{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q796Z1","secondaryAccessions":["P71081"],"uniProtkbId":"NTDP_BACSU","entryAudit":{"firstPublicDate":"2006-09-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-07-28","entryVersion":103,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Bacillus subtilis (strain 168)","taxonId":224308,"lineage":["Bacteria","Bacillati","Bacillota","Bacilli","Caryophanales","Bacillaceae","Bacillus"]},"proteinExistence":"3: Inferred from homology","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"value":"Nucleoside triphosphate/diphosphate phosphatase"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"value":"3.6.1.15"},{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"value":"3.6.1.6"}]}},"genes":[{"geneName":{"value":"ygaC"},"orderedLocusNames":[{"value":"BSU08680"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"value":"Has nucleoside phosphatase activity towards nucleoside triphosphates and nucleoside diphosphates"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:23680"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57930"},{"database":"ChEBI","id":"CHEBI:61557"}],"ecNumber":"3.6.1.15","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}]}},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:36799"},{"database":"ChEBI","id":"CHEBI:15377"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:43474"},{"database":"ChEBI","id":"CHEBI:57930"},{"database":"ChEBI","id":"CHEBI:58043"}],"ecNumber":"3.6.1.6","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}]}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"value":"Belongs to the Ntdp family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"CAB04796.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":176,"modifier":"EXACT"}},"description":"Nucleoside triphosphate/diphosphate phosphatase","featureId":"PRO_0000248092"},{"type":"Active site","location":{"start":{"value":23,"modifier":"EXACT"},"end":{"value":23,"modifier":"EXACT"}},"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}]},{"type":"Binding site","location":{"start":{"value":87,"modifier":"EXACT"},"end":{"value":87,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":103,"modifier":"EXACT"},"end":{"value":103,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":105,"modifier":"EXACT"},"end":{"value":105,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":107,"modifier":"EXACT"},"end":{"value":107,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":120,"modifier":"EXACT"},"end":{"value":120,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":123,"modifier":"EXACT"},"end":{"value":123,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"HAMAP-Rule","id":"MF_01568"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Sequence conflict","location":{"start":{"value":159,"modifier":"EXACT"},"end":{"value":159,"modifier":"EXACT"}},"description":"in Ref. 1; CAB04796","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"F","alternativeSequences":["Y"]}}],"keywords":[{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"9202460","citationType":"journal article","authors":["Cummings N.J.","Connerton I.F."],"citationCrossReferences":[{"database":"PubMed","id":"9202460"},{"database":"DOI","id":"10.1099/00221287-143-6-1855"}],"title":"The Bacillus subtilis 168 chromosome from sspE to katA.","publicationDate":"1997","journal":"Microbiology","firstPage":"1855","lastPage":"1859","volume":"143"},"referencePositions":["NUCLEOTIDE SEQUENCE [GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"9384377","citationType":"journal article","authors":["Kunst F.","Ogasawara N.","Moszer I.","Albertini A.M.","Alloni G.","Azevedo V.","Bertero M.G.","Bessieres P.","Bolotin A.","Borchert S.","Borriss R.","Boursier L.","Brans A.","Braun M.","Brignell S.C.","Bron S.","Brouillet S.","Bruschi C.V.","Caldwell B.","Capuano V.","Carter N.M.","Choi S.-K.","Codani J.-J.","Connerton I.F.","Cummings N.J.","Daniel R.A.","Denizot F.","Devine K.M.","Duesterhoeft A.","Ehrlich S.D.","Emmerson P.T.","Entian K.-D.","Errington J.","Fabret C.","Ferrari E.","Foulger D.","Fritz C.","Fujita M.","Fujita Y.","Fuma S.","Galizzi A.","Galleron N.","Ghim S.-Y.","Glaser P.","Goffeau A.","Golightly E.J.","Grandi G.","Guiseppi G.","Guy B.J.","Haga K.","Haiech J.","Harwood C.R.","Henaut A.","Hilbert H.","Holsappel S.","Hosono S.","Hullo M.-F.","Itaya M.","Jones L.-M.","Joris B.","Karamata D.","Kasahara Y.","Klaerr-Blanchard M.","Klein C.","Kobayashi Y.","Koetter P.","Koningstein G.","Krogh S.","Kumano M.","Kurita K.","Lapidus A.","Lardinois S.","Lauber J.","Lazarevic V.","Lee S.-M.","Levine A.","Liu H.","Masuda S.","Mauel C.","Medigue C.","Medina N.","Mellado R.P.","Mizuno M.","Moestl D.","Nakai S.","Noback M.","Noone D.","O'Reilly M.","Ogawa K.","Ogiwara A.","Oudega B.","Park S.-H.","Parro V.","Pohl T.M.","Portetelle D.","Porwollik S.","Prescott A.M.","Presecan E.","Pujic P.","Purnelle B.","Rapoport G.","Rey M.","Reynolds S.","Rieger M.","Rivolta C.","Rocha E.","Roche B.","Rose M.","Sadaie Y.","Sato T.","Scanlan E.","Schleich S.","Schroeter R.","Scoffone F.","Sekiguchi J.","Sekowska A.","Seror S.J.","Serror P.","Shin B.-S.","Soldo B.","Sorokin A.","Tacconi E.","Takagi T.","Takahashi H.","Takemaru K.","Takeuchi M.","Tamakoshi A.","Tanaka T.","Terpstra P.","Tognoni A.","Tosato V.","Uchiyama S.","Vandenbol M.","Vannier F.","Vassarotti A.","Viari A.","Wambutt R.","Wedler E.","Wedler H.","Weitzenegger T.","Winters P.","Wipat A.","Yamamoto H.","Yamane K.","Yasumoto K.","Yata K.","Yoshida K.","Yoshikawa H.