FamilyName","value":"the gap junction-forming innexin (innexin) family"}]},{"database":"GlyCosmos","id":"Q7L1W4","properties":[{"key":"glycosylation","value":"2 sites, 1 glycan"}]},{"database":"GlyGen","id":"Q7L1W4","properties":[{"key":"glycosylation","value":"9 sites, 1 N-linked glycan (1 site), 3 O-linked glycans (8 sites)"}]},{"database":"iPTMnet","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"LRRC8D","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"51701663","properties":[{"key":"Description","value":"-"}]},{"database":"jPOST","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000338887","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"68752","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"TopDownProteomics","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2631","properties":[{"key":"antibodies","value":"48 antibodies from 17 providers"}]},{"database":"DNASU","id":"55144","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000337338.9","properties":[{"key":"ProteinId","value":"ENSP00000338887.5"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000394593.7","properties":[{"key":"ProteinId","value":"ENSP00000378093.3"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906496.1","properties":[{"key":"ProteinId","value":"ENSP00000576555.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906497.1","properties":[{"key":"ProteinId","value":"ENSP00000576556.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906498.1","properties":[{"key":"ProteinId","value":"ENSP00000576557.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906499.1","properties":[{"key":"ProteinId","value":"ENSP00000576558.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906500.1","properties":[{"key":"ProteinId","value":"ENSP00000576559.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906501.1","properties":[{"key":"ProteinId","value":"ENSP00000576560.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906502.1","properties":[{"key":"ProteinId","value":"ENSP00000576561.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906503.1","properties":[{"key":"ProteinId","value":"ENSP00000576562.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906504.1","properties":[{"key":"ProteinId","value":"ENSP00000576563.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906505.1","properties":[{"key":"ProteinId","value":"ENSP00000576564.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906506.1","properties":[{"key":"ProteinId","value":"ENSP00000576565.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906507.1","properties":[{"key":"ProteinId","value":"ENSP00000576566.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906508.1","properties":[{"key":"ProteinId","value":"ENSP00000576567.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906509.1","properties":[{"key":"ProteinId","value":"ENSP00000576568.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906510.1","properties":[{"key":"ProteinId","value":"ENSP00000576569.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906512.1","properties":[{"key":"ProteinId","value":"ENSP00000576570.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906513.1","properties":[{"key":"ProteinId","value":"ENSP00000576571.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906514.1","properties":[{"key":"ProteinId","value":"ENSP00000576574.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906516.1","properties":[{"key":"ProteinId","value":"ENSP00000576575.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906518.1","properties":[{"key":"ProteinId","value":"ENSP00000576576.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906519.1","properties":[{"key":"ProteinId","value":"ENSP00000576577.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906520.1","properties":[{"key":"ProteinId","value":"ENSP00000576578.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000906521.1","properties":[{"key":"ProteinId","value":"ENSP00000576580.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000932575.1","properties":[{"key":"ProteinId","value":"ENSP00000602634.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000932576.1","properties":[{"key":"ProteinId","value":"ENSP00000602635.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000932577.1","properties":[{"key":"ProteinId","value":"ENSP00000602636.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000947385.1","properties":[{"key":"ProteinId","value":"ENSP00000617444.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000947386.1","properties":[{"key":"ProteinId","value":"ENSP00000617445.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000947387.1","properties":[{"key":"ProteinId","value":"ENSP00000617446.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"Ensembl","id":"ENST00000947388.1","properties":[{"key":"ProteinId","value":"ENSP00000617447.1"},{"key":"GeneId","value":"ENSG00000171492.15"}]},{"database":"GeneID","id":"55144","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:55144","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000337338.9","properties":[{"key":"ProteinId","value":"ENSP00000338887.5"},{"key":"RefSeqNucleotideId","value":"NM_001134479.2"},{"key":"RefSeqProteinId","value":"NP_001127951.1"}]},{"database":"UCSC","id":"uc001dnm.4","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:16992","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA30464","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"55144","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"55144","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"LRRC8D","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:16992","properties":[{"key":"GeneName","value":"LRRC8D"}]},{"database":"HPA","id":"ENSG00000171492","properties":[{"key":"ExpressionPatterns","value":"Low tissue