{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6WKZ8","secondaryAccessions":["Q6DIB9","Q80U31","Q8BUL9","Q8CGW0","Q8K2I6","Q8R0V7","Q8R130"],"uniProtkbId":"UBR2_MOUSE","entryAudit":{"firstPublicDate":"2005-08-16","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2005-08-16","entryVersion":166,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Mus musculus","commonName":"Mouse","taxonId":10090,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Glires","Rodentia","Myomorpha","Muroidea","Muridae","Murinae","Mus","Mus"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"value":"E3 ubiquitin-protein ligase UBR2"},"ecNumbers":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31268597"}],"value":"2.3.2.27"}]},"alternativeNames":[{"fullName":{"value":"N-recognin-2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15548684"}],"value":"Ubiquitin-protein ligase E3-alpha-2"}},{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"15548684"}],"value":"Ubiquitin-protein ligase E3-alpha-II"}}]},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000312","source":"MGI","id":"MGI:1861099"}],"value":"Ubr2"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"12693553"}],"value":"Kiaa0349"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19008229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28708824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28806172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30872531"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31268597"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38225265"}],"value":"E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:14585983, PubMed:19008229, PubMed:30872531, PubMed:31268597). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:14585983, PubMed:19008229, PubMed:30872531, PubMed:31268597). Recognizes both type-1 and type-2 N-degrons, containing positively charged amino acids (Arg, Lys and His) and bulky and hydrophobic amino acids, respectively (PubMed:19008229). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). In contrast, it strongly binds methylated N-degrons (By similarity). Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A (PubMed:14585983, PubMed:20080676). Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (PubMed:28708824). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1B following NLRP1B activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1B, which polymerizes and forms the NLRP1B inflammasome followed by host cell pyroptosis (PubMed:30872531, PubMed:31268597). Plays a role in T-cell receptor signaling by inducing 'Lys-63'-linked ubiquitination of lymphocyte cell-specific kinase LCK (PubMed:38225265). This activity is regulated by DUSP22, which induces 'Lys-48'-linked ubiquitination of UBR2, leading to its proteasomal degradation by SCF E3 ubiquitin-protein ligase complex (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.","ecNumber":"2.3.2.27","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19008229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31268597"}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"19008229"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"30872531"}],"value":"Protein modification; protein ubiquitination"}],"commentType":"PATHWAY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"21103378"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28806172"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"31268597"}],"value":"Interacts with UBE2B; promotes the UBE2B-H2A interaction and the ubiquitination of histone H2A by UBE2B and UBR2 (PubMed:14585983, PubMed:20080676). Interacts with RECQL4 (By similarity). Interacts with Tex19.1 and Tex19.2; does not lead to Tex19.1 degradation and stabilizes it (PubMed:21103378). Interacts with L1RE1 (PubMed:28806172). Interacts with CASP8 (By similarity). Interacts with ATXN3 (By similarity). Interacts with UBE2O (PubMed:31268597)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"}],"value":"Associated with chromatin during meiosis"}]},"subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"}],"value":"Nucleus","id":"SL-0191"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"}],"value":"Chromosome","id":"SL-0468"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q6WKZ8-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q6WKZ8-2"],"sequenceIds":["VSP_015173"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q6WKZ8-3"],"sequenceIds":["VSP_015172","VSP_015173"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15548684"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16311597"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28806172"}],"value":"Highly expressed in skeletal muscle. Also expressed in heart, kidney and testis. Expressed in acinar cells of the pancreas. In testes, expressed primarily in spermatocytes. Expressed in cerebellum (PubMed:28806172)"}],"commentType":"TISSUE SPECIFICITY"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15548684"}],"value":"In models of cancer cachexia, induced specifically at the onset and during the progression of muscle wasting"}],"commentType":"INDUCTION"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"value":"The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif (By similarity). The UBR-type zinc finger forms a pocket that mediates recognition of type 1 N-degrons (By similarity). It exhibits preference for arginine in the first position, and a lower preference for lysine and histidine (By similarity). It binds N-degrons with a methylated arginine