{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6TV19","uniProtkbId":"DICER_DANRE","entryAudit":{"firstPublicDate":"2009-05-05","lastAnnotationUpdateDate":"2026-09-02","lastSequenceUpdateDate":"2009-05-05","entryVersion":131,"sequenceVersion":2},"annotationScore":5.0,"organism":{"scientificName":"Danio rerio","commonName":"Zebrafish","synonyms":["Brachydanio rerio"],"taxonId":7955,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Actinopterygii","Neopterygii","Teleostei","Ostariophysi","Cypriniformes","Danionidae","Danioninae","Danio"]},"proteinExistence":"2: Evidence at transcript level","proteinDescription":{"recommendedName":{"fullName":{"value":"Endoribonuclease Dicer"},"ecNumbers":[{"value":"3.1.26.3"}]}},"genes":[{"geneName":{"value":"dicer1"}}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity)"}],"commentType":"FUNCTION"},{"commentType":"CATALYTIC ACTIVITY","reaction":{"name":"Endonucleolytic cleavage to 5'-phosphomonoester.","ecNumber":"3.1.26.3"}},{"commentType":"COFACTOR","cofactors":[{"name":"Mg(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:18420"}},{"name":"Mn(2+)","evidences":[{"evidenceCode":"ECO:0000250"}],"cofactorCrossReference":{"database":"ChEBI","id":"CHEBI:29035"}}],"note":{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Binds 2 magnesium or manganese ions per subunit."}]}},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2; dicer1 and tarbp2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto ago2. Note that the trimeric RLC/miRLC is also referred to as RISC (By similarity)"}],"commentType":"SUBUNIT"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250"}],"value":"Cytoplasm","id":"SL-0086"}}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00657"}],"value":"Belongs to the helicase family. Dicer subfamily"}],"commentType":"SIMILARITY"}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":1865,"modifier":"EXACT"}},"description":"Endoribonuclease Dicer","featureId":"PRO_0000373985"},{"type":"Domain","location":{"start":{"value":41,"modifier":"EXACT"},"end":{"value":213,"modifier":"EXACT"}},"description":"Helicase ATP-binding","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00541"}]},{"type":"Domain","location":{"start":{"value":419,"modifier":"EXACT"},"end":{"value":588,"modifier":"EXACT"}},"description":"Helicase C-terminal","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00542"}]},{"type":"Domain","location":{"start":{"value":616,"modifier":"EXACT"},"end":{"value":708,"modifier":"EXACT"}},"description":"Dicer dsRNA-binding fold","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00657"}]},{"type":"Domain","location":{"start":{"value":881,"modifier":"EXACT"},"end":{"value":1028,"modifier":"EXACT"}},"description":"PAZ","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00142"}]},{"type":"Domain","location":{"start":{"value":1262,"modifier":"EXACT"},"end":{"value":1385,"modifier":"EXACT"}},"description":"RNase III 1","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00177"}]},{"type":"Domain","location":{"start":{"value":1609,"modifier":"EXACT"},"end":{"value":1767,"modifier":"EXACT"}},"description":"RNase III 2","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00177"}]},{"type":"Domain","location":{"start":{"value":1792,"modifier":"EXACT"},"end":{"value":1857,"modifier":"EXACT"}},"description":"DRBM","evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00266"}]},{"type":"Region","location":{"start":{"value":397,"modifier":"EXACT"},"end":{"value":417,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":713,"modifier":"EXACT"},"end":{"value":732,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1142,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1190,"modifier":"EXACT"},"end":{"value":1259,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":1373,"modifier":"EXACT"},"end":{"value":1417,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Motif","location":{"start":{"value":161,"modifier":"EXACT"},"end":{"value":164,"modifier":"EXACT"}},"description":"DECH box"},{"type":"Compositional