{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q7KVH9","secondaryAccessions":["Q9W1L0"],"uniProtkbId":"TFP8L_DROME","entryAudit":{"firstPublicDate":"2007-05-01","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-05-01","entryVersion":119,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Drosophila melanogaster","commonName":"Fruit fly","taxonId":7227,"lineage":["Eukaryota","Metazoa","Ecdysozoa","Arthropoda","Altocrustacea","Allotriocarida","Hexapoda","Insecta","Pterygota","Neoptera","Eumetabola","Endopterygota","Aparaglossata","Panorpida","Diptera","Brachycera","Muscomorpha","Ephydroidea","Drosophilidae","Drosophila","Sophophora"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25836674"}],"value":"Protein salivary glands marred"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Tumor necrosis factor alpha-induced protein 8-like protein"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"TNF alpha-induced protein 8-like protein"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25836674"},{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0034894"}],"value":"sigmar"},"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"FlyBase","id":"FBgn0034894"}],"value":"CG4091"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"Important for modulating JNK signaling, cytoskeletal remodeling and autophagy in larval salivary glands (PubMed:25836674). During salivary gland development, involved in the positive regulation of the JNK signaling pathway, acting downstream of the TNF ligand egr and upstream of bsk (PubMed:25836674)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"Interacts with the Ste20-like MAP kinase msn"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"Localizes to actin containing cellular projections and microtubules"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"Cytoplasm, cytoskeleton","id":"SL-0090"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"synonyms":[{"value":"A"},{"value":"B"}],"isoformIds":["Q7KVH9-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"synonyms":[{"value":"C"}],"isoformIds":["Q7KVH9-2"],"sequenceIds":["VSP_024915"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"In larval salivary glands, not detected until 23 hours after puparium formation (APF), prior to the onset of salivary gland histolysis (at protein level) (PubMed:25836674). In larval salivary glands, not detected until 20 hours APF, then expression levels dramatically increase 23 hours APF (PubMed:25836674). Expressed in the larval midgut, at the 3rd instar wandering stage, with expression levels increasing at 0 hr APF after the ecdysone pulse (PubMed:25836674). At 3 and 5 hours APF, expression levels in the midgut reduce slightly but remain elevated compared to expression levels in 3rd instar wandering larvae (PubMed:25836674). In embryos, expressed in the embryonic brain and midgut (PubMed:25836674)"}],"commentType":"DEVELOPMENTAL STAGE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"25836674"}],"value":"Viable and develops to adulthood (PubMed:25836674). However, pupal salivary glands are abnormal with large empty vacuole-like structures, tubulin disorganization, and reduced autophagy flux (PubMed:25836674). Salivary glands appear normal up to the wandering larval stage, but then exhibit a slight increase in overall length until in pupae 23 hours after puparium formation, salivary glands are significantly longer and wider (PubMed:25836674). Salivary gland histolysis occurs but appears to be delayed (PubMed:25836674). In salivary glands, bsk activation and thus JNK signaling appears to be disrupted as nuclear localization of bsk is absent in large areas of the salivary gland tissues (PubMed:25836674)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"25836674"}],"value":"The name 'sigmar' is an abbreviation for salivary glands marred which describes the mutant phenotype"}],"commentType":"MISCELLANEOUS"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the TNFAIP8 family"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":188,"modifier":"EXACT"}},"description":"Protein salivary glands marred","featureId":"PRO_0000285780"},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"in isoform 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