or lysine in the first position (By similarity)"}],"commentType":"DOMAIN"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"value":"Dephosphorylated by DUSP22 at Ser-1694 and Tyr-1697, leading to subsequent ubiquitination and proteasomal degradation"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"value":"'Lys-48'-linked ubiquitinated at Lys-94, Lys-779 and Lys-1599 following DUSP22-mediated dephosphorylation of Ser-1694 and Tyr-1697 which promotes UBR2 interaction with the SCF(FBW1A) E3 ubiquitin-protein ligase complex"}],"commentType":"PTM"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16488448"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"16606826"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28708824"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"38225265"}],"value":"Male mice are viable but not fertile, due to massive apoptosis of spermatocytes (PubMed:38225265). They have a reduction of testis weight of 68% and no detectable sperm in their epididymis. The seminiferous tubules contain reduced numbers of post-meiotic round, elongated spermatids and accumulation of pyknotic and zygotene-like nuclei. Female mice show severe prenatal lethality, but the rare survivors are fertile. Fibroblast cells display spontaneous chromosome instability and fragility (PubMed:14585983, PubMed:16488448, PubMed:28708824). UBR1 and UBR2 double knockout embryos die at mid-gestation, with defects in neurogenesis and cardiovascular development. These defects include reduced proliferation as well as precocious migration and differentiation of neural progenitor cells (PubMed:16606826). Decrease in T-cell receptor-stimulated cytokines production and Th1 and Th17 differentiation in T-cells (PubMed:38225265). 'Lys-63'-linked ubiquitination and phosphorylation of Lck are obliterated (PubMed:38225265)"}],"commentType":"DISRUPTION PHENOTYPE"},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the E3 ubiquitin-protein ligase UBR1-like family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH25617.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH31403.1","note":"Truncated N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Miscellaneous discrepancy","sequence":"BAC65536.3","note":"Intron retention.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Initiator methionine","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1,"modifier":"EXACT"}},"description":"Removed","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Chain","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":1755,"modifier":"EXACT"}},"description":"E3 ubiquitin-protein ligase UBR2","featureId":"PRO_0000056141"},{"type":"Zinc finger","location":{"start":{"value":97,"modifier":"EXACT"},"end":{"value":168,"modifier":"EXACT"}},"description":"UBR-type","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00508"}]},{"type":"Zinc finger","location":{"start":{"value":1108,"modifier":"EXACT"},"end":{"value":1214,"modifier":"EXACT"}},"description":"RING-type; atypical"},{"type":"Region","location":{"start":{"value":1012,"modifier":"EXACT"},"end":{"value":1033,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Coiled coil","location":{"start":{"value":1019,"modifier":"EXACT"},"end":{"value":1054,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000255"}]},{"type":"Compositional bias","location":{"start":{"value":1021,"modifier":"EXACT"},"end":{"value":1033,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":99,"modifier":"EXACT"},"end":{"value":99,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":112,"modifier":"EXACT"},"end":{"value":112,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":115,"modifier":"EXACT"},"end":{"value":115,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":124,"modifier":"EXACT"},"end":{"value":124,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":127,"modifier":"EXACT"},"end":{"value":127,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":133,"modifier":"EXACT"},"end":{"value":133,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":136,"modifier":"EXACT"},"end":{"value":136,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"2"}},{"type":"Binding site","location":{"start":{"value":148,"modifier":"EXACT"},"end":{"value":148,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60466"},{"database":"ChEBI","id":"CHEBI:29965"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"a peptide","id":"ChEBI:CHEBI:60466"},"ligandPart":{"name":"L-arginine residue","id":"ChEBI:CHEBI:29965"}},{"type":"Binding site","location":{"start":{"value":149,"modifier":"EXACT"},"end":{"value":149,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"1"}},{"type":"Binding site","location":{"start":{"value":150,"modifier":"EXACT"},"end":{"value":150,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60466"},{"database":"ChEBI","id":"CHEBI:29965"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"a peptide","id":"ChEBI:CHEBI:60466"},"ligandPart":{"name":"L-arginine residue","id":"ChEBI:CHEBI:29965"}},{"type":"Binding site","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":151,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":153,"modifier":"EXACT"},"end":{"value":153,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:60466"},{"database":"ChEBI","id":"CHEBI:29965"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"a peptide","id":"ChEBI:CHEBI:60466"},"ligandPart":{"name":"L-arginine residue","id":"ChEBI:CHEBI:29965"}},{"type":"Binding