{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6YTW6","secondaryAccessions":["A0A0P0X8P5","Q94LM4"],"uniProtkbId":"LFR_ORYSJ","entryAudit":{"firstPublicDate":"2021-04-07","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2004-07-05","entryVersion":119,"sequenceVersion":1},"annotationScore":5.0,"organism":{"scientificName":"Oryza sativa subsp. japonica","commonName":"Rice","taxonId":39947,"lineage":["Eukaryota","Viridiplantae","Streptophyta","Embryophyta","Tracheophyta","Spermatophyta","Magnoliopsida","Liliopsida","Poales","Poaceae","BOP clade","Oryzoideae","Oryzeae","Oryzinae","Oryza","Oryza sativa"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Armadillo repeat-containing protein LFR"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32808364"}],"value":"Protein LFR ortholog"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32808364"}],"value":"OsLFR"}]}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"32808364"}],"value":"LFR"},"orderedLocusNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAH94023.1"}],"value":"Os07g0609766"},{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"LOC_Os07g41900"}],"orfNames":[{"evidences":[{"evidenceCode":"ECO:0000312","source":"EMBL","id":"BAC84651.1"}],"value":"OSJNBb0018L13.27"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32808364"}],"value":"Plays critical roles in both embryo and endosperm development (PubMed:32808364). Required for free nuclei division and cellularization in early endosperm development, by preventing premature cell death in the endosperm (PubMed:32808364). Involved in the regulation of pattern formation and organ differentiation during embryogenesis, by regulating genes involved in the early stages of seed development (PubMed:32808364)"}],"commentType":"FUNCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32808364"}],"value":"Interacts with CHR719, SWI3A and SWI3C"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32808364"}],"value":"Nucleus","id":"SL-0191"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32808364"}],"value":"Expressed at low levels in coleoptiles, leaf tongues, mature leaves and nodes during the vegetative phase (PubMed:32808364). Highly expressed in reproductive tissues such as young panicles, early developing seeds, embryos and endosperms (PubMed:32808364)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"32808364"}],"value":"Embryonic lethality when homozygous due to defects in endosperm and embryo"}],"commentType":"DISRUPTION PHENOTYPE"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous gene model prediction","sequence":"BAT02600.1","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":460,"modifier":"EXACT"}},"description":"Armadillo repeat-containing protein LFR","featureId":"PRO_0000452394"},{"type":"Repeat","location":{"start":{"value":225,"modifier":"EXACT"},"end":{"value":267,"modifier":"EXACT"}},"description":"ARM 1","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":321,"modifier":"EXACT"},"end":{"value":360,"modifier":"EXACT"}},"description":"ARM 2","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Repeat","location":{"start":{"value":364,"modifier":"EXACT"},"end":{"value":405,"modifier":"EXACT"}},"description":"ARM 3","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":32,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":10,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]}],"keywords":[{"id":"KW-0217","category":"Molecular function","name":"Developmental protein"},{"id":"KW-0341","category":"Biological process","name":"Growth regulation"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"}],"references":[{"referenceNumber":1,"citation":{"id":"16100779","citationType":"journal article","authoringGroup":["International rice genome sequencing project (IRGSP)"],"citationCrossReferences":[{"database":"PubMed","id":"16100779"},{"database":"DOI","id":"10.1038/nature03895"}],"title":"The map-based sequence of the rice genome.","publicationDate":"2005","journal":"Nature","firstPage":"793","lastPage":"800","volume":"436"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"18089549","citationType":"journal article","authoringGroup":["The rice annotation project (RAP)"],"citationCrossReferences":[{"database":"PubMed","id":"18089549"},{"database":"DOI","id":"10.1093/nar/gkm978"}],"title":"The rice annotation project database (RAP-DB): 2008 update.","publicationDate":"2008","journal":"Nucleic Acids Res.","firstPage":"D1028","lastPage":"D1033","volume":"36"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"24280374","citationType":"journal article","authors":["Kawahara Y.","de la Bastide M.","Hamilton J.P.","Kanamori H.","McCombie W.R.","Ouyang S.","Schwartz D.C.","Tanaka T.","Wu J.","Zhou S.","Childs K.L.","Davidson R.M.","Lin H.","Quesada-Ocampo L.","Vaillancourt B.","Sakai H.","Lee S.S.","Kim J.","Numa H.","Itoh T.","Buell C.R.","Matsumoto T."],"citationCrossReferences":[{"database":"PubMed","id":"24280374"},{"database":"DOI","id":"10.1186/1939-8433-6-4"}],"title":"Improvement of the Oryza sativa Nipponbare reference genome using next generation sequence and optical map data.","publicationDate":"2013","journal":"Rice","firstPage":"4","lastPage":"4","volume":"6"},"referencePositions":["GENOME REANNOTATION"],"referenceComments":[{"value":"cv. Nipponbare","type":"STRAIN"}]},{"referenceNumber":4,"citation":{"id":"32808364","citationType":"journal article","authors":["Qi D.","Wen Q.","Meng Z.","Yuan S.","Guo H.","Zhao H.","Cui S."],"citationCrossReferences":[{"database":"PubMed","id":"32808364"},{"database":"DOI","id":"10.1111/tpj.14967"}],"title":"OsLFR is essential for early endosperm and embryo development by interacting with SWI/SNF complex members in Oryza sativa.","publicationDate":"2020","journal":"Plant J.","firstPage":"901","lastPage":"916","volume":"104"},"referencePositions":["FUNCTION","INTERACTION WITH CHR719; SWI3A AND SWI3C","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AC079038","properties":[{"key":"ProteinId","value":"AAK55772.