{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6UX52","uniProtkbId":"IL40_HUMAN","entryAudit":{"firstPublicDate":"2007-01-23","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2012-05-16","entryVersion":141,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Protein IL-40"}},"alternativeNames":[{"fullName":{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28978694"}],"value":"Interleukin-40"},"shortNames":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28978694"}],"value":"IL-40"}]}],"flag":"Precursor"},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:34490"}],"value":"C17orf99"},"synonyms":[{"evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"28978694"}],"value":"IL40"}],"orfNames":[{"value":"UNQ464/PRO809"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q9CX63"}],"value":"Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28978694"}],"value":"Secreted","id":"SL-0243"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"28978694"}],"value":"Expressed in fetal liver and bone marrow (PubMed:28978694). Expressed in peripheral blood lymphocyte B cells (PubMed:28978694)"}],"commentType":"TISSUE SPECIFICITY"}],"features":[{"type":"Signal","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":20,"modifier":"EXACT"}},"description":"","evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"15340161"}]},{"type":"Chain","location":{"start":{"value":21,"modifier":"EXACT"},"end":{"value":265,"modifier":"EXACT"}},"description":"Protein IL-40","featureId":"PRO_0000272654"},{"type":"Glycosylation","location":{"start":{"value":86,"modifier":"EXACT"},"end":{"value":86,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Glycosylation","location":{"start":{"value":132,"modifier":"EXACT"},"end":{"value":132,"modifier":"EXACT"}},"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}],"featureId":""},{"type":"Natural variant","location":{"start":{"value":101,"modifier":"EXACT"},"end":{"value":101,"modifier":"EXACT"}},"description":"in dbSNP:rs4071641","featureCrossReferences":[{"database":"dbSNP","id":"rs4071641"}],"evidences":[{"evidenceCode":"ECO:0000269","source":"PubMed","id":"12975309"}],"featureId":"VAR_067466","alternativeSequence":{"originalSequence":"W","alternativeSequences":["R"]}}],"keywords":[{"id":"KW-1064","category":"Biological process","name":"Adaptive immunity"},{"id":"KW-0202","category":"Molecular function","name":"Cytokine"},{"id":"KW-0903","category":"Technical term","name":"Direct protein sequencing"},{"id":"KW-0325","category":"PTM","name":"Glycoprotein"},{"id":"KW-0391","category":"Biological process","name":"Immunity"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0964","category":"Cellular component","name":"Secreted"},{"id":"KW-0732","category":"Domain","name":"Signal"}],"references":[{"referenceNumber":1,"citation":{"id":"12975309","citationType":"journal article","authors":["Clark H.F.","Gurney A.L.","Abaya E.","Baker K.","Baldwin D.T.","Brush J.","Chen J.","Chow B.","Chui C.","Crowley C.","Currell B.","Deuel B.","Dowd P.","Eaton D.","Foster J.S.","Grimaldi C.","Gu Q.","Hass P.E.","Heldens S.","Huang A.","Kim H.S.","Klimowski L.","Jin Y.","Johnson S.","Lee J.","Lewis L.","Liao D.","Mark M.R.","Robbie E.","Sanchez C.","Schoenfeld J.","Seshagiri S.","Simmons L.","Singh J.","Smith V.","Stinson J.","Vagts A.","Vandlen R.L.","Watanabe C.","Wieand D.","Woods K.","Xie M.-H.","Yansura D.G.","Yi S.","Yu G.","Yuan J.","Zhang M.","Zhang Z.","Goddard A.D.","Wood W.I.","Godowski P.J.","Gray A.M."],"citationCrossReferences":[{"database":"PubMed","id":"12975309"},{"database":"DOI","id":"10.1101/gr.1293003"}],"title":"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.","publicationDate":"2003","journal":"Genome Res.","firstPage":"2265","lastPage":"2270","volume":"13"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]","VARIANT ARG-101"]},{"referenceNumber":2,"citation":{"id":"16625196","citationType":"journal article","authors":["Zody M.C.","Garber M.","Adams D.J.","Sharpe T.","Harrow J.","Lupski J.R.","Nicholson C.","Searle S.M.","Wilming L.","Young S.K.","Abouelleil A.","Allen N.R.","Bi W.","Bloom T.","Borowsky M.L.","Bugalter B.E.","Butler J.","Chang J.L.","Chen C.