site","location":{"start":{"value":163,"modifier":"EXACT"},"end":{"value":163,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":166,"modifier":"EXACT"},"end":{"value":166,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"3"}},{"type":"Binding site","location":{"start":{"value":1108,"modifier":"EXACT"},"end":{"value":1108,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1111,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1168,"modifier":"EXACT"},"end":{"value":1168,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1170,"modifier":"EXACT"},"end":{"value":1170,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1173,"modifier":"EXACT"},"end":{"value":1173,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1176,"modifier":"EXACT"},"end":{"value":1176,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"4"}},{"type":"Binding site","location":{"start":{"value":1210,"modifier":"EXACT"},"end":{"value":1210,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Binding site","location":{"start":{"value":1213,"modifier":"EXACT"},"end":{"value":1213,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:29105"}],"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"P19812"}],"ligand":{"name":"Zn(2+)","id":"ChEBI:CHEBI:29105","label":"5"}},{"type":"Modified residue","location":{"start":{"value":2,"modifier":"EXACT"},"end":{"value":2,"modifier":"EXACT"}},"description":"N-acetylalanine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Modified residue","location":{"start":{"value":476,"modifier":"EXACT"},"end":{"value":476,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Modified residue","location":{"start":{"value":1694,"modifier":"EXACT"},"end":{"value":1694,"modifier":"EXACT"}},"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Modified residue","location":{"start":{"value":1697,"modifier":"EXACT"},"end":{"value":1697,"modifier":"EXACT"}},"description":"Phosphotyrosine","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":94,"modifier":"EXACT"},"end":{"value":94,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":158,"modifier":"EXACT"},"end":{"value":158,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":165,"modifier":"EXACT"},"end":{"value":165,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":248,"modifier":"EXACT"},"end":{"value":248,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":255,"modifier":"EXACT"},"end":{"value":255,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":470,"modifier":"EXACT"},"end":{"value":470,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":488,"modifier":"EXACT"},"end":{"value":488,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":568,"modifier":"EXACT"},"end":{"value":568,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":779,"modifier":"EXACT"},"end":{"value":779,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":789,"modifier":"EXACT"},"end":{"value":789,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":1496,"modifier":"EXACT"},"end":{"value":1496,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":1599,"modifier":"EXACT"},"end":{"value":1599,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Cross-link","location":{"start":{"value":1689,"modifier":"EXACT"},"end":{"value":1689,"modifier":"EXACT"}},"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q8IWV8"}]},{"type":"Alternative sequence","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":197,"modifier":"EXACT"}},"description":"in isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_015172","alternativeSequence":{}},{"type":"Alternative sequence","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":426,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000303","source":"PubMed","id":"16141072"}],"featureId":"VSP_015173","alternativeSequence":{"originalSequence":"RQLQRDFMEDDHERAVSVTALSVQFFTAPT","alternativeSequences":["ERLQRDYVTDDHDREFSVADLSVQIFTVPS"]}},{"type":"Sequence conflict","location":{"start":{"value":59,"modifier":"EXACT"},"end":{"value":59,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"Q","alternativeSequences":["L"]}},{"type":"Sequence conflict","location":{"start":{"value":137,"modifier":"EXACT"},"end":{"value":137,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202 and 3; BAC65536","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["Q"]}},{"type":"Sequence conflict","location":{"start":{"value":143,"modifier":"EXACT"},"end":{"value":143,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":271,"modifier":"EXACT"},"end":{"value":271,"modifier":"EXACT"}},"description":"in Ref. 2; AAL32102","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":429,"modifier":"EXACT"},"end":{"value":435,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"RMLLTEE","alternativeSequences":["PNAPHRKK"]}},{"type":"Sequence conflict","location":{"start":{"value":656,"modifier":"EXACT"},"end":{"value":656,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"L","alternativeSequences":["P"]}},{"type":"Sequence conflict","location":{"start":{"value":979,"modifier":"EXACT"},"end":{"value":979,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"A","alternativeSequences":["S"]}},{"type":"Sequence conflict","location":{"start":{"value":1050,"modifier":"EXACT"},"end":{"value":1050,"modifier":"EXACT"}},"description":"in Ref. 5; BAC38864","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"S","alternativeSequences":["F"]}},{"type":"Sequence conflict","location":{"start":{"value":1332,"modifier":"EXACT"},"end":{"value":1332,"modifier":"EXACT"}},"description":"in Ref. 1; AAQ17202","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["W"]}},{"type":"Sequence