specificity"}]},{"database":"MIM","id":"612890","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000171492","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000171492","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG0619","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000154043","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_019019_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"FANGCKC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"676979at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q7L1W4","properties":[{"key":"Number of GO annotations","value":"6 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-HSA-5223345","properties":[{"key":"PathwayName","value":"Miscellaneous transport and binding events"}]},{"database":"SignaLink","id":"Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000171492","properties":[{"key":"NominatedTarget","value":"Agora Nominated Target for Alzheimer's Disease"}]},{"database":"BioGRID-ORCS","id":"55144","properties":[{"key":"hits","value":"13 hits in 1154 CRISPR screens"}]},{"database":"ChiTaRS","id":"LRRC8D","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GeneWiki","id":"LRRC8D","properties":[{"key":"Description","value":"-"}]},{"database":"GenomeRNAi","id":"55144","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q7L1W4","properties":[{"key":"DevelopmentLevel","value":"Tbio"}]},{"database":"PRO","id":"PR:Q7L1W4","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 1"}]},{"database":"RNAct","id":"Q7L1W4","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000171492","properties":[{"key":"ExpressionPatterns","value":"Expressed in inferior vagus X ganglion and 206 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q7L1W4","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24790029"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"24782309"}]},{"database":"GO","id":"GO:0016020","properties":[{"key":"GoTerm","value":"C:membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32415200"}]},{"database":"GO","id":"GO:0034702","properties":[{"key":"GoTerm","value":"C:monoatomic ion channel complex"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28193731"}]},{"database":"GO","id":"GO:0005886","properties":[{"key":"GoTerm","value":"C:plasma membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"24790029"}]},{"database":"GO","id":"GO:0005225","properties":[{"key":"GoTerm","value":"F:volume-sensitive anion channel activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32415200"}]},{"database":"GO","id":"GO:0015810","properties":[{"key":"GoTerm","value":"P:aspartate transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28193731"}]},{"database":"GO","id":"GO:0071470","properties":[{"key":"GoTerm","value":"P:cellular response to osmotic stress"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28193731"}]},{"database":"GO","id":"GO:0001678","properties":[{"key":"GoTerm","value":"P:intracellular glucose homeostasis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0098656","properties":[{"key":"GoTerm","value":"P:monoatomic anion transmembrane transport"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32415200"}]},{"database":"GO","id":"GO:0034214","properties":[{"key":"GoTerm","value":"P:protein hexamerization"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32415200"}]},{"database":"GO","id":"GO:0015734","properties":[{"key":"GoTerm","value":"P:taurine transmembrane transport"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28193731"}]},{"database":"FunFam","id":"3.80.10.10:FF:000123","properties":[{"key":"EntryName","value":"Volume-regulated anion channel subunit LRRC8D"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.80.10.10","properties":[{"key":"EntryName","value":"Ribonuclease Inhibitor"},{"key":"MatchStatus","value":"3"}]},{"database":"InterPro","id":"IPR001611","properties":[{"key":"EntryName","value":"Leu-rich_rpt"}]},{"database":"InterPro","id":"IPR003591","properties":[{"key":"EntryName","value":"Leu-rich_rpt_typical-subtyp"}]},{"database":"InterPro","id":"IPR032675","properties":[{"key":"EntryName","value":"LRR_dom_sf"}]},{"database":"InterPro","id":"IPR050216","properties":[{"key":"EntryName","value":"LRR_domain-containing"}]},{"database":"InterPro","id":"IPR021040","properties":[{"key":"EntryName","value":"LRRC8_Pannexin-like"}]},{"database":"PANTHER","id":"PTHR48051","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR48051:SF58","properties":[{"key":"EntryName","value":"VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF13855","properties":[{"key":"EntryName","value":"LRR_8"},{"key":"MatchStatus","value":"2"}]},{"database":"Pfam","id":"PF12534","properties":[{"key":"EntryName","value":"Pannexin_like"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00365","properties":[{"key":"EntryName","value":"LRR_SD22"},{"key":"MatchStatus","value":"3"}]},{"database":"SMART","id":"SM00369","properties":[{"key":"EntryName","value":"LRR_TYP"},{"key":"MatchStatus","value":"7"}]},{"database":"SUPFAM","id":"SSF52058","properties":[{"key":"EntryName","value":"L domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51450","properties":[{"key":"EntryName","value":"LRR"},{"key":"MatchStatus","value":"9"}]}],"sequence":{"value":"MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDFALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEVKEALNQDINIPFANGI","length":858,"molWeight":98201,"crc64":"52A8B6EEF6F0FE2B","md5":"0DB8750F39DA16555182E1FF47979DD7"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":3,"SUBUNIT":1,"INTERACTION":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"SEQUENCE CAUTION":2},"countByFeatureType":{"Chain":1,"Topological domain":5,"Transmembrane":4,"Repeat":13,"Region":1,"Compositional bias":1,"Modified residue":3,"Disulfide bond":1,"Natural variant":1,"Mutagenesis":2},"uniParcId":"UPI00001BBFBA"}}