{"entryType":"UniProtKB reviewed (Swiss-Prot)","primaryAccession":"Q6PI97","secondaryAccessions":["E9PAN0","Q6ZRL3"],"uniProtkbId":"HOATZ_HUMAN","entryAudit":{"firstPublicDate":"2008-04-08","lastAnnotationUpdateDate":"2026-06-10","lastSequenceUpdateDate":"2008-04-08","entryVersion":121,"sequenceVersion":2},"annotationScore":3.0,"organism":{"scientificName":"Homo sapiens","commonName":"Human","taxonId":9606,"lineage":["Eukaryota","Metazoa","Chordata","Craniata","Vertebrata","Euteleostomi","Mammalia","Eutheria","Euarchontoglires","Primates","Haplorrhini","Catarrhini","Hominidae","Homo"]},"proteinExistence":"1: Evidence at protein level","proteinDescription":{"recommendedName":{"fullName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25061"}],"value":"Cilia- and flagella-associated protein HOATZ"}}},"genes":[{"geneName":{"evidences":[{"evidenceCode":"ECO:0000312","source":"HGNC","id":"HGNC:25061"}],"value":"HOATZ"},"synonyms":[{"value":"C11orf88"},{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80Y73"}],"value":"HOATZIN"}]}],"comments":[{"texts":[{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80Y73"}],"value":"Required for motile ciliogenesis and flagellar genesis by mediating the maturation of the glycolytic enzyme ENO4"}],"commentType":"FUNCTION"},{"commentType":"SUBCELLULAR LOCATION","subcellularLocations":[{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80Y73"}],"value":"Cytoplasm","id":"SL-0086"}},{"location":{"evidences":[{"evidenceCode":"ECO:0000250","source":"UniProtKB","id":"Q80Y73"}],"value":"Cell projection, cilium","id":"SL-0066"}}]},{"commentType":"ALTERNATIVE PRODUCTS","events":["Alternative splicing"],"isoforms":[{"name":{"value":"1"},"isoformIds":["Q6PI97-1"],"isoformSequenceStatus":"Displayed"},{"name":{"value":"2"},"isoformIds":["Q6PI97-2"],"sequenceIds":["VSP_032883","VSP_032884"],"isoformSequenceStatus":"Described"},{"name":{"value":"3"},"isoformIds":["Q6PI97-3"],"sequenceIds":["VSP_032883"],"isoformSequenceStatus":"Described"}]},{"texts":[{"evidences":[{"evidenceCode":"ECO:0000305"}],"value":"Belongs to the HOATZ family"}],"commentType":"SIMILARITY"},{"commentType":"SEQUENCE CAUTION","sequenceCautionType":"Erroneous initiation","sequence":"AAH39505.1","note":"Extended N-terminus.","evidences":[{"evidenceCode":"ECO:0000305"}]}],"features":[{"type":"Chain","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Cilia- and flagella-associated protein HOATZ","featureId":"PRO_0000328995"},{"type":"Region","location":{"start":{"value":1,"modifier":"EXACT"},"end":{"value":21,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":52,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Region","location":{"start":{"value":144,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"Disordered","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Compositional bias","location":{"start":{"value":75,"modifier":"EXACT"},"end":{"value":89,"modifier":"EXACT"}},"description":"Polar residues","evidences":[{"evidenceCode":"ECO:0000256","source":"SAM","id":"MobiDB-lite"}]},{"type":"Alternative sequence","location":{"start":{"value":113,"modifier":"EXACT"},"end":{"value":113,"modifier":"EXACT"}},"description":"in isoform 2 and isoform 3","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_032883","alternativeSequence":{"originalSequence":"K","alternativeSequences":["KTRSHSVTQNEVQWHDHGSLQPQLSRIQ"]}},{"type":"Alternative sequence","location":{"start":{"value":151,"modifier":"EXACT"},"end":{"value":169,"modifier":"EXACT"}},"description":"in isoform 2","evidences":[{"evidenceCode":"ECO:0000303","source":"PubMed","id":"14702039"}],"featureId":"VSP_032884","alternativeSequence":{"originalSequence":"KKVVSESDKEDQEEVKTLD","alternativeSequences":["E"]}}],"keywords":[{"id":"KW-0025","category":"Coding sequence diversity","name":"Alternative splicing"},{"id":"KW-0966","category":"Cellular component","name":"Cell projection"},{"id":"KW-0963","category":"Cellular