-K.","Cook A.","Corum B.","Cuomo C.A.","de Jong P.J.","DeCaprio D.","Dewar K.","FitzGerald M.","Gilbert J.","Gibson R.","Gnerre S.","Goldstein S.","Grafham D.V.","Grocock R.","Hafez N.","Hagopian D.S.","Hart E.","Norman C.H.","Humphray S.","Jaffe D.B.","Jones M.","Kamal M.","Khodiyar V.K.","LaButti K.","Laird G.","Lehoczky J.","Liu X.","Lokyitsang T.","Loveland J.","Lui A.","Macdonald P.","Major J.E.","Matthews L.","Mauceli E.","McCarroll S.A.","Mihalev A.H.","Mudge J.","Nguyen C.","Nicol R.","O'Leary S.B.","Osoegawa K.","Schwartz D.C.","Shaw-Smith C.","Stankiewicz P.","Steward C.","Swarbreck D.","Venkataraman V.","Whittaker C.A.","Yang X.","Zimmer A.R.","Bradley A.","Hubbard T.","Birren B.W.","Rogers J.","Lander E.S.","Nusbaum C."],"citationCrossReferences":[{"database":"PubMed","id":"16625196"},{"database":"DOI","id":"10.1038/nature04689"}],"title":"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.","publicationDate":"2006","journal":"Nature","firstPage":"1045","lastPage":"1049","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15340161","citationType":"journal article","authors":["Zhang Z.","Henzel W.J."],"citationCrossReferences":[{"database":"PubMed","id":"15340161"},{"database":"DOI","id":"10.1110/ps.04682504"}],"title":"Signal peptide prediction based on analysis of experimentally verified cleavage sites.","publicationDate":"2004","journal":"Protein Sci.","firstPage":"2819","lastPage":"2824","volume":"13"},"referencePositions":["PROTEIN SEQUENCE OF 21-35"]},{"referenceNumber":4,"citation":{"id":"28978694","citationType":"journal article","authors":["Catalan-Dibene J.","Vazquez M.I.","Luu V.P.","Nuccio S.P.","Karimzadeh A.","Kastenschmidt J.M.","Villalta S.A.","Ushach I.","Pone E.J.","Casali P.","Raffatellu M.","Burkhardt A.M.","Hernandez-Ruiz M.","Heller G.","Hevezi P.A.","Zlotnik A."],"citationCrossReferences":[{"database":"PubMed","id":"28978694"},{"database":"DOI","id":"10.4049/jimmunol.1700534"}],"title":"Identification of IL-40, a novel B cell-associated cytokine.","publicationDate":"2017","journal":"J. Immunol.","firstPage":"3326","lastPage":"3335","volume":"199"},"referencePositions":["SUBCELLULAR LOCATION","TISSUE SPECIFICITY"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AY358510","properties":[{"key":"ProteinId","value":"AAQ88874.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AC021593","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"CCDS","id":"CCDS54171.1","properties":[{"key":"Description","value":"-"}]},{"database":"RefSeq","id":"NP_001156547.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001163075.2"}]},{"database":"AlphaFoldDB","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"936687","properties":[{"key":"Interactions","value":"1"}]},{"database":"FunCoup","id":"Q6UX52","properties":[{"key":"Number of interactors","value":"118"}]},{"database":"GlyCosmos","id":"Q6UX52","properties":[{"key":"glycosylation","value":"2 sites, No reported glycans"}]},{"database":"GlyGen","id":"Q6UX52","properties":[{"key":"glycosylation","value":"2 sites"}]},{"database":"iPTMnet","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C17orf99","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"387912830","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000343493","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"Antibodypedia","id":"32542","properties":[{"key":"antibodies","value":"25 antibodies from 12 