bias","location":{"start":{"value":400,"modifier":"EXACT"},"end":{"value":411,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1111,"modifier":"EXACT"},"end":{"value":1128,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1192,"modifier":"EXACT"},"end":{"value":1201,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1240,"modifier":"EXACT"},"end":{"value":1252,"modifier":"EXACT"}},"description":"Low complexity","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1374,"modifier":"EXACT"},"end":{"value":1388,"modifier":"EXACT"}},"description":"Basic and acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":1394,"modifier":"EXACT"},"end":{"value":1409,"modifier":"EXACT"}},"description":"Acidic residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Binding site","location":{"start":{"value":54,"modifier":"EXACT"},"end":{"value":61,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:30616"}],"evidences":[{"evidenceCode":"ECO:0000255","source":"PROSITE-ProRule","id":"PRU00541"}],"ligand":{"name":"ATP","id":"ChEBI:CHEBI:30616"}},{"type":"Binding site","location":{"start":{"value":1298,"modifier":"EXACT"},"end":{"value":1298,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":1377,"modifier":"EXACT"},"end":{"value":1377,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":1380,"modifier":"EXACT"},"end":{"value":1380,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"1"}},{"type":"Binding site","location":{"start":{"value":1648,"modifier":"EXACT"},"end":{"value":1648,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":1753,"modifier":"EXACT"},"end":{"value":1753,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Binding site","location":{"start":{"value":1756,"modifier":"EXACT"},"end":{"value":1756,"modifier":"EXACT"}},"description":"","featureCrossReferences":[{"database":"ChEBI","id":"CHEBI:18420"}],"evidences":[{"evidenceCode":"ECO:0000250"}],"ligand":{"name":"Mg(2+)","id":"ChEBI:CHEBI:18420","label":"2"}},{"type":"Site","location":{"start":{"value":1749,"modifier":"EXACT"},"end":{"value":1749,"modifier":"EXACT"}},"description":"Important for activity","evidences":[{"evidenceCode":"ECO:0000250"}]},{"type":"Sequence conflict","location":{"start":{"value":739,"modifier":"EXACT"},"end":{"value":751,"modifier":"EXACT"}},"description":"in Ref. 2; AAQ90464","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"IPECLRGCYPVPE","alternativeSequences":["VK"]}},{"type":"Sequence conflict","location":{"start":{"value":921,"modifier":"EXACT"},"end":{"value":921,"modifier":"EXACT"}},"description":"in Ref. 2; AAQ90464","evidences":[{"evidenceCode":"ECO:0000305"}],"alternativeSequence":{"originalSequence":"R","alternativeSequences":["K"]}}],"keywords":[{"id":"KW-0067","category":"Ligand","name":"ATP-binding"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-0255","category":"Molecular function","name":"Endonuclease"},{"id":"KW-0347","category":"Molecular function","name":"Helicase"},{"id":"KW-0378","category":"Molecular function","name":"Hydrolase"},{"id":"KW-0460","category":"Ligand","name":"Magnesium"},{"id":"KW-0464","category":"Ligand","name":"Manganese"},{"id":"KW-0479","category":"Ligand","name":"Metal-binding"},{"id":"KW-0540","category":"Molecular function","name":"Nuclease"},{"id":"KW-0547","category":"Ligand","name":"Nucleotide-binding"},{"id":"KW-0597","category":"PTM","name":"Phosphoprotein"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"},{"id":"KW-0677","category":"Domain","name":"Repeat"},{"id":"KW-0694","category":"Molecular function","name":"RNA-binding"},{"id":"KW-0943","category":"Biological process","name":"RNA-mediated gene silencing"}],"references":[{"referenceNumber":1,"citation":{"id":"23594743","citationType":"journal article","authors":["Howe K.","Clark M.D.","Torroja C.F.","Torrance J.","Berthelot C.","Muffato M.","Collins J.E.","Humphray S.","McLaren K.","Matthews L.","McLaren S.","Sealy I.","Caccamo M.","Churcher C.","Scott C.","Barrett J.C.","Koch R.","Rauch G.J.","White S.","Chow W.","Kilian B.","Quintais L.T.","Guerra-Assuncao J.A.","Zhou Y.","Gu Y.","Yen J.","Vogel J.H.","Eyre T.","Redmond S.","Banerjee R.","Chi J.","Fu B.","Langley E.","Maguire S.F.","Laird G.K.","Lloyd D.","Kenyon E.","Donaldson S.","Sehra H.","Almeida-King J.","Loveland J.","Trevanion S.","Jones M.","Quail M.","Willey