component","name":"Cytoplasm"},{"id":"KW-1267","category":"Technical term","name":"Proteomics identification"},{"id":"KW-1185","category":"Technical term","name":"Reference proteome"}],"references":[{"referenceNumber":1,"citation":{"id":"14702039","citationType":"journal article","authors":["Ota T.","Suzuki Y.","Nishikawa T.","Otsuki T.","Sugiyama T.","Irie R.","Wakamatsu A.","Hayashi K.","Sato H.","Nagai K.","Kimura K.","Makita H.","Sekine M.","Obayashi M.","Nishi T.","Shibahara T.","Tanaka T.","Ishii S.","Yamamoto J.","Saito K.","Kawai Y.","Isono Y.","Nakamura Y.","Nagahari K.","Murakami K.","Yasuda T.","Iwayanagi T.","Wagatsuma M.","Shiratori A.","Sudo H.","Hosoiri T.","Kaku Y.","Kodaira H.","Kondo H.","Sugawara M.","Takahashi M.","Kanda K.","Yokoi T.","Furuya T.","Kikkawa E.","Omura Y.","Abe K.","Kamihara K.","Katsuta N.","Sato K.","Tanikawa M.","Yamazaki M.","Ninomiya K.","Ishibashi T.","Yamashita H.","Murakawa K.","Fujimori K.","Tanai H.","Kimata M.","Watanabe M.","Hiraoka S.","Chiba Y.","Ishida S.","Ono Y.","Takiguchi S.","Watanabe S.","Yosida M.","Hotuta T.","Kusano J.","Kanehori K.","Takahashi-Fujii A.","Hara H.","Tanase T.-O.","Nomura Y.","Togiya S.","Komai F.","Hara R.","Takeuchi K.","Arita M.","Imose N.","Musashino K.","Yuuki H.","Oshima A.","Sasaki N.","Aotsuka S.","Yoshikawa Y.","Matsunawa H.","Ichihara T.","Shiohata N.","Sano S.","Moriya S.","Momiyama H.","Satoh N.","Takami S.","Terashima Y.","Suzuki O.","Nakagawa S.","Senoh A.","Mizoguchi H.","Goto Y.","Shimizu F.","Wakebe H.","Hishigaki H.","Watanabe T.","Sugiyama A.","Takemoto M.","Kawakami B.","Yamazaki M.","Watanabe K.","Kumagai A.","Itakura S.","Fukuzumi Y.","Fujimori Y.","Komiyama M.","Tashiro H.","Tanigami A.","Fujiwara T.","Ono T.","Yamada K.","Fujii Y.","Ozaki K.","Hirao M.","Ohmori Y.","Kawabata A.","Hikiji T.","Kobatake N.","Inagaki H.","Ikema Y.","Okamoto S.","Okitani R.","Kawakami T.","Noguchi S.","Itoh T.","Shigeta K.","Senba T.","Matsumura K.","Nakajima Y.","Mizuno T.","Morinaga M.","Sasaki M.","Togashi T.","Oyama M.","Hata H.","Watanabe M.","Komatsu T.","Mizushima-Sugano J.","Satoh T.","Shirai Y.","Takahashi Y.","Nakagawa K.","Okumura K.","Nagase T.","Nomura N.","Kikuchi H.","Masuho Y.","Yamashita R.","Nakai K.","Yada T.","Nakamura Y.","Ohara O.","Isogai T.","Sugano S."],"citationCrossReferences":[{"database":"PubMed","id":"14702039"},{"database":"DOI","id":"10.1038/ng1285"}],"title":"Complete sequencing and characterization of 21,243 full-length human cDNAs.","publicationDate":"2004","journal":"Nat. Genet.","firstPage":"40","lastPage":"45","volume":"36"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)"],"referenceComments":[{"value":"Testis","type":"TISSUE"}]},{"referenceNumber":2,"citation":{"id":"16554811","citationType":"journal article","authors":["Taylor T.D.","Noguchi H.","Totoki Y.","Toyoda A.","Kuroki Y.","Dewar K.","Lloyd C.","Itoh T.","Takeda T.","Kim D.-W.","She X.","Barlow K.F.","Bloom T.","Bruford E.","Chang J.L.","Cuomo C.A.","Eichler E.","FitzGerald M.G.","Jaffe D.B.","LaButti K.","Nicol R.","Park H.-S.","Seaman C.","Sougnez C.","Yang X.","Zimmer A.R.","Zody M.C.","Birren B.W.","Nusbaum C.","Fujiyama A.","Hattori M.","Rogers J.","Lander E.S.","Sakaki Y."],"citationCrossReferences":[{"database":"PubMed","id":"16554811"},{"database":"DOI","id":"10.1038/nature04632"}],"title":"Human chromosome 11 DNA sequence and analysis including novel gene identification.","publicationDate":"2006","journal":"Nature","firstPage":"497","lastPage":"500","volume":"440"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]"]},{"referenceNumber":3,"citation":{"id":"15489334","citationType":"journal article","authoringGroup":["The MGC Project Team"],"citationCrossReferences":[{"database":"PubMed","id":"15489334"},{"database":"DOI","id":"10.1101/gr.2596504"}],"title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).","publicationDate":"2004","journal":"Genome