conflict","location":{"start":{"value":1619,"modifier":"EXACT"},"end":{"value":1619,"modifier":"EXACT"}},"description":"in Ref. 4; AAH26391","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"C","alternativeSequences":["S"]}}],"keywords":[{"id":"KW-0007","category":"PTM","name":"Acetylation"},{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0158","category":"Cellular component","name":"Chromosome"},{"id":"KW-0175","category":"Domain","name":"Coiled coil"},{"id":"KW-1017","category":"PTM","name":"Isopeptide bond"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0539","category":"Cellular component","name":"Nucleus"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0808","category":"Molecular function","name":"Transferase"},{"id":"KW-0832","category":"PTM","name":"Ubl conjugation"},{"id":"KW-0833","category":"Biological process","name":"Ubl conjugation pathway"},{"id":"KW-0862","category":"Ligand","name":"Zinc"},{"id":"KW-0863","category":"Domain","name":"Zinc-finger"}],"references":[{"referenceNumber":1,"citation":{"id":"14585983","citationType":"journal article","authors":["Kwon Y.T.","Xia Z.","An J.Y.","Tasaki T.","Davydov I.V.","Seo J.W.","Sheng J.","Xie Y.","Varshavsky A."],"citationCrossReferences":[{"database":"PubMed","id":"14585983"},{"database":"DOI","id":"10.1128/mcb.23.22.8255-8271.2003"}],"title":"Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway.","publicationDate":"2003","journal":"Mol. Cell. Biol.","firstPage":"8255","lastPage":"8271","volume":"23"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)","INTERACTION WITH UBE2B","SUBCELLULAR LOCATION","TISSUE SPECIFICITY","FUNCTION","CATALYTIC ACTIVITY","PATHWAY","DISRUPTION PHENOTYPE"]},{"referenceNumber":2,"citation":{"id":"15548684","citationType":"journal article","authors":["Kwak K.S.","Zhou X.","Solomon V.","Baracos V.E.","Davis J.","Bannon A.W.","Boyle W.J.","Lacey D.L.","Han H.Q."],"citationCrossReferences":[{"database":"PubMed","id":"15548684"},{"database":"DOI","id":"10.1158/0008-5472.can-04-2102"}],"title":"Regulation of protein catabolism by muscle-specific and cytokine-inducible ubiquitin ligase E3alpha-II during cancer cachexia.","publicationDate":"2004","journal":"Cancer Res.","firstPage":"8193","lastPage":"8198","volume":"64"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)","TISSUE SPECIFICITY","INDUCTION"],"referenceComments":[{"value":"C3H/HeN","type":"STRAIN"}]},{"referenceNumber":3,"citation":{"id":"12693553","citationType":"journal article","authors":["Okazaki N.","Kikuno R.","Ohara R.","Inamoto S.","Aizawa H.","Yuasa S.","Nakajima D.","Nagase T.","Ohara O.","Koga H."],"citationCrossReferences":[{"database":"PubMed","id":"12693553"},{"database":"DOI","id":"10.1093/dnares/10.1.35"}],"title":"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.","publicationDate":"2003","journal":"DNA Res.","firstPage":"35","lastPage":"48","volume":"10"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]"]},{"referenceNumber":4,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)"],"referenceComments":[{"value":"FVB/N","type":"STRAIN"},{"value":"Brain","type":"TISSUE"},{"value":"Mammary gland","type":"TISSUE"},{"value":"Salivary gland","type":"TISSUE"}]},{"referenceNumber":5,"citation":{"id":"16141072","citationType":"journal article","authors":["Carninci P.","Kasukawa T.","Katayama S.","Gough J.","Frith M.C.","Maeda N.","Oyama R.","Ravasi T.","Lenhard B.","Wells C.","Kodzius R.","Shimokawa K.","Bajic V.B.","Brenner S.E.","Batalov S.","Forrest A.R.","Zavolan M.","Davis M.J.","Wilming L.G.","Aidinis V.","Allen J.E.","Ambesi-Impiombato A.","Apweiler R.","Aturaliya R.N.","Bailey T.L.","Bansal M.","Baxter L.","Beisel K.W.","Bersano T.","Bono H.","Chalk A.M.","Chiu K.P.","Choudhary V.","Christoffels A.","Clutterbuck D.R.","Crowe M.L.","Dalla E.","Dalrymple B.P.","de Bono B.","Della Gatta G.","di Bernardo D.","Down T.","Engstrom P.","Fagiolini M.","Faulkner G.","Fletcher C.F.","Fukushima T.","Furuno M.","Futaki S.","Gariboldi M.","Georgii-Hemming P.","Gingeras T.R.","Gojobori T.","Green R.E.","Gustincich S.","Harbers M.","Hayashi Y.","Hensch T.K.","Hirokawa N.","Hill D.","Huminiecki L.","Iacono M.","Ikeo K.","Iwama A.","Ishikawa T.","Jakt M.","Kanapin A.","Katoh M.","Kawasawa Y.","Kelso J.","Kitamura H.","Kitano H.","Kollias G.","Krishnan S.P.","Kruger A.","Kummerfeld S.K.","Kurochkin I.V.","Lareau L.F.","Lazarevic D.","Lipovich L.","Liu J.","Liuni S.","McWilliam S.","Madan Babu M.","Madera M.","Marchionni L.","Matsuda H.","Matsuzawa S.","Miki H.","Mignone F.","Miyake S.","Morris K.","Mottagui-Tabar S.","Mulder N.","Nakano N.","Nakauchi H.","Ng P.","Nilsson R.","Nishiguchi S.","Nishikawa S.","Nori F.","Ohara O.","Okazaki Y.","Orlando V.","Pang K.C.","Pavan W.J.","Pavesi G.","Pesole G.","Petrovsky N.","Piazza S.","Reed J.","Reid J.F.","Ring B.Z.","Ringwald M.","Rost B.","Ruan Y.","Salzberg S.L.","Sandelin A.","Schneider C.","Schoenbach C.","Sekiguchi K.","Semple C.A.","Seno S.","Sessa L.","Sheng Y.","Shibata Y.","Shimada H.","Shimada K.","Silva D.","Sinclair B.","Sperling S.","Stupka E.","Sugiura K.","Sultana R.","Takenaka Y.","Taki K.","Tammoja K.","Tan S.L.","Tang S.","Taylor M.S.","Tegner J.","Teichmann S.A.","Ueda H.R.","van Nimwegen E.","Verardo R.","Wei C.L.","Yagi K.","Yamanishi H.","Zabarovsky E.","Zhu S.","Zimmer A.","Hide W.","Bult C.","Grimmond S.M.","Teasdale R.D.","Liu E.T.","Brusic V.","Quackenbush J.","Wahlestedt C.","Mattick J.S.","Hume D.A.","Kai C.","Sasaki D.","Tomaru Y.","Fukuda S.","Kanamori-Katayama M.","Suzuki