D.","Hunt A.","Burton J.","Sims S.","McLay K.","Plumb B.","Davis J.","Clee C.","Oliver K.","Clark R.","Riddle C.","Elliot D.","Threadgold G.","Harden G.","Ware D.","Begum S.","Mortimore B.","Kerry G.","Heath P.","Phillimore B.","Tracey A.","Corby N.","Dunn M.","Johnson C.","Wood J.","Clark S.","Pelan S.","Griffiths G.","Smith M.","Glithero R.","Howden P.","Barker N.","Lloyd C.","Stevens C.","Harley J.","Holt K.","Panagiotidis G.","Lovell J.","Beasley H.","Henderson C.","Gordon D.","Auger K.","Wright D.","Collins J.","Raisen C.","Dyer L.","Leung K.","Robertson L.","Ambridge K.","Leongamornlert D.","McGuire S.","Gilderthorp R.","Griffiths C.","Manthravadi D.","Nichol S.","Barker G.","Whitehead S.","Kay M.","Brown J.","Murnane C.","Gray E.","Humphries M.","Sycamore N.","Barker D.","Saunders D.","Wallis J.","Babbage A.","Hammond S.","Mashreghi-Mohammadi M.","Barr L.","Martin S.","Wray P.","Ellington A.","Matthews N.","Ellwood M.","Woodmansey R.","Clark G.","Cooper J.","Tromans A.","Grafham D.","Skuce C.","Pandian R.","Andrews R.","Harrison E.","Kimberley A.","Garnett J.","Fosker N.","Hall R.","Garner P.","Kelly D.","Bird C.","Palmer S.","Gehring I.","Berger A.","Dooley C.M.","Ersan-Urun Z.","Eser C.","Geiger H.","Geisler M.","Karotki L.","Kirn A.","Konantz J.","Konantz M.","Oberlander M.","Rudolph-Geiger S.","Teucke M.","Lanz C.","Raddatz G.","Osoegawa K.","Zhu B.","Rapp A.","Widaa S.","Langford C.","Yang F.","Schuster S.C.","Carter N.P.","Harrow J.","Ning Z.","Herrero J.","Searle S.M.","Enright A.","Geisler R.","Plasterk R.H.","Lee C.","Westerfield M.","de Jong P.J.","Zon L.I.","Postlethwait J.H.","Nusslein-Volhard C.","Hubbard T.J.","Roest Crollius H.","Rogers J.","Stemple D.L."],"citationCrossReferences":[{"database":"PubMed","id":"23594743"},{"database":"DOI","id":"10.1038/nature12111"}],"title":"The zebrafish reference genome sequence and its relationship to the human genome.","publicationDate":"2013","journal":"Nature","firstPage":"498","lastPage":"503","volume":"496"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"],"referenceComments":[{"value":"Tuebingen","type":"STRAIN"}]},{"referenceNumber":2,"citation":{"id":"14528306","citationType":"journal article","authors":["Wienholds E.","Koudijs M.J.","van Eeden F.J.M.","Cuppen E.","Plasterk R.H.A."],"citationCrossReferences":[{"database":"PubMed","id":"14528306"},{"database":"DOI","id":"10.1038/ng1251"}],"title":"The microRNA-producing enzyme Dicer1 is essential for zebrafish development.","publicationDate":"2003","journal":"Nat. Genet.","firstPage":"217","lastPage":"218","volume":"35"},"referencePositions":["NUCLEOTIDE SEQUENCE [MRNA] OF 612-1865"]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AL772219","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"AY386319","properties":[{"key":"ProteinId","value":"AAQ90464.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"RefSeq","id":"NP_001154925.2","properties":[{"key":"NucleotideSequenceId","value":"NM_001161453.3"}]},{"database":"RefSeq","id":"XP_005158722.2","properties":[{"key":"NucleotideSequenceId","value":"XM_005158665.6"}]},{"database":"RefSeq","id":"XP_005158723.2","properties":[{"key":"NucleotideSequenceId","value":"XM_005158666.6"}]},{"database":"AlphaFoldDB","id":"Q6TV19","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6TV19","properties":[{"key":"Description","value":"-"}]},{"database":"FunCoup","id":"Q6TV19","properties":[{"key":"Number of interactors","value":"1486"}]},{"database":"STRING","id":"7955.ENSDARP00000045880","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"7955-ENSDARP00000045880","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6TV19","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENSDART00000045881","properties":[{"key":"ProteinId","value":"ENSDARP00000045880"},{"key":"GeneId","value":"ENSDARG00000001129"}]},{"database":"GeneID","id":"324724","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"dre:324724","properties":[{"key":"Description","value":"-"}]},{"database":"AGR","id":"ZFIN:ZDB-GENE-030131-3445","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"23405","properties":[{"key":"Description","value":"-"}]},{"database":"ZFIN","id":