ID   DHR13_HUMAN             Reviewed;         377 AA.
AC   Q6UX07; B4DJC5; Q96BH7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 154.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 13;
DE            EC=1.1.-.- {ECO:0000305};
DE   AltName: Full=Short chain dehydrogenase/reductase family 7C member 5 {ECO:0000303|PubMed:19027726};
DE            Short=Protein SDR7C5 {ECO:0000303|PubMed:19027726};
DE   Flags: Precursor;
GN   Name=DHRS13 {ECO:0000312|HGNC:HGNC:28326};
GN   Synonyms=SDR7C5 {ECO:0000303|PubMed:19027726}; ORFNames=UNQ419/PRO853;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Subthalamic nucleus {ECO:0000312|EMBL:BAG58787.1};
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA   Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA   Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA   Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA   Adamski J., Oppermann U.;
RT   "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT   nomenclature initiative.";
RL   Chem. Biol. Interact. 178:94-98(2009).
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6UX07-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6UX07-2; Sequence=VSP_029640;
CC       Name=3;
CC         IsoId=Q6UX07-3; Sequence=VSP_057529;
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AY358566; AAQ88929.1; -; mRNA.
DR   EMBL; AK296017; BAG58787.1; -; mRNA.
DR   EMBL; AC024267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471159; EAW51159.1; -; Genomic_DNA.
DR   EMBL; CH471159; EAW51153.1; -; Genomic_DNA.
DR   EMBL; BC015582; AAH15582.1; -; mRNA.
DR   CCDS; CCDS11246.2; -. [Q6UX07-1]
DR   RefSeq; NP_653284.2; NM_144683.3. [Q6UX07-1]
DR   AlphaFoldDB; Q6UX07; -.
DR   SMR; Q6UX07; -.
DR   BioGRID; 127030; 40.
DR   IntAct; Q6UX07; 5.
DR   STRING; 9606.ENSP00000368173; -.
DR   iPTMnet; Q6UX07; -.
DR   PhosphoSitePlus; Q6UX07; -.
DR   SwissPalm; Q6UX07; -.
DR   BioMuta; DHRS13; -.
DR   DMDM; 74738164; -.
DR   EPD; Q6UX07; -.
DR   jPOST; Q6UX07; -.
DR   MassIVE; Q6UX07; -.
DR   MaxQB; Q6UX07; -.
DR   PaxDb; 9606-ENSP00000368173; -.
DR   PeptideAtlas; Q6UX07; -.
DR   ProteomicsDB; 4366; -.
DR   ProteomicsDB; 67548; -. [Q6UX07-1]
DR   ProteomicsDB; 67549; -. [Q6UX07-2]
DR   Pumba; Q6UX07; -.
DR   TopDownProteomics; Q6UX07-1; -. [Q6UX07-1]
DR   Antibodypedia; 14931; 88 antibodies from 15 providers.
DR   DNASU; 147015; -.
DR   Ensembl; ENST00000378895.9; ENSP00000368173.4; ENSG00000167536.14. [Q6UX07-1]
DR   Ensembl; ENST00000394901.7; ENSP00000378361.3; ENSG00000167536.14. [Q6UX07-2]
DR   Ensembl; ENST00000426464.2; ENSP00000412826.2; ENSG00000167536.14. [Q6UX07-3]
DR   GeneID; 147015; -.
DR   KEGG; hsa:147015; -.
DR   MANE-Select; ENST00000378895.9; ENSP00000368173.4; NM_144683.4; NP_653284.2.
DR   UCSC; uc002hdd.5; human. [Q6UX07-1]
DR   UCSC; uc010wba.3; human.
DR   AGR; HGNC:28326; -.
DR   CTD; 147015; -.
DR   DisGeNET; 147015; -.
DR   GeneCards; DHRS13; -.
DR   HGNC; HGNC:28326; DHRS13.
DR   HPA; ENSG00000167536; Tissue enhanced (bone).
DR   MIM; 616157; gene.
DR   neXtProt; NX_Q6UX07; -.
DR   OpenTargets; ENSG00000167536; -.
DR   PharmGKB; PA147358144; -.
DR   VEuPathDB; HostDB:ENSG00000167536; -.
DR   eggNOG; KOG1208; Eukaryota.
DR   GeneTree; ENSGT00940000155599; -.
DR   HOGENOM; CLU_010194_44_5_1; -.
DR   InParanoid; Q6UX07; -.
DR   OMA; NEVIFMM; -.
DR   OrthoDB; 2466675at2759; -.
DR   PhylomeDB; Q6UX07; -.
DR   TreeFam; TF105429; -.
DR   PathwayCommons; Q6UX07; -.
DR   SignaLink; Q6UX07; -.
DR   BioGRID-ORCS; 147015; 21 hits in 1162 CRISPR screens.
DR   ChiTaRS; DHRS13; human.
DR   GenomeRNAi; 147015; -.
DR   Pharos; Q6UX07; Tdark.
DR   PRO; PR:Q6UX07; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q6UX07; Protein.
DR   Bgee; ENSG00000167536; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 105 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd05327; retinol-DH_like_SDR_c_like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43157:SF44; DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 13; 1.
DR   PANTHER; PTHR43157; PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   Genevisible; Q6UX07; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; NAD; NADP; Oxidoreductase; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..377
FT                   /note="Dehydrogenase/reductase SDR family member 13"
FT                   /id="PRO_0000311920"
FT   REGION          309..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        197
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         46
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         48
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         170
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         197
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         201
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         232
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   VAR_SEQ         1..50
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_029640"
FT   VAR_SEQ         43..123
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_057529"
FT   VARIANT         191
FT                   /note="R -> Q (in dbSNP:rs2277666)"
FT                   /id="VAR_037348"
FT   VARIANT         336
FT                   /note="L -> Q (in dbSNP:rs4795472)"
FT                   /id="VAR_037349"
SQ   SEQUENCE   377 AA;  40849 MW;  742688974BBDA564 CRC64;
     MEALLLGAGL LLGAYVLVYY NLVKAPPCGG MGNLRGRTAV VTGANSGIGK MTALELARRG
     ARVVLACRSQ ERGEAAAFDL RQESGNNEVI FMALDLASLA SVRAFATAFL SSEPRLDILI
     HNAGISSCGR TREAFNLLLR VNHIGPFLLT HLLLPCLKAC APSRVVVVAS AAHCRGRLDF
     KRLDRPVVGW RQELRAYADT KLANVLFARE LANQLEATGV TCYAAHPGPV NSELFLRHVP
     GWLRPLLRPL AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA
     HRLWEASKRL AGLGPGEDAE PDEDPQSEDS EAPSSLSTPH PEEPTVSQPY PSPQSSPDLS
     KMTHRIQAKV EPEIQLS
//