M.","Aoki J.","Arakawa T.","Iida J.","Imamura K.","Itoh M.","Kato T.","Kawaji H.","Kawagashira N.","Kawashima T.","Kojima M.","Kondo S.","Konno H.","Nakano K.","Ninomiya N.","Nishio T.","Okada M.","Plessy C.","Shibata K.","Shiraki T.","Suzuki S.","Tagami M.","Waki K.","Watahiki A.","Okamura-Oho Y.","Suzuki H.","Kawai J.","Hayashizaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16141072"},{"database":"DOI","id":"10.1126/science.1112014"}],"title":"The transcriptional landscape of the mammalian genome.","publicationDate":"2005","journal":"Science","firstPage":"1559","lastPage":"1563","volume":"309"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1058 (ISOFORM 3)"],"referenceComments":[{"value":"C57BL/6J","type":"STRAIN"},{"value":"Thymus","type":"TISSUE"}]},{"referenceNumber":6,"citation":{"id":"16311597","citationType":"journal article","authors":["Zenker M.","Mayerle J.","Lerch M.M.","Tagariello A.","Zerres K.","Durie P.R.","Beier M.","Hulskamp G.","Guzman C.","Rehder H.","Beemer F.A.","Hamel B.C.J.","Vanlieferinghen P.","Gershoni-Baruch R.","Vieira M.W.","Dumic M.","Auslender R.","Gil-da-Silva-Lopes V.L.","Steinlicht S.","Rauh M.","Shalev S.A.","Thiel C.","Winterpacht A.","Kwon Y.T.","Varshavsky A.","Reis A."],"citationCrossReferences":[{"database":"PubMed","id":"16311597"},{"database":"DOI","id":"10.1038/ng1681"}],"title":"Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).","publicationDate":"2005","journal":"Nat. Genet.","firstPage":"1345","lastPage":"1350","volume":"37"},"referencePositions":["TISSUE SPECIFICITY"]},{"referenceNumber":7,"citation":{"id":"16488448","citationType":"journal article","authors":["Ouyang Y.","Kwon Y.T.","An J.Y.","Eller D.","Tsai S.-C.","Diaz-Perez S.","Troke J.J.","Teitell M.A.","Marahrens Y."],"citationCrossReferences":[{"database":"PubMed","id":"16488448"},{"database":"DOI","id":"10.1016/j.mrfmmm.2005.12.016"}],"title":"Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair.","publicationDate":"2006","journal":"Mutat. Res.","firstPage":"64","lastPage":"75","volume":"596"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":8,"citation":{"id":"16606826","citationType":"journal article","authors":["An J.Y.","Seo J.W.","Tasaki T.","Lee M.J.","Varshavsky A.","Kwon Y.T."],"citationCrossReferences":[{"database":"PubMed","id":"16606826"},{"database":"DOI","id":"10.1073/pnas.0601700103"}],"title":"Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.","publicationDate":"2006","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"6212","lastPage":"6217","volume":"103"},"referencePositions":["DISRUPTION PHENOTYPE"]},{"referenceNumber":9,"citation":{"id":"19008229","citationType":"journal article","authors":["Tasaki T.","Zakrzewska A.","Dudgeon D.D.","Jiang Y.","Lazo J.S.","Kwon Y.T."],"citationCrossReferences":[{"database":"PubMed","id":"19008229"},{"database":"DOI","id":"10.1074/jbc.m803641200"}],"title":"The substrate recognition domains of the N-end rule pathway.","publicationDate":"2009","journal":"J. Biol. Chem.","firstPage":"1884","lastPage":"1895","volume":"284"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","PATHWAY"]},{"referenceNumber":10,"citation":{"id":"21183079","citationType":"journal article","authors":["Huttlin E.L.","Jedrychowski M.P.","Elias J.E.","Goswami T.","Rad R.","Beausoleil S.A.","Villen J.","Haas W.","Sowa M.E.","Gygi S.P."],"citationCrossReferences":[{"database":"PubMed","id":"21183079"},{"database":"DOI","id":"10.1016/j.cell.2010.12.001"}],"title":"A tissue-specific atlas of mouse protein phosphorylation and expression.","publicationDate":"2010","journal":"Cell","firstPage":"1174","lastPage":"1189","volume":"143"},"referencePositions":["IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]"],"referenceComments":[{"value":"Brain","type":"TISSUE"},{"value":"Brown adipose tissue","type":"TISSUE"},{"value":"Heart","type":"TISSUE"},{"value":"Kidney","type":"TISSUE"},{"value":"Liver","type":"TISSUE"},{"value":"Lung","type":"TISSUE"},{"value":"Pancreas","type":"TISSUE"},{"value":"Spleen","type":"TISSUE"},{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":11,"citation":{"id":"20080676","citationType":"journal article","authors":["An J.Y.","Kim E.-A.","Jiang Y.","Zakrzewska A.","Kim D.E.","Lee M.J.","Mook-Jung I.","Zhang Y.","Kwon Y.T."],"citationCrossReferences":[{"database":"PubMed","id":"20080676"},{"database":"DOI","id":"10.1073/pnas.0910267107"}],"title":"UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.","publicationDate":"2010","journal":"Proc. Natl. Acad. Sci. U.S.A.","firstPage":"1912","lastPage":"1917","volume":"107"},"referencePositions":["FUNCTION","SUBCELLULAR LOCATION","INTERACTION WITH UBE2B AND HISTONE H2A"]},{"referenceNumber":12,"citation":{"id":"21103378","citationType":"journal article","authors":["Yang F.","Cheng Y.","An J.Y.","Kwon Y.T.","Eckardt S.","Leu N.A.","McLaughlin K.J.","Wang P.J."],"citationCrossReferences":[{"database":"PubMed","id":"21103378"},{"database":"DOI","id":"10.1371/journal.pone.0014017"}],"title":"The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.","publicationDate":"2010","journal":"PLoS ONE","firstPage":"E14017","lastPage":"E14017","volume":"5"},"referencePositions":["INTERACTION WITH TEX19.1 AND TEX19.2"]},{"referenceNumber":13,"citation":{"id":"28806172","citationType":"journal article","authors":["MacLennan M.","Garcia-Canadas M.","Reichmann J.","Khazina E.","Wagner G.","Playfoot C.J.","Salvador-Palomeque C.","Mann A.R.","Peressini P.","Sanchez L.","Dobie K.","Read D.","Hung C.C.","Eskeland R.","Meehan