"ZDB-GENE-030131-3445","properties":[{"key":"GeneName","value":"dicer1"}]},{"database":"eggNOG","id":"KOG0701","properties":[{"key":"ToxonomicScope","value":"Eukaryota"}]},{"database":"GeneTree","id":"ENSGT00940000156287","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_000907_4_4_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6TV19","properties":[{"key":"Description","value":"-"}]},{"database":"OrthoDB","id":"2392202at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PhylomeDB","id":"Q6TV19","properties":[{"key":"Description","value":"-"}]},{"database":"PRO","id":"PR:Q6TV19","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000000437","properties":[{"key":"Component","value":"Chromosome 17"}]},{"database":"Bgee","id":"ENSDARG00000001129","properties":[{"key":"ExpressionPatterns","value":"Expressed in cardiac ventricle and 26 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6TV19","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0005634","properties":[{"key":"GoTerm","value":"C:nucleus"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0016442","properties":[{"key":"GoTerm","value":"C:RISC complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0070578","properties":[{"key":"GoTerm","value":"C:RISC-loading complex"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005524","properties":[{"key":"GoTerm","value":"F:ATP binding"},{"key":"GoEvidenceType","value":"IEA:InterPro"}]},{"database":"GO","id":"GO:0004530","properties":[{"key":"GoTerm","value":"F:deoxyribonuclease I activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0070883","properties":[{"key":"GoTerm","value":"F:pre-miRNA binding"},{"key":"GoEvidenceType","value":"IDA:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"20448148"}]},{"database":"GO","id":"GO:0004525","properties":[{"key":"GoTerm","value":"F:ribonuclease III activity"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0003723","properties":[{"key":"GoTerm","value":"F:RNA binding"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0006309","properties":[{"key":"GoTerm","value":"P:apoptotic DNA fragmentation"},{"key":"GoEvidenceType","value":"IBA:GO_Central"}]},{"database":"GO","id":"GO:0035196","properties":[{"key":"GoTerm","value":"P:miRNA processing"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"14528306"},{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20448148"}]},{"database":"GO","id":"GO:0035279","properties":[{"key":"GoTerm","value":"P:miRNA-mediated gene silencing by mRNA destabilization"},{"key":"GoEvidenceType","value":"IGI:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000316","source":"PubMed","id":"16484454"}]},{"database":"GO","id":"GO:0035195","properties":[{"key":"GoTerm","value":"P:miRNA-mediated post-transcriptional gene silencing"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"16484454"}]},{"database":"GO","id":"GO:0031054","properties":[{"key":"GoTerm","value":"P:pre-miRNA processing"},{"key":"GoEvidenceType","value":"IDA:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000314","source":"PubMed","id":"31029426"}]},{"database":"GO","id":"GO:0050767","properties":[{"key":"GoTerm","value":"P:regulation of neurogenesis"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"25662174"}]},{"database":"GO","id":"GO:0030422","properties":[{"key":"GoTerm","value":"P:siRNA processing"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0021591","properties":[{"key":"GoTerm","value":"P:ventricular system development"},{"key":"GoEvidenceType","value":"IMP:ZFIN"}],"evidences":[{"evidenceCode":"ECO:0000315","source":"PubMed","id":"20448148"}]},{"database":"CDD","id":"cd18034","properties":[{"key":"EntryName","value":"DEXHc_dicer"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd15903","properties":[{"key":"EntryName","value":"Dicer_PBD"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd10843","properties":[{"key":"EntryName","value":"DSRM_DICER"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd02843","properties":[{"key":"EntryName","value":"PAZ_dicer_like"},{"key":"MatchStatus","value":"1"}]},{"database":"CDD","id":"cd00593","properties":[{"key":"EntryName","value":"RIBOc"},{"key":"MatchStatus","value":"2"}]},{"database":"CDD","id":"cd18802","properties":[{"key":"EntryName","value":"SF2_C_dicer"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1520.10:FF:000023","properties":[{"key":"EntryName","value":"Endoribonuclease