{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q71B07","secondaryAccessions":["Q6PB46","Q80W29","Q8BLA9","Q8BZL3","Q8BZW5"],"uniProtkbId":"D19L3_MOUSE","entryAudit":{"firstPublicDate":"2007-12-04","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2007-12-04","entryVersion":115,"sequenceVersion":2},"annotationScore":4.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"Protein C-mannosyl-transferase DPY19L3"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28202721"}],"value":"2.4.1.-"}]},"alternativeNames":[{"fullName":{"value":"Dpy-19-like protein 3"}},{"fullName":{"value":"Protein dpy-19 homolog 3"}}]},"genes":[{"geneName":{"value":"Dpy19l3"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28202721"}],"value":"C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. The reaction occurs on the luminal side of the endoplasmic reticulum and involves the transfer of a mannose unit from a dolichylphosphate mannose (Dol-P-Man) donor to an acceptor protein containing a WxxW or WxxC consensus sequence (PubMed:28202721). C-mannosylates RSPO1, a Wnt signaling regulator, preferentially at the first Trp residue in the sequence WxxW (By similarity). C-mannosylates the netrin receptor UNC5A, preferentially at the third tryptophan of WxxWxxWxxC sequence (PubMed:28202721)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"L-tryptophyl-[protein] + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = C-alpha-D-mannosyl-L-tryptophyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)","reactionCrossReferences":[{"database":"Rhea","id":"RHEA:77219"},{"database":"Rhea","id":"RHEA-COMP:15365"},{"database":"Rhea","id":"RHEA-COMP:18864"},{"database":"Rhea","id":"RHEA-COMP:19498"},{"database":"Rhea","id":"RHEA-COMP:19501"},{"database":"ChEBI","id":"CHEBI:15378"},{"database":"ChEBI","id":"CHEBI:29954"},{"database":"ChEBI","id":"CHEBI:57683"},{"database":"ChEBI","id":"CHEBI:58211"},{"database":"ChEBI","id":"CHEBI:195646"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28202721"}]},"physiologicalReactions":[{"directionType":"left-to-right","reactionCrossReference":{"database":"Rhea","id":"RHEA:77220"},"evidences":[{"evidenceCode":"ECO:0000305","source":"PubMed","id":"28202721"}]}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28202721"}],"value":"Protein modification; protein glycosylation"}],"commentType":"PATHWAY"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28202721"}],"value":"Endoplasmic reticulum membrane","id":"SL-0097"},"topology":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}],"value":"Multi-pass membrane protein","id":"SL-9909"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}],"value":"The C-terminal luminal region is essential for C-mannosyltransferase activity"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the dpy-19 family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Frameshift","sequence":"AAH59897.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":716,"modifier":"EXACT"}},"description":"Protein C-mannosyl-transferase DPY19L3","featureId":"PRO_0000311902"},{"type":"Topological domain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":43,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":44,"modifier":"EXACT"},"end":{"value":64,"modifier":"EXACT"}},"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":65,"modifier":"EXACT"},"end":{"value":154,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":155,"modifier":"EXACT"},"end":{"value":182,"modifier":"EXACT"}},"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Topological domain","location":{"start":{"value":183,"modifier":"EXACT"},"end":{"value":184,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Intramembrane","location":{"start":{"value":185,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"Name=3","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":198,"modifier":"EXACT"},"end":{"value":215,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Intramembrane","location":{"start":{"value":216,"modifier":"EXACT"},"end":{"value":230,"modifier":"EXACT"}},"description":"Name=4","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":231,"modifier":"EXACT"},"end":{"value":239,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":240,"modifier":"EXACT"},"end":{"value":256,"modifier":"EXACT"}},"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":257,"modifier":"EXACT"},"end":{"value":262,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":263,"modifier":"EXACT"},"end":{"value":279,"modifier":"EXACT"}},"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":280,"modifier":"EXACT"},"end":{"value":289,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":290,"modifier":"EXACT"},"end":{"value":306,"modifier":"EXACT"}},"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":307,"modifier":"EXACT"},"end":{"value":308,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":309,"modifier":"EXACT"},"end":{"value":323,"modifier":"EXACT"}},"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":324,"modifier":"EXACT"},"end":{"value":338,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":339,"modifier":"EXACT"},"end":{"value":359,"modifier":"EXACT"}},"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":360,"modifier":"EXACT"},"end":{"value":414,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":415,"modifier":"EXACT"},"end":{"value":437,"modifier":"EXACT"}},"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":438,"modifier":"EXACT"},"end":{"value":465,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":466,"modifier":"EXACT"},"end":{"value":485,"modifier":"EXACT"}},"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":486,"modifier":"EXACT"},"end":{"value":487,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":499,"modifier":"EXACT"}},"description":"Helical; Name=12","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":500,"modifier":"EXACT"},"end":{"value":522,"modifier":"EXACT"}},"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Transmembrane","location":{"start":{"value":523,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"Helical; Name=13","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Topological domain","location":{"start":{"value":540,"modifier":"EXACT"},"end":{"value":716,"modifier":"EXACT"}},"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}]},{"type":"Glycosylation","location":{"start":{"value":118,"modifier":"EXACT"},"end":{"value":118,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":704,"modifier":"EXACT"},"end":{"value":704,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q6ZPD9"}],"featureId":""},{"type":"Sequence conflict","location":{"start":{"value":208,"modifier":"EXACT"},"end":{"value":208,"modifier":"EXACT"}},"description":"in Ref. 3; AAH50065","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"T","alternativeSequences":["A"]}},{"type":"Sequence conflict","location":{"start":{"value":210,"modifier":"EXACT"},"end":{"value":210,"modifier":"EXACT"}},"description":"in Ref. 2; BAC28266","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"P","alternativeSequences":["T"]}},{"type":"Sequence conflict","location":{"start":{"value":382,"modifier":"EXACT"},"end":{"value":383,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ10888","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"FG","alternativeSequences":["LV"]}},{"type":"Sequence conflict","location":{"start":{"value":539,"modifier":"EXACT"},"end":{"value":539,"modifier":"EXACT"}},"description":"in Ref. 2; BAC28636","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":590,"modifier":"EXACT"},"end":{"value":590,"modifier":"EXACT"}},"description":"in Ref. 3; AAH50065","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["R"]}},{"type":"Sequence conflict","location":{"start":{"value":650,"modifier":"EXACT"},"end":{"value":650,"modifier":"EXACT"}},"description":"in Ref. 3; AAH50065","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"G","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0256","category":"Cellular component","name":"Endoplasmic reticulum"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0328","category":"Molecular function","name":"Glycosyltransferase"},{"id":"KW-0472","category":"Cellular component","name":"Membrane"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0812","category":"Domain","name":"Transmembrane"},{"id":"KW-1133","category":"Domain","name":"Transmembrane helix"}],"references":[{"referenceNumber":1,"citation":{"id":"CI-7J72UMCNH23B2","citationType":"submission","authors":["Ding P.","Han W.","Rui M.","Wang Y.","Song Q.","Zhang Y.","Ma D."],"publicationDate":"AUG-2002","submissionDatabase":"EMBL/GenBank/DDBJ databases"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA]"],"referenceComments":[{"value":"Heart","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Corpora quadrigemina","type":"TISSUE"},{"value":"Diencephalon","type":"TISSUE"},{"value":"Lung","type":"TISSUE"}]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"value":"Embryo","type":"TISSUE"}]},{"referenceNumber":4,"citation":{"id":"28202721","citationType":"journal article","authors":["Shcherbakova A.","Tiemann B.","Buettner F.F.","Bakker H."],"citationCrossReferences":[{"database":"PubMed","id":"28202721"},{"database":"DOI","id":"10.1073/pnas.1613165114"}],"title":"Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3.","publicationDate":"2017","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"2574","lastPage":"2579","volume":"114"},"referencePositions":["SUBCELLULAR LOCATION","FUNCTION","CATALYTIC ACTIVITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AF538322","properties":[{"key":"ProteinId","value":"AAQ10888.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK033395","properties":[{"key":"ProteinId","value":"BAC28266.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK034217","properties":[{"key":"ProteinId","value":"BAC28636.