ID   LCN15_HUMAN             Reviewed;         184 AA.
AC   Q6UWW0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 136.
DE   RecName: Full=Lipocalin-15;
DE   Flags: Precursor;
GN   Name=LCN15; ORFNames=UNQ2541/PRO6093;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 19-177.
RG   Structural genomics consortium (SGC);
RT   "Crystal structure of the human lipocalin 15.";
RL   Submitted (DEC-2012) to the PDB data bank.
CC   -!- INTERACTION:
CC       Q6UWW0; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176085, EBI-16439278;
CC       Q6UWW0; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-12176085, EBI-25492395;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY358618; AAQ88981.1; -; mRNA.
DR   EMBL; AL355987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC093893; AAH93893.1; -; mRNA.
DR   EMBL; BC093895; AAH93895.1; -; mRNA.
DR   CCDS; CCDS7006.1; -.
DR   RefSeq; NP_976222.1; NM_203347.1.
DR   PDB; 2XST; X-ray; 1.63 A; A=19-177.
DR   PDBsum; 2XST; -.
DR   AlphaFoldDB; Q6UWW0; -.
DR   SMR; Q6UWW0; -.
DR   BioGRID; 133279; 14.
DR   IntAct; Q6UWW0; 9.
DR   STRING; 9606.ENSP00000313833; -.
DR   BioMuta; LCN15; -.
DR   DMDM; 74749403; -.
DR   MassIVE; Q6UWW0; -.
DR   PaxDb; 9606-ENSP00000313833; -.
DR   PeptideAtlas; Q6UWW0; -.
DR   ProteomicsDB; 67531; -.
DR   Antibodypedia; 53301; 42 antibodies from 10 providers.
DR   DNASU; 389812; -.
DR   Ensembl; ENST00000316144.6; ENSP00000313833.5; ENSG00000177984.7.
DR   GeneID; 389812; -.
DR   KEGG; hsa:389812; -.
DR   MANE-Select; ENST00000316144.6; ENSP00000313833.5; NM_203347.2; NP_976222.1.
DR   UCSC; uc004cjd.3; human.
DR   AGR; HGNC:33777; -.
DR   CTD; 389812; -.
DR   GeneCards; LCN15; -.
DR   HGNC; HGNC:33777; LCN15.
DR   HPA; ENSG00000177984; Tissue enhanced (intestine, seminal vesicle).
DR   neXtProt; NX_Q6UWW0; -.
DR   OpenTargets; ENSG00000177984; -.
DR   PharmGKB; PA164722091; -.
DR   VEuPathDB; HostDB:ENSG00000177984; -.
DR   eggNOG; ENOG502S13A; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_094061_3_1_1; -.
DR   InParanoid; Q6UWW0; -.
DR   OMA; WAEVLVQ; -.
DR   OrthoDB; 3932172at2759; -.
DR   PhylomeDB; Q6UWW0; -.
DR   TreeFam; TF336103; -.
DR   PathwayCommons; Q6UWW0; -.
DR   Reactome; R-HSA-804914; Transport of fatty acids.
DR   SignaLink; Q6UWW0; -.
DR   BioGRID-ORCS; 389812; 41 hits in 1144 CRISPR screens.
DR   EvolutionaryTrace; Q6UWW0; -.
DR   GenomeRNAi; 389812; -.
DR   Pharos; Q6UWW0; Tdark.
DR   PRO; PR:Q6UWW0; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q6UWW0; Protein.
DR   Bgee; ENSG00000177984; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 75 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   CDD; cd19422; lipocalin_15-like; 1.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   PANTHER; PTHR11430; LIPOCALIN; 1.
DR   PANTHER; PTHR11430:SF64; LIPOCALIN-15; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR00179; LIPOCALIN.
DR   PRINTS; PR01254; PGNDSYNTHASE.
DR   SUPFAM; SSF50814; Lipocalins; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
DR   Genevisible; Q6UWW0; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..184
FT                   /note="Lipocalin-15"
FT                   /id="PRO_0000317518"
FT   DISULFID        83..176
FT                   /evidence="ECO:0000250"
FT   VARIANT         152
FT                   /note="S -> A (in dbSNP:rs2297723)"
FT                   /id="VAR_059453"
FT   VARIANT         164
FT                   /note="K -> E (in dbSNP:rs2297722)"
FT                   /id="VAR_059454"
FT   TURN            30..33
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          35..44
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           47..52
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           53..55
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          59..65
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           67..69
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          71..76
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          85..92
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          98..101
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           102..104
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          106..114
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          116..128
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          131..144
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           147..156
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           157..160
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   HELIX           164..166
FT                   /evidence="ECO:0007829|PDB:2XST"
FT   STRAND          167..169
FT                   /evidence="ECO:0007829|PDB:2XST"
SQ   SEQUENCE   184 AA;  20454 MW;  CEE57C05BD0C8ED8 CRC64;
     MMSFLLGAIL TLLWAPTAQA EVLLQPDFNA EKFSGLWYVV SMASDCRVFL GKKDHLSMST
     RAIRPTEEGG LHVHMEFPGA DGCNQVDAEY LKVGSEGHFR VPALGYLDVR IVDTDYSSFA
     VLYIYKELEG ALSTMVQLYS RTQDVSPQAL KSFQDFYPTL GLPKDMMVML PQSDACNPES
     KEAP
//