dcr-1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000628","properties":[{"key":"EntryName","value":"Endoribonuclease Dicer"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.20:FF:000015","properties":[{"key":"EntryName","value":"endoribonuclease Dicer"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.30.160.380:FF:000002","properties":[{"key":"EntryName","value":"Endoribonuclease Dicer isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"3.40.50.300:FF:000588","properties":[{"key":"EntryName","value":"Endoribonuclease Dicer isoform 1"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"2.170.260.10:FF:000002","properties":[{"key":"EntryName","value":"Putative Endoribonuclease Dicer"},{"key":"MatchStatus","value":"1"}]},{"database":"FunFam","id":"1.10.1520.10:FF:000005","properties":[{"key":"EntryName","value":"Putative endoribonuclease dicer"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.20","properties":[{"key":"EntryName","value":"-"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.30.160.380","properties":[{"key":"EntryName","value":"Dicer dimerisation domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"3.40.50.300","properties":[{"key":"EntryName","value":"P-loop containing nucleotide triphosphate hydrolases"},{"key":"MatchStatus","value":"2"}]},{"database":"Gene3D","id":"2.170.260.10","properties":[{"key":"EntryName","value":"paz domain"},{"key":"MatchStatus","value":"1"}]},{"database":"Gene3D","id":"1.10.1520.10","properties":[{"key":"EntryName","value":"Ribonuclease III domain"},{"key":"MatchStatus","value":"2"}]},{"database":"InterPro","id":"IPR011545","properties":[{"key":"EntryName","value":"DEAD/DEAH_box_helicase_dom"}]},{"database":"InterPro","id":"IPR038248","properties":[{"key":"EntryName","value":"Dicer_dimer_sf"}]},{"database":"InterPro","id":"IPR005034","properties":[{"key":"EntryName","value":"Dicer_dimerisation"}]},{"database":"InterPro","id":"IPR044441","properties":[{"key":"EntryName","value":"DICER_DSRM"}]},{"database":"InterPro","id":"IPR048513","properties":[{"key":"EntryName","value":"Dicer_PBD"}]},{"database":"InterPro","id":"IPR048512","properties":[{"key":"EntryName","value":"Dicer_platform"}]},{"database":"InterPro","id":"IPR014720","properties":[{"key":"EntryName","value":"dsRBD_dom"}]},{"database":"InterPro","id":"IPR014001","properties":[{"key":"EntryName","value":"Helicase_ATP-bd"}]},{"database":"InterPro","id":"IPR001650","properties":[{"key":"EntryName","value":"Helicase_C-like"}]},{"database":"InterPro","id":"IPR027417","properties":[{"key":"EntryName","value":"P-loop_NTPase"}]},{"database":"InterPro","id":"IPR003100","properties":[{"key":"EntryName","value":"PAZ_dom"}]},{"database":"InterPro","id":"IPR036085","properties":[{"key":"EntryName","value":"PAZ_dom_sf"}]},{"database":"InterPro","id":"IPR000999","properties":[{"key":"EntryName","value":"RNase_III_dom"}]},{"database":"InterPro","id":"IPR036389","properties":[{"key":"EntryName","value":"RNase_III_sf"}]},{"database":"PANTHER","id":"PTHR14950","properties":[{"key":"EntryName","value":"DICER-RELATED"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR14950:SF37","properties":[{"key":"EntryName","value":"ENDORIBONUCLEASE DICER"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00270","properties":[{"key":"EntryName","value":"DEAD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF03368","properties":[{"key":"EntryName","value":"Dicer_dimer"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20932","properties":[{"key":"EntryName","value":"Dicer_dsRBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20930","properties":[{"key":"EntryName","value":"Dicer_PBD"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF20931","properties":[{"key":"EntryName","value":"Dicer_platform"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00271","properties":[{"key":"EntryName","value":"Helicase_C"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF02170","properties":