-F.","Zumstein E.","Yoshikawa H.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"9384377"},{"database":"DOI","id":"10.1038/36786"}],"title":"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.","publicationDate":"1997","journal":"Nature","firstPage":"249","lastPage":"256","volume":"390"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"168","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"19383706","citationType":"journal article","authors":["Barbe V.","Cruveiller S.","Kunst F.","Lenoble P.","Meurice G.","Sekowska A.","Vallenet D.","Wang T.","Moszer I.","Medigue C.","Danchin A."],"citationCrossReferences":[{"database":"PubMed","id":"19383706"},{"database":"DOI","id":"10.1099/mic.0.027839-0"}],"title":"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later.","publicationDate":"2009","journal":"Microbiology","firstPage":"1758","lastPage":"1775","volume":"155"},"referencePositions":["SEQUENCE REVISION TO 159"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"Z82044","properties":[{"key":"ProteinId","value":"CAB04796.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AL009126","properties":[{"key":"ProteinId","value":"CAB12696.3"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"PIR","id":"F69815","properties":[{"key":"EntryName","value":"F69815"}]},{"database":"RefSeq","id":"NP_388748.3","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"RefSeq","id":"WP_003223272.1","properties":[{"key":"NucleotideSequenceId","value":"NC_000964.3"}]},{"database":"AlphaFoldDB","id":"Q796Z1","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q796Z1","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q796Z1","properties":[{"key":"Number of interactors","value":"3"}]},{"database":"STRING","id":"224308.BSU08680","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"224308-BSU08680","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblBacteria","id":"CAB12696","properties":[{"key":"ProteinId","value":"CAB12696"},{"key":"GeneId","value":"BSU_08680"}]},{"database":"GeneID","id":"86874679","properties":[{"key":"Description","value":"-"}]},{"database":"GeneID","id":"936192","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"bsu:BSU08680","properties":[{"key":"Description","value":"-"}]},{"database":"PATRIC","id":"fig|224308.179.peg.936","properties":[{"key":"GeneDesignation","value":"-"}]},{"database":"eggNOG","id":"COG3557","properties":[{"key":"ToxonomicScope","value":"Bacteria"}]},{"database":"InParanoid","id":"Q796Z1","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"1645325at2","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q796Z1","properties":[{"key":"Description","value":"-"}]},{"database":"BioCyc","id":"BSUB:BSU08680-MONOMER","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q796Z1","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000001570","properties":[{"key":"Component","value":"Chromosome"}]},{"database":"AbasyAtlas","id":"Q796Z1","properties":[{"key":"Description","value":"-"}]},{"database":"GO","id":"GO:0000287","properties":[{"key":"GoTerm","value":"F:magnesium ion binding"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0017110","properties":[{"key":"GoTerm","value":"F:nucleoside diphosphate phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"GO","id":"GO:0017111","properties":[{"key":"GoTerm","value":"F:ribonucleoside triphosphate phosphatase activity"},{"key":"GoEvidenceType","value":"IEA:UniProtKB-UniRule"}]},{"database":"Gene3D","id":"2.40.380.10","properties":[{"key":"EntryName","value":"FomD-like"},{"key":"MatchStatus","value":"1"}]},{"database":"HAMAP","id":"MF_01568","properties":[{"key":"EntryName","value":"Ntdp"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR007295","properties":[{"key":"EntryName","value":"DUF402"}]},{"database":"InterPro","id":"IPR035930","properties":[{"key":"EntryName","value":"FomD-like_sf"}]},{"database":"InterPro","id":"IPR050212","properties":[{"key":"EntryName","value":"Ntdp-like"}]},{"database":"InterPro","id":"IPR016882","properties":[{"key":"EntryName","value":"SA1684"}]},{"database":"NCBIfam","id":"NF049996","properties":[{"key":"EntryName","value":"NtdP"},{"key":"MatchStatus","value":"1"}]},{"database":"NCBIfam","id":"NF010183","properties":[{"key":"EntryName","value":"PRK13662.1"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39159","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR39159:SF1","properties":[{"key":"EntryName","value":"UPF0374 PROTEIN YGAC"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF04167","properties":[{"key":"EntryName","value":"DUF402"},{"key":"MatchStatus","value":"1"}]},{"database":"PIRSF","id":"PIRSF028345","properties":[{"key":"EntryName","value":"UCP028345"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF159234","properties":[{"key":"EntryName","value":"FomD-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDRTMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYIDYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFAPEFVDMWYERYLRYTK","length":176,"molWeight":21140,"crc64":"76E5C04BB04434E0","md5":"42DE01A191F9D108BB72244E1064FC26"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":2,"COFACTOR":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Active site":1,"Binding site":7,"Sequence conflict":1},"uniParcId":"UPI000195C540"}}