providers"}]},{"database":"DNASU","id":"100141515","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000340363.10","properties":[{"key":"ProteinId","value":"ENSP00000343493.4"},{"key":"GeneId","value":"ENSG00000187997.12"}]},{"database":"GeneID","id":"100141515","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:100141515","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000340363.10","properties":[{"key":"ProteinId","value":"ENSP00000343493.4"},{"key":"RefSeqNucleotideId","value":"NM_001163075.2"},{"key":"RefSeqProteinId","value":"NP_001156547.1"}]},{"database":"UCSC","id":"uc002jus.5","properties":[{"key":"OrganismName","value":"human"}]},{"database":"AGR","id":"HGNC:34490","properties":[{"key":"Description","value":"-"}]},{"database":"ClinPGx","id":"PA162378601","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"100141515","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"100141515","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"C17orf99","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:34490","properties":[{"key":"GeneName","value":"C17orf99"}]},{"database":"HPA","id":"ENSG00000187997","properties":[{"key":"ExpressionPatterns","value":"Tissue enriched (bone)"}]},{"database":"MIM","id":"621418","properties":[{"key":"Type","value":"gene"}]},{"database":"OpenTargets","id":"ENSG00000187997","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000187997","properties":[{"key":"Description","value":"-"}]},{"database":"eggNOG","id":"ENOG502SPUE","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT01050000244808","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"AEMSCWA","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"9524734at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6UX52","properties":[{"key":"Number of GO annotations","value":"4 GO annotations based on evolutionary models"}]},{"database":"PathwayCommons","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"SignaLink","id":"Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000187997","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"100141515","properties":[{"key":"hits","value":"10 hits in 1142 CRISPR screens"}]},{"database":"ChiTaRS","id":"C17orf99","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"100141515","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6UX52","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q6UX52","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"RNAct","id":"Q6UX52","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000187997","properties":[{"key":"ExpressionPatterns","value":"Expressed in colonic epithelium and 96 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6UX52","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0009897","properties":[{"key":"GoTerm","value":"C:external side of plasma membrane"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005576","properties":[{"key":"GoTerm","value":"C:extracellular region"},{"key":"GoEvidenceType","value":"IDA:UniProtKB"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"28978694"}]},{"database":"GO","id":"GO:0004888","properties":[{"key":"GoTerm","value":"F:transmembrane signaling receptor activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0007166","properties":[{"key":"GoTerm","value":"P:cell surface receptor signaling pathway"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006955","properties":[{"key":"GoTerm","value":"P:immune response"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0002313","properties":[{"key":"GoTerm","value":"P:mature B cell differentiation involved in immune response"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:2000558","properties":[{"key":"GoTerm","value":"P:positive regulation of immunoglobulin production in mucosal tissue"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR040878","properties":[{"key":"EntryName","value":"IL-40-like_Ig"}]},{"database":"Pfam","id":"PF17736","properties":[{"key":"EntryName","value":"Ig_C17orf99"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MGLPGLFCLAVLAASSFSKAREEEITPVVSIAYKVLEVFPKGRWVLITCCAPQPPPPITYSLCGTKNIKVAKKVVKTHEPASFNLNVTLKSSPDLLTYFCWASSTSGAHVDSARLQMHWELWSKPVSELRANFTLQDRGAGPRVEMICQASSGSPPITNSLIGKDGQVHLQQRPCHRQPANFSFLPSQTSDWFWCQAANNANVQHSALTVVPPGGDQKMEDWQGPLESPILALPLYRSTRRLSEEEFGGFRIGNGEVRGRKAAAM","length":265,"molWeight":29091,"crc64":"0F3EB3BEDD972DC6","md5":"0AF7015C110EC1C9CD12D7B639596110"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"TISSUE SPECIFICITY":1},"countByFeatureType":{"Signal":1,"Chain":1,"Glycosylation":2,"Natural variant":1},"uniParcId":"UPI000049DE67"}}