R.R.","Weichenrieder O.","Garcia-Perez J.L.","Adams I.R."],"citationCrossReferences":[{"database":"PubMed","id":"28806172"},{"database":"DOI","id":"10.7554/elife.26152"}],"title":"Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells.","publicationDate":"2017","journal":"Elife","firstPage":"0","lastPage":"0","volume":"6"},"referencePositions":["FUNCTION","INTERACTION WITH L1RE1","TISSUE SPECIFICITY"]},{"referenceNumber":14,"citation":{"id":"28708824","citationType":"journal article","authors":["Crichton J.H.","Playfoot C.J.","MacLennan M.","Read D.","Cooke H.J.","Adams I.R."],"citationCrossReferences":[{"database":"PubMed","id":"28708824"},{"database":"DOI","id":"10.1371/journal.pgen.1006904"}],"title":"Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes.","publicationDate":"2017","journal":"PLoS Genet.","firstPage":"E1006904","lastPage":"E1006904","volume":"13"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]},{"referenceNumber":15,"citation":{"id":"31268597","citationType":"journal article","authors":["Xu H.","Shi J.","Gao H.","Liu Y.","Yang Z.","Shao F.","Dong N."],"citationCrossReferences":[{"database":"PubMed","id":"31268597"},{"database":"DOI","id":"10.15252/embj.2019101996"}],"title":"The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin.","publicationDate":"2019","journal":"EMBO J.","firstPage":"e101996","lastPage":"e101996","volume":"38"},"referencePositions":["FUNCTION","CATALYTIC ACTIVITY","PATHWAY","INTERACTION WITH UBE2O"]},{"referenceNumber":16,"citation":{"id":"30872531","citationType":"journal article","authors":["Chui A.J.","Okondo M.C.","Rao S.D.","Gai K.","Griswold A.R.","Johnson D.C.","Ball D.P.","Taabazuing C.Y.","Orth E.L.","Vittimberga B.A.","Bachovchin D.A."],"citationCrossReferences":[{"database":"PubMed","id":"30872531"},{"database":"DOI","id":"10.1126/science.aau1208"}],"title":"N-terminal degradation activates the NLRP1B inflammasome.","publicationDate":"2019","journal":"Science","firstPage":"82","lastPage":"85","volume":"364"},"referencePositions":["FUNCTION","PATHWAY"]},{"referenceNumber":17,"citation":{"id":"38225265","citationType":"journal article","authors":["Shih Y.C.","Chen H.F.","Wu C.Y.","Ciou Y.R.","Wang C.W.","Chuang H.C.","Tan T.H."],"citationCrossReferences":[{"database":"PubMed","id":"38225265"},{"database":"DOI","id":"10.1038/s41467-024-44843-w"}],"title":"The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling.","publicationDate":"2024","journal":"Nat. Commun.","firstPage":"532","lastPage":"532","volume":"15"},"referencePositions":["FUNCTION","DISRUPTION PHENOTYPE"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY280958","properties":[{"key":"ProteinId","value":"AAQ17202.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AY061885","properties":[{"key":"ProteinId","value":"AAL32102.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK122254","properties":[{"key":"ProteinId","value":"BAC65536.3"},{"key":"Status","value":"ALT_SEQ"},{"key":"MoleculeType","value":"Unassigned_DNA"}]},{"database":"EMBL","id":"BC025617","properties":[{"key":"ProteinId","value":"AAH25617.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC026391","properties":[{"key":"ProteinId","value":"AAH26391.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC031403","properties":[{"key":"ProteinId","value":"AAH31403.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"BC075642","properties":[{"key":"ProteinId","value":"AAH75642.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AK083320","properties":[{"key":"ProteinId","value":"BAC38864.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS28845.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6WKZ8-1"},{"database":"CCDS","id":"CCDS50127.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6WKZ8-2"},{"database":"RefSeq","id":"NP_001170845.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001177374.2"}],"isoformId":"Q6WKZ8-2"},{"database":"RefSeq","id":"NP_666190.2","properties":[{"key":"NucleotideSequenceId","value":"NM_146078.4"}],"isoformId":"Q6WKZ8-1"},{"database":"AlphaFoldDB","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"BMRB","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"230327","properties":[{"key":"Interactions","value":"4"}]},{"database":"ELM","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6WKZ8","properties":[{"key":"Number of interactors","value":"2173"}]},{"database":"STRING","id":"10090.ENSMUSP00000108963","properties":[{"key":"Description","value":"-"}]},{"database":"GlyGen","id":"Q6WKZ8","properties":[{"key":"glycosylation","value":"2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)"}]},{"database":"iPTMnet","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"SwissPalm","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"10090-ENSMUSP00000108963","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"300072","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6WKZ8-1"},{"database":"ProteomicsDB","id":"300073","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6WKZ8-2"},{"database":"ProteomicsDB","id":"300074","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6WKZ8-3"},{"database":"Pumba","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"30162","properties":[{"key":"antibodies","value":"231 antibodies from 32 providers"}]},{"database":"DNASU","id":"224826","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSMUST00000113335.4","properties":[{"key":"ProteinId","value":"ENSMUSP00000108961.3"},{"key":"GeneId","value":"ENSMUSG00000023977.16"}],"isoformId":"Q6WKZ8-2"},{"database":"Ensembl","id":"ENSMUST00000113337.10","properties":[{"key":"ProteinId","value":"ENSMUSP00000108963.3"},{"key":"GeneId","value":"ENSMUSG00000023977.16"}],"isoformId":"Q6WKZ8-1"},{"database":"GeneID","id":"224826","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"mmu:224826","properties":[{"key":"Description","value":"-"}]},{"database":"UCSC","id":"uc012aus.