Res.","firstPage":"2121","lastPage":"2127","volume":"14"},"referencePositions":["NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-169 (ISOFORM 1)"],"referenceComments":[{"value":"Duodenum","type":"TISSUE"}]}],"uniProtKBCrossReferences":[{"database":"EMBL","id":"AK128145","properties":[{"key":"ProteinId","value":"BAC87297.1"},{"key":"Status","value":"-"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"EMBL","id":"AP002008","properties":[{"key":"ProteinId","value":"-"},{"key":"Status","value":"NOT_ANNOTATED_CDS"},{"key":"MoleculeType","value":"Genomic_DNA"}]},{"database":"EMBL","id":"BC039505","properties":[{"key":"ProteinId","value":"AAH39505.1"},{"key":"Status","value":"ALT_INIT"},{"key":"MoleculeType","value":"mRNA"}]},{"database":"CCDS","id":"CCDS41712.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6PI97-3"},{"database":"CCDS","id":"CCDS41713.1","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6PI97-1"},{"database":"RefSeq","id":"NP_001093858.1","properties":[{"key":"NucleotideSequenceId","value":"NM_001100388.2"}],"isoformId":"Q6PI97-1"},{"database":"RefSeq","id":"NP_997313.2","properties":[{"key":"NucleotideSequenceId","value":"NM_207430.2"}],"isoformId":"Q6PI97-3"},{"database":"AlphaFoldDB","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"SMR","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"BioGRID","id":"134462","properties":[{"key":"Interactions","value":"2"}]},{"database":"FunCoup","id":"Q6PI97","properties":[{"key":"Number of interactors","value":"32"}]},{"database":"STRING","id":"9606.ENSP00000333845","properties":[{"key":"Description","value":"-"}]},{"database":"iPTMnet","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"PhosphoSitePlus","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"BioMuta","id":"C11orf88","properties":[{"key":"Description","value":"-"}]},{"database":"DMDM","id":"182705208","properties":[{"key":"Description","value":"-"}]},{"database":"MassIVE","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"PaxDb","id":"9606-ENSP00000333845","properties":[{"key":"Description","value":"-"}]},{"database":"PeptideAtlas","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"19051","properties":[{"key":"Description","value":"-"}]},{"database":"ProteomicsDB","id":"67145","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6PI97-1"},{"database":"ProteomicsDB","id":"67146","properties":[{"key":"Description","value":"-"}],"isoformId":"Q6PI97-2"},{"database":"Antibodypedia","id":"62221","properties":[{"key":"antibodies","value":"2 antibodies from 2 providers"}]},{"database":"DNASU","id":"399949","properties":[{"key":"Description","value":"-"}]},{"database":"Ensembl","id":"ENST00000332814.6","properties":[{"key":"ProteinId","value":"ENSP00000333845.6"},{"key":"GeneId","value":"ENSG00000183644.15"}],"isoformId":"Q6PI97-3"},{"database":"Ensembl","id":"ENST00000375618.9","properties":[{"key":"ProteinId","value":"ENSP00000364768.4"},{"key":"GeneId","value":"ENSG00000183644.15"}],"isoformId":"Q6PI97-1"},{"database":"GeneID","id":"399949","properties":[{"key":"Description","value":"-"}]},{"database":"KEGG","id":"hsa:399949","properties":[{"key":"Description","value":"-"}]},{"database":"MANE-Select","id":"ENST00000375618.9","properties":[{"key":"ProteinId","value":"ENSP00000364768.4"},{"key":"RefSeqNucleotideId","value":"NM_001100388.2"},{"key":"RefSeqProteinId","value":"NP_001093858.1"}]},{"database":"UCSC","id":"uc001pln.5","properties":[{"key":"OrganismName","value":"human"}],"isoformId":"Q6PI97-1"},{"database":"AGR","id":"HGNC:25061","properties":[{"key":"Description","value":"-"}]},{"database":"CTD","id":"399949","properties":[{"key":"Description","value":"-"}]},{"database":"DisGeNET","id":"399949","properties":[{"key":"Description","value":"-"}]},{"database":"GeneCards","id":"HOATZ","properties":[{"key":"Description","value":"-"}]},{"database":"HGNC","id":"HGNC:25061","properties":[{"key":"GeneName","value":"HOATZ"}]},{"database":"HPA","id":"ENSG00000183644","properties":[{"key":"ExpressionPatterns","value":"Group