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Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. Plays a role in rapid sperm motility via mediating timely mRNA turnover (PubMed:34733855)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"A5YKK6"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20133598"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32905781"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34210974"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"34733855"}],"value":"Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits (By similarity). In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8 (By similarity). Interacts in a ligand-dependent fashion with ESR1 and RXRA (By similarity). Interacts with NANOS2, TOB1 and ZFP36 (PubMed:20133598). Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct (By similarity). Interacts with YTHDF2; the interaction is direct and promotes recruitment of the CCR4-NOT complex to N6-methyladenosine (m6A)-containing mRNAs, leading to their deadenylation and subsequent degradation (PubMed:32905781). Interacts with EIF4ENIF1/4E-T (By similarity). Interacts in an RNA-independent manner with BICC1 (via KH domains) (PubMed:34210974). Interacts with TEX13A; the interaction may inhibit CNOT1 binding to mRNA and subsequently CNOT1-mediated mRNA degradation (PubMed:34733855). 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