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP005895","properties":[{"key":"ProteinId","value":"BAC84651.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP008213","properties":[{"key":"ProteinId","value":"BAH94023.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AP014963","properties":[{"key":"ProteinId","value":"BAT02600.1"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"AlphaFoldDB","id":"Q6YTW6","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6YTW6","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6YTW6","properties":[{"key":"Number of interactors","value":"1947"}]},{"database":"STRING","id":"39947.A0A0P0X8P5","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"39947-A0A0P0X8P5","properties":[{"key":"Description","value":"-"}]},{"database":"EnsemblPlants","id":"Os07t0609766-01","properties":[{"key":"ProteinId","value":"Os07t0609766-01"},{"key":"GeneId","value":"Os07g0609766"}]},{"database":"Gramene","id":"Os07t0609766-01","properties":[{"key":"ProteinId","value":"Os07t0609766-01"},{"key":"GeneId","value":"Os07g0609766"}]},{"database":"KEGG","id":"dosa:Os07g0609766","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"osa:9271563","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502QU15","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"InParanoid","id":"Q6YTW6","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"10044343at2759","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000059680","properties":[{"key":"Component","value":"Chromosome 7"}]},{"database":"GO","id":"GO:0035060","properties":[{"key":"GoTerm","value":"C:brahma complex"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0005654","properties":[{"key":"GoTerm","value":"C:nucleoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"32808364"}]},{"database":"GO","id":"GO:0016514","properties":[{"key":"GoTerm","value":"C:SWI/SNF complex"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006338","properties":[{"key":"GoTerm","value":"P:chromatin remodeling"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0009793","properties":[{"key":"GoTerm","value":"P:embryo development ending in seed dormancy"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32808364"}]},{"database":"GO","id":"GO:0045893","properties":[{"key":"GoTerm","value":"P:positive regulation of DNA-templated transcription"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:2000014","properties":[{"key":"GoTerm","value":"P:regulation of endosperm development"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32808364"}]},{"database":"GO","id":"GO:0051783","properties":[{"key":"GoTerm","value":"P:regulation of nuclear division"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"32808364"}]},{"database":"GO","id":"GO:0006357","properties":[{"key":"GoTerm","value":"P:regulation of transcription by RNA polymerase II"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"Gene3D","id":"1.25.10.10","properties":[{"key":"EntryName","value":"Leucine-rich Repeat Variant"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR011989","properties":[{"key":"EntryName","value":"ARM-like"}]},{"database":"InterPro","id":"IPR016024","properties":[{"key":"EntryName","value":"ARM-type_fold"}]},{"database":"InterPro","id":"IPR021906","properties":[{"key":"EntryName","value":"BAF250/Osa"}]},{"database":"InterPro","id":"IPR033388","properties":[{"key":"EntryName","value":"BAF250_C"}]},{"database":"PANTHER","id":"PTHR12656","properties":[{"key":"EntryName","value":"BRG-1 ASSOCIATED FACTOR 250 BAF250"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR12656:SF5","properties":[{"key":"EntryName","value":"TRITHORAX GROUP PROTEIN OSA"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF12031","properties":[{"key":"EntryName","value":"BAF250_C"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF48371","properties":[{"key":"EntryName","value":"ARM repeat"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MSHVRSAPAGKSGGGGGSTPAKRGRPFGSTTGSGAAAAAAAAAIGDAAAPAALVGPSLQVLTALSDQNNKRIVLALQSGLKSEILWALNALTVLSFKEKDDLRRDTTPLAKVPGLLDALLQVIDDWRDIAMPKDHTKPPRVRTLGVNTTLSGFGHENVEKVYSDTTTPSDDQTKTADSTVTKKRSAGFLFDEEGLFNVDDEGRTEKQQCAVAASNIIRNFSFMPENETVMVQHRHCLETVFQCLEDQNTEDDELITNMLETLVNLAPVLDLRIFSSSKPSFIKITEKRAVQAIMGMLASSIRVWHCAAAELIGRLIINPDNEPFLLPAIPQIYKRLVDLLSVPAVDAQAAAISALYNVAEVNMDFRLKLASERWAVDRLLKVVKTPHPVPEVCRKASMIVESLVSEPQNRMHLLVHENTFAEILTSEGKYSDTFARILYELTARPSNKVTAGQAIWGNIN","length":460,"molWeight":50005,"crc64":"8CFCEC9231977779","md5":"24FC9201EE9433B9174BD99CFF7F789A"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1,"DISRUPTION PHENOTYPE":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Repeat":3,"Region":1,"Compositional bias":1},"uniParcId":"UPI00000A1257"}}