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK045758","properties":[{"key":"ProteinId","value":"BAC32483.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC050065","properties":[{"key":"ProteinId","value":"AAH50065.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC059897","properties":[{"key":"ProteinId","value":"AAH59897.1"},{"key":"Status","value":"ALT_FRAME"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS21155.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_848819.2","properties":[{"key":"NucleotideSequenceId","value":"NM_178704.3"}]},{"database":"AlphaFoldDB","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"231376","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q71B07","properties":[{"key":"Number of interactors","value":"1564"}]},{"database":"STRING","id":"10090.ENSMUSP00000054747","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q71B07","properties":[{"key":"glycosylation","value":"2 sites, 1 N-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000054747","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"279357","properties":[{"key":"Description","value":"-"}]},{"database":"Pumba","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"2035","properties":[{"key":"antibodies","value":"94 antibodies from 15 providers"}]},{"database":"DNASU","id":"233115","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000051377.15","properties":[{"key":"ProteinId","value":"ENSMUSP00000054747.9"},{"key":"GeneId","value":"ENSMUSG00000043671.15"}]},{"database":"GeneID","id":"233115","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:233115","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc009gkg.2","properties":[{"key":"OrganismName","value":"mouse"}]},{"database":"AGR","id":"MGI:2443952","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"147991","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:2443952","properties":[{"key":"GeneName","value":"Dpy19l3"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000043671","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG4587","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00530000063023","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_014404_1_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"HPHYENK","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"6019623at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"BRENDA","id":"2.4.1.B72","properties":[{"key":"OrganismId","value":"3474"}]},{"database":"UniPathway","id":"UPA00378","properties":[{"key":"RectionId","value":"-"}]},{"database":"BioGRID-ORCS","id":"233115","properties":[{"key":"hits","value":"2 hits in 77 CRISPR screens"}]},{"database":"PRO","id":"PR:Q71B07","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"RNAct","id":"Q71B07","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000043671","properties":[{"key":"ExpressionPatterns","value":"Expressed in embryonic post-anal tail and 211 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q71B07","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005789","properties":[{"key":"GoTerm","value":"C:endoplasmic reticulum membrane"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28202721"}]},{"database":"GO","id":"GO:0000030","properties":[{"key":"GoTerm","value":"F:mannosyltransferase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28202721"}]},{"database":"CDD","id":"cd20181","properties":[{"key":"EntryName","value":"Dpy19L3"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR018732","properties":[{"key":"EntryName","value":"Dpy-19/Dpy-19-like"}]},{"database":"InterPro","id":"IPR047465","properties":[{"key":"EntryName","value":"Dpy19L3"}]},{"database":"PANTHER","id":"PTHR31488:SF4","properties":[{"key":"EntryName","value":"C-MANNOSYLTRANSFERASE DPY19L3-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR31488","properties":[{"key":"EntryName","value":"DPY-19-LIKE 1, LIKE (H. SAPIENS)"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF10034","properties":[{"key":"EntryName","value":"Dpy19"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MMYIRQRKETKPIEVSEDFPSPKEDVKLEKKLPSGCASGRFWKILSSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAMKATWLYGIQISCLLLVCTLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGSFLTRIWKLLLHLLLVFCLTLFLNNIIKKVLNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLVVTVVTASVVAFHNLSDSTSLKSMDQTRKRAVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEVWELLLRLVHLCNPKRIWVLRYLVPVLTLLYLCYKSWPGVMDELSELKEFYDPDTVELMTWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRFCEEIKRNLPSYAAHFTRVFQNKTFHVYKLSRNK","length":716,"molWeight":82990,"crc64":"E801A69F9E8F9E93","md5":"95880FC648313F1F7814F13EF563E381"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBCELLULAR LOCATION":1,"DOMAIN":1,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Topological domain":14,"Transmembrane":11,"Intramembrane":2,"Glycosylation":2,"Sequence conflict":6},"uniParcId":"UPI00000EB492"}}