[{"key":"EntryName","value":"PAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF00636","properties":[{"key":"EntryName","value":"Ribonuclease_3"},{"key":"MatchStatus","value":"2"}]},{"database":"SMART","id":"SM00487","properties":[{"key":"EntryName","value":"DEXDc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00358","properties":[{"key":"EntryName","value":"DSRM"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00490","properties":[{"key":"EntryName","value":"HELICc"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00949","properties":[{"key":"EntryName","value":"PAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"SMART","id":"SM00535","properties":[{"key":"EntryName","value":"RIBOc"},{"key":"MatchStatus","value":"2"}]},{"database":"SUPFAM","id":"SSF54768","properties":[{"key":"EntryName","value":"dsRNA-binding domain-like"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF52540","properties":[{"key":"EntryName","value":"P-loop containing nucleoside triphosphate hydrolases"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF101690","properties":[{"key":"EntryName","value":"PAZ domain"},{"key":"MatchStatus","value":"1"}]},{"database":"SUPFAM","id":"SSF69065","properties":[{"key":"EntryName","value":"RNase III domain-like"},{"key":"MatchStatus","value":"2"}]},{"database":"PROSITE","id":"PS51327","properties":[{"key":"EntryName","value":"DICER_DSRBF"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50137","properties":[{"key":"EntryName","value":"DS_RBD"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51192","properties":[{"key":"EntryName","value":"HELICASE_ATP_BIND_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS51194","properties":[{"key":"EntryName","value":"HELICASE_CTER"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50821","properties":[{"key":"EntryName","value":"PAZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS00517","properties":[{"key":"EntryName","value":"RNASE_3_1"},{"key":"MatchStatus","value":"1"}]},{"database":"PROSITE","id":"PS50142","properties":[{"key":"EntryName","value":"RNASE_3_2"},{"key":"MatchStatus","value":"2"}]}],"sequence":{"value":"MAGLQLVTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALEHNTIVCLNTGSGKTFIAVLLIKELSHQIRGENGKRTVFLVNAASSVAQQASTVRTHSDLQVGDYMSEDMTSWPEEMWNREMIENQVLVMTCHIFLHVLKNGVLPLSKINLLVFDECHLAITGHPYREIMKICEGCPSCPRILGLTASILNGKCDPCDLEEKIQNLEKILQSNAETATDLVVLDRYASQPREEVLDCGQYQDQSGLSERLLNELDEALNFLNDCNLSVHREDRDPTFISKQVLNDCRAVLTVLGPWCADKAAGIMVRELQKYIKHEQEELNRKFLLFTDTILRKIHALCEEHFSPASLDLKFVTPKVIRLLEILHEYKPFERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEAEAKEKTEANFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHSIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPVSNYIMLADSERTKTFQEDLKTYKAIEKILRNKCSKSAECNDFELEPVTDDDNVLPPYVLRSEDGGPRVTMNTAIGHVNRYCARLPSDPFTHLAPKCKTVEMNTGGYRSTLFLPINSPLRVPVTGPVMNCARLAEKAVALLCCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCSPKAIPECLRGCYPVPEQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPRIPHFPVYTRSGEVTISIELQKSGFSLSAEQLELITRLHQYIFSHILRLEKPALEFKPVEADSAYCVLPLNIVEDSNTLDLDFKFMEDIEKSEARIGIPNTQYTKQNPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLSNVNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRSQTAIDAGVGAQTLPPDFRYPNLDFGWKKSIDSKSFISCPSACMEEDDDHCKLGTSSDSNHTAPESCSMEVSQPPEGAPNTPDEKLETLTLPVTDLNKDCFPNLPNGTQADSDDLPHRSDVCQCSQLGPLERDLSTQTTTSVSVRPSPAGEPQPWPSDECTGRSSDLCDPHVKKPTSKHCPKSETATSTPAPSETSSEDCRSACAGPAWDSPKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSSTDKWDSDENKDLANGKASDDEDEDDDDEPEEAEVEPSKEDVNVEDDLEYYYEHIRFIDSMLIGSGAFGKKISLQPTDPGYEWKAPKKAHNSHFSPDGGADEFDYSSWDAMCYLDPSKAGEEDDFVVGFWNPSEENCGTDIGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPPEKQSSGGSAELQYGWLKIPPRCMFEHPDAERTLNHLISGFLNFESKINYTFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVQNN","length":1865,"molWeight":210817,"crc64":"55B1700E719B2007","md5":"1B004FC278861C85A1A9EC1AD38B6E54"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"CATALYTIC ACTIVITY":1,"COFACTOR":1,"SUBUNIT":1,"SUBCELLULAR LOCATION":1,"SIMILARITY":1},"countByFeatureType":{"Chain":1,"Domain":7,"Region":5,"Motif":1,"Compositional bias":6,"Binding site":7,"Site":1,"Sequence conflict":2},"uniParcId":"UPI0000EB6D59"}}