enriched (choroid plexus, fallopian tube)"}]},{"database":"OpenTargets","id":"ENSG00000183644","properties":[{"key":"Description","value":"-"}]},{"database":"VEuPathDB","id":"HostDB:ENSG00000183644","properties":[{"key":"Description","value":"-"}]},{"database":"GeneTree","id":"ENSGT00390000002677","properties":[{"key":"Description","value":"-"}]},{"database":"HOGENOM","id":"CLU_122904_0_0_1","properties":[{"key":"Description","value":"-"}]},{"database":"InParanoid","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"OMA","id":"TVCSERQ","properties":[{"key":"Fingerprint","value":"-"}]},{"database":"OrthoDB","id":"10004365at2759","properties":[{"key":"Description","value":"-"}]},{"database":"PAN-GO","id":"Q6PI97","properties":[{"key":"Number of GO annotations","value":"0 GO annotations based on evolutionary models"}]},{"database":"PhylomeDB","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"PathwayCommons","id":"Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"Agora","id":"ENSG00000183644","properties":[{"key":"NominatedTarget","value":"-"}]},{"database":"BioGRID-ORCS","id":"399949","properties":[{"key":"hits","value":"18 hits in 1109 CRISPR screens"}]},{"database":"ChiTaRS","id":"C11orf88","properties":[{"key":"OrganismName","value":"human"}]},{"database":"GenomeRNAi","id":"399949","properties":[{"key":"Description","value":"-"}]},{"database":"Pharos","id":"Q6PI97","properties":[{"key":"DevelopmentLevel","value":"Tdark"}]},{"database":"PRO","id":"PR:Q6PI97","properties":[{"key":"Description","value":"-"}]},{"database":"Proteomes","id":"UP000005640","properties":[{"key":"Component","value":"Chromosome 11"}]},{"database":"RNAct","id":"Q6PI97","properties":[{"key":"moleculeType","value":"protein"}]},{"database":"Bgee","id":"ENSG00000183644","properties":[{"key":"ExpressionPatterns","value":"Expressed in right uterine tube and 97 other cell types or tissues"}]},{"database":"ExpressionAtlas","id":"Q6PI97","properties":[{"key":"ExpressionPatterns","value":"baseline and differential"}]},{"database":"GO","id":"GO:0005929","properties":[{"key":"GoTerm","value":"C:cilium"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0005737","properties":[{"key":"GoTerm","value":"C:cytoplasm"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0035082","properties":[{"key":"GoTerm","value":"P:axoneme assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0060271","properties":[{"key":"GoTerm","value":"P:cilium assembly"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0030317","properties":[{"key":"GoTerm","value":"P:flagellated sperm motility"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"GO","id":"GO:0007283","properties":[{"key":"GoTerm","value":"P:spermatogenesis"},{"key":"GoEvidenceType","value":"ISS:UniProtKB"}]},{"database":"InterPro","id":"IPR040681","properties":[{"key":"EntryName","value":"HOATZ-like"}]},{"database":"PANTHER","id":"PTHR47231:SF1","properties":[{"key":"EntryName","value":"CILIA- AND FLAGELLA-ASSOCIATED PROTEIN HOATZ"},{"key":"MatchStatus","value":"1"}]},{"database":"PANTHER","id":"PTHR47231","properties":[{"key":"EntryName","value":"UPF0722 PROTEIN C11ORF88"},{"key":"MatchStatus","value":"1"}]},{"database":"Pfam","id":"PF17664","properties":[{"key":"EntryName","value":"HOATZ-like"},{"key":"MatchStatus","value":"1"}]}],"sequence":{"value":"METGPSEEPSGRKESQEMCPPGLLVFAGSSEQDANLAKQFWISASMYPPSESQLVLRRDSSQRLPVARPRRSRGSENSHSSQSFHLASNKNRDIFAEALKIQESEEKVKYLQKAKTREEILQLLRKQREERISKELISLPYKPKAKEHKAKKVVSESDKEDQEEVKTLD","length":169,"molWeight":19340,"crc64":"D52B248E1197299D","md5":"F232B4BAFCE46CED3D78BD16BFD58FAD"},"extraAttributes":{"countByCommentType":{"FUNCTION":1,"SUBCELLULAR LOCATION":1,"ALTERNATIVE PRODUCTS":3,"SIMILARITY":1,"SEQUENCE CAUTION":1},"countByFeatureType":{"Chain":1,"Region":3,"Compositional bias":1,"Alternative sequence":2},"uniParcId":"UPI00001FA33D"}}