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q6WKZ8-1"},{"database":"UCSC","id":"uc012auu.1","properties":[{"key":"OrganismName","value":"mouse"}],"isoformId":"Q6WKZ8-3"},{"database":"AGR","id":"MGI:1861099","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23304","properties":[{"key":"Description","value":"-"}]},{"database":"MGI","id":"MGI:1861099","properties":[{"key":"GeneName","value":"Ubr2"}]},{"database":"VEuPathDB","id":"HostDB:ENSMUSG00000023977","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"KOG1140","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00950000183075","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_001801_2_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"GEASYMC","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"26387at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"Reactome","id":"R-MMU-983168","properties":[{"key":"PathwayName","value":"Antigen processing: Ubiquitination & Proteasome degradation"}]},{"database":"UniPathway","id":"UPA00143","properties":[{"key":"RectionId","value":"-"}]},{"database":"BioGRID-ORCS","id":"224826","properties":[{"key":"hits","value":"5 hits in 81 CRISPR screens"}]},{"database":"PRO","id":"PR:Q6WKZ8","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000589","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q6WKZ8","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSMUSG00000023977","properties":[{"key":"ExpressionPatterns","value":"Expressed in rostral migratory stream and 235 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6WKZ8","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0000785","properties":[{"key":"GoTerm","value":"C:chromatin"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20080676"}]},{"database":"GO","id":"GO:0005694","properties":[{"key":"GoTerm","value":"C:chromosome"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"EXP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"14585983"},{"evidenceCode":"ECO:0000269","source":"PubMed","id":"20080676"}]},{"database":"GO","id":"GO:0000151","properties":[{"key":"GoTerm","value":"C:ubiquitin ligase complex"},{"key":"GoEvidenceType","value":"IGI:MGI"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"11689692"}]},{"database":"GO","id":"GO:0141053","properties":[{"key":"GoTerm","value":"F:histone H2A ubiquitin ligase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20080676"}]},{"database":"GO","id":"GO:0070728","properties":[{"key":"GoTerm","value":"F:L-leucine binding"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0061630","properties":[{"key":"GoTerm","value":"F:ubiquitin protein ligase activity"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19008229"},{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31268597"}]},{"database":"GO","id":"GO:0008270","properties":[{"key":"GoTerm","value":"F:zinc ion binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0071233","properties":[{"key":"GoTerm","value":"P:cellular response to L-leucine"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0031507","properties":[{"key":"GoTerm","value":"P:heterochromatin formation"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20080676"}]},{"database":"GO","id":"GO:0007141","properties":[{"key":"GoTerm","value":"P:male meiosis I"},{"key":"GoEvidenceType","value":"IMP:MGI"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14585983"}]},{"database":"GO","id":"GO:0007140","properties":[{"key":"GoTerm","value":"P:male meiotic nuclear division"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28708824"}]},{"database":"GO","id":"GO:0032007","properties":[{"key":"GoTerm","value":"P:negative regulation of TOR signaling"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0050862","properties":[{"key":"GoTerm","value":"P:positive regulation of T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0043161","properties":[{"key":"GoTerm","value":"P:proteasome-mediated ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0070534","properties":[{"key":"GoTerm","value":"P:protein K63-linked ubiquitination"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0016567","properties":[{"key":"GoTerm","value":"P:protein ubiquitination"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007131","properties":[{"key":"GoTerm","value":"P:reciprocal meiotic recombination"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28708824"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28708824"}]},{"database":"GO","id":"GO:0050852","properties":[{"key":"GoTerm","value":"P:T cell receptor signaling pathway"},{"key":"GoEvidenceType","value":"ISO:GO_Central"}]},{"database":"GO","id":"GO:0010526","properties":[{"key":"GoTerm","value":"P:transposable element silencing"},{"key":"GoEvidenceType","value":"IMP:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"28806172"}]},{"database":"GO","id":"GO:0006511","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process"},{"key":"GoEvidenceType","value":"IDA:MGI"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"14585983"}]},{"database":"GO","id":"GO:0071596","properties":[{"key":"GoTerm","value":"P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"19008229"}]},{"database":"CDD","id":"cd19679","properties":[{"key":"EntryName","value":"UBR-box_UBR2"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.10.110.30:FF:000001","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase UBR2 isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.10.2670:FF:000001","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase UBR2 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.1390.10:FF:000003","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase UBR2 isoform X1"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"2.10.110.30","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.1390.10","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.10.2670","properties":[{"key":"EntryName","value":"E3 ubiquitin-protein ligase"},{"key":"MatchStatus","value":"1"}]},{"database":"InterPro","id":"IPR063352","properties":[{"key":"EntryName","value":"ARM_UBR_1_2_3"}]},{"database":"InterPro","id":"IPR003769","properties":[{"key":"EntryName","value":"ClpS_core"}]},{"database":"InterPro","id":"IPR042065","properties":[{"key":"EntryName","value":"E3_ELL-like"}]},{"database":"InterPro","id":"IPR044046","properties":[{"key":"EntryName","value":"E3_ligase_UBR-like_C"}]},{"database":"InterPro","id":"IPR014719","properties":[{"key":"EntryName","value":"Ribosomal_bL12_C/ClpS-like"}]},{"database":"InterPro","id":"IPR047508","properties":[{"key":"EntryName","value":"UBR-box_UBR2"}]},{"database":"InterPro","id":"IPR039164","properties":[{"key":"EntryName","value":"UBR1-like"}]},{"database":"InterPro","id":"IPR055194","properties":[{"key":"EntryName","value":"UBR1-like_WH"}]},{"database":"InterPro","id":"IPR036390","properties":[{"key":"EntryName","value":"WH_DNA-bd_sf"}]},{"database":"InterPro","id":"IPR003126","properties":[{"key":"EntryName","value":"Znf_UBR"}]},{"database":"PANTHER","id":"PTHR21497:SF28","properties":[{"key":"EntryName","value":"E3 UBIQUITIN-PROTEIN LIGASE UBR2"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR21497","properties":[{"key":"EntryName","value":"UBIQUITIN LIGASE E3 ALPHA-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF30856","properties":[{"key":"EntryName","value":"ARM_UBR_1_2_3"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02617","properties":[{"key":"EntryName","value":"ClpS"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF18995","properties":[{"key":"EntryName","value":"PRT6_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF22960","properties":[{"key":"EntryName","value":"WHD_UBR1"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02207","properties":[{"key":"EntryName","value":"zf-UBR"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00396","properties":[{"key":"EntryName","value":"ZnF_UBR1"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF54736","properties":[{"key":"EntryName","value":"ClpS-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF46785","properties":[{"key":"EntryName","value":"Winged helix' DNA-binding domain"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51157","properties":[{"key":"EntryName","value":"ZF_UBR"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"MASEMEPEVQAIDRSLLECSAEEIAGRWLQATDLNREVYQHLAHCVPKIYCRGPNPFPQKEDTLAQHILLGPMEWYICAEDPALGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHKLSSSEVVEEEDPLVHLSEDVIARTYNIFAIMFRYAVDILTWEKESELPEDLEVAEKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCDQAKTVIVRNTSRQTKPLKVQVMHSSVAAHQNFGLKALSWLGSVIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLNDSKLWKGARSVYHQLFMSSLLMDLKYKKLFALRFAKNYRQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLLTEENLMTVIIKAFMDHLKHRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQKFLQGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMVQDWCALDEKVLIEAYKKCLAVLTQCHGGFTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPISRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDIVMLQTGVSMMDPNHFLMIMLSRFELYQLFSTPDYGKRFSSEVTHKDVVQQNNTLIEEMLYLIIMLVGERFNPGVGQVAATDEIKREIIHQLSIKPMAHSELVKSLPEDENKETGMESVIESVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEAQRKLKRENKEDTALPPPALPPFCPLFASLVNILQCDVMLYIMGTILQWAVEHHGSAWSESMLQRVLHLIGMALQEEKHHLENAVEGHVQTFTFTQKISKPGDAPHNSPSILAMLETLQNAPSLEAHKDMIRWLLKMFNAIKKIRECSSSSPVAEAEGTIMEESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDTSASATLDSSPPVSDAALTALGPAQTQVPEPRQFVTCILCQEEQEVTVGSRAMVLAAFVQRSTVLSKDRTKTIADPEKYDPLFMHPDLSCGTHTGSCGHVMHAHCWQRYFDSVQAKEQRRQQRLRLHTSYDVENGEFLCPLCECLSNTVIPLLLPPRSILSRRLNFSDQPDLAQWTRAVTQQIKVVQMLRRKHNAADTSSSEDTEAMNIIPIPEGFRPDFYPRNPYSDSIKEMLTTFGTAAYKVGLKVHPNEGDPRVPILCWGTCAYTIQSIERILSDEEKPVFGPLPCRLDDCLRSLTRFAAAHWTVALLPVVQGHFCKLFASLVPSDSYEDLPCILDIDMFHLLVGLVLAFPALQCQDFSGSSLATGDLHIFHLVTMAHIVQILLTSCTEENGMDQENPTGEEELAILSLHKTLHQYTGSALKEAPSGWHLWRSVRAAIMPFLKCSALFFHYLNGVPAPPDLQVSGTSHFEHLCNYLSLPTNLIHLFQENSDIMNSLIESWCQNSEVKRYLNGERGAISYPRGANKLIDLPEDYSSLINQASNFSCPKSGGDKSRAPTLCLVCGSLLCSQSYCCQAELEGEDVGACTAHTYSCGSGAGIFLRVRECQVLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCQERFRKIQKLWQQHSITEEIGHAQEANQTLVGIDWQHL","length":1755,"molWeight":199155,"crc64":"E6D413D674FBBFDA","md5":"EF338EB82A196B655A0938652CBBC98E"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"PATHWAY":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"TISSUE SPECIFICITY":1,"INDUCTION":1,"DOMAIN":1,"PTM":2,"DISRUPTION PHENOTYPE":1,"SIMILARITY":1,"SEQUENCE CAUTION":3},"countByFeatureType":{"Initiator methionine":1,"Chain":1,"Zinc finger":2,"Region":1,"Coiled coil":1,"Compositional bias":1,"Binding site":23,"Modified residue":4,"Cross-link":13,"Alternative sequence":2,"Sequence conflict":10},"uniParcId":"UPI00001EB1FC"}}